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Academic interests
I am passionate about studying epigenetics, especially its role in gene expression within cancer and developmental biology, where abnormal regulation can lead to shifts in cell programming. I’m eager to integrate wet-lab and bioinformatics approaches to explore multiomics for understanding epigenome regulation—utilizing WGS with both short- and long-read sequencing, transcription factor analysis, RNA-seq, ChIP-seq, ATAC-seq, and Hi-C sequencing. I’m also interested in investigating how transcription factor mutations and abnormal epigenetic profiles can drive cancer development, using advanced NGS techniques.
Background
I focused on the INO80 chromatin remodeler and its regulation of estrogen receptor (ER) activity in breast cancer models during my Master's degree. My research demonstrated the cooperation and physical interactions between INO80 and ER, enabling dynamic ER regulation in gene expression through RNA-seq, ChIP-seq, and gene knockdown techniques in luminal breast cancer cell lines. Currently, I am working with sarcoma cancer cell lines, where most display a complex genomic structure and regulation of epigenetic aberrations. Using multiomics approaches, I aim to investigate how the interplay of genomic and epigenetic aberrations drives high aggressiveness in osteosarcoma, liposarcoma, and rhabdomyosarcoma.