Autophagy
Dysfunctional autophagy is linked to several pathophysiological conditions, including cancer and neurodegenerative disorders. The main focus of the “Simonsen Lab” is to characterize of the molecular mechanisms involved in cargo sequestration and autophagosome biogenesis during non-selective and selective types of autophagy with a long-term goal to identify novel targets for diagnosis or treatment of human disease.
The Simonsen Lab 2019 (form left): Matthew Yoke Wui Ng, Chara Charsou, Gunnveig T Bjørndal, Anne Simonsen, Laura Trachsel Moncho, Ana Lapao, Camilla Bergsmark, Kristiane Søreng, Serhiy Pankiv, Laura Rodriguez de la Ballina, Nagham T Asp, Alf Håkon Lystad, Benan John Mathai. Not present: Aleksander Aas. Foto: Sigmund Karlsen.
About the group
Work in our laboratory is currently focused on identification of novel lipid-binding proteins involved in different types of autophagy and elucidation of their function in autophagy and link to disease. To address these challenges, we use a combination of cell biological, biochemical, imaging, genomic and computational approaches, as well as disease-related model systems.
Research Projects
- BEACH proteins (link til ny side)
- Lipid-binding proteins in autophagy
- CANCELL - Centre for Cancer Cell Reprogramming
Our research is funded by
- The University of Oslo
- The Research Council of Norway
- The Norwegian Cancer Society
- H-2020 MSC COFUND and ITN actions