Andreas Lossius

Associate Professor - Division of Anatomy
Image of Andreas Lossius
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo
Other affiliations Department of Education (Student)

Academic interests

Our research group aim to do high quality research in the field of neuroimmunology, combining molecular biology, proteomics and cellular biology. The main focus is on multiple sclerosis (MS) and the dysregulated immune responses in blood and the cerebrospinal fluid. We have previously used high-throughput sequencing to chart the T- and B-cell receptor repertoires in blood and the cerebrospinal fluid of MS patients in great detail. Current projects are focusing on the pathogenic mechanisms of the B-cell response in the cerebrospinal fluid, and how to explain the perpetuating synthesis of oligoclonal immunoglobulin G, visualized as oligoclonal bands on isoelectric focusing gels.

Education

  • PhD in Medicine, University of Oslo, 2014
  • MD, Faculty of Medicine, University of Oslo, 2005

Curriculum vitae (CV)

Publications

  • Høglund, Rune Alexander; Torsetnes, Silje Bøen; Lossius, Peter Andreas Vold; Bogen, Bjarne; Homan, E. Jane; Bremel, Robert & Holmøy, Trygve (2019). Human cysteine cathepsins degrade immunoglobulin G in vitro in a predictable manner. International Journal of Molecular Sciences.  ISSN 1422-0067.  20:4843(19), s 1- 19 . doi: 10.3390/ijms20194843 Full text in Research Archive.
  • Myhr, Kjell-Morten; Torkildsen, Øivind; Lossius, Peter Andreas Vold; Bø, Lars & Holmøy, Trygve (2019). B cell depletion in the treatment of multiple sclerosis. Expert Opinion on Biological Therapy.  ISSN 1471-2598.  19(3), s 261- 271 . doi: 10.1080/14712598.2019.1568407
  • Tomescu-Baciu, Alina; Johansen, Jorunn; Holmøy, Trygve; Greiff, Victor; Stensland, Maria; De Souza, Gustavo Antonio; Vartdal, Frode & Lossius, Peter Andreas Vold (2019). Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  333:576966, s 1- 7 . doi: 10.1016/j.jneuroim.2019.576966 Full text in Research Archive. Show summary
  • Høglund, Rune Alexander; Polak, Justyna; Vartdal, Frode; Holmøy, Trygve & Lossius, Peter Andreas Vold (2018). B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate. Multiple Sclerosis and Related Disorders.  ISSN 2211-0348.  26, s 90- 95 . doi: 10.1016/j.msard.2018.08.032 Full text in Research Archive.
  • Tomescu-Baciu, Alina; Vartdal, Frode; Holmøy, Trygve; Vedeler, Christian A. & Lossius, Peter Andreas Vold (2018). G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis. Annals of clinical and translational neurology.  ISSN 2328-9503.  5(10), s 1303- 1309 . doi: 10.1002/acn3.642 Full text in Research Archive.
  • Høglund, Rune Alexander; Lossius, Peter Andreas Vold; Johansen, Jorunn; Homan, Jane; Saltyte Benth, Jurate; Robins, Harlan; Bogen, Bjarne; Bremel, Robert D & Holmøy, Trygve (2017). In silico prediction analysis of idiotope-driven T-B cell collaboration in multiple sclerosis. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01255 Full text in Research Archive.
  • Lossius, Peter Andreas Vold; Tomescu-Baciu, Alina; Holmøy, Trygve; Vedeler, Christian A.; Røsjø, Egil Rørvik; Lorentzen, Åslaug Rudjord; Casetta, Ilaria & Vartdal, Frode (2017). Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis. Annals of clinical and translational neurology.  ISSN 2328-9503.  4(10), s 756- 761 . doi: 10.1002/acn3.451 Full text in Research Archive.
  • Røsjø, Egil Rørvik; Lossius, Peter Andreas Vold; Abdelmagid, Nada; Lindstrøm, Jonas Christoffer; Kampman, Margitta Theodora; Jørgensen, Lone; Sundström, Peter; Olsson, Tomas; Steffensen, Linn Hofsøy; Torkildsen, Øivind & Holmøy, Trygve (2017). Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis. Multiple Sclerosis.  ISSN 1352-4585.  23(3), s 395- 402 . doi: 10.1177/1352458516654310
  • Lossius, Peter Andreas Vold; Johansen, Jorunn; Vartdal, Frode & Holmøy, Trygve (2016). High-throughput sequencing of immune repertoires in multiple sclerosis. Annals of clinical and translational neurology.  ISSN 2328-9503.  3(4), s 295- 306 . doi: 10.1002/acn3.295 Full text in Research Archive.
  • Johansen, Jorunn; Vartdal, Frode; Desmarais, Cindy; Tutturen, Astrid Elisabeth Voorham; De Souza, Gustavo Antonio; Lossius, Peter Andreas Vold & Holmøy, Trygve (2015). Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome. Clinical Immunology.  ISSN 1521-6616.  160(2), s 211- 225 . doi: 10.1016/j.clim.2015.06.001
  • Løken-Amsrud, Kristin Ingeleiv; Lossius, Peter Andreas Vold; Torkildsen, Øivind & Holmøy, Trygve (2015). Miljøets betydning ved multippel sklerose. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  135(9), s 856- 860 . doi: 10.4045/tidsskr.14.0751
  • Wesnes, Kristin; Riise, Trond; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Holmøy, Trygve; Kampman, Margitta Theodora; Landtblom, Anne Marie; Lauer, Klaus; Lossius, Peter Andreas Vold; Magalhaes, Sandra; Pekmezovic, Tatjana; Bjørnevik, Kjetil Lauvland; Wolfson, Christina; Pugliatti, Maura & Myhr, Kjell-Morten (2015). Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study. Multiple Sclerosis.  ISSN 1352-4585.  21(4), s 388- 395 . doi: 10.1177/1352458514546785
  • Bjørnevik, Kjetil Lauvland; Riise, Trond; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Holmøy, Trygve; Kampman, Margitta Theodora; Landtblom, Anne-Marie; Lauer, Klaus; Lossius, Peter Andreas Vold; Magalhaes, Sandra; Myhr, Kjell-Morten; Pekmezovic, Tatjana; Wesnes, Kristin; Wolfson, Christina & Pugliatti, Maura (2014). Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study. Multiple Sclerosis.  ISSN 1352-4585.  20(8), s 1042- 1049 . doi: 10.1177/1352458513513968
  • Lossius, Peter Andreas Vold; Johansen, Jorunn; Vartdal, Frode; Robins, Harlan; Saltyte Benth, Jurate; Holmøy, Trygve & Olweus, Johanna (2014). High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells. European Journal of Immunology.  ISSN 0014-2980.  44(11), s 3439- 3452 . doi: 10.1002/eji.201444662
  • Lossius, Peter Andreas Vold; Riise, Trond; Pugliatti, Maura; Bjørnevik, Kjetil Lauvland; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Kampman, Margitta Theodora; Landtblom, Anne Marie; Lauer, Klaus; Magalhaes, Sandra; Myhr, Kjell-Morten; Pekmezovic, Tatjana; Wesnes, Kristin; Wolfson, Christina & Holmøy, Trygve (2014). Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study. Multiple Sclerosis.  ISSN 1352-4585.  20(6), s 669- 674 . doi: 10.1177/1352458513505693
  • Holmøy, Trygve; Lossius, Peter Andreas Vold; Gundersen, Thomas Erik; Moen, Stine Marit; Castellazzi, Massimilano; Fainardi, Enrico & Casetta, Ilaria (2012). Intrathecal levels of vitamin D and IgG in multiple sclerosis. Acta Neurologica Scandinavica.  ISSN 0001-6314.  125(6), s e28- e31 . doi: 10.1111/j.1600-0404.2011.01577.x
  • Vold, Lossius Peter Andreas; Johansen, Jorunn; Torkildsen, Øivind; Vartdal, Frode & Holmøy, Trygve (2012). Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation. Viruses.  ISSN 1999-4915.  4(12), s 3701- 3730 . doi: 10.3390/v4123701
  • Lossius, Peter Andreas Vold; Vartdal, Frode & Holmøy, Trygve (2011). Vitamin D sensitive EBNA-1 specific T cells in the cerebrospinal fluid of patients with multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  240, s 87- 96 . doi: 10.1016/j.jneuroim.2011.09.011

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Published Jan. 7, 2020 9:21 AM - Last modified Feb. 19, 2020 10:00 PM

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