Research
Metabolic programs are upstream determinants of T cell outcomes. T cell processes—including activation, proliferation, and memory development—are all driven by metabolic reprogramming, which can be modulated to enhance performance in health and disease. T cells are dysfunctional in conditions of autoimmunity and cancer. Whereas T cells appear hyperactive in patients suffering from autoimmunity, patients with cancer often harbor hypoactive T cells. Our overarching research question is to decipher T cell metabolic programs under conditions of autoimmunity and cancer in order to identify metabolic hot-spots that can be used to target hyper- and hypoactive T cell activity.