The chromatin biology group focuses on epigenetic regulation in embryonic stem cells and cancer.
Back from left: Tasmia Jinnurine, Naima Azouzi, Beata Nadratowska-Wesolowska, Emily Martinsen, Marit Ledsaak, Aruna Abraham and Ankush Sharma
Front row from left: Mari B. Gornitzka, Martin Falck, Ragnhild Eskeland (PI), Martine Mesel, Hallvard A. Wæhler and Marie Rogne
Photo: Gunnar F. Lothe
The main interest in our lab is to understand how gene activity is regulated by local composition (histone modifications and variants), chromatin structure and nuclear organisation. We uniquely combine in vitro and in vivo approaches to study these epigenetic mechanisms during in embryonic stem cell differentiation, in cancer cells and after exposure to drugs.
Figure: Our aim is to investigate how chromatin organisation is disrupted in the context of genomic variation and epigenetic remodelling in cancer to unravel molecular mechanisms that can form the basis for new novel therapy strategies. (Illustration: Private)
Learn more about cancer epigenetics in our new YouTube video.
Our research is funded by:
Anders Jahre Legat
Nansenfondet og de forbundne fond
Wedel Jarlsberg Fond