Metabolic regulation of inflammation
Our research group investigates how macronutrient metabolism can be used to regulate inflammation associated with obesity and obesity related comorbidities.
About the group
Positive energy balance by over-eating is associated with obesity, a condition which increases the chances of developing cardio vascular disease (CVD) and type 2 diabetes (T2D) mellitus.
A challenging aspect of obesity is to understand how cellular mechanisms such as abnormal metabolism leads to pathophysiological effects and clinical disease.
Common to morbidity associated with obesity is chronic inflammation and chronically activated and proliferating lymphocytes which consume large amounts of the simple carbohydrate glucose (Gluc) and the amino acid glutamine (Gln). Restriction of Gluc and/or Gln metabolism is incompatible with a proper immune response. Hence, targeting lymphocyte metabolism is an intriguing concept in order to regulate propagation of obesity associated inflammation.
Many inflammatory responses occurs under hypoxic conditions (O2 < 1 %). Cellular metabolism of Gluc and Gln is strongly influenced by oxygen.
Protein kinase A (PKA) which inhibits lymphocyte activation regulates Gluc metabolism in the liver and transcriptional effects by Gln in muscle. Despite this a link between PKA activity, inhibition of lymphocyte proliferation and regulation Gluc and Gln metabolism in these cells has not been established.