The influence of a blood protein, FSAP, on the outcome of stroke in mouse models.
Structure-function studies and protein biochemistry of FSAP.
Characterization of the interaction partners and receptors of FSAP in the circulation and on cells.
Use phage display libraries to identify peptides and nanobodies that modulate FSAP activity.
Interaction of FSAP with neutrophil extracellular traps (NETs), histones, and DNA, and influence on innate immunity.
Brain organoid transplantation in mice to study mechanisms and treatments in stroke.