Arild Andre Østhus

• Rana, Mohammad Usman; Østhus, Arild Andre; Heimdal, Ketil Riddervold; Jebsen, Peter Wilhelm; Rootwelt-Revheim, Mona-Elisabeth & Osnes, Terje (2020). Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment. Acta Oto-Laryngologica. ISSN 0001-6489. p. 1–7. doi: 10.1080/00016489.2020.1845397. Full text in Research Archive Show summary

  Background Head and neck paragangliomas (HNPG) are rare and predominantly benign tumours, originating from the neuroendocrine paraganglionic system. A considerable proportion of HNPGs are hereditary, depending on the population. Aims/objectives The purpose of this study was to estimate the rate of hereditary HNPGs in a Scandinavian (Norwegian) population, report long-term experience with HNPGs and offer all patients diagnosed an updated follow-up, with emphasis on identifying hereditary HNPGs through genetic screening and multifocality by 18 F-2-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Material and methods Our study was a partly retrospective and partly prospective cohort study. It included patients with HNPG diagnosed at Oslo University Hospital (OUH), Rikshospitalet between 1990 and 2017. The patients underwent genetic testing, 18F-FDG PET/CT and measurement of catecholamines and meta-nephrines in the plasma. All resection specimens and biopsies were subjected to histopathological review. The genetic testing protocol consisted of testing for mutations in the following genes; SDHD, SDHB, SDHC, VHL and RET. Results Sixty-three patients were included in the study with a median age of 49 years (range 12 − 80). Cranial nerve dysfunction was present upon diagnosis in 13%, and 14% had multifocal paraganglioma (PG) disease. Fifty-six patients (89% of all the patients) underwent genetic testing, and 29% of these had a PG related mutation. Seven of the eight patients (88%) with multifocal PGs who underwent genetic testing had a mutation. In two of the patients, the 18F-FDG PET/CT revealed unknown and subclinical multifocality. Conclusions and significance This is the first study with systematic genetic workup and PET/CT imaging in Scandinavia of HNPG patients. The mutation rate was within the lower range reported in the literature with respect to HNPGs. Combining genetic testing and PET/CT imaging in the diagnostic workup of HNPGs is valuable.

• Aarstad, Hans Jørgen; Østhus, Arild Andre; Aarstad, Helene Hersvik; Lybak, Stein & Aarstad, Anne Kari Hersvik (2019). EORTC Quality of Life Questionnaire Head and Neck (H&N)-35 scores from H&N squamous cell carcinoma patients obtained at diagnosis and at 6, 9 and 12 months following diagnosis predict 10-year overall survival. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. 276(12), p. 3495–3505. doi: 10.1007/s00405-019-05630-2. Full text in Research Archive
• Aarstad, Hans Jørgen; Østhus, Arild Andre; Aarstad, Helene Hersvik; Lybak, Stein & Aarstad, Anne Kari Hersvik (2017). General health-related quality of life scores from head and neck squamous cell carcinoma patients obtained throughout the first year following diagnosis predicted up to 10-year overall survival. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. 275(1), p. 207–217. doi: 10.1007/s00405-017-4800-8. Full text in Research Archive
• Aarstad, Hans Jørgen; Østhus, Arild Andre; Olofsson, Jan & Aarstad, Anne Kari Hersvik (2014). Level of distress predicts subsequent survival in successfully treated head and neck cancer patients: a prospective cohort study. Acta Oto-Laryngologica. ISSN 0001-6489. 134(2), p. 211–219. doi: 10.3109/00016489.2013.841989. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari; Olofsson, Jan & Aarstad, Hans Jørgen (2013). Comorbidity is an independent predictor of health-related quality of life in a longitudinal cohort of head and neck cancer patients. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. 270(5), p. 1721–1728. doi: 10.1007/s00405-012-2207-0. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2013). Prediction of 5 year survival from level of perceived distress in newly diagnosed head and neck squamous cell carcinoma patients. Oral Oncology. ISSN 1368-8375. 49(9), p. 964–969. doi: 10.1016/j.oraloncology.2013.06.006. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2013). Prediction of survival by pretreatment health-related quality-of-life scores in a prospective cohort of patients with head and neck squamous cell carcinoma. Archives of Otolaryngology - Head & Neck Surgery. ISSN 0886-4470. 139(1), p. 14–20. doi: 10.1001/jamaoto.2013.1056. Full text in Research Archive
• Beisland, Elisabeth; Aarstad, Anne Kari Hersvik; Østhus, Arild Andre & Aarstad, Hans Jørgen (2013). Stability of distress and health-related quality of life as well as relation to neuroticism, coping and TNM stage in head and neck cancer patients during follow- up. Acta Oto-Laryngologica. ISSN 0001-6489. 133(2), p. 209–217. doi: 10.3109/00016489.2012.720032. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2011). Health-related quality of life scores in long-term head and neck cancer survivors predict subsequent survival: a prospective cohort study. Clinical Otolaryngology. ISSN 1749-4478. 36(4), p. 361–368. doi: 10.1111/j.1749-4486.2011.02342.x. Full text in Research Archive
• Aarstad, Anne Kari Hersvik; Beisland, Elisabeth; Østhus, Arild André & Aarstad, Hans Jørgen (2011). Distress, quality of life, neuroticism and psychological coping are related in head and neck cancer patients during follow-up. Acta Oncologica. ISSN 0284-186X. 50(3), p. 390–398. doi: 10.3109/0284186X.2010.504227. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2011). Head and neck specific Health Related Quality of Life scores predict subsequent survival in successfully treated head and neck cancer patients: A prospective cohort study. Oral Oncology. ISSN 1368-8375. 47(10), p. 974–979. doi: 10.1016/j.oraloncology.2011.07.010. Full text in Research Archive

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• Aarstad, Anne Kari Hersvik; Østhus, Arild Andre; Olofsson, Jan & Aarstad, Hans Jørgen (2012). GHQ scores predict uniquely survival in successfully treated head and neck cancer patients: a prospective study. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2012). Pre-Treatment Health Related Quality of Life Scores Predict Survival in a Prospective Cohort of Head and Neck Squamous Cell Carsinoma Patients. Full text in Research Archive
• Aarstad, Hans Jørgen; Østhus, Arild Andre; Olofsson, Jan & Aarstad, Anne Kari Hersvik (2012). Distress scores predict uniquely survival in successfully treated head and neck cancer patients:a prospective study. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2011). Neuroticism predicts pre-and posttreatment health-related quality of life sum scores. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Anne Kari Hersvik; Olofsson, Jan & Aarstad, Hans Jørgen (2011). Pre-treatment comorbidity predicts pre-and post treatment health-related quality of life sum scores. Full text in Research Archive
• Aarstad, Hans Jørgen; Aarstad, Anne Kari Hersvik; Østhus, Arild Andre & Olofsson, Jan (2011). Do health related quality of life score predict survival in former head and neck cancer patients? Full text in Research Archive
• Aarstad, Anne Kari Hersvik; Beisland, Elisabeth; Østhus, Arild Andre & Aarstad, Hans Jørgen (2010). Distress and quality of life in head and neck cancer patients during follow up. Full text in Research Archive
• Østhus, Arild Andre; Aarstad, Hans Jørgen & Aarstad, Anne Kari Hersvik (2013). Health Related Quality of Life and Distress Scores Predict Survival in Head and Neck Cancer Patients. Universitetet i Bergen. ISSN 9788230824443. Full text in Research Archive

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