shreeshu

• Uchai, Shreeshti; Andersen, Lene Frost; Thoresen, Magne; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2024). Does the association between adiposity measures and pre-frailty among older adults vary by social position? Findings from the Tromsø study 2015/2016. BMC Public Health. 24(1). doi: 10.1186/s12889-024-18939-3. Full text in Research Archive Show summary

  Introduction - Pre-frailty provides an ideal opportunity to prevent physical frailty and promote healthy ageing. Excess adiposity has been associated with an increased risk of pre-frailty, but limited studies have explored whether the association between adiposity measures and pre-frailty varies by social position.<p> <p>Methods - We used data from the seventh survey of the Tromsø Study (Tromsø7) conducted in 2015–2016. Our primary sample consisted of 2,945 women and 2,794 men aged ≥ 65 years. Pre-frailty was defined as the presence of one or two of the five frailty components: low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity. Adiposity was defined by body mass index (BMI), waist circumference (WC), fat mass index (FMI) and visceral adipose tissue (VAT) mass. Education and subjective social position were used as measures of social position. Poisson regression with robust variance was used to assess the association between adiposity measures and pre-frailty, and the interaction term between adiposity measures and social position measures were utilised to explore whether the association varied by social position.<p> <p>Results - In our sample, 28.7% of women and 25.5% of men were pre-frail. We found sub-multiplicative interaction of BMI-defined obesity with education in women and subjective social position in men with respect to development of pre-frailty. No other adiposity measures showed significant variation by education or subjective social position. Regardless of the levels of education or subjective social position, participants with excess adiposity (high BMI, high WC, high FMI and high VAT mass) had a higher risk of pre-frailty compared to those with low adiposity.<p> <p>Conclusion - We consistently observed that women and men with excess adiposity had a greater risk of pre-frailty than those with low adiposity, with only slight variation by social position. These results emphasize the importance of preventing excess adiposity to promote healthy ageing and prevent frailty among all older adults across social strata.

• Uchai, Shreeshti; Andersen, Lene Frost; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2023). Body mass index, waist circumference and pre-frailty/frailty: the Tromsø study 1994−2016. BMJ Open. 13:e065707(2), p. 1–11. doi: 10.1136/bmjopen-2022-065707. Full text in Research Archive Show summary

  Objective This study investigated the association between obesity, assessed using body mass index (BMI) and waist circumference (WC), and pre-frailty/frailty among older adults over 21 years of follow-up. <p>Design Prospective cohort study. <p>Setting Population-based study among communitydwelling adults in Tromsø municipality, Norway. <p>Participants 2340women and 2169 men aged ≥45 years attending the Tromsø study in 1994–1995 (Tromsø4) and 2015–2016 (Tromsø7), with additional BMI and WC measurements in 2001 (Tromsø5) and 2007–2008 (Tromsø6). <p>Primary outcome measure Physical frailty was defined as the presence of three or more and pre-frailty as the presence of one to two of the five frailty components suggested by Fried et al: low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity. <p>Results Participants with baseline obesity (adjusted OR 2.41, 95% CI 1.93 to 3.02), assessed by BMI, were more likely to be pre-frail/frail than those with normal BMI. Participants with high (OR 2.14, 95%CI 1.59 to 2.87) or moderately high (OR 1.57, 95%CI 1.21 to 2.03) baseline WC were more likely to be pre-frail/frail than those with normal WC. Those at baseline with normal BMI but moderately high/high WC or overweight with normal WC had no significantly increased odds for pre-frailty/frailty. However, those with both obesity and moderately high/ high WC had increased odds of pre-frailty/frailty. Higher odds of pre-frailty/frailty were observed among those in ‘overweight to obesity’ or ‘increasing obesity’ trajectories than those with stable normal BMI. Compared with participants in a stable normal WC trajectory, those with high WC throughout follow-up were more likely to be prefrail/frail. <p>Conclusion Both general and abdominal obesity, especially over time during adulthood, is associated with an increased risk of pre-frailty/frailty in later years. Thus maintaining normal BMI and WC throughout adult life is important.

• Uchai, Shreeshti; Andersen, Lene Frost; Johansson, Jonas; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2023). Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015. The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 27, p. 403–410. doi: 10.1007/s12603-023-1920-2. Full text in Research Archive Show summary

  Objectives Aging is associated with changes in body composition. Excess adiposity among older adults has been linked with metabolic syndromes and aggravated age-associated decline in physical functioning. Few longitudinal studies have explored the association between dual-energy X-ray absorptiometry (DXA)-derived total as well as central adiposity measures and frailty. We examined the association of DXA-derived total and central adiposity with pre-frailty/frailty among Norwegian adults after 8 years of follow-up. Design Prospective observational study. Setting Community-dwelling adults from Tromsø, Norway. Measurements Adiposity was defined by fat mass index (FMI) and visceral adipose tissue (VAT) mass assessed using DXA measures. Frailty status was assessed by low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity level. Pre-frail and frail participants at baseline were excluded. Sex-stratified multivariable logistic regression models were used to investigate the association. Results Participants comprised 234 women (mean age 68 years) and 146 men (mean age 69 years) attending the population-based Tromsø Study in 2007–2008 (Tromsø6) and 2015–2016 (Tromsø7). At the end of follow-up, 25.6% of the women and 27.4% of the men were pre-frail/frail. Compared with women in the lowest tertiles, those in the highest tertile of baseline FMI (odds ratio [OR] 4.42, 95% confidence interval [CI] 1.88–10.35) and VAT mass (OR 2.47, 95% CI 1.10–5.50), respectively had higher odds for pre-frailty/frailty at follow-up. Conclusion We found a higher likelihood of pre-frailty/frailty in later years among women with general and central adiposity in adulthood, highlighting the importance of preventing excess adiposity for healthy aging.

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• Uchai, Shreeshti; Mamun, Abdullah; Karmacharya, Biraj Man; Dale, Elina; Ames, Heather Melanie R & Rawal, Lal Bahadur [Show all 11 contributors for this article] (2025). Application of EPIS (Exploration, Preparation, Implementation, Sustainment)framework across different phases of IpreventNCD project. Full text in Research Archive
• Uchai, Shreeshti; Andersen, Lene Frost; Johansson, Jonas Lars; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2023). Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015. Full text in Research Archive
• Uchai, Shreeshti; Andersen, Lene Frost; Johansson, Jonas Lars; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2023). Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015. Full text in Research Archive
• Uchai, Shreeshti; Andersen, Lene Frost; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2022). Body Mass Index and Waist Circumference as predictors of Pre-frailty/frailty among older adults (Poster). Full text in Research Archive
• Uchai, Shreeshti; Andersen, Lene Frost; Hopstock, Laila Arnesdatter & Hjartåker, Anette (2021). Body Mass Index and Waist Circumference as predictors of Pre-frailty/frailty among older adults. Full text in Research Archive

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