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Glial cells

The research group Glial cells was founded by professor Erlend Nagelhus. The group explores functions of astrocytes, the starshaped glial cells, in the healthy brain and in neurological disorders by two-photon laser scanning microscopy.

Bildet er tatt med et 2-foton lasermikroskop og viser en astrocytt med røde utløpere som kontakter en liten blodåre (grønn) i hjernebarken på en mus. Vannkanalene er lokalisert rundt blodårene, i enden av astrocyttutløperne. For å kunne ta bildet måtte selvlysende fargestoffer injiseres i hjernen og blodårene.

Photo: Erlend Nagelhus, UiO.

This minimally invasive technique offers real-time imaging of physiological and pathophysiological processes in the brain of living animals. Through a cranial window we study the activity of neurons and astrocytes, brain waste clearance and cerebral blood flow in awake and sleeping mice.

Understanding neuronal-glial-vascular interactions may provide new treatment strategies for a range of brain disorders with ion and water dyshomeostasis, including migraine, epilepsy and Alzheimer's disease.

 

Published Sep. 18, 2013 12:56 PM - Last modified Jan. 20, 2020 11:37 AM