Anne Flem Jacobsen

• Lahmami, Gulim; Räisänen, Sari; Jacobsen, Anne Flem; Yli, Branislava Markovic; Tingleff, Tiril & Laine, Katariina (2023). Trends in Term Intrapartum Stillbirth in Norway. JAMA Network Open. ISSN 2574-3805. 6(9). doi: 10.1001/jamanetworkopen.2023.34830. Full text in Research Archive
• Berge, Magnus Bollum; Kessler, Jørg; Yli, Branislava Markovic; Staff, Anne Cathrine; Gunnes, Nina & Jacobsen, Anne Flem (2023). Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 102(8), p. 1106–1114. doi: 10.1111/aogs.14597. Full text in Research Archive
• Bistervels, Ingrid M.; Wiegers, Hanke M.G.; Ní Áinle, Fionnuala; Bleker, Suzanne M.; Chauleur, Céline & Donnelly, Jennifer [Show all 15 contributors for this article] (2022). Onset of labor and use of analgesia in women using thromboprophylaxis with 2 doses of low-molecular-weight heparin: insights from the Highlow study. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 21(1), p. 57–67. doi: 10.1016/j.jtha.2022.11.004.
• Waldum, Åsa; Lukasse, Mirjam; Staff, Anne Cathrine; Falk, Ragnhild Sørum; Sørbye, Ingvil & Jacobsen, Anne Flem (2022). Intrapartum pudendal nerve block analgesia and childbirth experience in primiparous women with vaginal birth: A cohort study. Birth. ISSN 0730-7659. p. 1–10. doi: 10.1111/birt.12697. Full text in Research Archive Show summary

  Background A negative childbirth experience has short- and long-term consequences for both mother and child. This study aimed to investigate the association between intrapartum pudendal nerve block (PNB) analgesia and childbirth experience. Methods Primiparous women with a singleton cephalic vaginal live births at term at Oslo University Hospital from January 1, 2017, to June 1, 2019, were eligible for inclusion. The main outcome was total score on a childbirth experience questionnaire (range 1.0–4.0, higher score indicates better childbirth experience). An absolute risk difference of 0.10 was considered clinically relevant. Propensity score matching was used to adjust for differences in baseline characteristics between women with and without PNB. The analyses were stratified by spontaneous vs instrumental birth. Subanalyses of the questionnaire's domains (own capacity, professional support, perceived safety, and participation) were performed. Results Of 979 participating women, mean age was 32 years. Childbirth experience did not differ between women with and without PNB, either in spontaneous (absolute risk difference of the mean: −0.05, P value 0.36) or in instrumental birth (absolute risk difference of the mean: 0.03, P value 0.61). There were no statistically significant differences between PNB group scores for the separate domains. Conclusions Women's childbirth experiences did not differ between birthing people with or without PNB, either in spontaneous or in instrumental births. The clinical implications of our study should be interpreted in light of the pain-relieving effects of PNB.PNB should be provided on clinical indication, including for individuals with severe labor pain.

• Bistervels, Ingrid M; Buchmüller, Andrea; Wiegers, Hanke M G; Ní Áinle, Fionnuala; Tardy, Bernard & Donnelly, Jennifer [Show all 16 contributors for this article] (2022). Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial. The Lancet. ISSN 0140-6736. 400(10365), p. 1777–1787. doi: 10.1016/S0140-6736(22)02128-6. Full text in Research Archive
• Brigtsen, Anne Karin; Jacobsen, Anne Flem; Dedi, Lumnije; Melby, Kjetil K.; Nygaard, Cathrine Skorpen & Fugelseth, Drude [Show all 7 contributors for this article] (2022). Group B Streptococcus colonization at delivery is associated with maternal peripartum infection. PLOS ONE. ISSN 1932-6203. 17(4). doi: 10.1371/journal.pone.0264309. Full text in Research Archive
• Sugulle, Meryam; Halldórsdóttir, Erna; Kvile, Janne; Berntzen, Line Dahlgaard & Jacobsen, Anne Flem (2021). Prospective assessment of vacuum deliveries from midpelvic station in a tertiary care university hospital: Frequency, failure rates, labor characteristics and maternal and neonatal complications. PLOS ONE. ISSN 1932-6203. 16(11), p. 1–12. doi: 10.1371/journal.pone.0259926. Full text in Research Archive
• Jacobsen, Anne Flem & Sandset, Per Morten (2021). Prior Thromboembolic Disease and Assisted Reproductive Therapy. Seminars in Reproductive Medicine. ISSN 1526-8004. doi: 10.1055/s-0041-1732375. Full text in Research Archive
• Waldum, Åsa; Staff, Anne Cathrine; Lukasse, Mirjam; Falk, Ragnhild Sørum; Sørbye, Ingvil & Jacobsen, Anne Flem (2021). Intrapartum pudendal nerve block analgesia and risk of postpartum urinary retention: a cohort study. International Urogynecology Journal. ISSN 0937-3462. 32, p. 2383–2391. doi: 10.1007/s00192-021-04768-0. Full text in Research Archive Show summary

  Introduction and hypothesis: Pudendal nerve block analgesia (PNB) is used as pain relief in the final stage of childbirth. We hypothesized that PNB is associated with higher rates of postpartum urinary retention. Methods: We performed a cohort study among primiparous women with a singleton, cephalic vaginal birth at Oslo University Hospital, Norway. Women receiving PNB were included in the exposed group, while the subsequent woman giving birth without PNB was included in the unexposed group. We compared the likelihood of postpartum urinary retention, defined as catheterization within 3 h after birth. Logistic regression analysis stratified by mode of delivery was performed adjusting for epidural analgesia, episiotomy and birth unit. Results: Of the 1007 included women, 499 were exposed to PNB and 508 were unexposed. In adjusted analyses, women exposed to PNB did not differ in likelihood of postpartum urinary retention compared to women unexposed to PNB in either spontaneous (odds ratio[OR]: 0.82, 95% confidence interval [CI] 0.55–1.22) or instrumental (OR 1.45, 95% CI 0.89–2.39) births. Furthermore, no differences between the groups were observed with excessive residual urine volume or catheterization after > 3 h. Conclusions: PNB was associated with neither risk of postpartum urinary retention nor excessive residual urine volume and is therefore unlikely to hamper future bladder function.

• Berdzuli, Nino; Lomia, Nino; Staff, Anne Cathrine; Lazdane, Gunta; Pestvenidze, Ekaterine & Jacobsen, Anne Flem (2021). Audit of early and late maternal deaths in georgia: Potential for improving substandard obstetric care. International Journal of Women's Health. ISSN 1179-1411. 13, p. 205–219. doi: 10.2147/IJWH.S288763. Full text in Research Archive
• Berdzuli, Nino; Lomia, Nino; Staff, Anne Cathrine; Kereselidze, Maia; Lazdane, Gunta & Jacobsen, Anne Flem (2020). Maternal mortality in Georgia: Incidence, causes and level of underreporting: A national reproductive age mortality study 2014. International Journal of Women's Health. ISSN 1179-1411. 12, p. 277–286. doi: 10.2147/IJWH.S227349. Full text in Research Archive
• Waldum, Åsa; Jacobsen, Anne Flem; Lukasse, Mirjam; Staff, Anne Cathrine; Falk, Ragnhild Sørum & Vangen, Siri [Show all 7 contributors for this article] (2020). The provision of epidural analgesia during labor according to maternal birthplace: a Norwegian register study. BMC Pregnancy and Childbirth. ISSN 1471-2393. 20(321). doi: 10.1186/s12884-020-03021-8. Full text in Research Archive Show summary

  Background: The provision of epidural analgesia during labor is ideally a shared decision between the woman and her health care provider. However, immigrant characteristics such as maternal birthplace could affect decision-making and thus access to pain relief. We aimed to assess disparities in the provision of epidural analgesia in planned vaginal birth according to maternal region of birth. Methods: We performed a nation-wide register study of 842,496 live-born singleton deliveries in Norway between 2000 and 2015. Maternal birthplace was categorized according to the Global Burden of Disease framework. The provision of epidural analgesia was compared in regression models stratified by parity and mode of delivery. Results: Compared to native-born women, primiparous women from Latin America/Caribbean countries with an instrumental vaginal delivery were most likely to be provided epidural analgesia (OR 2.12, 95%CI 1.69–2.66), whilst multiparous women from Sub-Saharan Africa with a spontaneous vaginal delivery were least likely to be provided epidural analgesia (OR 0.42, 95% C 0.39–0.44). Longer residence time was associated with a higher likelihood of being provided analgesia, whereas effects of maternal education varied by Global Burden of Disease group. Conclusions: Disparities in the likelihood of being provided epidural analgesia were observed by maternal birthplace. Further studies are needed to consider whether the identified disparities represent women’s own preferences or if they are the result of heterogeneous access to analgesia during labor.

• Sørbye, Ingvil; Oppegaard, Kevin Sunde; Weeks, Andrew; Marsdal, Kjersti Engen & Jacobsen, Anne Flem (2020). Induction of labor and nulliparity: A nationwide clinical practice pilot evaluation. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 99(12), p. 1700–1709. doi: 10.1111/aogs.13948. Full text in Research Archive
• Lahmami, Gulim; Räisänen, Sari; Jacobsen, Anne Flem; Sole, Kristina Baker; BJARKØ, LISA & Laine, Katariina (2020). Adverse perinatal outcomes in 665,244 term and post-term deliveries—a Norwegian population-based study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. ISSN 0301-2115. 247, p. 212–218. doi: 10.1016/j.ejogrb.2020.02.028.
• Borgen, Iren; Småstuen, Milada Cvancarova; Jacobsen, Anne Flem; Garnweidner-Holme, Lisa; Fayyad, Seraj & Noll, Josef [Show all 7 contributors for this article] (2019). Effect of the Pregnant+ smartphone application in women with gestational diabetes mellitus: A randomised controlled trial in Norway. BMJ Open. ISSN 2044-6055. 9(11). doi: 10.1136/bmjopen-2019-030884. Show summary

  Objective To assess the effect of the Pregnant+ app on the 2-hour glucose level of the routine postpartum oral glucose tolerance test (OGTT) among women with gestational diabetes mellitus (GDM). The Pregnant+ app was designed to provide information about GDM, and promote physical activity and a healthy diet. Design A multicentre, non-blinded randomised controlled trial. Setting Five diabetes outpatient clinics in the Oslo region. Participants Women ≥18 years old with a 2-hour OGTT blood glucose level ≥9 mmol/L who owned a smartphone; understood Norwegian, Urdu or Somali; and were <33 weeks pregnant. A total of 238 women were randomised; 158 women completed the OGTT post partum. Intervention The Pregnant+ app and usual care, the control group received usual care. Primary and secondary outcomes The primary outcome was the 2-hour blood glucose level of the routine postpartum OGTT. Secondary outcomes reported were mode of delivery, induction of labour, Apgar score, birth weight, transfer to the neonatal intensive care unit and breast feeding practice. Blood glucose levels during pregnancy, knowledge of diabetes, diet and physical activity are not reported. Results No difference was found for the 2-hour blood glucose level of the postpartum OGTT, with 6.7 mmol/L (95% CI 6.2 to 7.1) in the intervention group and 6.0 mmol/L (95% CI 5.6 to 6.3) in the control group. The significant difference in the proportion of emergency caesarean sections between the intervention group, 10 (8.8%) and the usual care group, 27 (22.1%), disappeared when adjusted for parity. There were no differences in birth weight, breast feeding practice, obstetric complications or transfer to the intensive neonatal care unit. No adverse events were registered. Conclusion The Pregnant+ app had no effect on 2-hour glucose level at routine postpartum OGTT. After controlling for parity, the difference in emergency caesarean section was not statistically significant.

• Iversen, Johanne Kolvik; Jacobsen, Anne Flem; Mikkelsen, Thea Falkenberg & Eggebø, Torbjørn Moe (2019). Structured clinical examinations in labor: rekindling the craft of obstetrics. Journal of Maternal-Fetal & Neonatal Medicine. ISSN 1476-7058. p. 1–8. doi: 10.1080/14767058.2019.1651283. Full text in Research Archive
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Wik, Hilde Skuterud; Jacobsen, Anne Flem; Mollnes, Tom Eirik & Kanse, Sandip [Show all 7 contributors for this article] (2019). Elevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosis. Thrombosis and Haemostasis. ISSN 0340-6245. 119(9), p. 1481–1488. doi: 10.1055/s-0039-1692426. Full text in Research Archive
• Borgen, Iren; Garnweidner-Holme, Lisa; Jacobsen, Anne Flem; Fayyad, Seraj; Småstuen, Milada Cvancarova & Lukasse, Mirjam (2019). Knowledge of gestational diabetes mellitus at first consultation in a multi-ethnic pregnant population in the Oslo region, Norway - a cross-sectional study. Ethnicity and Health. ISSN 1355-7858. doi: 10.1080/13557858.2019.1655530.
• Olsson, Maja; Stanne, Tara M.; Pedersén, Annie; Lorentzen, Erik; Kara, Emrah & Martinez-Palaciàn, Adoraciòn [Show all 14 contributors for this article] (2018). Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 16(10), p. 2024–2034. doi: 10.1111/jth.14258. Full text in Research Archive
• Turowski, Gitta Erika; Parks, W. Tony; Arbuckle, Susan; Jacobsen, Anne Flem & Heazell, Alexsander (2018). The structure and utility of the placental pathology report. APMIS - Journal of Pathologiy, Microbiology and Immunology. ISSN 0903-4641. 126(7), p. 638–646. doi: 10.1111/apm.12842.
• Nyfløt, Lill Trine; Sandven, Irene; Stray-Pedersen, Babill; Pettersen, Silje; Al-Zirqi, Iqbal Ahmad Abdelwahab & Rosenberg, Margit [Show all 8 contributors for this article] (2017). Risk factors for severe postpartum hemorrhage: A case-control study. BMC Pregnancy and Childbirth. ISSN 1471-2393. 17:17, p. 1–9. doi: 10.1186/s12884-016-1217-0. Full text in Research Archive
• Borgen, Iren; Garnweidner-Holme, Lisa; Jacobsen, Anne Flem; Bjerkan, Kirsti; Fayyad, Seraj & Joranger, Pål [Show all 13 contributors for this article] (2017). Smartphone application for women with gestational diabetes mellitus: a study protocol for a multicentre randomised controlled trial. BMJ Open. ISSN 2044-6055. 7(3). doi: 10.1136/bmjopen-2016-013117. Full text in Research Archive
• Bleker, Suzanne M.; Büchmuller, Andrea; Chauleur, Céline; Áinle, Fionnuala Ni; Donnelly, Jennifer & Verhamme, Peter [Show all 16 contributors for this article] (2016). Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. Thrombosis Research. ISSN 0049-3848. 144, p. 62–68. doi: 10.1016/j.thromres.2016.06.001.
• Tinholt, Mari; Sandset, Per Morten; Mowinckel, Marie-Christine; Garred, Øystein; Sahlberg, Kristine Kleivi & Kristensen, Vessela N. [Show all 10 contributors for this article] (2016). Determinants of acquired activated protein C resistance and D-dimer in breast cancer. Thrombosis Research. ISSN 0049-3848. 145, p. 78–83. doi: 10.1016/j.thromres.2016.08.003.
• Bates, Shannon M.; Alonso-Coello, Pablo; Tikkinen, Kari A.O.; Ebrahim, Shanil; Lopes, Luciane Cruz & McDonald, Sarah D. [Show all 17 contributors for this article] (2016). Women's values and preferences and health state valuations for thromboprophylaxis during pregnancy: A cross-sectional interview study. Thrombosis Research. ISSN 0049-3848. 140, p. 22–29. doi: 10.1016/j.thromres.2015.12.015.
• Garabet, Lamya Samir Noori; Gilboe, Inge-Margrethe; Mowinckel, Marie-Christine; Jacobsen, Anne Flem; Mollnes, Tom Eirik & Sandset, Per Morten [Show all 7 contributors for this article] (2016). Antiphospholipid antibodies are associated with low levels of complement C3 and C4 in patients with systemic Lupus Erythematosus. Scandinavian Journal of Immunology. ISSN 0300-9475. 84(2), p. 95–99. doi: 10.1111/sji.12445.
• Smedberg, Janne; Bråthen, Marie; Waka, Marthe Sætre; Jacobsen, Anne Flem; Gjerdalen, Guri & Nordeng, Hedvig Marie Egeland (2016). Medication use and drug-related problems among women at maternity wards—a cross-sectional study from two Norwegian hospitals. European Journal of Clinical Pharmacology. ISSN 0031-6970. 72(7), p. 849–857. doi: 10.1007/s00228-016-2042-0.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Mowinckel, Marie-Christine & Sandset, Per Morten (2016). The role of inflammation in post-thrombotic syndrome after pregnancy-related deep vein thrombosis: A population-based, cross-sectional study. Thrombosis Research. ISSN 0049-3848. 138, p. 16–21. doi: 10.1016/j.thromres.2015.12.014.
• Eckman, Mark H.; Alonso-Coello, Pablo; Guyatt, Gordon H.; Ebrahim, Shanil; Tikkinen, Kari A.O. & Lopes, Luciane Cruz [Show all 17 contributors for this article] (2015). Women's values and preferences for thromboprophylaxis during pregnancy: A comparison of direct-choice and decision analysis using patient specific utilities. Thrombosis Research. ISSN 0049-3848. 136(2), p. 341–347. doi: 10.1016/j.thromres.2015.05.020.
• Brigtsen, Anne Karin; Jacobsen, Anne Flem; Dedi, Lumnije; Melby, Kjetil K.; Fugelseth, Drude & Whitelaw, Andrew (2015). Maternal colonization with Group B streptococcus is associated with an increased rate of infants transferred to the neonatal intensive care unit. Neonatology. ISSN 1661-7800. 108, p. 157–163. doi: 10.1159/000434716.
• Brigtsen, Anne Karin; Dedi, Lumnije; Melby, Kjetil K.; Holberg-Petersen, Mona; Radtke, Andreas & Lyng, Randi Valsø [Show all 10 contributors for this article] (2015). Comparison of PCR and serotyping of Group B Streptococcus in pregnant women: The Oslo GBS-study. Journal of Microbiological Methods. ISSN 0167-7012. 108, p. 31–35. doi: 10.1016/j.mimet.2014.11.001.
• Mala, Tom; Harsem, Nina Kittelsen; Røstad, Signe; Mathisen, Lene Cecilie & Jacobsen, Anne Flem (2014). Perforation of the Pregnant Uterus during Laparoscopy for Suspected Internal Herniation after Gastric Bypass. Case Reports in Obstetrics and Gynecology. ISSN 2090-6692. 2014. doi: 10.1155/2014/720181.
• Tinholt, Mari; Viken, Marte K; Dahm, Anders Erik A; Vollan, Hans Kristian Moen; Sahlberg, Kristine Kleivi & Garred, Øystein [Show all 16 contributors for this article] (2014). Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study. BMC Cancer. ISSN 1471-2407. 14. doi: 10.1186/1471-2407-14-845.
• Kristiansen, Annette; Brandt, Linn; Agoritsas, Thomas; Akl, Elie A.; Berge, Eivind & Bondi, Johan Fridtjof [Show all 19 contributors for this article] (2014). Adaptation of trustworthy guidelines developed using the GRADE methodology: a novel five-step process. Chest. ISSN 0012-3692. 146(3), p. 727–734. doi: 10.1378/chest.13-2828. Show summary

  BACKGROUND: Adaptation of guidelines for use at the national or local level can facilitate their implementation. We developed and evaluated an adaptation process in adherence with standards for trustworthy guidelines and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, aiming for efficiency and transparency. This article is the first in a series describing our adaptation of Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines for a Norwegian setting. METHODS: Informed by the ADAPTE framework, we developed a five-step adaptation process customized to guidelines developed using GRADE: (1) planning, (2) initial assessment of the recommendations, (3) modification, (4) publication, and (5) evaluation. We developed a taxonomy for describing how and why recommendations from the parent guideline were modified and applied a mixed-methods case study design for evaluation of the process. RESULTS: We published the adapted guideline in November 2013 in a novel multilayered format. The taxonomy for adaptation facilitated transparency of the modification process for both the guideline developers and the end users. We excluded 30 and modified 131 of the 333 original recommendations according to the taxonomy and developed eight new recommendations. Unforeseen obstacles related to acquiring a licensing agreement and procuring a publisher resulted in a 9-month delay. We propose modifications of the adaptation process to overcome these obstacles in the future. CONCLUSIONS: This case study demonstrates the feasibility of a novel guideline adaptation process. Replication is needed to further validate the usefulness of the process in increasing the organizational and methodologic efficiency of guideline adaptation.

• Vangen, Siri; Ellingsen, Liv; Andersgaard, Alice Beathe; Jacobsen, Anne Flem; Lorentzen, Bjørg & Nyfløt, Lill Trine [Show all 10 contributors for this article] (2014). Mødredødsfall i Norge 2005-09. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(8), p. 836–839. doi: 10.4045/tidsskr.13.0203.
• Kristiansen, Annette; Brandt, Linn; Agoritsas, Thomas; Akl, Elie A; Berge, Eivind & Jacobsen, Anne Flem [Show all 10 contributors for this article] (2014). Applying new strategies for the national adaptation, updating and dissemination of trustworthy guidelines: Results from the Norwegian adaptation of the American College of chest physicans evidence-based guidelines on antithrombotic therapy and the prevention of thrombosis, 9th edidion. Chest. ISSN 0012-3692. 146(3), p. 735–761. doi: 10.1378/chest.13-2993. Show summary

  BACKGROUND: The Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (AT9) represent trustworthy international guidelines for antithrombotic treatment and thromboprophylaxis. We describe major changes to the format and content resulting from applying new strategies for guideline adaptation and dissemination. METHODS: A Norwegian guideline panel of 46 experts completed a structured and systematic adaptation process, updated the recommendations based on new evidence, and rewrote the recommendations in an electronic multilayered presentation format. We published the adapted guideline using the web-based Making GRADE the Irresistible Choice Guideline Authoring and Publication Platform. RESULTS: We applied a novel presentation format to 333 recommendations from 11 of the 15 management chapters in AT9 and condensed and restructured them into 249 recommendations in a multilayered format. We added additional relevant information, such as 29 best-practice statements about new oral anticoagulants and practical information sections for 121 recommendations. Common reasons for modifications included feasibility of the recommendations in a national context, disagreement with applied baseline risk estimates, and reevaluation of the balance between the benefits and harms of interventions in relation to assumed typical patient preferences and values. The adapted guideline was published and disseminated online in November 2013. CONCLUSIONS: New strategies for adapting, updating, and disseminating trustworthy guidelines proved feasible and will provide Norwegian health-care professionals and patients with up-to-date guidance tailored to national circumstances.

• HELGADOTTIR, LINDA BJØRK; Turowski, Gitta Erika; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Roald, Borghild [Show all 7 contributors for this article] (2013). Classification of stillbirths and risk factors by cause of death a case-control study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 92(3), p. 325–333. doi: 10.1111/aogs.12044.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Fagerland, Morten; Sandvik, Leiv & Sandset, Per Morten (2013). Long-term mortality and incidence of cancer after pregnancy-related venous thrombosis: Results of a population-based cohort study. Thrombosis Research. ISSN 0049-3848. 131(6), p. 497–501. doi: 10.1016/j.thromres.2013.04.035.
• Jacobsen, Anne Flem & Sandset, Per Morten (2012). Venous thromboembolism associated with pregnancy and hormonal therapy. Baillière's Best Practice & Research: Clinical Haematology. ISSN 1521-6926. 25(3), p. 319–332. doi: 10.1016/j.beha.2012.07.006.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Prevalence and predictors for post-thrombotic syndrome 3 to 16 years after pregnancy-related venous thrombosis: a population-based, cross-sectional, case-control study. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 10(5), p. 840–847. doi: 10.1111/j.1538-7836.2012.04690.x.
• Dahm, Anders Erik A; Bezemer, Irene D; Bergrem, Astrid; Jacobsen, Anne Flem; Jacobsen, Eva-Marie & Skretting, Grethe [Show all 8 contributors for this article] (2012). Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis. British Journal of Haematology. ISSN 0007-1048. 157(6), p. 753–761. doi: 10.1111/j.1365-2141.2012.09121.x.
• HELGADOTTIR, LINDA BJØRK; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Jacobsen, Eva-Marie (2012). The association of antiphospholipid antibodies with intrauterine fetal death: A case-control study. Thrombosis Research. ISSN 0049-3848. 130(1), p. 32–37. doi: 10.1016/j.thromres.2011.11.029.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Long-term impact of pregnancy-related venous thrombosis on quality-of-life, general health and functioning: results of a cross-sectional, case–control study. BMJ Open. ISSN 2044-6055. 2. doi: 10.1136/bmjopen-2012-002048.
• Bergrem, Astrid; Dahm, Anders Erik A; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Differential haemostatic risk factors for pregnancy-related deep-vein thrombosis and pulmonary embolism A population-based case-control study. Thrombosis and Haemostasis. ISSN 0340-6245. 108(6), p. 1165–1171. doi: 10.1160/TH12-05-0350.
• HELGADOTTIR, LINDA BJØRK; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Jacobsen, Eva-Marie (2011). The association of inherited thrombophilia and intrauterine fetal death: a case-control study. Blood Coagulation and Fibrinolysis. ISSN 0957-5235. 22(8), p. 651–656. doi: 10.1097/MBC.0b013e32834a614c.
• Skuterud Wik, Hilde; Enden, Tone Rønnaug; Jacobsen, Anne Flem & Sandset, Per Morten (2011). Long-term quality of life after pregnancy-related deep vein thrombosis and the influence of socioeconomic factors and comorbidity. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 9(10), p. 1931–1936. doi: 10.1111/j.1538-7836.2011.04468.x.
• Bergrem, Astrid; Dahm, Anders Erik A; Jacobsen, Anne Flem; Mowinckel, Marie-Christine; Sandvik, Leiv & Sandset, Per Morten (2011). Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. British Journal of Haematology. ISSN 0007-1048. 154(2), p. 241–247. doi: 10.1111/j.1365-2141.2011.08712.x. Show summary

  Resistance to activated protein C (aPC) is most commonly due to the F5 rs6025 (factor V Leiden) polymorphism, which increases the risk of venous thrombosis. In the present population-based study of 313 cases and 353 controls, we investigated whether reduced sensitivity to aPC was associated with a history of pregnancy-related venous thrombosis. Calibrated automated thrombography was used to determine the sensitivity to aPC, and normalized aPC sensitivity ratio (n-aPC-sr) was calculated. Pregnant women and women using oral contraceptives and/or anticoagulants were excluded due to the effect on the n-aPC-sr. In women without the F5 rs6025 polymorphism, free tissue factor pathway inhibitor (TFPI), free protein S and protein C activity were associated with n-aPC-sr. Unadjusted odds ratio for venous thrombosis for women with n-aPC-sr in the 4th quartile as compared with n-aPC-sr below the 4th quartile was 2·4 (95% confidence interval 1·7-3·6). Adjusting for free protein S, free TFPI and age did not influence the odds ratios. Also in carriers of the F5 rs6025 polymorphism the risk for venous thrombosis was increased for women with higher n-aPC-sr. Our findings substantiate the importance of the aPC resistant phenotype as a risk factor for pregnancy-related venous thrombosis.

• HELGADOTTIR, LINDA BJØRK; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Jacobsen, Eva-Marie (2011). Incidence and risk factors of fetal death in Norway: a case-control study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 90(4), p. 390–397. doi: 10.1111/j.1600-0412.2011.01079.x. Show summary

  Objective. To estimate incidence and risk factors for intrauterine fetal death (IUFD) in a Norwegian study-population applying two different control groups. Design. Case-control study. Setting. Two university hospitals in Oslo, Norway, January 1990 through December 2003. Sample. The cases: 377 women with IUFD. Controls: 1) all women delivering at the study-hospitals in the period (facility-based), and 2) 1 215 women with live births at one study-hospital in the period (selected). Methods. Information from cases and selected controls was collected from medical records. Data on facility-based controls were provided by the Medical Birth Registry of Norway. Data were analyzed using chi-squared test and logistic regression. Main outcome measures. Incidence of IUFD and adjusted odds ratios of risk factors. Results. The incidence was 4.1/1 000 deliveries. Small-for-gestational age (SGA) and placental abruption were the strongest risk factors for IUFD. Hypertensive disorders were of low risk if not associated with SGA. Low to moderate risk factors were pre-pregnancy diabetes mellitus, thyroid disease, placenta previa, gestational diabetes, smoking and twin pregnancy. Advanced maternal age was significant when compared with facility-based controls. Risk estimates pointed in the same direction independent of control-group. Hypertension appeared overestimated when using facility-based controls, whereas advanced age was underestimated in the analysis among selected controls. Conclusion. SGA has a strong association with IUFD, and the risk of hypertensive disorders is mediated through SGA. The other risk factors, except placental abruption, are of low prevalence and of limited importance in the prevention of a relatively low incidence, although dramatic, event like IUFD.

• Jacobsen, Anne Flem; Dahm, Anders Erik A; Bergrem, Astrid; Jacobsen, Eva-Marie & Sandset, Per Morten (2010). Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 8(11), p. 2443–2449. doi: 10.1111/j.1538-7836.2010.04038.x. Show summary

  Background Pregnancy is associated with a ten-fold increased risk of venous thrombosis (VT) with different risk profiles for the ante- and postnatal periods. The purpose of this study was to assess the risk of pregnancy-related VT associated with the factor V Leiden and the prothrombin gene G20210A polymorphisms. Materials and Methods The study comprised 377155 women with 613232 pregnancies at 18 Norwegian hospitals from 1 January 1990 to 31 December 2003. Of total 559 cases with a validated first lifetime diagnosis of VT in pregnancy or within 14 weeks post-partum, and 1229 controls naive for VT, 313 cases and 353 controls donated biological material. Results The odds ratios for venous thrombosis during pregnancy or puerperium were 5.0 (95% CI 3.1 to 8.3) and 9.4 (2.1-42.4) for heterozygous carriers of the factor V Leiden and the prothrombin gene polymorphisms, respectively. All homozygous carriers of the factor V Leiden (n=8) and the prothrombin polymorphism (n=1) developed VT indicating a very high risk of VT. We estimated that pregnancy-related VT occurred in 1.1/1000 non-carriers, in 5.4/1000 heterozygous carriers of factor V Leiden, and in 9.4/1000 heterozygous carriers of the prothrombin polymorphism. To avoid one VT, the number of pregnant women needed to screen for these two polymorphisms and the number needed to be given thromboprophylaxis were 2015 and 157, respectively. Conclusions Although the relative risk for VT during pregnancy and after delivery was increased among carriers of the factor V Leiden and the prothrombin polymorphisms, the overall probability for pregnancy-related VT was low. Trial registration www.clinicaltrials.gov identifier number NCT00856076.

• Bergrem, Astrid; Jacobsen, Eva-Marie; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Skogstad, Marie Jeanette & Sandset, Per Morten (2010). The association of antiphospholipid antibodies with pregnancy-related first time venous thrombosis - a population-based case-control study. Thrombosis Research. ISSN 0049-3848. 125(5), p. E222–E227. doi: 10.1016/j.thromres.2009.12.006. Show summary

  In this population-based case-control study we explored the association of antiphospholipid antibodies with pregnancy-related venous thrombosis. From 1990 through 2003 615 pregnant women were identified at 18 hospitals in Norway with a diagnosis of first time VT. In 2006, 531 of 559 eligible cases and 1092 of 1229 eligible controls were invited for further investigations. The final study population comprised 313 cases and 353 controls, who completed a comprehensive questionnaire and donated a single blood sample, 3-16years after index pregnancy. We report the results on lupus anticoagulant, anticardiolipin antibodies, and anti-ss(2) glycoprotein-1 antibodies alone, in combination, and with the contribution of the factor V Leiden and the prothrombin gene G20210A polymorphisms. Cut-off values for APAs were chosen according to current international consensus. 29 (9.3%) of the cases and 24 (6.8%) of the controls had at least one positive test for APAs (OR 1.4; 95% CI 0.8-2.5). Nine cases (2.8%) and no controls had more than one positive test (multi-positivity) for APAs. After excluding women with factor V Leiden or prothrombin polymorphisms, still 6 cases were multi-positive for APAs. We conclude that multi-positivity, but not single-positivity, for APAs was weakly associated with a history of ante- and postnatal VT.

• Jacobsen, Anne Flem; Skjeldestad, Finn Egil & Sandset, Per Morten (2008). Incidence and Risk Patterns of Venous Thromboembolism In Pregnancy and Puerperium – A Register-Based Case-Control Study. American Journal of Obstetrics and Gynecology. ISSN 0002-9378. 198(2), p. 233.e1–233.e7. doi: 10.1016/j.ajog.2007.08.041. Show summary

  Objective: To estimate the incidence of venous thromboembolism (VTE) in pregnancy and puerperium and to identify risk factors for pregnancy-related VTE. Study Design: A register-based case-control study with 613232 pregnancies from 1990 to 2003 in eleven Norwegian counties. Medical records for eligible cases were revisited and relevant medical data were transferred to a specific case-report-form. The diagnosis of VTE was based on strict criteria. Data were analyzed by chi-square test and forward stepwise logistic regression. Results: In total 615 cases were detected. The incidence of VTE was 1/1000 pregnancies. The ante- and postnatal incidences were quite similar. Antenatal risk factors were assisted reproduction, gestational diabetes, age over 35 years, multiple pregnancies, and primi-parity. Postnatal risk factors were Cesarean section, preeclampsia, assisted reproduction, abruptio placenta, and placenta previa. Conclusion: We found different ante- and postnatal risk patterns. Assisted reproduction and gestational diabetes were significant antenatal risk factors while Cesarean section and preeclampsia were strong postnatal risk factors.

• Jacobsen, Anne Flem; Skjeldestad, Finn Egil & Sandset, Per Morten (2008). Ante-and postnatal risk factors of venous thrombosis – a hospital-based case-control study. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 6, p. 905–912. doi: 10.1111/j.1538-7836.2008.02961.x. Show summary

  Objective: To study ante- and postnatal risk factors of venous thrombosis (VT) in pregnancy. Methods: A hospital-based case-control study. Cases were women with objectively verified VT during pregnancy or postpartum. Two controls were selected for each case. Validated risk factors were analyzed by chi-square test and logistic regression. Results: In total 559 cases with no prior VT, 268 ante- and 291 postnatal cases, were identified together with 1229 controls. Risk factor for antenatal VT were assisted reproduction technique (ART), antepartum immobilization, cigarette smoking, and slight weight gain (<7 kg). Conception after ART and multiple pregnancy showed additive effect, whereas antepartum immobilization and high body mass index (BMI) showed multiplicative effect on the risk for antepartum VT. No other interaction was found between risk factors for antepartum VT. Risk factors for postnatal VT were antepartum immobilization, cigarette smoking, IUGR, preeclampsia, emergency caesarean section, postpartum hemorrhage, infection, and surgery, and age and parity. Antepartum immobilization and high BMI and reoperation on the indication bleeding showed multiplicative effects on the risk of postnatal VT. Conclusions: Ante- and postpartum risk factors differed markedly. More attention should be paid to pregnant women of high BMI who are at risk for immobilization.

• Jacobsen, Anne Flem; Skjeldestad, Finn Egil & Sandset, Per Morten (2008). Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control study. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 6(6), p. 905–912. doi: 10.1111/j.1538-7836.2008.02961.x.
• Jacobsen, Anne Flem; Drolsum, Anders; Kløw, Nils-Einar; Dahl, Gunn Fallås; Qvigstad, Erik & Sandset, Per Morten (2004). Deep vein thrombosis after elective cesarean section. Thrombosis Research. ISSN 0049-3848. 113(5), p. 283–288. Show summary

  INTRODUCTION: Pregnancy is associated with an overall 5-10 fold increased risk of venous thromboembolism (VTE). The absolute risk is highest during and shortly after delivery. Although operative delivery further increases the risk of VTE, there is no consensus on thromboprophylaxis after an elective cesarean. The aim of the present study was to investigate the frequency of symptomatic and asymptomatic deep venous thrombosis (DVT) in a low risk cesarean section population. MATERIALS AND METHODS: Fifty-nine women undergoing elective cesarean section were screened for DVT using triplex Doppler sonography 3-5 days after delivery. Markers of activated coagulation were also followed and all women were screened for thrombophilia. Postoperative thromboprophylaxis was not given. During the same period all cases of symptomatic VTE were also recorded. RESULTS: No DVT was detected by ultrasonography and no women developed symptomatic VTE during the six weeks follow-up period after delivery. Six women had thrombophilia. During the study period, a cesarean section was performed in 1067/5364 (20%) deliveries. Five of these women (0.47%) developed symptomatic pulmonary embolism, and all of these women had additional risk factors for VTE. CONCLUSION: The risk of DVT among healthy pregnant women undergoing elective cesarean section is low, and general medical thromboprophylaxis is probably not justified.

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• Carlsen, Karin C. Lødrup; Staff, Anne Cathrine; Arnesen, Harald; Bechensteen, Anne Grete; Jacobsen, Anne Flem & Omenaas, Ernst (2009). Forskningshåndboken. Fra ide til publikasjon. 4. utgave 2009. Oslo universitetssykehus HF. ISBN 978-82-473-0022-0. 182 p.
• Carlsen, Karin C. Lødrup; Staff, Anne Cathrine; Arnesen, Harald; Bechensteen, Anne Grete; Jacobsen, Anne Flem & Omenaas, Ernst (2009). The Research Handbook, From Idea to Publication. Oslo universitetssykehus HF. ISBN 978-82-473-0022-0. 182 p. Show summary

  Engelsk nettversjon av Forskningshåndboken 2009.

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• Kessler, Jørg; Eggebø, Torbjørn Moe; Jacobsen, Anne Flem; Michelsen, Trond Melbye; Rasmussen, Svein & Yli, Branislava Markovic (2022). Can a population study assess the impact of fetal monitoring technology? Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. doi: 10.1111/aogs.14426.
• Bekkenes, Maria Egeland; Jørgensen, Marte Morin; Jacobsen, Anne Flem; Fagerland, Morten; Rakstad-Larsen, Helene & Solberg, Ole Geir [Show all 10 contributors for this article] (2021). A study protocol for the cardiac effects of a single dose of either oxytocin 2.5 IU or carbetocin 100 µg after caesarean delivery: A prospective randomized controlled multi-centre trial in Norway. F1000 Research. ISSN 2046-1402. 10:973, p. 1–17. doi: 10.12688/f1000research.73112.1. Full text in Research Archive
• Fiskvik, Hilde; Jacobsen, Anne F.; Iversen, Nina; Henriksson, Carola Elisabeth & Jacobsen, Eva-Marie (2021). Treatment of Homozygous Type II Antithrombin Heparin-Binding Site Deficiency in Pregnancy. Case Reports in Obstetrics and Gynecology. ISSN 2090-6692. 2021, p. 1–3. doi: 10.1155/2021/4393821.
• Brigtsen, Anne Karin; Jacobsen, Anne Flem; Dedi, Lumnije; Melby, Kjetil K.; Espeland, Cathrine Nygaard & Fugelseth, Drude [Show all 7 contributors for this article] (2019). Maternal peripartum infection in women colonized with group B Streptococcus at delivery: a prospective cohort study.
• Lukasse, Mirjam; Borgen, Iren; Garnweidner-Holme, Lisa; Småstuen, Milada Cvancarova & Jacobsen, Anne Flem (2019). Knowledge of gestational diabetes in a multi-ethnic population in the Oslo region - a cross-sectional study .
• Borgen, Iren; Garnweidner-Holme, Lisa; Jacobsen, Anne Flem & Lukasse, Mirjam (2018). Gravid+ APP - et digitalt verktøy for gravide med svangerskapsdiabetes.
• Borgen, Iren; Garnweidner-Holme, Lisa; Jacobsen, Anne Flem; Småstuen, Milada Cvancarova & Lukasse, Mirjam (2018). Kunnskap om svangerskapsdiabetes ved første konsultasjon i en flerkulturell populasjon i Oslo regionen - en tverrsnitt studie.
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Jacobsen, Anne Flem; Skuterud Wik, Hilde & Sandset, Per Morten (2017). High complement C3 increases the risk for postnatal venous thrombosis.
• Kessler, Jørg; Yli, Branislava Markovic; Stray-Pedersen, Babill; Jacobsen, Anne Flem; Saugstad, Ola Didrik & Henriksen, Tore (2016). Why did the authors perform a meta-analysis of studies with primary endpoints they consider clinically unimportant? Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 95(5), p. 606–607. doi: 10.1111/aogs.12876.
• Nordeng, Hedvig Marie Egeland; Waka, Marthe Sætre; Jacobsen, Anne Flem; Bråthen, Marie; Gjerdalen, Guri & Rosenberg, M (2015). Drug-related problems among pregnant and lactating women – a multi-center study from maternity wards in Norway.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem & Sandset, Per Morten (2015). Long-term outcome after pregnancy-related venous thrombosis. Thrombosis Research. ISSN 0049-3848. 135(1), p. S1–S4. doi: 10.1016/S0049-3848(15)50430-1.
• Dahm, Anders Erik A; Tiscia, Gianluca; Holmgren, Asbjørn; Jacobsen, Anne Flem; Skretting, Grethe & Grandone, E. [Show all 7 contributors for this article] (2015). Genetic variations in the annexin A5 gene and the risk of pregnancy-related venous thrombosis. Journal of Thrombosis and Haemostasis. ISSN 1538-7933. 13(3), p. 409–413. doi: 10.1111/jth.12817.
• Jacobsen, Anne Flem; Kristiansen, Annette; Bjørge, Line; Henriksen, Tore; Eilertsen, Anette Løken & Sandset, Per Morten (2014). Antikoagulasjon ved venøs trombose i svangerskapet. Tidsskrift for Den norske legeforening. ISSN 0029-2001. p. 926–926. doi: 10.4045/tidsskr.13.1605.
• Bergrem, Astrid; Dahm, Anders Erik A; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2013). Differential risk factors for pregnancy-related deep vein thrombosis and pulmonary embolism - Results from a population-based case-control study. Thrombosis Research. ISSN 0049-3848. 131, p. S75–S75.
• HELGADOTTIR, LINDA BJØRK; Turowski, Gitta Erika; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Roald, Borghild [Show all 7 contributors for this article] (2012). Classification of Stillbirths by Cause of Death and Risk Factor Analysis - a Case-control Study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 91, p. 86–86.
• Wik, Hilde Skuterud; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Long-term impact of venous thrombosis on quality of life, general health and functioning: A cross-sectional, case-control study. Thrombosis Research. ISSN 0049-3848. 130, p. S123–S124. doi: 10.1016/j.thromres.2012.08.061.
• Wik, Hilde Skuterud; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Mortality after pregnancy-related venous thrombosis. Thrombosis Research. ISSN 0049-3848. 130(Supp. 1), p. S124–S124. doi: 10.1016/j.thromres.2012.08.062.
• Bergrem, Astrid; Dahm, Anders Erik A; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2012). Differential risk factors for pregnancy related deep vein thrombosis and pulmonary embolism' results from a population-based case-control study. Thrombosis Research. ISSN 0049-3848. 130, p. S122–S123. doi: 10.1016/j.thromres.2012.08.059.
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Sandvik, Leiv & Sandset, Per Morten (2011). Prevalence and predictors for post-thrombotic syndrome (PTS) three to 16 years after first-time pregnancy related venous thrombosis - a population-based case-control study. Thrombosis Research. ISSN 0049-3848. 127, p. S127–S127.
• HELGADOTTIR, LINDA BJØRK; Skjeldestad, Finn Egil; Jacobsen, Anne Flem; Sandset, Per Morten & Jacobsen, Eva-Marie (2011). Antiphospholipid antibodies and the risk of intrauterine fetal death - Results of a case-control study. Thrombosis Research. ISSN 0049-3848. 127(S3), p. S125–S125.
• Bergrem, Astrid; Dahm, Anders Erik A; Jacobsen, Anne Flem; Mowinckel, Marie-Christine; Sandvik, Leiv & Sandset, Per Morten (2011). Reduced sensitivity to activated protein C in the absence of the factor V Leiden polymorphism is a risk factor for pregnancy related venous thrombosis. Thrombosis Research. ISSN 0049-3848. 127, p. S127–S127.
• Sandset, Per Morten; Arnesen, Harald; Jacobsen, Anne Flem & Wergeland, Håkon (2010). Prophylaxis against Prosthetic Mitral Valve Thrombosis with Unfractionated Heparin Administered by an Elastometric Infusion Pump. Thrombosis Research. ISSN 0049-3848. 126(3), p. E232–E234. doi: 10.1016/j.thromres.2010.05.005.
• Dahm, Anders Erik A; Bezemer, Irene D; Bergrem, Astrid; Jacobsen, Anne Flem; Jacobsen, Eva-Marie & Skretting, Grethe [Show all 8 contributors for this article] (2010). Candidate Gene Polymorphisms and the Risk for Pregnancy Related Venous Thrombosis. Blood. ISSN 0006-4971. 116(21), p. 1708–1709.
• HELGADOTTIR, LINDA BJØRK; Helgadottir, LB; Skjeldestad, FE; Jacobsen, AF; Turowski, G & Roald, B [Show all 9 contributors for this article] (2009). Incidence and classification of intrauterine fetal death (IUFD) in the Oslo area 1990-2003. Thrombosis Research. ISSN 0049-3848. 123, p. S137–S137.
• Jacobsen, Anne Flem; Skjeldestad, Finn Egil; Skogstad, Marie Jeanette & Sandset, Per Morten (2009). Epidemiology, risk factors and penetration of venous thrombosis (VT) in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A mutations. Thrombosis Research. ISSN 0049-3848. 123, p. S134–S134.
• Jacobsen, Anne Flem & Sandset, Per Morten (2007). Management of venous thromboembolism (VTE) in pregnancy. Thrombosis Research. ISSN 0049-3848. 119, p. S12–S13.
• Jacobsen, Anne Flem; Sandset, Per Morten & Skjeldestad, Finn Egil (2007). Incidence and risk factors of ante- and post-natal venous thromboembolism in pregnancy (VIP-study). Thromb Res 2007; 119, Suppl 1: S107, Abstract 39.
• Jacobsen, Anne Flem & Sandset, Per Morten (2007). Management of venous thromboembolism (VTE) in pregnancy.
• Sandset, Per Morten; Arnesen, Harald; Jacobsen, Anne Flem & WERGELAND, HÅKON (2007). Anticoagulant treatment in a hypercoagulable woman with mechanical prosthetic mitral valve - failure of high-dose low molecular weight heparin (LMWH) treatment. Thrombosis Research 2007; 119, Suppl 1: S115, abstract 66.
• Jacobsen, Anne Flem; Drolsum, Anders; Kløw, Nils-Einar; Dahl, Gunn Fallås; Qvigstad, Erik & Sandset, Per Morten (2004). Venous thromboembolism after elective cesarean section. Show summary

  Introduction: Pregnancy is associated with an overall 5-10 fold increased risk of venous thromboembolism (VTE). The absolute risk is highest during and shortly after delivery. Although operative delivery further increases the risk of VTE, there is no consensus on thromboprophylaxis after an elective cesarean. Aim: The aim of the study was to investigate the frequency of symptomatic and asymptomatic deep venous thrombosis (DVT), after low risk cesarean section. Materials and methods: Sixty-four women undergoing low risk elective cesarean section were screened for asymptomactic DVT using triplex Doppler sonography 3-5 days after delivery. Markers of activated coagulation were also followed and all women were screened for thrombophilia. Postoperative thromboprophylaxis was not given. Results: No DVT was detected by ultrasonography and no women developed symptomatic VTE during the six weeks follow-up period after delivery. Six women had thrombophilia. Five women were excluded because of infection, bleeding, or on patients own request, but none of these developed symptomatic VTE. During the same period, the department had 5364 deliveries. A cesarean section was performed in 1067 (20%) of the cases. In this cohort, we diagnosed objectively five (0.47%) cases of symptomatic postoperative pulmonary embolism (PE). No cases of symptomatic DVT were seen. All cases of PE had additional risk factors like obesity, severe preeclampsia, twin pregnancy, reoperation, immobilization, and placenta previa. Conclusion: The risk of DVT after low-risk, elective cesarean section is low, and general medical thromboprophylaxis is probably not justified.

• Øian, Pål; Jacobsen, Anne Flem & Kessler, Jørg (2014). Veileder i fødselshjelp 2014. Den norske legeforening.

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