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Glial cells

The group explores roles of astrocytes in neurological disorders by in vivo two-photon laser scanning microscopy.

Bildet er tatt med et 2-foton lasermikroskop og viser en astrocytt med røde utløpere som kontakter en liten blodåre (grønn) i hjernebarken på en mus. Vannkanalene er lokalisert rundt blodårene, i enden av astrocyttutløperne. For å kunne ta bildet måtte selvlysende fargestoffer injiseres i hjernen og blodårene.

Photo: Erlend Nagelhus, UiO.

This minimally invasive technique offers real-time imaging of physiological and pathophysiological processes in the brain of living animals. Through a cranial window or the thinned skull, we study the dynamics of neuronal and glial calcium signalling, cell morphology, metabolism and cerebral blood flow.

Currently, we are using gene knockout strategies to study the roles of glial aquaporins and associated molecules in extracellular volume dynamics, synaptic transmission and signaling at the blood-brain interface. The overall aim is to gain insight into mechanisms by which glia communicate with neurons and the vasculature. Understanding neuronal-glial-vascular interactions may provide new treatment strategies for brain disorders with perturbed circulation and water homeostasis.

Published Sep. 18, 2013 12:56 PM - Last modified Sep. 27, 2018 4:23 PM

Contact

Dept. of Molecular Medicine
Domus Medica
Gaustad
Sognsvannsveien 9
0372 Oslo
 

Group leader

Erlend Nagelhus