Frode Norheim

Image of Frode Norheim
Norwegian version of this page
Phone +47 22840206
Room 4114
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 Oslo

Academic interests

I have focused my research on genetic regulation of diet induced metabolic diseases and on the health benefits of exercise physiology. I study how diet and genes impacts chronic diseases such as non-alcoholic fatty liver disease, insulin resistance and obesity. I have recently also become interested in why the genetic regulation of a variety of metabolic disease varies between the sexes.  

Education

2013: PhD in Molecular nutrition in the laboratory of Professor Christian A. Drevon. Faculty of Medicine, Department of Nutrition, University of Oslo, Norway.

2008:  M.Sc: Molecular nutrition. Faculty of Medicine, Department of Nutrition, University of Oslo, Norway.

Employment

2018 - present: Researcher in the laboratory of Associate Professor Knut Tomas Dalen, Faculty of Medicine, Department of Nutrition and The Norwegian Transgenic Centre, University of Oslo, Norway

2015-2018: Postdoctoral fellow in the laboratory of Professor Aldons Jake Lusis, Department of Medicine, Division of Cardiology, University of California, Los Angeles (UCLA), USA

2014-2015: Postdoctoral fellow in the laboratory of Professor Christian A. Drevon. Faculty of Medicine, Department of Nutrition, UiO, Norway

Cooperation

  • Professor Aldons Jake Lusis, Mouse genetics and Non-Alcoholic Fatty Liver Disease (NAFLD), UCLA, USA
  • Professor Andrea Hevener, Molecular mechanisms of Exercise and NAFLD, UCLA, USA
  • Professor Emeritus Christian A. Drevon, Exercise, Hepatic lipids and NAFLD, University of Oslo, Norway
  • Associate Professor Knut Tomas Dalen, Effects of perilipins in metabolic diseases, University of Oslo, Norway

Publications

  • Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas; Refsum, Helga; Jensen, Jørgen; Birkeland, Kåre I. & Drevon, Christian A (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia.  ISSN 0012-186X.  s 1- 14 . doi: 10.1007/s00125-020-05296-0
  • Olsen, Thomas; Øvrebø, Bente; Haj-Yasein, Nadia Nabil; Lee-Ødegård, Sindre; Svendsen, Karianne; Hjorth, Marit; Bastani, Nasser Ezzatkhah; Norheim, Frode; Drevon, Christian A; Refsum, Helga Margaretha & Vinknes, Kathrine (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine.  ISSN 1479-5876. . doi: 10.1186/s12967-020-02288-x Full text in Research Archive.
  • Zhou, Zhenqi; Moore, Timothy M.; Drew, Brian G.; Ribas, Vicent; Wanagat, Jonathan; Civelek, Mete; Segawa, Mayuko; Wolf, Dane M.; Norheim, Frode; Seldin, Marcus M.; Strumwasser, Alexander R.; Whitney, Kate; Lester, Ellen; Reddish, Britany R.; Vergnes, Laurent; Reue, Karen; Rajbhandari, Prashant; Tontonoz, Peter; Lee, Jason; Mahata, Sushil K.; Hewitt, Sylvia C.; Shirihai, Orian; Gastonbury, Craig; Small, Kerrin S.; Laakso, Markku; Jensen, Jørgen; Lee, Sindre; Drevon, Christian A; Korach, Kenneth S.; Lusis, Aldons J. & Hevener, Andrea L. (2020). Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine.  ISSN 1946-6234.  12 . doi: 10.1126/SCITRANSLMED.AAX8096 Show summary
  • Lee-Ødegård, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight. Diabetologia.  ISSN 0012-186X.  62(6), s 1048- 1064 . doi: 10.1007/s00125-019-4866-5 Full text in Research Archive.
  • Norheim, Frode; Hasin-Brumshtein, Yehudit; Vergnes, Laurent; Chella Krishnan, Karthickeyan; Pan, Calvin; Seldin, Marcus M.; Hui, Simon T.; Mehrabian, Margarete; Zhou, Zhiqiang; Gupta, Sonul; Parks, Brian W.; Walch, Axel; Reue, Karen; Hofmann, Susanna M.; Arnold, Arthur P. & Lusis, Aldons J. (2019). Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell Metabolism.  ISSN 1550-4131.  29(4), s 932- 949.e4 . doi: 10.1016/j.cmet.2018.12.013
  • Lee-Ødegård, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael; Gundersen, Thomas Erik; Holen, Torgeir; Birkeland, Kåre I. & Drevon, Christian A (2018). Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports.  ISSN 2045-2322.  8:6531, s 1- 12 . doi: 10.1038/s41598-018-24976-x Full text in Research Archive.
  • Moore, Timothy M.; Zhou, Zhenqi; Cohn, Whitaker; Norheim, Frode; Lin, Amanda J.; Kalajian, Nareg; Strumwasser, Alexander R.; Cory, Kevin; Whitney, Kate; Ho, Theodore; Ho, Timothy; Lee, Joseph L.; Rucker, Daniel H.; Shirihai, Orian; van der Bliek, Alexander M.; Whitelegge, Julian P.; Seldin, Marcus M.; Lusis, Aldons J.; Lee-Ødegård, Sindre; Drevon, Christian A; Mahata, Sushil K.; Turcotte, Lorraine P. & Hevener, Andrea L. (2018). The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Molecular Metabolism.  ISSN 2212-8778.  21, s 51- 67 . doi: 10.1016/j.molmet.2018.11.012 Full text in Research Archive.
  • Norheim, Frode; Bjellaas, Thomas; Hui, Simon T; Chella Krishnan, Karthickeyan; Lee, Jakleen; Gupta, Sonul; Pan, Calvin; Hasin-Brumshtein, Yehudit; Parks, Brian W; Li, Daniel; Bui, Hai H.; Mosier, Marian; Wu, Yuping; Huertas-Vazquez, Adriana; Hazen, Stanley L.; Gundersen, Thomas E; Mehrabian, Margarete; Tang, Wilson; Hevener, Andrea L; Drevon, Christian A & Lusis, Aldons J (2018). Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance. Journal of Lipid Research.  ISSN 0022-2275.  59(7), s 1164- 1174 . doi: 10.1194/jlr.M081398
  • Seldin, Marcus M.; Koplev, Simon; Rajbhandari, Prashant; Vergnes, Laurent; Rosenberg, Gregory M; Meng, Yonghong; Pan, Calvin; Phuong, Thuy M.N.; Gharakhanian, Raffi; Che, Nam; Mäkinen, Selina; Shih, Diana M.; Civelek, Mete; Parks, Brian W.; Kim, Eric D.; Norheim, Frode; Chella Krishnan, Karthickeyan; Hasin-Brumshtein, Yehudit; Mehrabian, Margarete; Laakso, Markku; Drevon, Christian A; Koistinen, Heikki A.; Tontonoz, Peter; Reue, Karen; Cantor, Rita M.; Björkegren, Johan L.M. & Lusis, Aldons J. (2018). A strategy for discovery of endocrine interactions with application to whole-body metabolism. Cell Metabolism.  ISSN 1550-4131.  27(5), s 1138- 1155.e6 . doi: 10.1016/j.cmet.2018.03.015
  • Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Holen, Torgeir; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports.  ISSN 2051-817X.  5(5) . doi: 10.14814/phy2.13183 Full text in Research Archive. Show summary
  • Norheim, Frode; Hui, Simon T; Kulahcioglu, Emre; Mehrabian, Margarete; Cantor, Rita M; Pan, Calvin; Parks, Brian W & Lusis, Aldons J (2017). Genetic and hormonal Control of hepatic steatosis in female and male mice. Journal of Lipid Research.  ISSN 0022-2275.  s 178- 187 . doi: 10.1194/jlr.M071522 Full text in Research Archive.
  • Görgens, Sven W.; Hjorth, Marit; Eckardt, Kristin; Wichert, Stefan; Norheim, Frode; Holen, Torgeir; Lee, Sindre; Langleite, Torgrim Mikal; Birkeland, Kåre I.; Stadheim, Hans Kristian; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Kolnes, Anders J.; Jensen, Jørgen; Drevon, Christian A & Eckel, Jürgen (2016). The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation. Acta Physiologica.  ISSN 1748-1708.  216(3), s 330- 345 . doi: 10.1111/apha.12579 Show summary
  • Hjorth, Marit; Pourteymour, Shirin; Goergens, S W; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A & Norheim, Frode (2016). Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells. Acta Physiologica.  ISSN 1748-1708.  217(1), s 45- 60 . doi: 10.1111/apha.12631
  • Holen, Torgeir; Norheim, Frode; Gundersen, Thomas Erik; Mitry, Patricia; Linseisen, Jakob; Iversen, Per Ole & Drevon, Christian A (2016). Biomarkers for nutrient intake with focus on alternative sampling techniques. Genes & Nutrition.  ISSN 1555-8932.  11:12 . doi: 10.1186/s12263-016-0527-1
  • Langleite, Torgrim Mikal; Jensen, Jørgen; Norheim, Frode; Gulseth, Hanne Løvdal; Tangen, Daniel S.; Kolnes, Kristoffer Jensen; Heck, Ansgar; Storås, Tryggve; Lie, Guro Grøthe; Dahl, Marius; Kielland, Anders; Holen, Torgeir; NORENG, HANS JØRGEN; Stadheim, Hans Kristian; Bjørnerud, Atle; Johansen, Egil Ivar; Nellemann, Birgitte; Birkeland, Kåre I. & Drevon, Christian A (2016). Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  122(4), s 167- 179 . doi: 10.1080/13813455.2016.1202985
  • Lee, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; NORENG, HANS JØRGEN; Storås, Tryggve; Afman, Lydia A.; Frost, Gary; Bell, Jimmy D.; Thomas, E. Louise; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A & Holen, Torgeir (2016). Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging. Physiological Reports.  ISSN 2051-817X.  4(21) . doi: 10.14814/phy2.13019 Show summary
  • Albrecht, Elke; Norheim, Frode; Thiede, Bernd; Holen, Torgeir; Ohashi, Tomoo; Schering, Lisa; Lee, Sindre; Brenmoehl, Julia; Thomas, Selina; Drevon, Christian A; Erickson, Harold P & Maak, Steffen (2015). Irisin - A myth rather than an exercise-inducible myokine. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep08889
  • Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I.; Martinov, Vladimir Nikolkaev; Langleite, Torgrim Mikal; Eckardt, Kristin; Drevon, Christian A & Kolset, Svein Olav (2015). The effect of acute and long-term physical activity on extracelluar Matrix and serglycin in huuman skeletal muscle. Physiological Reports.  ISSN 2051-817X.  3:e12473(8), s 1- 19 . doi: 10.14814/phy2.12473
  • Hui, Simon T; Parks, Brian W; Org, Elin; Norheim, Frode; Che, Nam; Pan, Calvin; Castellani, Lawrence W; Charugundla, Sarada; Dirks, Darwin L; Psychogios, Nikolaos; Neuhaus, Isaac; Gerszten, Robert E; Kirchgessner, Todd; Gargalovic, Peter S & Lusis, Aldons J (2015). The genetic architecture of NAFLD among inbred strains of mice. eLIFE.  ISSN 2050-084X.  4(2015) . doi: 10.7554/eLife.05607 Full text in Research Archive.
  • Parks, Brian W; Sallam, Tamer; Mehrabian, Margarete; Psychogios, Nikolas; Hui, Simon T; Norheim, Frode; Castellani, Lawrence W; Rau, Christoph D; Pan, Calvin; Phun, Jennifer; Zhou, Zhenqi; Yang, Wen-Pin; Neuhaus, Isaac; Gargalovic, Peter S; Kirchgessner, Todd G; Graham, Mark; Lee, Richard; Tontonoz, Peter; Gerszten, Robert E; Hevener, Andrea L & Lusis, Aldons J (2015). Genetic architecture of insulin resistance in the mouse. Cell Metabolism.  ISSN 1550-4131.  21(2), s 334- 346 . doi: 10.1016/j.cmet.2015.01.002
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit; Bindesbøll, Christian; Dalen, Knut Tomas; Birkeland, Kåre I.; Drevon, Christian A; Holen, Torgeir & Norheim, Frode (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports.  ISSN 2051-817X.  3:e12481(8), s 1- 15 . doi: 10.14814/phy2.12481
  • Li, Yuchuan; Lee, Sindre; Langleite, Torgrim Mikal; Norheim, Frode; Pourteymour, Shirin; Jensen, Jørgen; Stadheim, Hans Kristian; Storås, Tryggve; Davanger, Svend; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Drevon, Christian A & Holen, Torgeir (2014). Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention. Physiological Reports.  ISSN 2051-817X.  2(11) . doi: 10.14814/phy2.12187
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas & Drevon, Christian A (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports.  ISSN 2051-817X.  2(8) . doi: 10.14814/phy2.12109
  • Norheim, Frode; Langleite, Torgrim Mikal; Hjorth, Marit; Holen, Torgeir; Kielland, Anders; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2014). The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal.  ISSN 1742-464X.  281(3), s 739- 749 . doi: 10.1111/febs.12619 Show summary
  • Hanssen, Knut Egil; Kvamme, Nils Helge; Nilsen, Tormod Skogstad; Rønnestad, Bent; Ambjørnsen, Inger Karine; Norheim, Frode; Kadi, Fawzi; Hallén, Jostein; Drevon, Christian A & Raastad, Truls (2013). The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  23(6), s 728- 739 . doi: 10.1111/j.1600-0838.2012.01452.x
  • Parks, Brian W.; Nam, Elizabeth; Org, Elin; Kostem, Emrah; Norheim, Frode; Hui, Simon T.; Pan, Calvin; Civelek, Mete; Rau, Christoph D.; Bennett, Brian J.; Mehrabian, Margarete; Ursell, Luke K.; He, Aiqing; Castellani, Lawrence W.; Zinker, Bradley; Kirby, Mark; Drake, Thomas A.; Drevon, Christian A; Knight, Rob; Gargalovic, Peter; Kirchgessner, Todd; Eskin, Eleazar & Lusis, Aldons J. (2013). Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice. Cell Metabolism.  ISSN 1550-4131.  17(1), s 141- 152 . doi: 10.1016/j.cmet.2012.12.007
  • Raschke, Silja; Elsen, Manuela; Gassenhuber, Hans; Sommerfeld, Mark; Schwahn, Uwe; Brockmann, Barbara; Jung, Raphael; Wisløff, Ulrik; Tjønna, Arnt Erik; Raastad, Truls; Hallén, Jostein; Norheim, Frode; Drevon, Christian A; Romacho, Tania; Eckardt, Kristin & Eckel, Juergen (2013). Evidence against a Beneficial Effect of Irisin in Humans. PLOS ONE.  ISSN 1932-6203.  8(9) . doi: 10.1371/journal.pone.0073680 Full text in Research Archive. Show summary
  • Gjelstad, Ingrid Merethe Fange; Haugen, Fred; Gulseth, Hanne Løvdal; Norheim, Frode; Jans, Annike; Bakke, Siril Skaret; Raastad, Truls; Tjønna, Arnt Erik; Wisløff, Ulrik; Blaak, Ellen E.; Riserus, Ulf; Gaster, Michael; Roche, Helen M.; Birkeland, Kåre I. & Drevon, Christian A (2012). Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance. Archives of Physiology and Biochemistry.  ISSN 1381-3455.  118(1), s 22- 30 . doi: 10.3109/13813455.2011.630009
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild & Drevon, Christian A (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients.  ISSN 2072-6643.  4(12), s 1898- 1944 . doi: 10.3390/nu4121898 Show summary
  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Rustan, Arild; Drevon, Christian A & Haugen, Fred (2011). Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  301(5), s E1013- E1021 . doi: 10.1152/ajpendo.00326.2011
  • Haugen, Fred; Norheim, Frode; Lian, Henrik; Wensaas, Andreas Johansen; Dueland, Svein; Berg, Ole; Funderud, Ane; Skålhegg, Bjørn Steen; Raastad, Truls & Drevon, Christian A (2010). IL-7 is expressed and secreted by human skeletal muscle cells. American Journal of Physiology - Cell Physiology.  ISSN 0363-6143.  298(4), s C807- C816 . doi: 10.1152/ajpcell.00094.2009 Show summary

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  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Drevon, Christian A & Haugen, Fred (2010). The human skeletal muscle secretome - identification of the most abundantly secreted proteins in vitro and their regulation in response to training in vivo. Cardiovascular Research (CVR).  ISSN 0008-6363.  87, s S120- S120
  • Gjelstad, Ingrid Merethe Fange; Norheim, Frode; Raastad, Truls; Birkeland, Kåre I. & Drevon, Christian A (2009). Change in expression levels of lipid droplet coat protein in human skeletal muscle during strength training. Diabetologia.  ISSN 0012-186X.  52, s S270- S270

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Published Apr. 13, 2011 2:40 PM - Last modified June 22, 2020 2:11 PM

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