Our focus is to understand the role of intracellular lipid droplets and how alterations in these may lead to various lipid-mediated diseases.
Many of the common life-threatening diseases in the Norwegian population are linked to disturbances in lipid metabolism. A central component in these various pathogenic conditions is marked changes in lipid droplet number, size and/or distribution. The contribution of disturbances in lipid droplet metabolism to altered lipid storage and disease development is currently poorly investigated.
The lipid droplet group focuses on understanding the molecular regulation of lipid droplet formation and degradation. Our primary interests are 1) map transcriptional factors regulating expression of key proteins important for lipid droplet synthesis and degradation, 2) understand the biological role proteins found bound to the lipid droplet surface using animal models, 3) identify components interacting at the lipid droplet surface and explore the use of such interactions as potential new targets to treat lipid mediated diseases.