Annika Elisabet Michelsen

• Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika; Lekva, Tove; Aakhus, Svend; Holm, Sverre; Halvorsen, Bente; Finsen, Alexandra; Vinge, Leif Erik; Nymo, Ståle Haugset; Espeland, Torvald; Ranheim, Trine; Aukrust, Pål; Vaage, Ingvar Jarle; Auensen, Andreas; Gullestad, Lars & Ueland, Thor (2020). YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circulation: Heart Failure.  ISSN 1941-3289.  13(10), s e006643 . doi: 10.1161/CIRCHEARTFAILURE.119.006643 Full text in Research Archive.
• Gelpi, Marco; Vestad, Beate; Hansen, Simen Hyll; Holm, Kristian; Drivsholm, Ninna; Götz, Alexandra; Kirkby, Nikolai; Lindegaard, Birgitte; Lebech, Anne-Mette; Hoel, Hedda Benedicte; Michelsen, Annika; Ueland, Thor; Gerstoft, Jan; Lundgren, Jens D.; Hov, Johannes Espolin Roksund; Nielsen, Susanne D. & Trøseid, Marius (2020). Impact of human immunodeficiency virus-related gut microbiota alterations on metabolic comorbid conditions. Clinical Infectious Diseases.  ISSN 1058-4838.  71(8), s e359- e367 . doi: 10.1093/cid/ciz1235 Full text in Research Archive.
• Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G.; Skjelland, Mona; Skagen, Karolina Ryeng; Becker, Richard C.; Lindbäck, Johan; Himmelmann, Anders; Solberg, Rigmor; Johansen, Harald Thidemann; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål; Ueland, Thor; Wallentin, Lars & Halvorsen, Bente (2020). Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. Journal of the American Heart Association (JAHA).  ISSN 2047-9980.  e016360 . doi: 10.1161/JAHA.120.016360 Full text in Research Archive.
• Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor; Michelsen, Annika; Otterdal, Kari; Muller, Karl Erik; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato & Trøseid, Marius (2020). Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement. Journal of Internal Medicine.  ISSN 0954-6820. . doi: 10.1111/joim.13178 Full text in Research Archive.
• Hoel, Hedda Benedicte; Ueland, Thor; Hove-Skovsgaard, Malene; Hartling, Hans Jakob; Gelpi, Marco; Benfield, Thomas; Ullum, Henrik; Michelsen, Annika; Aukrust, Pål; Nielsen, Susanne Dam & Trøseid, Marius (2020). Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection. Open Forum Infectious Diseases.  ISSN 2328-8957.  29(7) . doi: 10.1093/ofid/ofaa033 Full text in Research Archive.
• Hoel, Hedda Benedicte; Ueland, Thor; Knudsen, Andreas; Kjær, Andreas; Michelsen, Annika; Sagen, Ellen Lund; Halvorsen, Bente; Yndestad, Arne; Nielsen, Susanne Dam; Aukrust, Pål; Lebech, Anne-Mette & Trøseid, Marius (2020). Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals. Journal of Infectious Diseases.  ISSN 0022-1899.  221(4), s 506- 509 . doi: 10.1093/infdis/jiz253
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Gregersen, Ida; Sagen, Ellen Lund; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Langeland, Nina & Aukrust, Pål (2020). Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: Potential immune-regulatory role during malaria. BMC Infectious Diseases.  ISSN 1471-2334.  20(65), s 1- 11 . doi: 10.1186/s12879-020-4783-8 Full text in Research Archive.
• Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca; Hammarström, Clara Louise; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Mjøen, Geir; Dahle, Dag Olav; Midtvedt, Karsten; Eide, Ivar Anders; Hartmann, Anders & Holdaas, Hallvard (2020). Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLOS ONE.  ISSN 1932-6203.  15:e0243759(12), s 1- 14 . doi: 10.1371/journal.pone.0243759 Full text in Research Archive.
• Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian; Michelsen, Annika; Jenum, Synne; Jørgensen, Marthe Jøntvedt; Barratt-Due, Andreas; Skeie, Linda Gail; Nordøy, Ingvild; Fraz, Mai Sasaki Aanensen; Paulsen, Else Quist; Pischke, Soeren; Johal, Simreen Kaur; Hesstvedt, Liv; Bogen, Mette; Fevang, Børre; Halvorsen, Bente; Müller, Fredrik; Bekken, Gry Kloumann; Mollnes, Tom Eirik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma & Holter, Jan Cato (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  147(1), s 92- 98 . doi: 10.1016/j.jaci.2020.09.007 Full text in Research Archive.
• Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta & Kontny, Frederic (2019). C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  39(11), s 2402- 2410 . doi: 10.1161/ATVBAHA.119.312633 Full text in Research Archive.
• Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H.; Sagen, Ellen; Michelsen, Annika; Vinge, Leif Erik; Øie, Erik; Gullestad, Lars; Halvorsen, Bente; Hansen, Trond Vidar; Aukrust, Pål; Dalli, Jesmond & Yndestad, Arne (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine.  ISSN 2352-3964.  46, s 264- 273 . doi: 10.1016/j.ebiom.2019.07.024 Full text in Research Archive.
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund & Fevang, Børre (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports.  ISSN 2045-2322.  9:167, s 1- 10 . doi: 10.1038/s41598-018-35367-7 Full text in Research Archive.
• Kontny, Frederic; Andersen, Thomas; Ueland, Thor; Åkerblom, Axel; Lakic, Tatevik G.; Michelsen, Annika; Aukrust, Pål; Bertilsson, Maria; Becker, Richard C.; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F. & Wallentin, Lars (2019). Pentraxin-3 vs C-reactive Protein and Other Prognostic Biomarkers in Acute Coronary Syndrome: A Substudy of the Platelet Inhibition and Patients Outcomes (PLATO) Trial.. European Heart Journal: Acute Cardiovascular Care.  ISSN 2048-8726.  00(0), s 1- 10 . doi: 10.1177/2048872619846334 Full text in Research Archive.
• Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein & Halvorsen, Bente (2019). Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages. Atherosclerosis.  ISSN 0021-9150.  s 1- 9 . doi: 10.1016/j.atherosclerosis.2019.12.008 Full text in Research Archive.
• Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K; Hussain, Amjad Iqbal; Pettersen, Kjell; Aakhus, Svend; Espeland, Torvald; Lunde, Ida Gjervold; Kirschfink, Michael; Nilsson, Per; Mollnes, Tom Eirik; Gullestad, Lars; Aukrust, Pål; Yndestad, Arne & Louwe, Maria Cornelia (2019). Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis. Journal of Immunology.  ISSN 0022-1767.  203(7), s 1973- 1980 . doi: 10.4049/jimmunol.1801244 Full text in Research Archive.
• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Ståle Haugset; Lauritzen, Trine; Oppen, Kjersti; Husebye, Einar; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål & Heggelund, Lars (2019). Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph.  ISSN 2312-508X.  5(1) . doi: 10.1183/23120541.00014-2019 Full text in Research Archive.
• Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews.  ISSN 1520-7552.  :e3114, s 1- 9 . doi: 10.1002/dmrr.3114 Full text in Research Archive.
• Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X. . doi: 10.1210/clinem/dgz119 Full text in Research Archive.
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål & Wallentin, Lars (2019). Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  39(2), s 294- 302 . doi: 10.1161/ATVBAHA.118.311042
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C; Bertilson, Maria; Budaj, Andrzej; Cornel, Jan H; Himmelmann, Anders; James, Stefan K; Siegbahn, Agneta; Storey, Robert F; Kontny, Frederic; Aukrust, Pål & Wallentin, Lars (2019). ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis.  ISSN 0021-9150.  s 35- 41 . doi: 10.1016/j.atherosclerosis.2019.11.031 Full text in Research Archive. Show summary

  Background and aims: Activated leukocyte cell adhesion molecule (ALCAM) is upregulated during inflammation and involved in transmigration of leukocytes and T-cell activation. We hypothesized that ALCAM might be associated with recurrent events in patients with acute coronary syndromes (ACS). Methods: ALCAM was measured in serum obtained on admission, at discharge, 1 month and 6 months in a subgroup of 5165 patients admitted with ACS and included in the PLATelet inhibition and patient Outcomes (PLATO) trial (NCT00391872). The association between ALCAM and the composite endpoint and its components, including cardiovascular (CV) death, non-procedural spontaneous myocardial infarction (MI) or stroke during 1-year follow-up, was assessed by Cox proportional hazards models with incremental addition of clinical risk factors and biomarkers (including high-sensitivity troponin T, N-terminal pro−B-type natriuretic peptide and growth differentiation factor-15). Results: The median (Q1-Q3) concentration of ALCAM at admission was 97 (80–116) ng/mL. A 50% higher level of ALCAM on admission was associated with a hazard ratio (HR) of 1.16 (95% confidence interval [1.00–1.34] p=0.043) for the composite endpoint in fully adjusted analysis, mainly driven by the association with CV death (HR 1.45 [1.16–1.82] p = 0.0012). Conclusions: In patients with ACS, admission level of ALCAM was independently associated with adverse outcome including CV death even after adjustment for established inflammatory and cardiac biomarkers.

• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica.  ISSN 0001-690X.  139, s 37- 45 . doi: 10.1111/acps.12971
• Heldal, Torbjørn Fossum; Ueland, Thor; Jenssen, Trond Geir; Hartmann, Anders; Reisæter, Anna Varberg; Aukrust, Pål; Michelsen, Annika & Åsberg, Anders (2018). Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study. Transplant International.  ISSN 0934-0874.  31(5), s 510- 519 . doi: 10.1111/tri.13116
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Ueland, Thor; Michelsen, Annika; Pettersen, Kjell; Aukrust, Pål; Mørkrid, Lars; Gullestad, Lars & Broch, Kaspar (2018). Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis. Open heart.  ISSN 2053-3624.  5:e000901(2), s 1- 10 . doi: 10.1136/openhrt-2018-000901 Full text in Research Archive.
• Lekva, Tove; Godang, Kristin; Michelsen, Annika; Qvigstad, Elisabeth; Normann, Kjersti Ringvoll; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Roland, Marie Cecilie & Ueland, Thor (2018). Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation. Scientific Reports.  ISSN 2045-2322.  8:13392, s 1- 9 . doi: 10.1038/s41598-018-31614-z Full text in Research Archive.
• Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari; Olsen, Maria Belland; Kong, Xiang Yi; Gude, Einar; Andreassen, Arne K.; Solbu, Dag; Karason, Kristjan; Dellgren, Göran; Gullestad, Lars; Aukrust, Pål & Ueland, Thor (2018). Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression. American Journal of Transplantation.  ISSN 1600-6135.  s 1- 11 . doi: 10.1111/ajt.15141 Full text in Research Archive. Show summary

  Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1.

• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Fevang, Børre; Aukrust, Pål; Langeland, Nina & Ueland, Thor (2018). Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria. BMC Infectious Diseases.  ISSN 1471-2334.  18 . doi: 10.1186/s12879-018-3593-8 Full text in Research Archive. Show summary

  BACKGROUND: The immune response during P. falciparum infection is a two-edged sword, involving dysregulation of the inflammatory responses with several types of immune cells participating. Here we examined T-cell, monocyte/macrophage and neutrophil activation during P. falciparum infection by using soluble activation markers for these leukocyte subsets. METHODS: In a prospective cross-sectional study clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) co-infection with HIV-1, as well as HIV-infected patients with similar symptoms but without malaria (n = 58) and healthy controls (n = 52). Soluble (s)CD25, sCD14, sCD163 and myeloperoxidase (MPO) as markers for T-cell, monocyte/macrophage and neutrophil activation, respectively as well as CX3CL1, granzyme B and TIM-3 as markers of T-cell subsets and T-cell exhaustion, were analyzed. RESULTS: All patient groups had raised levels of activation markers compared with healthy controls. Levels of sCD25 and MPO increased gradually from patient with HIV only to patient with malaria only, with the highest levels in the HIV/malaria group. In the malaria group as a whole, MPO, sCD14 and in particular sCD25 were correlated with disease severity. sCD163, sCD25 and in particular MPO correlated with the degree of parasitemia as assessed by qPCR. Patients with falciparum malaria also had signs of T-cell subset activation (i.e. increased granzyme B and CX3CL1) and T-cell exhaustion as assessed by high levels of TIM-3 particularly in patients co-infected with HIV. CONCLUSION: Our data support a marked immune activation in falciparum malaria involving all major leukocyte subsets with particular enhanced activation of neutrophils and T-cells in patients co-infected with HIV. Our findings also support a link between immune activation and immune exhaustion during falciparum malaria, particularly in relation to T-cell responses in patients co-infected with HIV

• Steineger, Johan Edvard; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Osnes, Terje; Heimdal, Ketil Riddervold & Dheyauldeen, Sinan (2018). Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis. The Laryngoscope.  ISSN 0023-852X.  129(1), s E44- E49 . doi: 10.1002/lary.27548
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente & Yndestad, Arne (2018). Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction. Open heart.  ISSN 2053-3624.  5(2) . doi: 10.1136/openhrt-2017-000765 Full text in Research Archive.
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne & Halvorsen, Bente (2018). Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  274, s 348- 350 . doi: 10.1016/j.ijcard.2018.06.093 Full text in Research Archive.
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål; Becker, Richard C.; Bertilsson, Maria; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic & Wallentin, Lars (2018). Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American Heart Association (JAHA).  ISSN 2047-9980.  7(2) . doi: 10.1161/JAHA.117.007009 Full text in Research Archive.
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve; Aukrust, Pål; Yndestad, Arne; Fiane, Arnt E; Andreassen, Arne K.; Aakhus, Svend; Dahl, Christen Peder; Gullestad, Lars; Broch, Kaspar & Ueland, Thor (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports.  ISSN 2045-2322.  7(1) . doi: 10.1038/s41598-017-03625-9 Full text in Research Archive.
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika; Ranheim, Trine; Alfsnes, Katrine; Fiane, Arnt E; Aakhus, Svend; Lunde, Ida Gjervold; Dahl, Christen Peder; Aukrust, Pål; Christensen, Geir Arve; Gullestad, Lars; Yndestad, Arne & Ueland, Thor (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine.  ISSN 0946-2716.  95(7), s 767- 777 . doi: 10.1007/s00109-017-1529-1
• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Bjerve, Kristian S; Michelsen, Annika; Aukrust, Pål; Schmidt, EB; Christensen, JH & Jenssen, Trond Geir (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition.  ISSN 1051-2276.  27(3), s 161- 168 . doi: 10.1053/j.jrn.2016.09.008 Show summary

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Holte, Espen; Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Broch, Kaspar; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Aakhus, Svend; Damås, Jan Kristian; Gullestad, Lars; Aukrust, Pål & Wiseth, Rune (2017). Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction. Heart.  ISSN 1355-6037.  103(19), s 1521- 1527 . doi: 10.1136/heartjnl-2016-310875
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R. & Andreassen, Ole Andreas (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin.  ISSN 0586-7614.  43(4), s 881- 890 . doi: 10.1093/schbul/sbw183 Full text in Research Archive.
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology.  ISSN 1475-2840.  16:5(1), s 1- 10 . doi: 10.1186/s12933-016-0492-4 Full text in Research Archive.
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Roland, Marie Cecilie; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up. Diabetes & vascular disease research.  ISSN 1479-1641.  14(6), s 525- 533 . doi: 10.1177/1479164117728011
• Lekva, Tove; Roland, Marie Cecilie; Michelsen, Annika; Friis, Camilla Margrethe; Aukrust, Pål; Bollerslev, Jens; Henriksen, Tore & Ueland, Thor (2017). Large reduction in adiponectin during pregnancy is associated with large-for-gestational-age newborns. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(7), s 2552- 2559 . doi: 10.1210/jc.2017-00289
• Norum, Hilde Margrethe; Broch, Kaspar; Michelsen, Annika; Lunde, Ida Gjervold; Lekva, Tove; Abraityte, Judita Aurelija; Dahl, Christen Peder; Fiane, Arnt E; Andreassen, Arne K.; Christensen, Geir Arve; Aakhus, Svend; Aukrust, Pål; Gullestad, Lars & Ueland, Thor (2017). The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy. Journal of Cardiovascular Translational Research.  ISSN 1937-5387.  s 1- 10 . doi: 10.1007/s12265-017-9748-y
• Shahini, Negar; Michelsen, Annika; Nilsson, Per; Ekholt, Karin; Gullestad, Lars; Broch, Kaspar; Dahl, Christen Peder; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Yndestad, Arne & Louwe, Maria Cornelia (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep42532 Full text in Research Archive.
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  24(11), s 1161- 1167 . doi: 10.1177/2047487317703826
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Åsvold, Bjørn Olav (2017). Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study. International Journal of Cardiology.  ISSN 0167-5273.  243, s 502- 504 . doi: 10.1016/j.ijcard.2017.05.106 Full text in Research Archive.
• Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars & Nytrøen, Kari (2017). Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients. Open heart.  ISSN 2053-3624.  4(2) . doi: 10.1136/openhrt-2017-000635 Full text in Research Archive.
• Arain, Fizza Kanwal; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Cleland, JG; Michelsen, Annika; McMurray, JJ; Wikstrand, J; Aukrust, Pål & Ueland, Thor (2016). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA. Biomarkers.  ISSN 1354-750X.  22(3-4), s 261- 267 . doi: 10.1080/1354750X.2016.1204003
• Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal; Wium, Cecilie; Lattanzio, Stefano; Formoso, Gloria; Di Fulvio, Patrizia; Otterdal, Kari; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Gregersen, Ida; Stavik, Benedicte; Bjerkeli, Vigdis; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Davi, Giovanni & Aukrust, Pål (2016). LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro. Diabetologia.  ISSN 0012-186X.  59, s 2134- 2144 . doi: 10.1007/s00125-016-4036-y Full text in Research Archive.
• Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Frydenlund, Didrik Søli; Holm, Kristian; Paulsen, Vemund; Michelsen, Annika; Jørgensen, Kristin Kaasen; Osnes, Liv T. N.; Bratlie, Jorunn; Eide, Tor Jacob; Dahl, Christen Peder; Holter, Ellen; Tronstad, Rune Rose; Hanevik, Kurt; Brattbakk, Hans-Richard; Kaveh, Fatemeh; Fiskerstrand, Torunn; Kran, Anne-Marte Bakken; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Lundin, Knut Erik Aslaksen & Fevang, Børre (2016). A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients with Common Variable Immunodeficiency. American Journal of Gastroenterology.  ISSN 0002-9270.  111(10), s 1467- 1475 . doi: 10.1038/ajg.2016.329
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika; Osnes, Liv T. N.; Holm, Kristian; Høivik, Marte; Rashidi, Azita; Dahl, Christen Peder; Vesterhus, Mette; Halvorsen, Bente; Mollnes, Tom Eirik; Berge, Rolf Kristian; Moum, Bjørn; Lundin, Knut Erik Aslaksen; Fevang, Børre; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål & Hov, Johannes Espolin Roksund (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.  ISSN 1933-0219. . doi: 10.1038/mi.2016.18
• Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar; Holte, Espen; Michelsen, Annika; Bendz, Bjørn; Amundsen, Brage H.; Espevik, Terje; Aakhus, Svend; Damås, Jan Kristian; Aukrust, Pål; Wiseth, Rune & Gullestad, Lars (2016). Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. European Heart Journal.  ISSN 0195-668X.  37(30), s 2406- 2413 . doi: 10.1093/eurheartj/ehw171 Full text in Research Archive.
• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Arain, Fizza Kanwal; Damås, Jan Kristian; Aukrust, Pål & Ueland, Thor (2016). Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway. Atherosclerosis.  ISSN 0021-9150.  244, s 188- 194 . doi: 10.1016/j.atherosclerosis.2015.11.022
• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål & Ueland, Thor (2016). Circulating PCSK9 and risk of myocardial infarction: The HUNT Study in Norway. JACC: Basic to Translational Science.  ISSN 2452-302X.  1(7), s 568- 575 . doi: 10.1016/j.jacbts.2016.06.007
• Lekva, Tove; Michelsen, Annika; Bollerslev, Jens; Norwitz, Errol R.; Aukrust, Pål; Henriksen, Tore & Ueland, Thor (2016). Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: A 5-year follow-up study. Cardiovascular Diabetology.  ISSN 1475-2840.  15(23) . doi: 10.1186/s12933-016-0345-1
• Palm, Øyvind; Ueland, Thor; Garen, Torhild Oddveig; Michelsen, Annika; Reiseter, Silje; Aukrust, Pål; Aaløkken, Trond Mogens & Molberg, Øyvind (2016). Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome. Clinical and Experimental Rheumatology.  ISSN 0392-856X.  34(4), s 690- 693
• Stylianou, Eva; Ueland, Thor; Borchsenius, Fredrik; Michelsen, Annika; Øvstebø, Reidun; Mollnes, Tom Eirik; Skjønsberg, Ole Henning & Aukrust, Pål (2016). Specific allergen immunotherapy: Effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  76(2), s 118- 127 . doi: 10.3109/00365513.2015.1110856
• Abbas, Azhar; Gregersen, Ida; Holm, Sverre; Daissormont, Isabelle; Bjerkeli, Vigdis; Krohg-Sørensen, Kirsten; Skagen, Karolina Ryeng; Dahl, Tuva Børresdatter; Russell, David; Almås, Trine; Bundgaard, Dorte; Alteheld, Lars Holger; Rashidi, Azita; Dahl, Christen Peder; Michelsen, Annika; Biessen, Erik A.; Aukrust, Pål; Halvorsen, Bente & Skjelland, Mona (2015). Interleukin 23 levels are increased in carotid atherosclerosis: Possible role for the interleukin 23/interleukin 17 axis. Stroke.  ISSN 0039-2499.  46(3), s 793- 799 . doi: 10.1161/STROKEAHA.114.006516
• Broch, Kaspar; Andreassen, Arne K.; Ueland, Thor; Michelsen, Annika; Stueflotten, Wenche; Aukrust, Pål; Aakhus, Svend & Gullestad, Lars (2015). Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure. International Journal of Cardiology.  ISSN 0167-5273.  179, s 378- 384 . doi: 10.1016/j.ijcard.2014.11.003
• Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Michelsen, Annika; Ueland, Thor; Hardie, Jon Andrew; Aukrust, Pål; Bakke, Per S. & Eagan, Tomas Mikal (2015). Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD. PLOS ONE.  ISSN 1932-6203.  10:e0121622(3) . doi: 10.1371/journal.pone.0121622 Full text in Research Archive.
• Prebensen, Christian; Ueland, Thor; Michelsen, Annika; Lind, Andreas; Pettersen, Frank Olav; Mollnes, Tom Eirik; Aukrust, Pål; Dyrhol-Riise, Anne Ma & Kvale, Dag (2015). High MIP-1β levels in plasma predict long-term immunological nonresponse to suppressive antiretroviral therapy in HIV infection. Journal of Acquired Immune Deficiency Syndromes.  ISSN 1525-4135.  69(4), s 395- 402 . doi: 10.1097/QAI.0000000000000617
• Reiseter, Silje; Molberg, Øyvind; Gunnarsson, Ragnar; Lund, May Brit; Aaløkken, Trond Mogens; Aukrust, Pål; Ueland, Thor; Garen, Torhild Oddveig; Brunborg, Cathrine; Michelsen, Annika; Abraityte, Judita Aurelija & Hoffmann-Vold, Anna-Maria (2015). Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study. Arthritis Research & Therapy.  ISSN 1478-6354.  17:231 . doi: 10.1186/s13075-015-0756-5 Full text in Research Archive.
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Løken-Amsrud, Kristin Ingeleiv; Bakke, Søren Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn G.; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Michelsen, Annika; Aukrust, Pål; Ueland, Thor & Holmøy, Trygve (2015). Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  280, s 21- 28 . doi: 10.1016/j.jneuroim.2015.02.001
• Røsjø, Egil Rørvik; Steffensen, Linn Hofsøy; Jørgensen, Lone; Lindstrøm, Jonas Christoffer; Saltyte Benth, Jurate; Michelsen, Annika; Aukrust, Pål; Ueland, Thor; Kampman, Margitta Theodora; Torkildsen, Øivind & Holmøy, Trygve (2015). Vitamin D supplementation and systemic inflammation in relapsing-remitting multiple sclerosis. Journal of Neurology.  ISSN 0340-5354.  262(12), s 2713- 2721 . doi: 10.1007/s00415-015-7902-5 Show summary

  Observational studies have suggested that vitamin D may reduce inflammation in relapsing-remitting multiple sclerosis (RRMS), but this has not been clearly confirmed in randomized controlled trials. To further explore the possible anti-inflammatory effects of vitamin D in RRMS, we examined the effect of high-dose oral vitamin D3 on eleven markers of systemic inflammation in 68 RRMS patients enrolled in a double-blinded randomized placebo-controlled trial of vitamin D3 supplementation (20,000 IU/week) (NCT00785473). Serum inflammation markers and 25-hydroxyvitamin D (25(OH)D) were measured at baseline and week 96, and no restrictions were set on additional standard immunomodulatory treatment for RRMS. The mean 25(OH)D level rose from 56 ± 29 to 123 ± 34 nmol/L among patients receiving vitamin D3 supplementation, whereas only a minor increase from 57 ± 22 to 63 ± 24 nmol/L was seen in the placebo group. However, no significant differences appeared between the vitamin D group and the placebo group for any of the inflammation markers. Patients on immunomodulatory therapy had significantly higher levels of interleukin-1 receptor antagonist and chemokine (C-X-C motif) ligand 16 than patients without immunomodulatory treatment, but there were no clear synergistic effects between immunomodulatory therapy and vitamin D3 supplementation on any of the inflammation markers. The rise in 25(OH)D levels after vitamin D3 supplementation was unaffected by immunomodulatory treatment. We conclude that in this study of RRMS patients, high-dose oral vitamin D3 supplementation prominently increased serum 25(OH)D levels without affecting markers of systemic inflammation, while a more anti-inflammatory phenotype was found among patients on immunomodulatory treatment.

• Stokke, Silje Agnethe; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Wergeland, Stig; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Bakke, Søren Jacob; Michelsen, Annika; Aukrust, Pål; Ueland, Thor; Sagen, Jørn V. & Torkildsen, Øivind (2015). Body mass index influence interferon-beta treatment response in multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  288, s 92- 97 . doi: 10.1016/j.jneuroim.2015.09.008
• Sveaas, Silje Halvorsen; Berg, Inger Jorid; Provan, Sella Aarrestad; Semb, Anne Grete; Hagen, Kåre Birger; Vøllestad, Nina Køpke; Fongen, Camilla; Olsen, Inge Christoffer; Michelsen, Annika; Ueland, Thor; Aukrust, Pål; Kvien, Tore Kristian & Dagfinrud, Hanne (2014). Efficacy of High Intensity Exercise on Disease Activity and Cardiovascular Risk in Active Axial Spondyloarthritis: A Randomized Controlled Pilot Study. PLOS ONE.  ISSN 1932-6203.  9(9) . doi: 10.1371/journal.pone.0108688
• Abbas, Azhar; Aukrust, Pål; Russell, David; Krohg-Sørensen, Kirsten; Almås, Trine; Bundgaard, Dorte; Bjerkeli, Vigdis; Sagen, Ellen Lund; Michelsen, Annika; Dahl, Tuva Børresdatter; Holm, Sverre; Ueland, Thor; Skjelland, Mona & Halvorsen, Bente (2014). Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis. PLOS ONE.  ISSN 1932-6203.  9(1:e84935) . doi: 10.1371/journal.pone.0084935
• Halvorsen, Bente; Dahl, Tuva Børresdatter; Smedbakken, Linda Merete; Singh, Anjana; Michelsen, Annika; Skjelland, Mona; Krohg-Sørensen, Kirsten; Russell, David; Höpken, Uta E.; Lipp, Martin; Damås, Jan Kristian; Holm, Sverre; Yndestad, Arne; Biessen, Erik A & Aukrust, Pål (2014). Increased levels of CCR7 ligands in carotid atherosclerosis: Different effects in macrophages and smooth muscle cells. Cardiovascular Research (CVR).  ISSN 0008-6363.  102(1), s 148- 156 . doi: 10.1093/cvr/cvu036
• Halvorsen, Bente; Smedbakken, Linda Merete; Michelsen, Annika; Skjelland, Mona; Bjerkeli, Vigdis; Sagen, Ellen Lund; Tasken, Kjetil; Bendz, Bjørn; Holm, Sverre; Gullestad, Lars; Biessen, Erik A & Aukrust, Pål (2014). Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13. Atherosclerosis.  ISSN 0021-9150.  234(2), s 352- 359 . doi: 10.1016/j.atherosclerosis.2014.03.021
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Michelsen, Annika; Aukrust, Pål; Ueland, Thor & Holmøy, Trygve (2014). Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  271(1-2), s 60- 65 . doi: 10.1016/j.jneuroim.2014.03.014 Show summary

  To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment.

• Ueland, Thor; Rollag, Halvor; Hartmann, Anders; Jardine, Alan George; Humar, Atul; Michelsen, Annika; Bignamini, Angelo Antonio; Åsberg, Anders & Aukrust, Pål (2014). Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients. American Journal of Transplantation.  ISSN 1600-6135.  14(1), s 210- 215 . doi: 10.1111/ajt.12506
• Wium, Cecilie; Eggesbø, Heidi Beate; Ueland, Thor; Michelsen, Annika; Torjesen, Peter A; Aukrust, Pål & Birkeland, Kåre I. (2014). Adipose tissue distribution in relation to insulin sensitivity and inflammation in Pakistani and Norwegian subjects with type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  74(8), s 700- 707 . doi: 10.3109/00365513.2014.953571
• Gullestad, Lars; Ørn, Stein; Dickstein, Kenneth; Eek, Christian; Edvardsen, Thor; Aakhus, Svend; Askevold, Erik Tandberg; Michelsen, Annika; Bendz, Bjørn; Skårdal, Rita; Smith, Hans-Jørgen; Yndestad, Arne; Ueland, Thor & Aukrust, Pål (2013). Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. International Journal of Cardiology.  ISSN 0167-5273.  168(1), s 212- 218 . doi: 10.1016/j.ijcard.2012.09.092 Show summary

  BACKGROUND: Left ventricular (LV) remodeling takes place after acute myocardial infarction (MI), potentially leading to overt heart failure (HF). Enhanced inflammation may contribute to LV remodeling. Our hypothesis was that the immunomodulating effects of intravenous immunoglobulin (IVIg) would be beneficial in patients with impaired myocardial function after MI by reducing myocardial remodeling and improving myocardial function. METHODS: Sixty-two patients with acute MI treated by percutaneous coronary intervention, with depressed LV ejection fraction (LVEF) were randomized in a double-blinded fashion to IVIg as induction therapy and thereafter as monthly infusions or placebo for 26weeks. The primary end point was changes in LVEF from baseline to 6months as assessed by MRI. RESULTS: Our main findings were: (i) LVEF increased significantly from 38±10 (mean±SD) to 45±13% after IVIg and from 42±9 to 49±12% after placebo with no difference between the groups. (ii) The scar area decreased significantly by 3% and 5% in the IVIg and placebo group, respectively, with no difference between the groups. (iii) During the induction therapy (baseline to day 5), IVIg induced both inflammatory (e.g., increase in tumor necrosis factor α and monocyte chemoattractant protein-1) and anti-inflammatory (e.g., increase in interleukin-10 and decrease in leukocyte counts) variables, but during maintenance therapy there were no differences in changes of inflammatory mediators between IVIg and placebo. CONCLUSIONS: IVIg therapy after ST elevation MI managed by primary PCI does not affect LV remodeling or function. This illustrates the challenges of therapeutic intervention directed against the cytokine network, to prevent post-MI remodeling.

• Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål & Ueland, Thor (2013). Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity. PLOS ONE.  ISSN 1932-6203.  8(9) . doi: 10.1371/journal.pone.0075021 Full text in Research Archive.
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Ringstad, Geir Andre; Olstad, Ole Kristoffer; Michelsen, Annika; Casar-Borota, Olivera; Bollerslev, Jens & Ueland, Thor (2013). Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas. Endocrinology.  ISSN 0013-7227.  154(9), s 3331- 3343 . doi: 10.1210/en.2013-1051
• Wium, Cecilie; AASHEIM, ERLEND T.; Ueland, Thor; Michelsen, Annika; Thorsby, Per Medbøe; Larsen, Ingegerd Frøyshov; Torjesen, Peter A; Aukrust, Pål & Birkeland, Kåre I. (2013). Differences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional study. BMC Endocrine Disorders.  ISSN 1472-6823.  13(49) . doi: 10.1186/1472-6823-13-49 Full text in Research Archive.
• Abbas, Azhar; Aukrust, Pål; Dahl, Tuva Børresdatter; Bjerkeli, Vigdis; Sagen, Ellen Lund; Michelsen, Annika; Russell, David; Krohg-Sørensen, Kirsten; Holm, Sverre; Skjelland, Mona & Halvorsen, Bente (2012). High Levels of S100A12 Are Associated With Recent Plaque Symptomatology in Patients With Carotid Atherosclerosis. Stroke.  ISSN 0039-2499.  43(5), s 1347- 1353 . doi: 10.1161/STROKEAHA.111.642256
• Burdess, A.; Michelsen, Annika; Brosstad, Frank Roger; Fox, K. A. A.; Newby, D. E. & Nimmo, A. F. (2012). Platelet activation in patients with peripheral vascular disease: Reproducibility and comparability of platelet markers. Thrombosis Research.  ISSN 0049-3848.  129(1), s 50- 55 . doi: 10.1016/j.thromres.2011.08.015
• Dieset, Ingrid; Djurovic, Srdjan; Tesli, Martin Steen; Hope, Sigrun; Mattingsdal, Morten; Michelsen, Annika; Joa, Inge; Larsen, Tor Ketil; Agartz, Ingrid; Melle, Ingrid; Røssberg, Jan Ivar; Aukrust, Pål; Andreassen, Ole Andreas & Ueland, Thor (2012). Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder. American Journal of Psychiatry.  ISSN 0002-953X.  169(12), s 1292- 1300 . doi: 10.1176/appi.ajp.2012.11091431 Show summary

  OBJECTIVE: Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of the strongest candidate risk genes for schizophrenia and bipolar disorder is the NOTCH4 gene within the major histocompatibility complex. The authors investigated the NOTCH4 gene expression in individuals with bipolar disorder and schizophrenia relative to healthy comparison subjects and identified putative expression quantitative trait loci in and around the NOTCH4 gene. METHOD: The authors measured and compared NOTCH4 mRNA in whole blood in 690 individuals (479 patients and 211 healthy comparison subjects) and adjusted for a range of confounders. The authors also genotyped 20 single-nucleotide polymorphisms (SNPs) and investigated possible associations between expression quantitative trait loci and NOTCH4 expression. RESULTS: The authors found a strong association between NOTCH4 expression and bipolar disorder after adjusting for a range of confounders and multiple testing. In addition, seven SNPs within the NOTCH4 gene region were associated with enhanced NOTCH4 mRNA levels. Three of these expression quantitative trait loci were independent (not in linkage disequilibrium). CONCLUSIONS: The results indicate that the association between NOTCH4 DNA markers and bipolar disorder is related to altered function at the mRNA level, supporting the notion that NOTCH4 pathways are involved in the pathophysiology of bipolar disorder.

• Smedbakken, Linda Merete; Halvorsen, Bente; Daissormont, Isabelle; Ranheim, Trine; Michelsen, Annika; Skjelland, Mona; Sagen, Ellen Lund; Folkersen, Lasse; Krohg-Sørensen, Kirsten; Russell, David; Holm, Sverre; Ueland, Thor; Fevang, Børre; Hedin, Ulf; Yndestad, Arne; Gullestad, Lars; Hansson, Göran K; Biessen, Erik A & Aukrust, Pål (2012). Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization. Atherosclerosis.  ISSN 0021-9150.  224(1), s 266- 273 . doi: 10.1016/j.atherosclerosis.2012.06.071
• Holm, Sverre; Ueland, Thor; Dahl, Tuva Børresdatter; Michelsen, Annika; Skjelland, Mona; Russell, David; Nymo, Ståle Haugset; Krohg-Sørensen, Kirsten; Clausen, Ole Petter Fraas; Atar, Dan; Januzzi, James L.; Aukrust, Pål; Jensen, Jesper K. & Halvorsen, Bente (2011). Fatty Acid Binding Protein 4 Is Associated with Carotid Atherosclerosis and Outcome in Patients with Acute Ischemic Stroke. PLOS ONE.  ISSN 1932-6203.  6(12) . doi: 10.1371/journal.pone.0028785 Show summary

  Background and Purpose: Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking and associated inflammation. To further elucidate the role of FABP4 in atherogenesis in humans, we examined the regulation of FABP4 in carotid atherosclerosis and ischemic stroke. Methods: We examined plasma FABP4 levels in asymptomatic (n = 28) and symptomatic (n = 31) patients with carotid atherosclerosis, as well as in 202 subjects with acute ischemic stroke. In a subgroup of patients we also analysed the expression of FABP4 within the atherosclerotic lesion. In addition, we investigated the ability of different stimuli with relevance to atherosclerosis to regulate FABP4 expression in monocytes/macrophages. Results: FABP4 levels were higher in patients with carotid atherosclerosis, both systemically and within the atherosclerotic lesion, with particular high mRNA levels in carotid plaques from patients with the most recent symptoms. Immunostaining of carotid plaques localized FABP4 to macrophages, while activated platelets and oxidized LDL were potent stimuli for FABP4 expression in monocytes/macrophages in vitro. When measured at the time of acute ischemic stroke, high plasma levels of FABP4 were significantly associated with total and cardiovascular mortality during follow-up, although we did not find that addition of FABP4 to the fully adjusted multivariate model had an effect on the prognostic discrimination for allcause mortality as assessed by c-statistics. Conclusions: FABP4 is linked to atherogenesis, plaque instability and adverse outcome in patients with carotid atherosclerosis and acute ischemic stroke.

• Aukrust, Pål; Halvorsen, Bente; Ueland, Thor; Michelsen, Annika; Skjelland, Mona; Gullestad, Lars; Yndestad, Arne & Otterdal, Kari (2010). Activated platelets and atherosclerosis. Expert Review of Cardiovascular Therapy.  ISSN 1477-9072.  8(9), s 1297- 1307 . doi: 10.1586/erc.10.92
• Breland, Unni Mathilde; Michelsen, Annika; Skjelland, Mona; Folkersen, L; Krohg-Sørensen, Kirsten; Russell, David; Ueland, Thor; Yndestad, Arne; Paulsson-Berne, G; Damås, Jan Kristian; Øie, Erik; Hansson, Göran K; Halvorsen, Bente & Aukrust, Pål (2010). Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation. Cardiovascular Research (CVR).  ISSN 0008-6363.  86(2), s 265- 273 . doi: 10.1093/cvr/cvq044
• Michelsen, Annika; Rathcke, CN; Skjelland, Mona; Holm, Sverre; Ranheim, Trine; Krohg-Sørensen, Kirsten; Klingvall, Marit Fodnes; Brosstad, Frank Roger; Øie, Erik; Vestergaard, H.; Aukrust, Pål & Halvorsen, Bente (2010). Increased YKL-40 expression in patients with carotid atherosclerosis. Atherosclerosis.  ISSN 0021-9150.  211(2), s 589- 595 . doi: 10.1016/j.atherosclerosis.2010.02.035
• Michelsen, Annika E.; Notø, Ann-Trude With; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brosstad, Frank & Hansen, John-Bjarne (2009). Elevated levels of platelet microparticles in carotid atherosclerosis and during the postprandial state. Thrombosis Research.  ISSN 0049-3848.  123(6), s 881- 886 . doi: 10.1016/j.thromres.2008.10.016
• Handberg, Aase; Skjelland, Mona; Michelsen, Annika; Sagen, Ellen Lund; Krohg-Sørensen, Kirsten; Russell, David; Dahl, Arve; Ueland, Thor; Øie, Erik; Aukrust, Pål & Halvorsen, Bente (2008). Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability. Stroke.  ISSN 0039-2499.  39, s 3092- 3095 . doi: 10.1161/STROKEAHA.108.517128
• Michelsen, A; Brodin, Ellen Elisabeth; Brosstad, F & Hansen, John-Bjarne (2008). Increased level of platelet microparticles in survivors of myocardial infarction. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  68, s 386- 392 . doi: 10.1080/00365510701794957
• Skjelland, Mona; Michelsen, Annika; Brosstad, Frank Roger; Svennevig, Jan Ludvig; Brucher, R & Russell, David (2008). Solid cerebral microemboli and cerebrovascular symptoms in patients with prosthetic heart valves. Stroke.  ISSN 0039-2499.  39 . doi: 10.1161/STROKEAHA.107.493031
• Cornelissen, JHC; van Bodegom, PM; Aerts, R; Callaghan, TV; van Logtestijn, RSP; Alatalo, J; Chapin, FS; Gerdol, R; Gudmundsson, J; Gwynn-Jones, D; Hartley, AE; Hik, DS; Hofgaard, A; Jonsdottir, IS; Karlsson, S; Klein, JA; Laundre, J; Magnusson, B; Michelsen, A; Molau, U; Onipchenko, VG; Quested, HM; Sandvik, SM; Schmidt, IK; Shaver, GR; Solheim, Bjørn; Soudzilovskaia, NA; Stenstrom, A; Tolvanen, A; Totland, O; Wada, N; Welker, JM & Zhao, XQ (2007). Global negative vegetation feedback to climate warming responses of leaf litter decomposition rates in cold biomes. Ecology Letters.  ISSN 1461-023X.  10 . doi: 10.1111/j.1461-0248.2007.01051.x
• Dahl, Tuva Børresdatter; Yndestad, Arne; Skjelland, Mona; Øie, Erik; Dahl, Arve; Michelsen, Annika; Damås, Jan Kristian; Tunheim, Siv Haugen; Ueland, Thor; Smith, Camilla; Bendz, Bjørn; Tonstad, Serena; Gullestad, Lars; Frøland, Stig Sophus; Krohg-Sørensen, Kirsten; Russell, David; Aukrust, Pål & Halvorsen, Bente (2007). Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation.  ISSN 0009-7322.  115, s 972- 980 . doi: 10.1161/CIRCULATIONAHA.106.665893
• Skjelland, Mona; Michelsen, Annika; Krogh-Sørensen, K; Tennøe, Bjørn; Dahl, Arve; Bakke, Jacob; Brosstad, Frank Roger; Damås, Jan Kristian; Russell, David; Halvorsen, Bente & Aukrust, Pål (2007). Plasma levels of granzyme B are increased in patients with lipid-rich carotid plaques as determined by echogenicity. Atherosclerosis.  ISSN 0021-9150.  195, s e142- e146
• Michelsen, Anikka; Wergeland, Ragnhild; Stokke, Oddvar & Brosstad, Frank Roger (2006). Development of a time-resolved immunofluorometric assay for quantifying platelet-derived microparticles in human plasma. Thrombosis Research.  ISSN 0049-3848.  117 . doi: 10.1016/j.thromres.2005.05.024

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• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker; Andersen, Trygve Brugger; Fuente, Ricardo León de la; Grundt, Heidi; Staines, Harry & Nilsen, Dennis W.T. (2020). Angiopoietin-like 4 protein is a long-term predictor of outcome in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library.. Show summary

  Introduction: Angiopoietin-like 4 protein (ANGPTL4) has multiple physiological functions including modulation of angiogenesis, vascular permeability and lipid-metabolism. Acting as an inhibitor of lipoprotein lipase, ANGPTL4 has previously been found to be associated with lipid levels and risk of coronary artery disease. Purpose: To assess the prognostic value of ANGPTL4 for long-term outcome, in addition to conventional clinical risk factors, in chest-pain patients admitted with clinically suspected acute coronary syndrome (ACS). Methods: 1853 patients from Norway and Northern-Argentina were consecutively included in this prospective 2-center cohort study. ANGPTL4 concentrations were measured in 1829 admission-samples by enzyme immunoassay. Data were pooled for analysis. Multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-months, comparing event rates across ANGPTL4-quartiles (Q1-4). Of patients with suspected ACS, 845 had a troponin T (TnT) value above the detection-limit. Subgroup analysis was performed for all-cause mortality in patients stratified according to TnT release >/≤ 0.01 ng/mL. Results: During 24-months follow-up, 254 patients (13.9%) died, of which 150 (8.2%) suffered cardiac death and 76 (4.2%) SCD. Patients who died had significantly higher admission-levels of ANGPTL4 compared to long-term survivors [4.99 (3.54 – 8.37) ng/mL versus 3.18 (2.14 – 4.78) ng/mL (median, 25 and 75% percentiles), p < 0.001]. A stepwise increase in risk of all-cause death was seen with increasing quartiles of ANGPTL4, Figure 1. For cardiac death, ANGPTL4-levels in Q4 [Hazard Ratio (HR) 2.86 (95% confidence interval (CI); 1.10 – 7.45), p = 0.031] as compared to Q1 were found to be an independent predictor of outcome. Similar results were seen for SCD in adjusted analysis for ANGPTL4-Q4 [HR 7.37 (95% CI; 1.75 – 31.1), p = 0.007] as compared to Q1. In subgroup analysis, ANGPTL4 concentrations in the highest quartile were significantly associated with increased risk of all-cause mortality in patients with TnT-release [HR 2.07 (95% CI, 1.06 – 4.02), p = 0.032], but not in patients without TnT-release. Conclusion: High admission-levels of ANGPTL4 were found to be an independent long-term predictor of all-cause mortality, cardiac death and SCD in patients with suspected ACS.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker; Andersen, Trygve Brugger; Fuente, Ricardo León de la & Nilsen, Dennis W.T. (2020). Angiopoietin-2 is a long-term predictor of all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected acute coronary syndrome.. Show summary

  Background: Angiopoietin-2 (ANGPT2) is an important regulator of angiogenesis. Higher levels of ANGPT2 have been found to be associated with an adverse cardiovascular risk factor profile potentially reflecting maladaptive vascular remodelling including atherosclerotic plaque destabilization. Purpose: To evaluate the prognostic utility of ANGPT2 added to conventional clinical risk factors for coronary heart disease, including B-type natriuretic peptide (BNP), troponin T (TnT) and C-reactive protein (CRP), in patients with suspected acute coronary syndrome (ACS). Methods: 871 chest-pain patients with clinically suspected ACS from South-Western Norway and 982 patients from Northern Argentina were consecutively included in a prospective transatlantic cohort study. We measured plasma-concentrations of ANGPT2 in admission-samples from 1815 patients by enzyme immunoassay. Univariable- and multivariable Cox proportional-hazards models, applying both loge-transformed continuous values and quartiles (Q1-4), were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-month follow-up. Of the patients with suspected ACS, 838 patients had TnT release above the detection-limit of 0.01 ng/mL. We performed subgroup analysis for all-cause mortality in patients with and without TnT release. Results: Median age in the total population was 66.0 (Q1-Q3; 55.0 – 76.8) years and 60.4% were males. At 24-month follow-up, 254 patients (14%) had died, of which 150 (8.3%) suffered cardiac death and 76 (4.2%) SCD. ANGPT2 levels were significantly higher in patients who died compared to long-term survivors [3.87 (2.40 – 7.54) ng/mL versus 2.11 (1.48 – 3.22) ng/mL (median, 25 and 75% percentiles), p < 0.001]. In multivariable analysis, ANGPT2 concentrations in the highest quartile (Q4) as compared to the lowest (Q1) were significantly associated with all-cause mortality [Hazard Ratio (HR) 1.96 (95% confidence interval (CI); 1.12 – 3.42), p = 0.018) and cardiac death [HR 2.23 (95% CI; 1.01 – 4.92), p = 0.047] at 24-month follow-up. For SCD, ANGPT2 concentrations in both Q3 [HR 3.59 (95% CI; 1.05 -12.3), p = 0.041] and Q4 [HR 3.81 (95% CI; 1.12 – 12.9), p = 0.032] as compared to Q1 were significantly related to outcome. These results were confirmed using loge-transformed continuous values of ANGPT2. ANGPT2 was also an independent predictor of all-cause mortality in both patients with and without TnT release. For patients with TnT > 0.01 ng/mL, HR for ANGPT2 in Q4 as compared to Q1 was 2.77 (95% CI; 1.41 – 5.44), p = 0.003. For patients with TnT ≤ 0.01, HR for ANGPT2-Q4 was 2.67 (95% CI; 1.08 – 6.62), p = 0.034. Conclusion: High levels of ANGPT2 were found to independently predict all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected ACS, irrespective of clinical demographics, troponin-release, CRP and BNP.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker; Andersen, Trygve Brugger; Fuente, Ricardo León de la; Staines, Harry & Nilsen, Dennis W.T. (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library. Show summary

  Introduction: The complement cascade is an important component of the innate immune system. Complement activation plays a major role in chronic inflammation and has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (C7) binds C5bC6 complex being part of the terminal complement complex (TCC/C5b-9). Purpose: To investigate the prognostic utility of complement C7 for long-term outcome in patients with suspected acute coronary syndrome (ACS). Methods: Complement C7 plasma-levels were measured by enzyme immunoassay in admission samples from 1823 patients included in a transatlantic prospective cohort study, which consecutively included hospital admitted chest-pain patients with clinically suspected ACS from South-Western Norway and Northern Argentina. Data were pooled for analysis. Univariable- and multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24 months, applying both quartiles (Q1-4) and loge-transformed continuous values of complement C7. Results: There were 253 (13.9%) deaths, of which 150 (8.2%) were categorized as cardiac death and 76 (4.2%) as SCD. Complement C7 levels were significantly higher in patients who died as compared to long-term survivors [176.9 (142.1 – 228.7) µg/mL versus 139.8 (110.6 – 179.7) µg/mL (median, 25 and 75% percentile), p < 0.001], and were significantly associated with 24-month survival [log rank p < 0.001 for all-cause mortality and cardiac death, log rank p = 0.035 for SCD]. In univariable analysis, patients with complement C7-concentrations in the highest quartiles had significantly increased risk of all-cause mortality (Figure 1), cardiac death [Q4: Hazard Ratio (HR) 4.58 (95% confidence interval (CI); 2.65 – 7.92), p < 0.001, Q3: HR 2.69 (95% CI; 1.51 – 4.80), p = 0.001] and SCD [Q4: HR 2.83 (95% CI; 1.36 – 5.90), p = 0.005, Q3: HR 2.33 (95% CI; 1.10 – 4.92), p = 0.027] compared to patients in the lowest quartile (Q1). After adjusting for conventional clinical risk factors for coronary heart disease, complement C7-concentrations in Q4 [HR 2.09 (95% CI; 1.23 – 3.57), p = 0.007] and Q3 [HR 2.21 (95% CI; 1.29 – 3.81), p = 0.004] remained significantly associated with all-cause mortality, reproduced using loge-transformed continuous values. Conclusion: High levels of complement C7 were found to independently predict long-term all-cause mortality in chest-pain patients with clinically suspected ACS.

• Lunde, Ngoc Nguyen Dieu; Gregersen, Ida; Holm, Sverre; Michelsen, Annika; Sporsheim, Bjørnar; Espevik, Terje; Solberg, Rigmor; Johansen, Harald Thidemann & Halvorsen, Bente (2018). Platelet-derived legumain, a cysteine protease involved in atherosclerosis.
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Kampman, Margitta Theodora; Løken-Amsrud, Kristin Ingeleiv; Steffensen, Linn Hofsøy; Bakke, Søren Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Benth, Jūratė Šaltytė; Lindstrøm, Jonas Christoffer; Mellgren, Svein Ivar; Jørgensen, Lone; Torkildsen, Øivind; Wergeland, Stig; Michelsen, Annika; Aukrust, Pål; Ueland, Thor & Holmøy, Trygve (2015). Vitamin D og interferon-behandling ved multippel sklerose.
• Holme, Pål Andre & Michelsen, Annika (2008). En 40 år gammel kvinne med svimmelhet og oppkast. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  128(1413)
• Krohg-Sørensen, Kirsten; Skjelland, Mona; Michelsen, Annika; Dahl, Arve; Tennøe, Bjørn; Bakke, Jacob; Russell, David; Halvorsen, Bente & Aukrust, Pål (2007). Lavekkogene lipidholdige carotisplakk er assosiert med økt granzyme B verdi i plasma.
• Skjelland, Mona; Michelsen, Anikke; Svennevig, Jan Ludvig; Brucher, Rainer & Russell, David (2005). The differentiation of cerebral microemboli in patients with implanted heart valves.

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