Patient-specific computer simulation of chemotherapy treatment in a heterogenous breast tumour. Simulated using a parallel solver of a stochastic, hybrid cellular automata. Background colors indicate oxygen pressure in the tumor tissue while cancer cells are represented by black dots. Please, see this publication and this publication for all details.
Academic interests
Mathematical oncology
Knowledge-driven machine learning
Biostatistics
Computational biology
Systems medicine
Digital twins
Personalized cancer medicine
In silico clinical trial design
We developed a new method called PhenoPop that reliably identifies tumor subpopulations exhibiting differential drug responses, and estimates their drug-sensitivities and frequencies within the bulk. Please, see this publication and this publication for all details.
Junior leader and co-coordinator of GlioMath-Dresden project, TU Dresden, Germany, 2012-2014.
PhD in Mathematical and Computational Biology (Advisors: Prof. MA Herrero and Prof. JM Perez-Pomares ), Department of Applied Mathematics, Complutense University of Madrid, Spain, 2012.
MSc in Physics and Mathematics - Biomathematics, University of Granada, Spain, 2008.
MSc in Mathematical Research - Applied Mathematics, Complutense University of Madrid, Spain, 2007.
Bachelor in Mathematics, University of Málaga, Spain, 2005.
Main Collaborations
Vessela Kristensen , Department of Medical Genetics, Oslo University Hospital, Norway (personalized breast cancer medicine).
Tugba Akman Yildiz , Department of Computer Engineering at the University of Turkish Aeronautical Association, Ankara (optimization of aromatase inhibitor treatment in breast cancer)
My work was featured by the association of Spanish researcher in Norway.
I am extremely grateful for the prestigious funding I got from the Norwegian Cancer Society
Old News
PhD defense of my student Even M Myklebust: Statistical modeling of cell population dynamics for personalized cancer medicine, December 9 at Runde auditorium, Domus Medica, Faculty of Medicine, University of Oslo.
@alvarokohn.bsky.social