Academic interests
My academic trajectory has centered on understanding how immune and vascular mechanisms shape brain function across development, health and disease. My current research focuses on neurovascular and neuroimmune interactions, with particular emphasis on perivascular macrophages, NETosis, vessel-astrocyte crosstalk, brain waste clearance mechanisms, and sleep-dependent vascular dynamics. My work bridges fundamental immunology and translational neuroscience, with relevance to neurovascular disorders such as Alzheimer’s disease and stroke.
Background
I obtained my PhD from Caen University (France), where I investigated the role of tissue-type plasminogen activator (tPA) in innate immunity and characterized T cell responses against N-methyl-D-aspartate (NMDA) receptors in autoimmune encephalitis. I subsequently pursued Postdoctoral research at the BB@C Institute in France, focusing on the long-term neurodevelopmental impact of general anesthesia.
I then joined the University of Oslo as a Postdoctoral Research Associate, working across the GliaLab-Letten Centre (Rune Enger’s group) and the Vascular Pathophysiology Laboratory (Sandip Kanse’s group). My expertise integrates neuroimmunology, vascular biology, and translational neuroscience, with a particular emphasis on neurovascular and neuroimmune mechanisms.
Fellowships
I am the recipient of a Marie Skłodowska-Curie European Postdoctoral Fellowship (Principal Investigator, 2025) and a Nasjonalforeningen for folkehelsen Postdoctoral Fellowship (Principal Investigator, 2024). Previously, I secured competitive regional funding for both my PhD and postdoctoral research projects in France.
Appointments
Postdoctoral Research Associate, University of Oslo, Norway (2025-2029).
Postdoctoral Research Associate, Caen University, France (2022-2024).
Positions held
- Member, International Society for Fibrinolysis & Proteolysis (ISFP&PA) - 2022-2024,
- Examiner, Pharmacy Thesis Committee, Faculty of Pharmacy, Caen University, France - 2023,
- President, OPTIC & Normandy Doc’ (PhD student and young researcher associations), Caen, France - 2019-2021. Led the organization of scientific outreach events for the public and managed an annual operating budget of €5,000,
- Member, Organizing Committee, Doctoral School Days Conference, Caen, France - 2019. Contributed to the organization of a scientific conference with a €10,000 budget.
Publications
2026 - Seillier C*, Bonnet AÉ*, Albadri S, Poirel N, Orliaguet G, Vivien D, Salaün JP. Effects of Repeated Early-life Anesthesia Exposure on Visual System Development in Mice. Anesthesiology. 2026 Mar 1;144(3):634-651. doi: 10.1097/ALN.0000000000005879.
2026 - Picot A, Jacqmarcq C, Seillier C, Martinez de Lizarrondo S, Gauberti M, Talukdar A, Khalin I, Mouriaux C, Mangin P, Goux D, Schmidt P, Vivien D, Bonnard T. Engineered nanoconjugates for simultaneous detection and degradation of stroke-associated microthrombi. Theranostics. 2026. doi: 10.7150/thno.119705.
2025 - Seillier C, Brochard S, Boumediene K, Vivien D, Le Mauff B, Toutirais O, Baugé C. Systemic immune alterations in a murine experimental model of osteoarthritis. BioRxiv 2025.11.22.689773; doi: https://doi.org/10.1101/2025.11.22.689773.
2025 - Brochard S, Vanlaeys A, Taieb M, Richard I, Aury-Landas J, Bernay B, Pontin J, Seillier C, Bon N, Picart B, Pecqueur C, Toutirais O, Vinatier C, Guicheux J, Maubert E, Agin V, Boumediene K, Bauge C. Inhibiting EZH2 Alleviates Osteoarthritis and Pain in an Experimental Murine Model Through Modulating Synovial and Macrophage Inflammation, Axon Guidance, and Osteoclastogenesis. BioRxiv 2025 Jan 22. doi: 10.1101/2025.01.19.633762.
2024 - Lesec L, Serrier J, Seillier C, Bernay B, Regnauld C, Furon J, Leprince J, Lefranc B, Vivien D, Docagne F, Le Mauff B, Toutirais O. Specific and polyfunctional T cell response against N-methyl-D-aspartate receptor in an autoantibody mediated encephalitis model. Biomedicines. 2024 Oct 25;12(11):2458. doi: 10.3390/biomedicines12112458.
2024 - Levard D, Seillier C, Bellemain Sagnard M, Fournier AP, Lemarchand E, Dembech C, Riou G, McDade K, Smith C, McQuaid C, Montagne A, Amann L, Prinz M, Vivien D, Rubio M. Central nervous system-associated macrophages modulate the immune response following stroke in aged mice. Nat Neurosci. 2024 Jul 3. doi: 10.1038/s41593-024-01695-3.
2024 - Seillier C, Lesec L, Hélie P, Marie C, Vivien D, Docagne F, Le Mauff B, Toutirais O. Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation. J Inflamm (Lond). 2024 Feb 14;21(1):4. doi: 10.1186/s12950-024-00375-0.
2023 - Seillier C*, Lesept F*, Toutirais O, Potzeha F, Blanc M, Vivien D. Targeting NMDA Receptors at the Neurovascular Unit: Past and Future Treatments for Central Nervous System Diseases. Int J Mol Sci. 2022 Sep 7;23(18):10336. doi: 10.3390/ijms231810336.
2022 - Seillier C, Hélie P, Petit G, Vivien D, Clemente D, Le Mauff B, Docagne F, Toutirais O. Roles of the tissue-type plasminogen activator in immune response. Cell Immunol. 2022 Jan;371:104451. doi: 10.1016/j.cellimm.2021.104451.
2021 - Hélie P, Camacho-Toledano C, Lesec L, Seillier C, Miralles AJ, Ortega MC, Guérit S, Lebas H, Bardou I, Vila-Del Sol V, Vivien D, Le Mauff B, Clemente D, Docagne F, Toutirais O. Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses. J Neuroinflammation. 2021 Feb 20;18(1):52. doi: 10.1186/s12974-021-02102-5.
2020 - Bosseboeuf A, Seillier C, Mennesson N, Allain-Maillet S, Fourny M, Tallet A, Piver E, Lehours P, Mégraud F, Berthelot L, Harb J, Bigot-Corbel E, Hermouet S. Analysis of the Targets and Glycosylation of Monoclonal IgAs From MGUS and Myeloma Patients. Front Immunol. 2020 May 27;11:854. doi: 10.3389/fimmu.2020.00854.
Published
Feb. 19, 2026 9:46 AM
- Last modified
Mar. 20, 2026 12:07 PM
