Annika Elisabet Michelsen

• Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Moe, Natasha; Aaløkken, Trond Mogens; Macpherson, Magnhild Eide & Nordøy, Ingvild [Show all 12 contributors for this article] (2022). Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency. Journal of Clinical Immunology. ISSN 0271-9142. p. 1–11. doi: 10.1007/s10875-022-01318-1. Full text in Research Archive
• Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen & Yang, Kuan [Show all 28 contributors for this article] (2022). Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. Journal of Internal Medicine. ISSN 0954-6820. p. 1–13. doi: 10.1111/joim.13549.
• Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland & Michelsen, Annika Elisabet [Show all 16 contributors for this article] (2022). Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology. Platelets. ISSN 0953-7104. 33(4), p. 640–644. doi: 10.1080/09537104.2022.2042238. Full text in Research Archive
• Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude & Skadberg, Øyvind [Show all 11 contributors for this article] (2022). Hepcidin predicts 5-year mortality after community-acquired pneumonia. Infectious Diseases. ISSN 2374-4235. 54(6), p. 403–409. doi: 10.1080/23744235.2021.2022194. Full text in Research Archive
• Simeone, Paola; Tripaldi, Romina; Michelsen, Annika Elisabet; Ueland, Thor; Liani, Rossella & Ciotti, Sonia [Show all 14 contributors for this article] (2022). Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss. Cardiovascular Diabetology. ISSN 1475-2840. 21(1), p. 1–12. doi: 10.1186/s12933-022-01469-w. Full text in Research Archive
• Lund Berven, Lise; Selvakumar, Joel Pradeepkumar; Havdal, Lise Beier; Stiansen-Sonerud, Tonje; Einvik, Gunnar & Leegaard, Truls Michael [Show all 10 contributors for this article] (2022). Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.837288.
• Vestad, Beate; Ueland, Thor; Lerum, Tøri Vigeland; Dahl, Tuva Børresdatter; Holm, Kristian & Barratt-Due, Andreas [Show all 37 contributors for this article] (2022). Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations. Journal of Internal Medicine. ISSN 0954-6820. 291(6), p. 801–812. doi: 10.1111/joim.13458. Show summary

  Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal (GI) tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long-term respiratory dysfunction remains unknown. Methods: Plasma was collected during hospital admission and after three months from the NOR-Solidarity trial (n = 181) and analysed for markers of gut barrier dysfunction and inflammation. At the three-month follow-up, pulmonary function was assessed by measuring the diffusing capacity of the lungs for carbon monoxide (DLCO ). Rectal swabs for gut microbiota analyses were collected (n = 97) and analysed by sequencing the 16S rRNA gene. Results: Gut microbiota diversity was reduced in COVID-19 patients with respiratory dysfunction, defined as DLCO below the lower limit of normal three months after hospitalisation. These patients also had an altered global gut microbiota composition, with reduced relative abundance of 20 bacterial taxa and increased abundance of five taxa, including Veillonella, potentially linked to fibrosis. During hospitalisation, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 -(P/F ratio)

• Holt, Margrethe Flesvig; Michelsen, Annika Elisabet; Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina & Massey, Richard J [Show all 15 contributors for this article] (2021). The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.800978. Full text in Research Archive
• Fevang, Børre; Wyller, Vegard Bruun Bratholm; Mollnes, Tom Eirik; Pedersen, Maria; Asprusten, Tarjei Tørre & Michelsen, Annika Elisabet [Show all 8 contributors for this article] (2021). Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.715102. Full text in Research Archive
• Langeland, Halvor Johannes Breivik; Damås, Jan Kristian; Mollnes, Tom Eirik; Ludviksen, Judith K; Ueland, Thor & Michelsen, Annika Elisabet [Show all 11 contributors for this article] (2021). The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study. Resuscitation. ISSN 0300-9572. 170, p. 115–125. doi: 10.1016/j.resuscitation.2021.11.026. Full text in Research Archive Show summary

  Background: Whole body ischemia and reperfusion injury after cardiac arrest leads to the massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous studies on the inflammatory effect on circulatory failure after cardiac arrest have either investigated a selected patient group or a limited part of the inflammatory mechanisms. We examined the association between cardiac arrest characteristics and inflammatory biomarkers, and between inflammatory biomarkers and circulatory failure after cardiac arrest, in an unselected patient cohort. Methods: This was a prospective study of 50 consecutive patients with out-of-hospital cardiac arrest. Circulation was invasively monitored from admission until day five, whereas inflammatory biomarkers, i.e. complement activation, cytokines and endothelial injury, were measured daily. We identified predictors for an increased inflammatory response, and associations between the inflammatory response and circulatory failure. Results: We found a marked and broad inflammatory response in patients after cardiac arrest, which was associated with clinical outcome. Long time to return of spontaneous circulation and high lactate level at admission were associated with increased complement activation (TCC and C3bc), pro-inflammatory cytokines (IL-6, IL-8) and endothelial injury (syndecan-1) at admission. These biomarkers were in turn significantly associated with lower mean arterial blood pressure, lower cardiac output and lower systemic vascular resistance, and increased need of circulatory support in the initial phase. High levels of TCC and IL-6 at admission were significantly associated with increased 30-days mortality. Conclusion: Inflammatory biomarkers, including complement activation, cytokines and endothelial injury, were associated with increased circulatory failure in the initial period after cardiac arrest.

• Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda & Aukrust, Pål [Show all 11 contributors for this article] (2021). Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism. Thrombosis Research. ISSN 0049-3848. 208, p. 121–126. doi: 10.1016/j.thromres.2021.10.020. Full text in Research Archive
• Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian & Broch, Kaspar [Show all 11 contributors for this article] (2021). Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction. Open heart. ISSN 2053-3624. 8(1). doi: 10.1136/openhrt-2020-001492. Full text in Research Archive
• Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter & Schultz, Nina Haagenrud [Show all 21 contributors for this article] (2021). Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia. European Heart Journal. ISSN 0195-668X. 42(39), p. 4064–4072. doi: 10.1093/eurheartj/ehab506. Full text in Research Archive
• Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam & Gregersen, Ida [Show all 10 contributors for this article] (2021). IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria. BMC Infectious Diseases. ISSN 1471-2334. 21. doi: 10.1186/s12879-021-06751-y. Full text in Research Archive
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Leon de la Fuente, Ricardo & Grundt, Magnea Heidi Jonsdottir [Show all 9 contributors for this article] (2021). Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome. BMC Cardiovascular Disorders. ISSN 1471-2261. 21(1), p. 1–12. doi: 10.1186/s12872-021-02306-w.
• Grimnes, Gro; Bhoelan, Soerajja; Hindberg, Kristian; Davids, Mark; Nieuwdorp, Max & Mollnes, Tom E. [Show all 11 contributors for this article] (2021). Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial. Thrombosis and Haemostasis. ISSN 0340-6245. 0, p. 1–12. doi: 10.1055/s-0041-1733906. Full text in Research Archive
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; de la Fuente, Ricardo Leon & Pønitz, Volker [Show all 10 contributors for this article] (2021). Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome. Journal of Internal Medicine. ISSN 0954-6820. p. 1–16. doi: 10.1111/joim.13339.
• Ueland, Thor; Astrup, Elisabeth; Otterdal, Kari; Lekva, Tove; Janardhanan, Jeshina & Prakash, John A. [Show all 11 contributors for this article] (2021). Secreted wnt antagonists in scrub typhus. PLoS Neglected Tropical Diseases. ISSN 1935-2727. 15(4), p. 1–12. doi: 10.1371/journal.pntd.0009185. Full text in Research Archive
• Schultz, Nina Haagenrud; Sørvoll, Ingvild Hausberg; Michelsen, Annika; Munthe, Ludvig Andre; Lund-Johansen, Fridtjof & Ahlen, Maria Therese [Show all 11 contributors for this article] (2021). Thrombosis and thrombocytopenia after CHADOX1 NCoV-19 vaccination. New England Journal of Medicine. ISSN 0028-4793. 384(22), p. 2124–2130. doi: 10.1056/NEJMoa2104882. Full text in Research Archive
• Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato & Lauritzen, Trine [Show all 12 contributors for this article] (2021). Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia. Open Forum Infectious Diseases. ISSN 2328-8957. 8(4). doi: 10.1093/ofid/ofab082. Full text in Research Archive
• Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca & Hammarström, Clara Louise [Show all 15 contributors for this article] (2020). Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLOS ONE. ISSN 1932-6203. 15:e0243759(12), p. 1–14. doi: 10.1371/journal.pone.0243759. Full text in Research Archive
• Gelpi, Marco; Vestad, Beate; Hansen, Simen Hyll; Holm, Kristian; Drivsholm, Ninna & Götz, Alexandra [Show all 17 contributors for this article] (2020). Impact of human immunodeficiency virus-related gut microbiota alterations on metabolic comorbid conditions. Clinical Infectious Diseases. ISSN 1058-4838. 71(8), p. e359–e367. doi: 10.1093/cid/ciz1235. Full text in Research Archive
• Arain, Fizza Kanwal; Abraityte, Judita Aurelija; Bogdanova, Mariia; Solberg, Ole Geir; Michelsen, Annika & Lekva, Tove [Show all 19 contributors for this article] (2020). YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circulation: Heart Failure. ISSN 1941-3289. 13(10). doi: 10.1161/CIRCHEARTFAILURE.119.006643. Full text in Research Archive
• Ueland, Thor; Heggelund, Lars; Lind, Andreas; Holten, Aleksander Rygh; Tonby, Kristian & Michelsen, Annika [Show all 26 contributors for this article] (2020). Elevated plasma sTIM-3 levels in patients with severe COVID-19. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 147(1), p. 92–98. doi: 10.1016/j.jaci.2020.09.007. Full text in Research Archive
• Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor & Michelsen, Annika [Show all 15 contributors for this article] (2020). Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.13178. Full text in Research Archive
• Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G. & Skjelland, Mona [Show all 20 contributors for this article] (2020). Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial. Journal of the American Heart Association (JAHA). ISSN 2047-9980. e016360. doi: 10.1161/JAHA.120.016360. Full text in Research Archive
• Hoel, Hedda Benedicte; Ueland, Thor; Knudsen, Andreas; Kjær, Andreas; Michelsen, Annika & Sagen, Ellen Lund [Show all 12 contributors for this article] (2020). Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals. Journal of Infectious Diseases. ISSN 0022-1899. 221(4), p. 506–509. doi: 10.1093/infdis/jiz253.
• Hoel, Hedda Benedicte; Ueland, Thor; Hove-Skovsgaard, Malene; Hartling, Hans Jakob; Gelpi, Marco & Benfield, Thomas [Show all 11 contributors for this article] (2020). Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection. Open Forum Infectious Diseases. ISSN 2328-8957. 29(7). doi: 10.1093/ofid/ofaa033. Full text in Research Archive
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Gregersen, Ida & Sagen, Ellen Lund [Show all 11 contributors for this article] (2020). Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: Potential immune-regulatory role during malaria. BMC Infectious Diseases. ISSN 1471-2334. 20(65), p. 1–11. doi: 10.1186/s12879-020-4783-8. Full text in Research Archive
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C & Bertilson, Maria [Show all 15 contributors for this article] (2019). ALCAM predicts future cardiovascular death in acute coronary syndromes: Insights from the PLATO trial. Atherosclerosis. ISSN 0021-9150. p. 35–41. doi: 10.1016/j.atherosclerosis.2019.11.031. Full text in Research Archive
• Ueland, Thor; Roland, Marie Cecilie; Michelsen, Annika; Godang, Kristin; Aukrust, Pål & Henriksen, Tore [Show all 8 contributors for this article] (2019). Elevated cholesteryl ester transfer protein activity early in pregnancy predicts prediabetes 5 years later. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. doi: 10.1210/clinem/dgz119. Full text in Research Archive
• Kontny, Frederic; Andersen, Thomas; Ueland, Thor; Åkerblom, Axel; Lakic, Tatevik G. & Michelsen, Annika [Show all 14 contributors for this article] (2019). Pentraxin-3 vs C-reactive Protein and Other Prognostic Biomarkers in Acute Coronary Syndrome: A Substudy of the Platelet Inhibition and Patients Outcomes (PLATO) Trial. European Heart Journal: Acute Cardiovascular Care. ISSN 2048-8726. 00(0), p. 1–10. doi: 10.1177/2048872619846334. Full text in Research Archive
• Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre & Kong, Xiang Yi [Show all 31 contributors for this article] (2019). Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages. Atherosclerosis. ISSN 0021-9150. p. 1–9. doi: 10.1016/j.atherosclerosis.2019.12.008. Full text in Research Archive
• Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria & Aukrust, Pål [Show all 13 contributors for this article] (2019). C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 39(11), p. 2402–2410. doi: 10.1161/ATVBAHA.119.312633. Full text in Research Archive
• Shahini, Negar; Ueland, Thor; Auensen, Andreas; Michelsen, Annika; Ludviksen, Judith K & Hussain, Amjad Iqbal [Show all 17 contributors for this article] (2019). Increased complement factor B and Bb levels are associated with mortality in patients with severe aortic stenosis. Journal of Immunology. ISSN 0022-1767. 203(7), p. 1973–1980. doi: 10.4049/jimmunol.1801244. Full text in Research Archive
• Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H. & Sagen, Ellen [Show all 15 contributors for this article] (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine. ISSN 2352-3964. 46, p. 264–273. doi: 10.1016/j.ebiom.2019.07.024. Full text in Research Archive
• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika; Nymo, Ståle Haugset; Lauritzen, Trine & Oppen, Kjersti [Show all 11 contributors for this article] (2019). Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort study. ERS Monograph. ISSN 2312-508X. 5(1). doi: 10.1183/23120541.00014-2019. Full text in Research Archive
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Show all 18 contributors for this article] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, p. 1–10. doi: 10.1038/s41598-018-35367-7. Full text in Research Archive
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Becker, Richard C. & Bertilsson, Maria [Show all 13 contributors for this article] (2019). Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 39(2), p. 294–302. doi: 10.1161/ATVBAHA.118.311042.
• Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Lekva, Tove (2019). Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews. ISSN 1520-7552. :e3114, p. 1–9. doi: 10.1002/dmrr.3114. Full text in Research Archive
• Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde & Haanshuus, Christel Gill [Show all 10 contributors for this article] (2018). Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria. BMC Infectious Diseases. ISSN 1471-2334. 18. doi: 10.1186/s12879-018-3593-8. Full text in Research Archive
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Ueland, Thor; Michelsen, Annika & Pettersen, Kjell [Show all 10 contributors for this article] (2018). Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis. Open heart. ISSN 2053-3624. 5:e000901(2), p. 1–10. doi: 10.1136/openhrt-2018-000901. Full text in Research Archive
• Steineger, Johan Edvard; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Osnes, Terje & Heimdal, Ketil Riddervold [Show all 7 contributors for this article] (2018). Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis. The Laryngoscope. ISSN 0023-852X. 129(1), p. E44–E49. doi: 10.1002/lary.27548.
• Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari & Olsen, Maria Belland [Show all 15 contributors for this article] (2018). Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression. American Journal of Transplantation. ISSN 1600-6135. p. 1–11. doi: 10.1111/ajt.15141. Full text in Research Archive Show summary

  Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1.

• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian & Aukrust, Pål [Show all 9 contributors for this article] (2018). Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction. Open heart. ISSN 2053-3624. 5(2). doi: 10.1136/openhrt-2017-000765. Full text in Research Archive
• Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna & Gran, Jon Michael [Show all 16 contributors for this article] (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139, p. 37–45. doi: 10.1111/acps.12971. Full text in Research Archive
• Lekva, Tove; Godang, Kristin; Michelsen, Annika; Qvigstad, Elisabeth; Normann, Kjersti Ringvoll & Norwitz, Errol R. [Show all 11 contributors for this article] (2018). Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation. Scientific Reports. ISSN 2045-2322. 8:13392, p. 1–9. doi: 10.1038/s41598-018-31614-z. Full text in Research Archive
• Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian & Holven, Kirsten Bjørklund [Show all 10 contributors for this article] (2018). Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction. International Journal of Cardiology. ISSN 0167-5273. 274, p. 348–350. doi: 10.1016/j.ijcard.2018.06.093. Full text in Research Archive
• Ueland, Thor; Åkerblom, Axel; Ghukasyan, Tatevik; Michelsen, Annika; Aukrust, Pål & Becker, Richard C. [Show all 13 contributors for this article] (2018). Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 7(2). doi: 10.1161/JAHA.117.007009. Full text in Research Archive
• Heldal, Torbjørn Fossum; Ueland, Thor; Jenssen, Trond Geir; Hartmann, Anders; Reisæter, Anna Varberg & Aukrust, Pål [Show all 8 contributors for this article] (2018). Inflammatory and related biomarkers are associated with post-transplant diabetes mellitus in kidney recipients: a retrospective study. Transplant International. ISSN 0934-0874. 31(5), p. 510–519. doi: 10.1111/tri.13116.
• Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth & Gullestad, Lars [Show all 7 contributors for this article] (2017). Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients. Open heart. ISSN 2053-3624. 4(2). doi: 10.1136/openhrt-2017-000635. Full text in Research Archive
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Roland, Marie Cecilie; Henriksen, Tore & Bollerslev, Jens [Show all 7 contributors for this article] (2017). CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up. Diabetes & vascular disease research. ISSN 1479-1641. 14(6), p. 525–533. doi: 10.1177/1479164117728011.
• Lekva, Tove; Roland, Marie Cecilie; Michelsen, Annika; Friis, Camilla Margrethe; Aukrust, Pål & Bollerslev, Jens [Show all 8 contributors for this article] (2017). Large reduction in adiponectin during pregnancy is associated with large-for-gestational-age newborns. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 102(7), p. 2552–2559. doi: 10.1210/jc.2017-00289.
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder & Michelsen, Annika [Show all 9 contributors for this article] (2017). Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 24(11), p. 1161–1167. doi: 10.1177/2047487317703826.
• Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon & Kleinman, Joel Edward [Show all 19 contributors for this article] (2017). A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue. Schizophrenia Bulletin. ISSN 0586-7614. 43(4), p. 881–890. doi: 10.1093/schbul/sbw183. Full text in Research Archive
• Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder & Michelsen, Annika [Show all 9 contributors for this article] (2017). Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study. International Journal of Cardiology. ISSN 0167-5273. 243, p. 502–504. doi: 10.1016/j.ijcard.2017.05.106. Full text in Research Archive
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve & Aukrust, Pål [Show all 14 contributors for this article] (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-03625-9. Full text in Research Archive
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika & Ranheim, Trine [Show all 16 contributors for this article] (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine. ISSN 0946-2716. 95(7), p. 767–777. doi: 10.1007/s00109-017-1529-1.
• Norum, Hilde Margrethe; Broch, Kaspar; Michelsen, Annika; Lunde, Ida Gjervold; Lekva, Tove & Abraityte, Judita Aurelija [Show all 14 contributors for this article] (2017). The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy. Journal of Cardiovascular Translational Research. ISSN 1937-5387. p. 1–10. doi: 10.1007/s12265-017-9748-y.
• Shahini, Negar; Michelsen, Annika; Nilsson, Per; Ekholt, Karin; Gullestad, Lars & Broch, Kaspar [Show all 12 contributors for this article] (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/srep42532. Full text in Research Archive
• Lekva, Tove; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens & Ueland, Thor (2017). Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus. Cardiovascular Diabetology. ISSN 1475-2840. 16:5(1), p. 1–10. doi: 10.1186/s12933-016-0492-4. Full text in Research Archive
• Holte, Espen; Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte & Broch, Kaspar [Show all 14 contributors for this article] (2017). Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction. Heart. ISSN 1355-6037. 103(19), p. 1521–1527. doi: 10.1136/heartjnl-2016-310875.
• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik & Hartmann, Anders [Show all 12 contributors for this article] (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition. ISSN 1051-2276. 27(3), p. 161–168. doi: 10.1053/j.jrn.2016.09.008. Show summary

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder & Michelsen, Annika [Show all 9 contributors for this article] (2016). Circulating PCSK9 and risk of myocardial infarction: The HUNT Study in Norway. JACC: Basic to Translational Science. ISSN 2452-302X. 1(7), p. 568–575. doi: 10.1016/j.jacbts.2016.06.007.
• Arain, Fizza Kanwal; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Cleland, JG & Michelsen, Annika [Show all 10 contributors for this article] (2016). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA. Biomarkers. ISSN 1354-750X. 22(3-4), p. 261–267. doi: 10.1080/1354750X.2016.1204003.
• Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Frydenlund, Didrik Søli; Holm, Kristian; Paulsen, Vemund & Michelsen, Annika [Show all 23 contributors for this article] (2016). A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients with Common Variable Immunodeficiency. American Journal of Gastroenterology. ISSN 0002-9270. 111(10), p. 1467–1475. doi: 10.1038/ajg.2016.329.
• Palm, Øyvind; Ueland, Thor; Garen, Torhild Oddveig; Michelsen, Annika; Reiseter, Silje & Aukrust, Pål [Show all 8 contributors for this article] (2016). Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome. Clinical and Experimental Rheumatology. ISSN 0392-856X. 34(4), p. 690–693.
• Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal & Wium, Cecilie [Show all 20 contributors for this article] (2016). LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro. Diabetologia. ISSN 0012-186X. 59, p. 2134–2144. doi: 10.1007/s00125-016-4036-y. Full text in Research Archive
• Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar & Holte, Espen [Show all 15 contributors for this article] (2016). Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. European Heart Journal. ISSN 0195-668X. 37(30), p. 2406–2413. doi: 10.1093/eurheartj/ehw171. Full text in Research Archive
• Stylianou, Eva; Ueland, Thor; Borchsenius, Fredrik; Michelsen, Annika; Øvstebø, Reidun & Mollnes, Tom Eirik [Show all 8 contributors for this article] (2016). Specific allergen immunotherapy: Effect on IgE, IgG4 and chemokines in patients with allergic rhinitis. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 76(2), p. 118–127. doi: 10.3109/00365513.2015.1110856.
• Lekva, Tove; Michelsen, Annika; Bollerslev, Jens; Norwitz, Errol R.; Aukrust, Pål & Henriksen, Tore [Show all 7 contributors for this article] (2016). Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: A 5-year follow-up study. Cardiovascular Diabetology. ISSN 1475-2840. 15(23). doi: 10.1186/s12933-016-0345-1.
• Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika & Osnes, Liv T. N. [Show all 21 contributors for this article] (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology. ISSN 1933-0219. doi: 10.1038/mi.2016.18.
• Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder & Michelsen, Annika [Show all 10 contributors for this article] (2016). Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway. Atherosclerosis. ISSN 0021-9150. 244, p. 188–194. doi: 10.1016/j.atherosclerosis.2015.11.022.
• Prebensen, Christian; Ueland, Thor; Michelsen, Annika; Lind, Andreas; Pettersen, Frank Olav & Mollnes, Tom Eirik [Show all 9 contributors for this article] (2015). High MIP-1β levels in plasma predict long-term immunological nonresponse to suppressive antiretroviral therapy in HIV infection. Journal of Acquired Immune Deficiency Syndromes. ISSN 1525-4135. 69(4), p. 395–402. doi: 10.1097/QAI.0000000000000617.
• Røsjø, Egil Rørvik; Steffensen, Linn Hofsøy; Jørgensen, Lone; Lindstrøm, Jonas Christoffer; Saltyte Benth, Jurate & Michelsen, Annika [Show all 11 contributors for this article] (2015). Vitamin D supplementation and systemic inflammation in relapsing-remitting multiple sclerosis. Journal of Neurology. ISSN 0340-5354. 262(12), p. 2713–2721. doi: 10.1007/s00415-015-7902-5. Show summary

  Observational studies have suggested that vitamin D may reduce inflammation in relapsing-remitting multiple sclerosis (RRMS), but this has not been clearly confirmed in randomized controlled trials. To further explore the possible anti-inflammatory effects of vitamin D in RRMS, we examined the effect of high-dose oral vitamin D3 on eleven markers of systemic inflammation in 68 RRMS patients enrolled in a double-blinded randomized placebo-controlled trial of vitamin D3 supplementation (20,000 IU/week) (NCT00785473). Serum inflammation markers and 25-hydroxyvitamin D (25(OH)D) were measured at baseline and week 96, and no restrictions were set on additional standard immunomodulatory treatment for RRMS. The mean 25(OH)D level rose from 56 ± 29 to 123 ± 34 nmol/L among patients receiving vitamin D3 supplementation, whereas only a minor increase from 57 ± 22 to 63 ± 24 nmol/L was seen in the placebo group. However, no significant differences appeared between the vitamin D group and the placebo group for any of the inflammation markers. Patients on immunomodulatory therapy had significantly higher levels of interleukin-1 receptor antagonist and chemokine (C-X-C motif) ligand 16 than patients without immunomodulatory treatment, but there were no clear synergistic effects between immunomodulatory therapy and vitamin D3 supplementation on any of the inflammation markers. The rise in 25(OH)D levels after vitamin D3 supplementation was unaffected by immunomodulatory treatment. We conclude that in this study of RRMS patients, high-dose oral vitamin D3 supplementation prominently increased serum 25(OH)D levels without affecting markers of systemic inflammation, while a more anti-inflammatory phenotype was found among patients on immunomodulatory treatment.

• Stokke, Silje Agnethe; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Wergeland, Stig & Beiske, Antonie Giæver [Show all 17 contributors for this article] (2015). Body mass index influence interferon-beta treatment response in multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 288, p. 92–97. doi: 10.1016/j.jneuroim.2015.09.008.
• Abbas, Azhar; Gregersen, Ida; Holm, Sverre; Daissormont, Isabelle; Bjerkeli, Vigdis & Krohg-Sørensen, Kirsten [Show all 19 contributors for this article] (2015). Interleukin 23 levels are increased in carotid atherosclerosis: Possible role for the interleukin 23/interleukin 17 axis. Stroke. ISSN 0039-2499. 46(3), p. 793–799. doi: 10.1161/STROKEAHA.114.006516.
• Reiseter, Silje; Molberg, Øyvind; Gunnarsson, Ragnar; Lund, May Brit; Aaløkken, Trond Mogens & Aukrust, Pål [Show all 12 contributors for this article] (2015). Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study. Arthritis Research & Therapy. ISSN 1478-6354. 17:231. doi: 10.1186/s13075-015-0756-5. Full text in Research Archive
• Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Michelsen, Annika; Ueland, Thor & Hardie, Jon Andrew [Show all 9 contributors for this article] (2015). Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD. PLOS ONE. ISSN 1932-6203. 10:e0121622(3). doi: 10.1371/journal.pone.0121622. Full text in Research Archive
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Løken-Amsrud, Kristin Ingeleiv; Bakke, Søren Jacob; Beiske, Antonie Giæver & Bjerve, Kristian S [Show all 17 contributors for this article] (2015). Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 280, p. 21–28. doi: 10.1016/j.jneuroim.2015.02.001.
• Broch, Kaspar; Andreassen, Arne K.; Ueland, Thor; Michelsen, Annika; Stueflotten, Wenche & Aukrust, Pål [Show all 8 contributors for this article] (2015). Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure. International Journal of Cardiology. ISSN 0167-5273. 179, p. 378–384. doi: 10.1016/j.ijcard.2014.11.003.
• Sveaas, Silje Halvorsen; Berg, Inger Jorid; Provan, Sella Aarrestad; Semb, Anne Grete; Hagen, Kåre Birger & Vøllestad, Nina Køpke [Show all 13 contributors for this article] (2014). Efficacy of High Intensity Exercise on Disease Activity and Cardiovascular Risk in Active Axial Spondyloarthritis: A Randomized Controlled Pilot Study. PLOS ONE. ISSN 1932-6203. 9(9). doi: 10.1371/journal.pone.0108688.
• Wium, Cecilie; Eggesbø, Heidi Beate; Ueland, Thor; Michelsen, Annika; Torjesen, Peter A & Aukrust, Pål [Show all 7 contributors for this article] (2014). Adipose tissue distribution in relation to insulin sensitivity and inflammation in Pakistani and Norwegian subjects with type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 74(8), p. 700–707. doi: 10.3109/00365513.2014.953571.
• Halvorsen, Bente ; Dahl, Tuva Børresdatter; Smedbakken, Linda Merete; Singh, Anjana; Michelsen, Annika & Skjelland, Mona [Show all 15 contributors for this article] (2014). Increased levels of CCR7 ligands in carotid atherosclerosis: Different effects in macrophages and smooth muscle cells. Cardiovascular Research (CVR). ISSN 0008-6363. 102(1), p. 148–156. doi: 10.1093/cvr/cvu036.
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver & Bjerve, Kristian S [Show all 17 contributors for this article] (2014). Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 271(1-2), p. 60–65. doi: 10.1016/j.jneuroim.2014.03.014. Show summary

  To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment.

• Halvorsen, Bente ; Smedbakken, Linda Merete; Michelsen, Annika ; Skjelland, Mona; Bjerkeli, Vigdis & Sagen, Ellen Lund [Show all 12 contributors for this article] (2014). Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13. Atherosclerosis. ISSN 0021-9150. 234(2), p. 352–359. doi: 10.1016/j.atherosclerosis.2014.03.021.
• Abbas, Azhar; Aukrust, Pål; Russell, David; Krohg-Sørensen, Kirsten; Almås, Trine & Bundgaard, Dorte [Show all 14 contributors for this article] (2014). Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis. PLOS ONE. ISSN 1932-6203. 9(1:e84935). doi: 10.1371/journal.pone.0084935.
• Ueland, Thor; Rollag, Halvor; Hartmann, Anders; Jardine, Alan George; Humar, Atul & Michelsen, Annika [Show all 9 contributors for this article] (2014). Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients. American Journal of Transplantation. ISSN 1600-6135. 14(1), p. 210–215. doi: 10.1111/ajt.12506.
• Wium, Cecilie; AASHEIM, ERLEND T.; Ueland, Thor; Michelsen, Annika ; Thorsby, Per Medbøe & Larsen, Ingegerd Frøyshov [Show all 9 contributors for this article] (2013). Differences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional study. BMC Endocrine Disorders. ISSN 1472-6823. 13(49). doi: 10.1186/1472-6823-13-49. Full text in Research Archive
• Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Ringstad, Geir Andre & Olstad, Ole Kristoffer [Show all 10 contributors for this article] (2013). Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas. Endocrinology. ISSN 0013-7227. 154(9), p. 3331–3343. doi: 10.1210/en.2013-1051.
• Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S & Hovdal, Harald Olav [Show all 16 contributors for this article] (2013). Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity. PLOS ONE. ISSN 1932-6203. 8(9). doi: 10.1371/journal.pone.0075021. Full text in Research Archive
• Gullestad, Lars; Ørn, Stein; Dickstein, Kenneth; Eek, Christian; Edvardsen, Thor & Aakhus, Svend [Show all 14 contributors for this article] (2013). Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. International Journal of Cardiology. ISSN 0167-5273. 168(1), p. 212–218. doi: 10.1016/j.ijcard.2012.09.092. Show summary

  BACKGROUND: Left ventricular (LV) remodeling takes place after acute myocardial infarction (MI), potentially leading to overt heart failure (HF). Enhanced inflammation may contribute to LV remodeling. Our hypothesis was that the immunomodulating effects of intravenous immunoglobulin (IVIg) would be beneficial in patients with impaired myocardial function after MI by reducing myocardial remodeling and improving myocardial function. METHODS: Sixty-two patients with acute MI treated by percutaneous coronary intervention, with depressed LV ejection fraction (LVEF) were randomized in a double-blinded fashion to IVIg as induction therapy and thereafter as monthly infusions or placebo for 26weeks. The primary end point was changes in LVEF from baseline to 6months as assessed by MRI. RESULTS: Our main findings were: (i) LVEF increased significantly from 38±10 (mean±SD) to 45±13% after IVIg and from 42±9 to 49±12% after placebo with no difference between the groups. (ii) The scar area decreased significantly by 3% and 5% in the IVIg and placebo group, respectively, with no difference between the groups. (iii) During the induction therapy (baseline to day 5), IVIg induced both inflammatory (e.g., increase in tumor necrosis factor α and monocyte chemoattractant protein-1) and anti-inflammatory (e.g., increase in interleukin-10 and decrease in leukocyte counts) variables, but during maintenance therapy there were no differences in changes of inflammatory mediators between IVIg and placebo. CONCLUSIONS: IVIg therapy after ST elevation MI managed by primary PCI does not affect LV remodeling or function. This illustrates the challenges of therapeutic intervention directed against the cytokine network, to prevent post-MI remodeling.

• Smedbakken, Linda Merete; Halvorsen, Bente ; Daissormont, Isabelle; Ranheim, Trine; Michelsen, Annika & Skjelland, Mona [Show all 19 contributors for this article] (2012). Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization. Atherosclerosis. ISSN 0021-9150. 224(1), p. 266–273. doi: 10.1016/j.atherosclerosis.2012.06.071.

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• Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet & Lerum, Tøri Vigeland [Show all 28 contributors for this article] (2022). High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19. Journal of Infectious Diseases. ISSN 0022-1899. doi: 10.1093/infdis/jiac313.
• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Show all 10 contributors for this article] (2020). Angiopoietin-like 4 protein is a long-term predictor of outcome in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library. Show summary

  Introduction: Angiopoietin-like 4 protein (ANGPTL4) has multiple physiological functions including modulation of angiogenesis, vascular permeability and lipid-metabolism. Acting as an inhibitor of lipoprotein lipase, ANGPTL4 has previously been found to be associated with lipid levels and risk of coronary artery disease. Purpose: To assess the prognostic value of ANGPTL4 for long-term outcome, in addition to conventional clinical risk factors, in chest-pain patients admitted with clinically suspected acute coronary syndrome (ACS). Methods: 1853 patients from Norway and Northern-Argentina were consecutively included in this prospective 2-center cohort study. ANGPTL4 concentrations were measured in 1829 admission-samples by enzyme immunoassay. Data were pooled for analysis. Multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-months, comparing event rates across ANGPTL4-quartiles (Q1-4). Of patients with suspected ACS, 845 had a troponin T (TnT) value above the detection-limit. Subgroup analysis was performed for all-cause mortality in patients stratified according to TnT release >/≤ 0.01 ng/mL. Results: During 24-months follow-up, 254 patients (13.9%) died, of which 150 (8.2%) suffered cardiac death and 76 (4.2%) SCD. Patients who died had significantly higher admission-levels of ANGPTL4 compared to long-term survivors [4.99 (3.54 – 8.37) ng/mL versus 3.18 (2.14 – 4.78) ng/mL (median, 25 and 75% percentiles), p < 0.001]. A stepwise increase in risk of all-cause death was seen with increasing quartiles of ANGPTL4, Figure 1. For cardiac death, ANGPTL4-levels in Q4 [Hazard Ratio (HR) 2.86 (95% confidence interval (CI); 1.10 – 7.45), p = 0.031] as compared to Q1 were found to be an independent predictor of outcome. Similar results were seen for SCD in adjusted analysis for ANGPTL4-Q4 [HR 7.37 (95% CI; 1.75 – 31.1), p = 0.007] as compared to Q1. In subgroup analysis, ANGPTL4 concentrations in the highest quartile were significantly associated with increased risk of all-cause mortality in patients with TnT-release [HR 2.07 (95% CI, 1.06 – 4.02), p = 0.032], but not in patients without TnT-release. Conclusion: High admission-levels of ANGPTL4 were found to be an independent long-term predictor of all-cause mortality, cardiac death and SCD in patients with suspected ACS.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Show all 9 contributors for this article] (2020). Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome. ESC 365 Library . Show summary

  Introduction: The complement cascade is an important component of the innate immune system. Complement activation plays a major role in chronic inflammation and has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (C7) binds C5bC6 complex being part of the terminal complement complex (TCC/C5b-9). Purpose: To investigate the prognostic utility of complement C7 for long-term outcome in patients with suspected acute coronary syndrome (ACS). Methods: Complement C7 plasma-levels were measured by enzyme immunoassay in admission samples from 1823 patients included in a transatlantic prospective cohort study, which consecutively included hospital admitted chest-pain patients with clinically suspected ACS from South-Western Norway and Northern Argentina. Data were pooled for analysis. Univariable- and multivariable Cox proportional-hazards models were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24 months, applying both quartiles (Q1-4) and loge-transformed continuous values of complement C7. Results: There were 253 (13.9%) deaths, of which 150 (8.2%) were categorized as cardiac death and 76 (4.2%) as SCD. Complement C7 levels were significantly higher in patients who died as compared to long-term survivors [176.9 (142.1 – 228.7) µg/mL versus 139.8 (110.6 – 179.7) µg/mL (median, 25 and 75% percentile), p < 0.001], and were significantly associated with 24-month survival [log rank p < 0.001 for all-cause mortality and cardiac death, log rank p = 0.035 for SCD]. In univariable analysis, patients with complement C7-concentrations in the highest quartiles had significantly increased risk of all-cause mortality (Figure 1), cardiac death [Q4: Hazard Ratio (HR) 4.58 (95% confidence interval (CI); 2.65 – 7.92), p < 0.001, Q3: HR 2.69 (95% CI; 1.51 – 4.80), p = 0.001] and SCD [Q4: HR 2.83 (95% CI; 1.36 – 5.90), p = 0.005, Q3: HR 2.33 (95% CI; 1.10 – 4.92), p = 0.027] compared to patients in the lowest quartile (Q1). After adjusting for conventional clinical risk factors for coronary heart disease, complement C7-concentrations in Q4 [HR 2.09 (95% CI; 1.23 – 3.57), p = 0.007] and Q3 [HR 2.21 (95% CI; 1.29 – 3.81), p = 0.004] remained significantly associated with all-cause mortality, reproduced using loge-transformed continuous values. Conclusion: High levels of complement C7 were found to independently predict long-term all-cause mortality in chest-pain patients with clinically suspected ACS.

• Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Pønitz, Volker & Andersen, Trygve Brugger [Show all 8 contributors for this article] (2020). Angiopoietin-2 is a long-term predictor of all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected acute coronary syndrome. Show summary

  Background: Angiopoietin-2 (ANGPT2) is an important regulator of angiogenesis. Higher levels of ANGPT2 have been found to be associated with an adverse cardiovascular risk factor profile potentially reflecting maladaptive vascular remodelling including atherosclerotic plaque destabilization. Purpose: To evaluate the prognostic utility of ANGPT2 added to conventional clinical risk factors for coronary heart disease, including B-type natriuretic peptide (BNP), troponin T (TnT) and C-reactive protein (CRP), in patients with suspected acute coronary syndrome (ACS). Methods: 871 chest-pain patients with clinically suspected ACS from South-Western Norway and 982 patients from Northern Argentina were consecutively included in a prospective transatlantic cohort study. We measured plasma-concentrations of ANGPT2 in admission-samples from 1815 patients by enzyme immunoassay. Univariable- and multivariable Cox proportional-hazards models, applying both loge-transformed continuous values and quartiles (Q1-4), were fitted for the analysis of all-cause mortality, cardiac death and sudden cardiac death (SCD) within 24-month follow-up. Of the patients with suspected ACS, 838 patients had TnT release above the detection-limit of 0.01 ng/mL. We performed subgroup analysis for all-cause mortality in patients with and without TnT release. Results: Median age in the total population was 66.0 (Q1-Q3; 55.0 – 76.8) years and 60.4% were males. At 24-month follow-up, 254 patients (14%) had died, of which 150 (8.3%) suffered cardiac death and 76 (4.2%) SCD. ANGPT2 levels were significantly higher in patients who died compared to long-term survivors [3.87 (2.40 – 7.54) ng/mL versus 2.11 (1.48 – 3.22) ng/mL (median, 25 and 75% percentiles), p < 0.001]. In multivariable analysis, ANGPT2 concentrations in the highest quartile (Q4) as compared to the lowest (Q1) were significantly associated with all-cause mortality [Hazard Ratio (HR) 1.96 (95% confidence interval (CI); 1.12 – 3.42), p = 0.018) and cardiac death [HR 2.23 (95% CI; 1.01 – 4.92), p = 0.047] at 24-month follow-up. For SCD, ANGPT2 concentrations in both Q3 [HR 3.59 (95% CI; 1.05 -12.3), p = 0.041] and Q4 [HR 3.81 (95% CI; 1.12 – 12.9), p = 0.032] as compared to Q1 were significantly related to outcome. These results were confirmed using loge-transformed continuous values of ANGPT2. ANGPT2 was also an independent predictor of all-cause mortality in both patients with and without TnT release. For patients with TnT > 0.01 ng/mL, HR for ANGPT2 in Q4 as compared to Q1 was 2.77 (95% CI; 1.41 – 5.44), p = 0.003. For patients with TnT ≤ 0.01, HR for ANGPT2-Q4 was 2.67 (95% CI; 1.08 – 6.62), p = 0.034. Conclusion: High levels of ANGPT2 were found to independently predict all-cause mortality, cardiac death and sudden cardiac death in chest-pain patients with suspected ACS, irrespective of clinical demographics, troponin-release, CRP and BNP.

• Siljan, William Ward; Holter, Jan Cato; Michelsen, Annika Elisabet; Nymo, Ståle Haugset; Norseth, Jon & Husebye, Einar [Show all 11 contributors for this article] (2018). Procalcitonin has wider applicability in community-acquired pneumonia than other biomarkers. European Respiratory Journal. ISSN 0903-1936. doi: 10.1183/13993003.congress-2018.PA2622.
• Lunde, Ngoc Nguyen Dieu; Gregersen, Ida; Holm, Sverre; Michelsen, Annika; Sporsheim, Bjørnar & Espevik, Terje [Show all 9 contributors for this article] (2018). Platelet-derived legumain, a cysteine protease involved in atherosclerosis .
• Røsjø, Egil Rørvik; Myhr, Kjell-Morten; Kampman, Margitta Theodora; Løken-Amsrud, Kristin Ingeleiv; Steffensen, Linn Hofsøy & Bakke, Søren Jacob [Show all 22 contributors for this article] (2015). Vitamin D og interferon-behandling ved multippel sklerose.

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