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GliaLab

The research group GliaLab explores functions of astrocytes, the starshaped glial cells, in the healthy brain, sleep and in neurological disorders. 

Astrocytes in green and neurons in red in the hippocampus from an awake head-fixed mouse.

Astrocytes in green (GCaMP6f) and neurons in red (jRGECO) in the hippocampus from an awake head-fixed mouse. Image: Rune Enger, UiO.

Our current research focuses on the interaction between glial cells, neurons and the blood vessels in the brain in physiology, in sleep, and in various neurological disorders. Understanding neuronal-glial-vascular interactions may provide new treatment strategies for a range of brain disorders with ion and water dyshomeostasis, including migraine, epilepsy and Alzheimer's disease.

The star-shaped astrocytes from the neocortex of a mouse visualised by the genetically encoded calcium sensor GCaMP6f.
The star-shaped astrocytes from the neocortex of a mouse visualised by the genetically encoded calcium sensor GCaMP6f. Image: Laura Bojarskaite

Our main methods are in vivo and in vitro two-photon microscopy in combination with genetically encoded fluorescent sensors and electrophysiology. Two-photon microscopy offers real-time imaging of physiological and pathophysiological processes in the brain of living animals. Through a cranial window we study the activity of neurons and astrocytes, brain waste clearance and cerebral blood flow in awake and sleeping mice.

 

Published Sep. 18, 2013 12:56 PM - Last modified Jan. 20, 2021 2:09 PM