Rune Enger

Associate Professor - Glia
Image of Rune Enger
Norwegian version of this page
Phone +47 22840261
Username
Visiting address Domus Medica Sognsvannsveien 9 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo

Academic interests

My research interests are mainly focussed on astrocyte–neuron interplay in the healthy and dysfunctioning brain. Broadly, I'm involved in projects belonging to the following categories:

  • What are the roles of astrocytic Ca2+ signals in the normal brain? Since the discovery that astrocytes can react with and communicate by local or spreading Ca2+ elevations, a range of different mechanisms have been linked to these signals. For instance, such signals have been proposed to influence neuronal network activity by release of transmitter substances in, or close by, synapses. Similarly, astrocytic Ca2+ signals have been proposed to influence vascular tone. Currently, I'm trying to outline the role of astroglial Ca2+ signals in spatial memory encoding and consolidation.
  • What are the mechanisms underlying cortical spreading depression (CSD)? CSD is the phenomenon underlying the perceptual disturbances of the migraine aura, and although first discovered over 70 years ago, key aspects of these events are still unknown. 
  • What are the roles of astrocytic Ca2+ signals in epileptic seizures and chronic epileptic brain tissue?

To answer these questions I work with advanced imaging techniques. Most importantly, two-photon microscopy in awake head-fixed mice, in combination with electrophysiology and molecular strategies.

Teaching

  • Human macroscopic and microscopic anatomy to 1. and 2. year medical students (MED1100 and MED2200).

Background

  • 2019– Associate professor, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2017–2019 10% associate professor, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2016–2019 Postdoctoral researcher, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • Dissertation June 2016.
  • 2013–2016 Ph.d. student, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2011–2013 Medical internship in internal medicine, surgery and as a general practitioner
  • 2004–2011 Cand.med. including the medical student research programme, University of Oslo
Published Jan. 29, 2014 1:44 PM - Last modified Jan. 20, 2021 2:24 PM

Research groups