The Letten Centre is a facility for two-photon laser scanning microscopy, a technique that offers real-time brain imaging with micrometer resolution.
Photo: Letten Centre, UiO.
The Centre was established in 2009 after a donation from Letten Fondation to the University of Oslo. The aim of the Centre is to provide insight into mechanisms that govern synapse development and turnover in the healthy and diseased brain.
The Centre hosts GliaLab.
This laboratory is investigating functions of astrocytes, the predominant glial cell type of the central nervous system. Our aim is to resolve roles of astrocytes in the healthy and diseased brain. We are focusing on neuronal-glial-vascular interactions and glial regulation of ion and water homeostasis.
Our principal technology is in vivo two-photon laser scanning microscopy, which offers real-time imaging of physiological and pathophysiological processes in the brain of living animals. Through a cranial window or thinned skull, we study the dynamics of neuronal and glial calcium signaling, metabolism, interstitial fluid movement, and blood flow.