Anita Göndör

Professor - Department of Clinical Molecular Biology

Norwegian version of this page

Email a.k.gondor@medisin.uio.no

Mobile phone 0046737121603

Username

Visiting address Sykehusveien 25 1474 Nordbyhagen

Postal address Akershus universitetssykehus 1478 Lørenskog

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Academic Interests

Interplay between circadian 3D genome organization and metabolism in complex diseases

Our group combines basic research on 4D genome biology with translational research on circadian medicine. We thus aim at understanding the regulation of circadian transcription within the compartmentalised, 3D architecture of the nucleus and its role in adaptive responses. We moreover aim at uncovering how deregulated circadian genome organization contributes to complex diseases, such as cancer and endocrine-metabolic diseases.

Projects

Molecular mechanisms underlying circadian chromatin transitions in the 3D architecture of the nucleus
Crosstalk between different regulatory layers within the cell, such as metabolism and 3D genome organization, during the circadian cycle
The role of perturbed 3D genome organisation in the emergence of immature and plastic tumor stem-like cell states that drive tumor evolution
Interplay between 3D genome organisation and metabolism in the development of Polycystic Ovarian Syndrome

Group Members

Yan Liu Kaiser, MD, PhD senior researcher, molecular pathologist

Yuri Stephan van Ekelenburg, PhD, postdoc

Funding

Kreftforeningen

UiO

Vacancies

Enquiries about experimental and computational postdoctoral positions are welcome.

Links

Curious about circadian rhythm

1.) Nodewalk assay to quantitate chromatin fiber interactomes in very small cell populations.

Vestlund, Johanna; Sumida, Noriyuki; Mehmood, Rashid; Bhartiya, Deeksha; Wu, Shuangyang & Göndör, Anita Nature Protocols 2022 Nov 25.

2.) Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.

Chachoua, Ilyas; Tzelepis, Ilias; Dai, Hao; Lim, Jia Pei; Lewandowska Ronnegren, Anna; Beccaria Casagrande, Felipe; Wu, Shuangyang; Vestlund, Johanna; Diettrich Mallet de Lima, Carolina; Bhartiya, Deeksha; Scholz A, Barbara; Martino, Mirco; Mehmood, Rashid & Göndör, Anita Nature Communications 2022 Jan.11;13(1).204

3.) WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.

Scholz BA, Sumida N, de Lima CDM, Chachoua I, Martino M, Tzelepis I, et al. Nat. Genet. 2019 12;51(12):1723-1731

4.) Circadian organization of the genome.

Mallet de Lima CD, Göndör A. Science 2018 03;359(6381):1212-1213

5.) Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.

Feinberg AP, Koldobskiy MA, Göndör A. Nat. Rev. Genet. 2016 May;17(5):284-99

6.) PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription.

Zhao H, Sifakis EG, Sumida N, Millán-Ariño L, Scholz BA, Svensson JP, et al. Mol. Cell 2015 Sep;59(6):984-97

Fonseca, Pedro; Cui, Weiyingqi; Struyf, Nona; Tong, Le; Chaurasiya, Ayushi & Casagrande, Felipe [Show all 16 contributors for this article] (2024). A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells. Journal of Experimental & Clinical Cancer Research. ISSN 1756-9966. 43(1). doi: 10.1186/s13046-024-03031-w.
Chachoua, Ilyas; Tzelepis, Ilias; Dai, Hao; Lim, Jia Pei; Lewandowska Ronnegren, Anna & Beccaria Casagrande, Felipe [Show all 14 contributors for this article] (2022). Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site. Nature Communications. ISSN 2041-1723. doi: 10.1038/s41467-021-27868-3.
Vestlund, Johanna; Sumida, Noriyuki; Mehmood, Rashid; Bhartiya, Deeksha; Wu, Shuangyang & Göndör, Anita (2022). The Nodewalk assay to quantitate chromatin fiber interactomes in very small cell populations. Nature Protocols. ISSN 1754-2189. doi: 10.1038/s41596-022-00774-8.

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Published Dec. 14, 2022 2:06 PM - Last modified Nov. 2, 2023 11:13 AM