Chromatin Biology

The chromatin biology group focuses on epigenetic regulation in embryonic stem cells and cancer.

Chromatin Biology Group picture

Back from left: Tasmia Jinnurine, Naima Azouzi, Beata Nadratowska-Wesolowska, Emily Martinsen, Marit Ledsaak, Aruna Abraham and Ankush Sharma

Front row from left: Mari B. Gornitzka, Martin Falck, Ragnhild Eskeland (PI), Martine Mesel, Hallvard A. Wæhler and Marie Rogne

Photo: Gunnar F. Lothe

The main interest in our lab is to understand how gene activity is regulated by local composition (histone modifications and variants), chromatin structure and nuclear organisation. We uniquely combine in vitro and in vivo approaches to study these epigenetic mechanisms during in embryonic stem cell differentiation, in cancer cells and after exposure to drugs.

Figure:  Our aim is to investigate how chromatin organisation is disrupted in the context of genomic variation and epigenetic remodelling in cancer to unravel molecular mechanisms that can form the basis for new novel therapy strategies. (Illustration: Private)

Eskeland is an Associate Professor at Department of Molecular Medicine, in the leader team of PharmaTox strategic research initiative and a partner PI in the Centre for Cancer Cell Reprogramming.

 

Learn more about cancer epigenetics in our new YouTube video.

Our research is funded by:

 

 

Anders Jahre Legat

Nansenfondet og de forbundne fond

MatNatStipend

Wedel Jarlsberg Fond

Published Jan. 18, 2019 7:17 AM - Last modified Oct. 7, 2020 3:13 PM