Rune Enger

Associate Professor - Glia
Image of Rune Enger
Norwegian version of this page
Phone +47 22840261
Username
Visiting address Domus Medica Sognsvannsveien 9 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo
Other affiliations Department of Education (Student)

Academic interests

My research interests are mainly focussed on astrocyte–neuron interplay in the healthy and dysfunctioning brain. Broadly, I'm involved in projects belonging to the following categories:

  • What are the roles of astrocytic Ca2+ signals in the normal brain? Since the discovery that astrocytes can react with and communicate by local or spreading Ca2+ elevations, a range of different mechanisms have been linked to these signals. For instance, such signals have been proposed to influence neuronal network activity by release of transmitter substances in, or close by, synapses. Similarly, astrocytic Ca2+ signals have been proposed to influence vascular tone. Currently, I'm trying to outline the role of astroglial Ca2+ signals in spatial memory encoding and consolidation.
  • What are the mechanisms underlying cortical spreading depression (CSD)? CSD is the phenomenon underlying the perceptual disturbances of the migraine aura, and although first discovered over 70 years ago, key aspects of these events are still unknown. 
  • What are the roles of astrocytic Ca2+ signals in epileptic seizures and chronic epileptic brain tissue?

To answer these questions I work with advanced imaging techniques. Most importantly, two-photon microscopy in awake head-fixed mice, in combination with electrophysiology and molecular strategies.

Teaching

  • Human macroscopic and microscopic anatomy to 1. and 2. year medical students (MED1100 and MED2200).

Background

  • 2019– Associate professor, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2017–2019 10% associate professor, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2016–2019 Postdoctoral researcher, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • Dissertation June 2016.
  • 2013–2016 Ph.d. student, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2011–2013 Medical internship in internal medicine, surgery and as a general practitioner
  • 2004–2011 Cand.med. including the medical student research programme, University of Oslo

Publications

  • Ellingsrud, Ada Johanne; Enger, Rune; Dukefoss, Didrik Bakke; Halnes, Geir; Pettersen, Klas Henning & Rognes, Marie E. (2021). Validating a computational framework for ionic electrodiffusion with cortical spreading depression as a case study. BioRxiv. ISSN 0362-4331. doi: 10.1101/2021.11.29.470301.
  • Heuser, Kjell & Enger, Rune (2021). Astrocytic Ca2+ Signaling in Epilepsy. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 15. doi: 10.3389/fncel.2021.695380.
  • Bjørnstad, Daniel Marelius; Åbjørsbråten, Knut Sindre; Hennestad, Eivind; Cunen, Celine; Hermansen, Gudmund Horn & Bojarskaite, Laura [Show all 9 contributors for this article] (2021). Begonia - a two-photon imaging analysis pipeline for astrocytic Ca2+ signals. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 15, p. 1–12. doi: 10.3389/fncel.2021.681066.
  • Hagen, Espen; Chambers, Anna; Einevoll, Gaute; Pettersen, Klas Henning; Enger, Rune & Stasik, Alexander Johannes (2021). RippleNet: a Recurrent Neural Network for Sharp Wave Ripple (SPW-R) Detection. Neuroinformatics. ISSN 1539-2791. 19, p. 493–514. doi: 10.1007/s12021-020-09496-2. Full text in Research Archive
  • Hagen, Espen; Chambers, Anna; Einevoll, Gaute; Pettersen, Klas Henning; Enger, Rune & Stasik, Alexander Johannes (2020). RippleNet: A Recurrent Neural Network for Sharp Wave Ripple (SPW-R) Detection. bioRxiv - the preprint server for biology. doi: 10.1101/2020.05.11.087874. Full text in Research Archive
  • Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas Henning; Cunen, Celine; Hermansen, Gudmund Horn & Åbjørsbråten, Knut Sindre [Show all 12 contributors for this article] (2020). Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-17062-2. Full text in Research Archive
  • Eide, Per Kristian; Hasan-Olive, Md Mahdi; Hansson, Hans-Arne & Enger, Rune (2020). Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension. Journal of Neuroscience Research. ISSN 0360-4012. p. 1–14. doi: 10.1002/jnr.24743.
  • Hasan-Olive, Md Mahdi; Enger, Rune; Hansson, Hans-Arne; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2019). Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients. Fluids and Barriers of the CNS. ISSN 2045-8118. 16:39, p. 1–16. doi: 10.1186/s12987-019-0160-7. Full text in Research Archive
  • Eilert-Olsen, Martine; Hjukse, Jarand Berg; Thoren, Anna; Tang, Wannan; Enger, Rune & Jensen, Vidar [Show all 8 contributors for this article] (2019). Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions. Glia. ISSN 0894-1491. 67(12), p. 2399–2409. doi: 10.1002/glia.23692. Full text in Research Archive
  • Hasan-Olive, Md Mahdi; Hansson, Hans-Arne; Enger, Rune; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2019). Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension. Journal of Neuropathology and Experimental Neurology. ISSN 0022-3069. 78(9), p. 808–818. doi: 10.1093/jnen/nlz063.
  • Rosic, Brana; Dukefoss, Didrik Bakke; Åbjørsbråten, Knut Sindre; Tang, Wannan; Jensen, Vidar & Ottersen, Ole Petter [Show all 8 contributors for this article] (2019). Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression. Glia. ISSN 0894-1491. 67(6), p. 1113–1121. doi: 10.1002/glia.23604. Full text in Research Archive
  • Heuser, Kjell; Nome, Cecilie; Pettersen, Klas; Åbjørsbråten, Knut Sindre; Jensen, Vidar & Tang, Wannan [Show all 10 contributors for this article] (2018). Ca2+ signals in astrocytes facilitate spread of epileptiform activity. Cerebral Cortex. ISSN 1047-3211. 28(11), p. 4036–4048. doi: 10.1093/cercor/bhy196. Full text in Research Archive
  • Hasan-Olive, Md Mahdi; Enger, Rune; Hansson, Hans-Arne; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2018). Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus. Glia. ISSN 0894-1491. 67, p. 91–100. doi: 10.1002/glia.23528.
  • Enger, Rune (2017). Automated gold particle quantification of immunogold labeled micrographs. Journal of Neuroscience Methods. ISSN 0165-0270. 286, p. 31–37. doi: 10.1016/j.jneumeth.2017.05.018. Full text in Research Archive
  • Eidsvaag, Vigdis Andersen; Enger, Rune; Hansson, Hans-Arne; Eide, Per Kristian & Nagelhus, Erlend Arnulf (2017). Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels. Glia. ISSN 0894-1491. 65(6), p. 964–973. doi: 10.1002/glia.23138. Full text in Research Archive
  • Enger, Rune; Dukefoss, Didrik Bakke; Tang, Wannan; Pettersen, Klas; Bjørnstad, Daniel Marelius & Helm, Paul Johannes [Show all 11 contributors for this article] (2016). Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bhw359.
  • Enger, Rune; Tang, Wannan; Vindedal, Gry Fluge; Jensen, Vidar; Helm, Paul Johannes & Sprengel, Rolf [Show all 8 contributors for this article] (2015). Dynamics of ionic shifts in cortical spreading depression. Cerebral Cortex. ISSN 1047-3211. 25(11), p. 4469–4476. doi: 10.1093/cercor/bhv054.
  • Tang, Wannan; Szokol, Karolina; Jensen, Vidar; Enger, Rune; Trivedi, Chintan A. & Hvalby, Øyvind Christian dødsbo [Show all 10 contributors for this article] (2015). Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. Journal of Neuroscience. ISSN 0270-6474. 35(7), p. 3016–3021. doi: 10.1523/JNEUROSCI.3319-14.2015.
  • Szokol, Karolina; Heuser, Kjell; Tang, Wannan; Jensen, Vidar; Enger, Rune & Bedner, Peter [Show all 10 contributors for this article] (2015). Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 9. doi: 10.3389/fncel.2015.00049. Full text in Research Archive
  • Enger, Rune; Gundersen, Georg Andreas; Haj-Yasein, Nadia Nabil; Eilert-Olsen, Martine; Thoren, Anna & Vindedal, Gry Fluge [Show all 11 contributors for this article] (2012). Molecular scaffolds underpinning macroglial polarization: An analysis of retinal Muller cells and brain astrocytes in mouse. Glia. ISSN 0894-1491. 60(12), p. 2018–2026. doi: 10.1002/glia.22416.
  • Eilert-Olsen, Martine; Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Enger, Rune; Gundersen, Georg Andreas & Hoddevik, Eystein Hellstrøm [Show all 14 contributors for this article] (2012). Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier. Glia. ISSN 0894-1491. 60(3), p. 432–440. doi: 10.1002/glia.22277.
  • Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K & Takano, Takahiro [Show all 17 contributors for this article] (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 108(2), p. 846–851. doi: 10.1073/pnas.1015217108.
  • Nase, Gabriele; Helm, Paul Johannes; Enger, Rune & Ottersen, Ole Petter (2008). Water entry into astrocytes during brain edema formation. Glia. ISSN 0894-1491. 56, p. 895–902. doi: 10.1002/glia.20664.

View all works in Cristin

  • Boccara, Charlotte N; Hu, Hua; Enger, Rune & Bojarskaite, Laura (2020). Hvorfor sover vi?

View all works in Cristin

Published Jan. 29, 2014 1:44 PM - Last modified Jan. 20, 2021 2:24 PM

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