Frode Amador Norheim

Associate Professor - Nutritional Molecular Biology
Image of Frode Amador Norheim
Norwegian version of this page
Phone +47 22840206
Mobile phone +4799621742
Room 2202
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 Oslo
Other affiliations Institutt for pedagogikk (Student)

Academic interests

Associate Professor in Molecular Nutrition.

I have focused my research on genetic regulation of diet induced metabolic diseases and on the health benefits of exercise physiology. I study how diet and genes impacts chronic diseases such as non-alcoholic fatty liver disease, insulin resistance and obesity. I have recently also become interested in why the genetic regulation of a variety of metabolic disease varies between the sexes.  


2013: PhD in Molecular nutrition in the laboratory of Professor Christian A. Drevon. Faculty of Medicine, Department of Nutrition, University of Oslo, Norway.

2008:  M.Sc: Molecular nutrition. Faculty of Medicine, Department of Nutrition, University of Oslo, Norway.


MED1100 (termin 1)

MED2200/ERN2200 (termin 1)




2021 - present: Associate professor in molecular nutrition, Faculty of Medicine, Department of Nutrition and The Norwegian Transgenic Centre, University of Oslo, Norway

2018 - 2021: Researcher in the laboratory of Associate Professor Knut Tomas Dalen, Faculty of Medicine, Department of Nutrition and The Norwegian Transgenic Centre, University of Oslo, Norway

2015-2018: Postdoctoral fellow in the laboratory of Professor Aldons Jake Lusis, Department of Medicine, Division of Cardiology, University of California, Los Angeles (UCLA), USA

2014-2015: Postdoctoral fellow in the laboratory of Professor Christian A. Drevon. Faculty of Medicine, Department of Nutrition, UiO, Norway


  • Professor Aldons Jake Lusis, Mouse genetics and Non-Alcoholic Fatty Liver Disease (NAFLD), UCLA, USA
  • Professor Andrea Hevener, Molecular mechanisms of Exercise and NAFLD, UCLA, USA
  • Professor Emeritus Christian A. Drevon, Exercise, Hepatic lipids and NAFLD, University of Oslo, Norway
  • Associate Professor Knut Tomas Dalen, Effects of perilipins in metabolic diseases, University of Oslo, Norway


  • Lee-Ødegård, Sindre; Olsen, Thomas; Norheim, Frode Amador; Drevon, Christian A. & Birkeland, Kåre Inge (2022). Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance. Metabolites. ISSN 2218-1989. doi: 10.3390/metabo12030208.
  • Maak, Steffen; Norheim, Frode Amador; Drevon, Christian A & Erickson, Harold P (2021). Progress and Challenges in the Biology of FNDC5 and Irisin. Endocrine reviews. ISSN 0163-769X. 42(4), p. 436–456. doi: 10.1210/endrev/bnab003. Full text in Research Archive
  • Aalberg, Karoline; Stavem, Knut; Norheim, Frode Amador; Russell, Michael Bjørn & Chaibi, Aleksander (2021). Effect of oral and transdermal oestrogen therapy on bone mineral density in functional hypothalamic amenorrhoea: A systematic review and meta-analysis. BMJ Open sport & exercise medicine. ISSN 2055-7647. 7(3). doi: 10.1136/bmjsem-2021-001112. Full text in Research Archive
  • Norheim, Frode Amador; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin & Parks, Brian W. [Show all 18 contributors for this article] (2021). Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Molecular Systems Biology. ISSN 1744-4292. 17. doi: 10.15252/msb.20209684. Full text in Research Archive
  • Tingstad, Ragna Husby; Norheim, Frode Amador; Haugen, Fred; Feng, Yuan Zeng; Tunsjø, Hege & Thoresen, G. Hege [Show all 9 contributors for this article] (2021). The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-03730-w. Full text in Research Archive
  • Doncheva, Atanaska Ivanova; Norheim, Frode Amador; Hjorth, Marit; Grujic, Mirjana; Paivandy, Aida & Dankel, Simon N [Show all 14 contributors for this article] (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. Journal of Immunology. ISSN 0022-1767. 208(1), p. 121–132. doi: 10.4049/jimmunol.2100231.
  • Moore, Timothy M.; Terrazas, Anthony; Strumwasser, Alexander R.; Lin, Amanda J.; Zhu, Xiaopeng & Anand, Akshay T. S. [Show all 13 contributors for this article] (2021). Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice. Physiological Reports. ISSN 2051-817X. 9(21). doi: 10.14814/phy2.15068.
  • Li, Yuchuan; Khanal, Prabhat; Norheim, Frode; Hjorth, Marit; Bjellaas, Thomas & Drevon, Christian A [Show all 9 contributors for this article] (2021). Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex. Journal of Lipid Research. ISSN 0022-2275. 62. doi: 10.1016/J.JLR.2021.100048. Full text in Research Archive
  • Li, Yuchuan; Torp, May-Kristin; Norheim, Frode; Khanal, Prabhat; Kimmel, Alan R. & Stensløkken, Kåre-Olav [Show all 8 contributors for this article] (2020). Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1866(4). doi: 10.1016/j.bbalip.2020.158873. Full text in Research Archive
  • Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas & Refsum, Helga [Show all 9 contributors for this article] (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia. ISSN 0012-186X. 64, p. 410–423. doi: 10.1007/s00125-020-05296-0. Full text in Research Archive
  • Zhou, Zhenqi; Moore, Timothy M.; Drew, Brian G.; Ribas, Vicent; Wanagat, Jonathan & Civelek, Mete [Show all 31 contributors for this article] (2020). Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine. ISSN 1946-6234. 12(555). doi: 10.1126/SCITRANSLMED.AAX8096. Full text in Research Archive
  • Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne & Hjorth, Marit [Show all 11 contributors for this article] (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine. ISSN 1479-5876. 18(122). doi: 10.1186/s12967-020-02288-x. Full text in Research Archive
  • Norheim, Frode; Hasin-Brumshtein, Yehudit; Vergnes, Laurent; Chella Krishnan, Karthickeyan; Pan, Calvin & Seldin, Marcus M. [Show all 16 contributors for this article] (2019). Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell Metabolism. ISSN 1550-4131. 29(4), p. 932–949.e4. doi: 10.1016/j.cmet.2018.12.013.
  • Lee-Ødegård, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight. Diabetologia. ISSN 0012-186X. 62(6), p. 1048–1064. doi: 10.1007/s00125-019-4866-5. Full text in Research Archive
  • Moore, Timothy M.; Zhou, Zhenqi; Cohn, Whitaker; Norheim, Frode; Lin, Amanda J. & Kalajian, Nareg [Show all 23 contributors for this article] (2018). The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Molecular Metabolism. ISSN 2212-8778. 21, p. 51–67. doi: 10.1016/j.molmet.2018.11.012. Full text in Research Archive
  • Seldin, Marcus M.; Koplev, Simon; Rajbhandari, Prashant; Vergnes, Laurent; Rosenberg, Gregory M & Meng, Yonghong [Show all 27 contributors for this article] (2018). A strategy for discovery of endocrine interactions with application to whole-body metabolism. Cell Metabolism. ISSN 1550-4131. 27(5), p. 1138–1155.e6. doi: 10.1016/j.cmet.2018.03.015.
  • Lee-Ødegård, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael & Gundersen, Thomas Erik [Show all 9 contributors for this article] (2018). Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports. ISSN 2045-2322. 8:6531, p. 1–12. doi: 10.1038/s41598-018-24976-x. Full text in Research Archive
  • Norheim, Frode; Bjellaas, Thomas; Hui, Simon T; Chella Krishnan, Karthickeyan; Lee, Jakleen & Gupta, Sonul [Show all 21 contributors for this article] (2018). Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance. Journal of Lipid Research. ISSN 0022-2275. 59(7), p. 1164–1174. doi: 10.1194/jlr.M081398.
  • Norheim, Frode; Hui, Simon T; Kulahcioglu, Emre; Mehrabian, Margarete; Cantor, Rita M & Pan, Calvin [Show all 8 contributors for this article] (2017). Genetic and hormonal Control of hepatic steatosis in female and male mice. Journal of Lipid Research. ISSN 0022-2275. p. 178–187. doi: 10.1194/jlr.M071522. Full text in Research Archive
  • Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Show all 12 contributors for this article] (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5). doi: 10.14814/phy2.13183. Full text in Research Archive
  • Lee, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; NORENG, HANS JØRGEN; Storås, Tryggve & Afman, Lydia A. [Show all 18 contributors for this article] (2016). Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging. Physiological Reports. ISSN 2051-817X. 4(21). doi: 10.14814/phy2.13019.
  • Langleite, Torgrim Mikal; Jensen, Jørgen; Norheim, Frode; Gulseth, Hanne Løvdal; Tangen, Daniel S. & Kolnes, Kristoffer Jensen [Show all 19 contributors for this article] (2016). Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men. Archives of Physiology and Biochemistry. ISSN 1381-3455. 122(4), p. 167–179. doi: 10.1080/13813455.2016.1202985.
  • Holen, Torgeir; Norheim, Frode; Gundersen, Thomas Erik; Mitry, Patricia; Linseisen, Jakob & Iversen, Per Ole [Show all 7 contributors for this article] (2016). Biomarkers for nutrient intake with focus on alternative sampling techniques. Genes & Nutrition. ISSN 1555-8932. 11:12. doi: 10.1186/s12263-016-0527-1.
  • Hjorth, Marit; Pourteymour, Shirin; Goergens, S W; Langleite, Torgrim Mikal; Lee, Sindre & Holen, Torgeir [Show all 11 contributors for this article] (2016). Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells. Acta Physiologica. ISSN 1748-1708. 217(1), p. 45–60. doi: 10.1111/apha.12631.
  • Görgens, Sven W.; Hjorth, Marit; Eckardt, Kristin; Wichert, Stefan; Norheim, Frode & Holen, Torgeir [Show all 16 contributors for this article] (2016). The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation. Acta Physiologica. ISSN 1748-1708. 216(3), p. 330–345. doi: 10.1111/apha.12579.
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit & Bindesbøll, Christian [Show all 11 contributors for this article] (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports. ISSN 2051-817X. 3:e12481(8), p. 1–15. doi: 10.14814/phy2.12481.
  • Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre & Holen, Torgeir [Show all 13 contributors for this article] (2015). The effect of acute and long-term physical activity on extracelluar Matrix and serglycin in huuman skeletal muscle. Physiological Reports. ISSN 2051-817X. 3:e12473(8), p. 1–19. doi: 10.14814/phy2.12473.
  • Hui, Simon T; Parks, Brian W; Org, Elin; Norheim, Frode; Che, Nam & Pan, Calvin [Show all 15 contributors for this article] (2015). The genetic architecture of NAFLD among inbred strains of mice. eLIFE. ISSN 2050-084X. 4(2015). doi: 10.7554/eLife.05607. Full text in Research Archive
  • Parks, Brian W; Sallam, Tamer; Mehrabian, Margarete; Psychogios, Nikolas; Hui, Simon T & Norheim, Frode [Show all 21 contributors for this article] (2015). Genetic architecture of insulin resistance in the mouse. Cell Metabolism. ISSN 1550-4131. 21(2), p. 334–346. doi: 10.1016/j.cmet.2015.01.002.
  • Albrecht, Elke; Norheim, Frode; Thiede, Bernd; Holen, Torgeir; Ohashi, Tomoo & Schering, Lisa [Show all 12 contributors for this article] (2015). Irisin - A myth rather than an exercise-inducible myokine. Scientific Reports. ISSN 2045-2322. 5. doi: 10.1038/srep08889.
  • Li, Yuchuan; Lee, Sindre; Langleite, Torgrim Mikal; Norheim, Frode; Pourteymour, Shirin & Jensen, Jørgen [Show all 13 contributors for this article] (2014). Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention. Physiological Reports. ISSN 2051-817X. 2(11). doi: 10.14814/phy2.12187.
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir & Bindesbøll, Christian [Show all 13 contributors for this article] (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports. ISSN 2051-817X. 2(8). doi: 10.14814/phy2.12109.
  • Norheim, Frode; Langleite, Torgrim Mikal; Hjorth, Marit; Holen, Torgeir; Kielland, Anders & Stadheim, Hans Kristian [Show all 10 contributors for this article] (2014). The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal. ISSN 1742-464X. 281(3), p. 739–749. doi: 10.1111/febs.12619.
  • Hanssen, Knut Egil; Kvamme, Nils Helge; Nilsen, Tormod Skogstad; Rønnestad, Bent; Ambjørnsen, Inger Karine & Norheim, Frode [Show all 10 contributors for this article] (2013). The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 23(6), p. 728–739. doi: 10.1111/j.1600-0838.2012.01452.x.
  • Raschke, Silja; Elsen, Manuela; Gassenhuber, Hans; Sommerfeld, Mark; Schwahn, Uwe & Brockmann, Barbara [Show all 16 contributors for this article] (2013). Evidence against a Beneficial Effect of Irisin in Humans. PLOS ONE. ISSN 1932-6203. 8(9). doi: 10.1371/journal.pone.0073680. Full text in Research Archive
  • Parks, Brian W.; Nam, Elizabeth; Org, Elin; Kostem, Emrah; Norheim, Frode & Hui, Simon T. [Show all 23 contributors for this article] (2013). Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice. Cell Metabolism. ISSN 1550-4131. 17(1), p. 141–152. doi: 10.1016/j.cmet.2012.12.007.
  • Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal & Holen, Torgeir [Show all 12 contributors for this article] (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients. ISSN 2072-6643. 4(12), p. 1898–1944. doi: 10.3390/nu4121898.
  • Gjelstad, Ingrid Merethe Fange; Haugen, Fred; Gulseth, Hanne Løvdal; Norheim, Frode; Jans, Annike & Bakke, Siril Skaret [Show all 15 contributors for this article] (2012). Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance. Archives of Physiology and Biochemistry. ISSN 1381-3455. 118(1), p. 22–30. doi: 10.3109/13813455.2011.630009.
  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Rustan, Arild; Drevon, Christian A & Haugen, Fred (2011). Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. American Journal of Physiology. Endocrinology and Metabolism. ISSN 0193-1849. 301(5), p. E1013–E1021. doi: 10.1152/ajpendo.00326.2011.
  • Haugen, Fred; Norheim, Frode; Lian, Henrik; Wensaas, Andreas Johansen; Dueland, Svein & Berg, Ole [Show all 10 contributors for this article] (2010). IL-7 is expressed and secreted by human skeletal muscle cells. American Journal of Physiology - Cell Physiology. ISSN 0363-6143. 298(4), p. C807–C816. doi: 10.1152/ajpcell.00094.2009.

View all works in Cristin

  • Norheim, Frode; Raastad, Truls; Thiede, Bernd; Drevon, Christian A & Haugen, Fred (2010). The human skeletal muscle secretome - identification of the most abundantly secreted proteins in vitro and their regulation in response to training in vivo. Cardiovascular Research (CVR). ISSN 0008-6363. 87, p. S120–S120.
  • Gjelstad, Ingrid Merethe Fange; Norheim, Frode; Raastad, Truls; Birkeland, Kåre I. & Drevon, Christian A (2009). Change in expression levels of lipid droplet coat protein in human skeletal muscle during strength training. Diabetologia. ISSN 0012-186X. 52, p. S270–S270.

View all works in Cristin

Published Apr. 13, 2011 2:40 PM - Last modified Mar. 22, 2022 1:43 PM