Cathrine Rein Carlson

• Lunde, Per Kristian; Manfra, Ornella; Støle, Thea Parsberg; Lunde, Marianne; Martinsen, Marita & Carlson, Cathrine Rein [Show all 7 contributors for this article] (2023). Polyarginine Cell-Penetrating Peptides Bind and Inhibit SERCA2. Cells. ISSN 2073-4409. 12(19). doi: 10.3390/cells12192358. Full text in Research Archive
• Pejšková, Lucie; Rønning, Sissel Beate; Kent, Matthew Peter; Solberg, Nina; Høst, Vibeke & To, Thu-Hien [Show all 13 contributors for this article] (2023). Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling. Frontiers in Physiology. ISSN 1664-042X. 14, p. 1–17. doi: 10.3389/fphys.2023.1301804. Full text in Research Archive Show summary

  The skeletal muscle deformity of commercial chickens (Gallus gallus), known as the wooden breast (WB), is associated with fibrotic myopathy of unknown etiology. For future breeding strategies and genetic improvements, it is essential to identify the molecular mechanisms underlying the phenotype. The pathophysiological hallmarks of WB include severe skeletal muscle fibrosis, inflammation, myofiber necrosis, and multifocal degeneration of muscle tissue. The transmembrane proteoglycans syndecans have a wide spectrum of biological functions and are master regulators of tissue homeostasis. They are upregulated and shed (cleaved) as a regulatory mechanism during tissue repair and regeneration. During the last decades, it has become clear that the syndecan family also has critical functions in skeletal muscle growth, however, their potential involvement in WB pathogenesis is unknown.

• Mitsou, Ioli; Carlson, Cathrine Rein; Multhaupt, Hinke A B; Brakebusch, Cord & Couchman, John R. (2023). Two Transient Receptor Potential Channels at Focal Adhesions. Journal of Histochemistry and Cytochemistry. ISSN 0022-1554. 71(9), p. 495–508. doi: 10.1369/00221554231194119.
• Vistnes, Maria; Murugan Erusappan, Pugazendhi; Sasi, Athiramol; Nordén, Einar Sjaastad; Bergo, Kaja Knudsen & Romaine, Andreas [Show all 22 contributors for this article] (2023). Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction. Cardiovascular Research (CVR). ISSN 0008-6363. 119(10), p. 1915–1927. doi: 10.1093/cvr/cvad078. Full text in Research Archive
• Perdreau-Dahl, Harmonie; Lipsett, David Bruce; Frisk, Michael; Kermani, Fatemeh; Carlson, Cathrine Rein & Brech, Andreas [Show all 19 contributors for this article] (2023). BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes. Circulation Research. ISSN 0009-7330. 132(11), p. E188–E205. doi: 10.1161/CIRCRESAHA.122.321732.
• Skogestad, Jonas; Albert, Ingrid; Hougen, Karina; Lothe, Gustav B; Lunde, Marianne & Eken, Olav Søvik [Show all 25 contributors for this article] (2023). Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice with Chronic Heart Failure. Circulation. ISSN 0009-7322. 147(16), p. 1221–1236. doi: 10.1161/CIRCULATIONAHA.121.054168.
• Lunde, Ida Gjervold; Aronsen, Jan Magnus; Melleby, Arne Olav; Strand, Mari Elen; Skogestad, Jonas & Bendiksen, Bård Andre [Show all 11 contributors for this article] (2022). Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy. Molecular Biology Reports. ISSN 0301-4851. 49(12), p. 11795–11809. doi: 10.1007/s11033-022-07985-y. Full text in Research Archive
• Støle, Thea Parsberg; Lunde, Marianne; Shen, Xin; Martinsen, Marita; Lunde, Per Kristian & Li, Jia [Show all 12 contributors for this article] (2022). The female syndecan-4^−/− heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 10. doi: 10.3389/fcell.2022.908126. Full text in Research Archive
• Carlson, Cathrine Rein; Aronsen, Jan Magnus; Bergan Dahl, Anna; Moutty, Marie Christine; Lunde, Marianne & Lunde, Per Kristian [Show all 22 contributors for this article] (2021). AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR. Circulation Research. ISSN 0009-7330. 130(1), p. 27–44. doi: 10.1161/CIRCRESAHA.120.317976. Full text in Research Archive
• Wanichawan, Pimthanya; Skogestad, Jonas; Lunde, Marianne; Støle, Thea Parsberg; Stensland, Maria & Nyman, Tuula Anneli [Show all 10 contributors for this article] (2021). Design of a proteolytically stable sodium-calcium exchanger 1 activator peptide for in vivo studies. Frontiers in Pharmacology. ISSN 1663-9812. 12(638646). doi: 10.3389/fphar.2021.638646. Full text in Research Archive
• Mathiesen, Sabrina Bech; Lunde, Marianne; Stensland, Maria; Martinsen, Marita; Nyman, Tuula Anneli & Christensen, Geir Arve [Show all 7 contributors for this article] (2020). The cardiac syndecan-2 interactome. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 8:792, p. 1–18. doi: 10.3389/fcell.2020.00792. Full text in Research Archive
• Herum, Kate Louise Møller; Romaine, Andreas; Wang, Ariel; Melleby, Arne Olav; Strand, Mari Elen & Pacheco, Julian [Show all 16 contributors for this article] (2020). Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 9(3). doi: 10.1161/JAHA.119.013518. Full text in Research Archive
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Pisconti, Addolorata; Høst, Vibeke & Lunde, Marianne [Show all 11 contributors for this article] (2020). Syndecan-4–/– Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. doi: 10.3389/fcell.2020.00730. Full text in Research Archive Show summary

  Background: Extracellular matrix (ECM) remodeling is essential for skeletal muscle development and adaption in response to environmental cues such as exercise and injury. The cell surface proteoglycan syndecan-4 has been reported to be essential for muscle differentiation, but few molecular mechanisms are known. Syndecan-4–/– mice are unable to regenerate damaged muscle, and display deficient satellite cell activation, proliferation, and differentiation. A reduced myofiber basal lamina has also been reported in syndecan-4–/– muscle, indicating possible defects in ECM production. To get a better understanding of the underlying molecular mechanisms, we have here investigated the effects of syndecan-4 genetic ablation on molecules involved in ECM remodeling and muscle growth, both under steady state conditions and in response to exercise. Methods: Tibialis anterior (TA) muscles from sedentary and exercised syndecan-4–/– and WT mice were analyzed by immunohistochemistry, real-time PCR and western blotting. Results: Compared to WT, we found that syndecan-4–/– mice had reduced body weight, reduced muscle weight, muscle fibers with a smaller cross-sectional area, and reduced expression of myogenic regulatory transcription factors. Sedentary syndecan-4–/– had also increased mRNA levels of syndecan-2, decorin, collagens, fibromodulin, biglycan, and LOX. Some of these latter ECM components were reduced at protein level, suggesting them to be more susceptible to degradation or less efficiently translated when syndecan-4 is absent. At the protein level, TRPC7 was reduced, whereas activation of the Akt/mTOR/S6K1 and Notch/HES-1 pathways were increased. Finally, although exercise induced upregulation of several of these components in WT, a further upregulation of these molecules was not observed in exercised syndecan-4–/– mice. Conclusion: Altogether our data suggest an important role of syndecan-4 in muscle development.

• Udjus, Camilla; Fadila, Cero; Halvorsen, Bente; Behmen, Dina; Carlson, Cathrine Rein & Bendiksen, Bård Andre [Show all 14 contributors for this article] (2019). Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 316(6), p. L999–L1012. doi: 10.1152/ajplung.00322.2018. Full text in Research Archive
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Eken, Olav Søvik; Sadredini, Mani; Myhre, Peder Langeland & Shen, Xin [Show all 24 contributors for this article] (2019). Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circulation: Arrhythmia and Electrophysiology. ISSN 1941-3149. 12(4). doi: 10.1161/CIRCEP.118.007045. Full text in Research Archive
• Mathiesen, Sabrina Bech; Lunde, Marianne; Aronsen, Jan Magnus; Romaine, Andreas; Kaupang, Anita & Martinsen, Marita [Show all 11 contributors for this article] (2019). The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP). Journal of Biological Chemistry. ISSN 0021-9258. 294(22), p. 8717–8731. doi: 10.1074/jbc.RA118.006423. Full text in Research Archive Show summary

  Costameres are signaling hubs at the sarcolemma and important contact points between the extracellular matrix and cell interior, sensing and transducing biomechanical signals into a cellular response. The transmembrane proteoglycan syndecan-4 localizes to these attachment points and has been shown to be important in the initial stages of cardiac remodeling, but its mechanistic function in the heart remains insufficiently understood. Here, we sought to map the cardiac interactome of syndecan-4 to better understand its function and downstream signaling mechanisms. By combining two different affinity purification methods with MS analysis, we found that the cardiac syndecan-4 interactome consists of 21 novel and 29 previously described interaction partners. Nine of the novel partners were further validated to bind syndecan-4 in HEK293 cells (i.e. CAVIN1/PTRF, CCT5, CDK9, EIF2S1, EIF4B, MPP7, PARVB, PFKM, and RASIP). We also found that 19 of the 50 interactome partners bind differently to syndecan-4 in the left ventricle lysate from aortic-banded heart failure (ABHF) rats compared with SHAM-operated animals. One of these partners was the well-known mechanotransducer muscle LIM protein (MLP), which showed direct and increased binding to syndecan-4 in ABHF. Nuclear translocation is important in MLP-mediated signaling, and we found less MLP in the nuclear-enriched fractions from syndecan-4-/- mouse left ventricles but increased nuclear MLP when syndecan-4 was overexpressed in a cardiomyocyte cell line. In the presence of a cell-permeable syndecan-4-MLP disruptor peptide, the nuclear MLP level was reduced. These findings suggest that syndecan-4 mediates nuclear translocation of MLP in the heart

• Skogestad, Jonas; Aronsen, Jan Magnus; Tovsrud, Nils; Wanichawan, Pimthanya; Hougen, Karina & Stokke, Mathis Korseberg [Show all 10 contributors for this article] (2019). Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes . Cardiovascular Research (CVR). ISSN 0008-6363. 116(1), p. 78–90. doi: 10.1093/cvr/cvz087.
• Simon, Dan N.; Wriston, Amanda; Fan, Qiong; Shabanowitz, Jeffrey; Florwick, Alyssa & Dharmaraj, Tejas [Show all 12 contributors for this article] (2018). OGT (O-GlcNAC transferase) selectively modifies multiple residues unique to Lamin A. Cells. ISSN 2073-4409. 7(44). doi: 10.3390/cells7050044. Full text in Research Archive
• Shen, Xin; van den Brink, Jonas; Hou, Yufeng; Colli, Dylan; Le, Christopher & Kolstad, Terje R Selnes [Show all 12 contributors for this article] (2018). 3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes. Journal of Physiology. ISSN 0022-3751. 597(2), p. 399–418. doi: 10.1113/JP277360. Full text in Research Archive
• Fan, Qiong; Moen, Anders; Anonsen, Jan Haug; Bindesbøll, Christian; Sæther, Thomas & Carlson, Cathrine Rein [Show all 7 contributors for this article] (2018). O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 499(2), p. 354–360. doi: 10.1016/j.bbrc.2018.03.164.
• Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Manfra, Ornella; De Souza, Gustavo Antonio; Lunde, Marianne & Martinsen, Marita [Show all 9 contributors for this article] (2017). Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Proteomics. ISSN 1615-9853. 17(17-18). doi: 10.1002/pmic.201600417.
• Weber, Jonasz J; Golla, Matthias; Guaitoli, Giambattista; Wanichawan, Pimthanya; Hayer, Stefanie N & Krahl, Ann-Christin [Show all 15 contributors for this article] (2017). A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3. Brain. ISSN 0006-8950. 140(5), p. 1280–1299. doi: 10.1093/brain/awx039.
• Lubner, Joshua M.; Dodge-Kafka, Kimberly L.; Carlson, Cathrine Rein; Church, George M.; Chou, Michael F. & Schwartz, Daniel (2017). Cushing's syndrome mutant PKAL205R exhibits altered substrate specificity. FEBS Letters. ISSN 0014-5793. 591(3), p. 459–467. doi: 10.1002/1873-3468.12562.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Dahl, Mai Britt; Sandbu, Ragnhild Askeland & Johansen, Rune Forstrøm [Show all 15 contributors for this article] (2017). Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. Circulation: Heart Failure. ISSN 1941-3289. 10(2). doi: 10.1161/CIRCHEARTFAILURE.116.003675.
• Lunde, Ida Gjervold; Herum, Kate Louise Møller; Carlson, Cathrine Rein & Christensen, Geir Arve (2016). Syndecans in heart fibrosis. Cell and Tissue Research. ISSN 0302-766X. 365(3), p. 539–552. doi: 10.1007/s00441-016-2454-2.
• Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita & Louch, William Edward [Show all 8 contributors for this article] (2016). Development of a high affinity peptide that prevents phospholemman (PLM) inhibition of the sodium-calcium exchanger 1 (NCX1). Biochemical Journal. ISSN 0264-6021. 473(15), p. 2413–2423. doi: 10.1042/BCJ20160465.
• Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani; Anderson, Mark E.; Carlson, Cathrine Rein & Lehnart, Stefan [Show all 8 contributors for this article] (2016). Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release. Cardiovascular Research (CVR). ISSN 0008-6363. 111(3), p. 295–306. doi: 10.1093/cvr/cvw095.
• Hafver, Tandekile Lubelwana; Hodne, Kjetil; Wanichawan, Pimthanya; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Per Kristian [Show all 14 contributors for this article] (2016). Protein phosphatase 1c associated with the cardiac sodium calcium exchanger 1 regulates its activity by dephosphorylating Serine 68-phosphorylated phospholemman. Journal of Biological Chemistry. ISSN 0021-9258. 291(9), p. 4561–4579. doi: 10.1074/jbc.M115.677898. Show summary

  The sodium (Na+)-calcium (Ca2+) exchanger 1 (NCX1) is an important regulator of intracellular Ca2+ homeostasis. Serine 68 phosphorylated phospholemman (pSer-68-PLM) inhibits NCX1 activity. In the context of Na+/K+ ATPase (NKA) regulation, pSer-68-PLM is dephosphorylated by protein phosphatase 1 (PP1). PP1 also associates with NCX1, however, the molecular basis of this association is unknown. In the present study, we aimed to analyze the mechanisms of PP1 targeting to the NCX1-pSer-68-PLM complex and hypothesized that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer-68-PLM dephosphorylation. Using a variety of molecular techniques, we show that PP1 catalytic subunit (PP1c) co-localized, co-fractionated, and co-immunoprecipitated with NCX1 in rat cardiomyocytes, left ventricle lysates and HEK293 cells. Bioinformatic analysis, immunoprecipitations, mutagenesis, pull-down experiments and peptide arrays constrained PP1c anchoring to the K-I/V-F-F motif in the first Ca2+ binding domain (CBD1) in NCX1. This binding site is also partially in agreement with the extended PP1 binding motif; K-I/V-F-F-X5-8-Φ1Φ2-X8-9-R. The cytosolic loop of NCX1, containing the K-I/V-F-F motif, had no effect on PP1 activity in an in vitro assay. Dephosphorylation of pSer-68-PLM in HEK293 cells was not observed when NCX1 was absent, when the K-I/V-F-F motif was mutated or when the PLM and PP1c binding sites were separated (mimicking calpain cleavage of NCX1). Co-expression of PLM and NCX1 inhibited NCX1 current (both modes). Moreover, co-expression of PLM with NCX1-(F407P) (mutated K-I/V-F-F motif) resulted in NCX1 current being completely abolished. In conclusion, NCX1 is a substrate-specifying PP1c regulator protein, indirectly regulating NCX1 activity through pSer-68-PLM dephosphorylation.

• Singh, Arpita; Rigatti, Marc; Carlson, Cathrine Rein; Moraru, Ion I. & Dodge-Kafka, Kimberly L. (2015). Analysis of AKAP7y Dimerization. Journal of signal transduction. ISSN 2090-1739. doi: 10.1155/2015/371626.
• Tinholt, Mari; Stavik, Benedicte; Louch, William Edward; Carlson, Cathrine Rein; Sletten, Marit & Ruf, Wolfram [Show all 9 contributors for this article] (2015). Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells. PLOS ONE. ISSN 1932-6203. 10(1). doi: 10.1371/journal.pone.0117404.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Kurola, Jouni & Johansen, Rune Forstrøm [Show all 18 contributors for this article] (2015). Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling. Journal of the American College of Cardiology. ISSN 0735-1097. 65(4), p. 339–351. doi: 10.1016/j.jacc.2014.10.065.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Lunde, Ida Gjervold; Herum, Kate Louise Møller & Marstein, Henriette [Show all 12 contributors for this article] (2015). Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice. Cardiovascular Research (CVR). ISSN 0008-6363. 106(1), p. 32–42. doi: 10.1093/cvr/cvv041.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Stang, Espen; Kolset, Svein Olav; Hollung, Kristin & Pedersen, Mona Elisabeth (2015). Syndecan-4 regulates muscle differentiation and is internalized from the plasma membrane during myogenesis. PLOS ONE. ISSN 1932-6203. 10(6). doi: 10.1371/journal.pone.0129288. Full text in Research Archive Show summary

  The cell surface proteoglycan syndecan-4 has been reported to be crucial for muscle differentiation, but the molecular mechanisms still remain to be fully understood. During in vitro differentiation of bovine muscle cells immunocytochemical analyses showed strong labelling of syndecan-4 intracellularly, in close proximity with Golgi structures, in membranes of intracellular vesicles and finally, in the nuclear area including the nuclear envelope. Chase experiments showed that syndecan-4 was internalized from the plasma membrane during this process. Furthermore, when syndecan-4 was knocked down by siRNA more myotubes were formed, and the expression of myogenic transcription factors, β1-integrin and actin was influenced. However, when bovine muscle cells were treated with a cell-penetrating peptide containing the cytoplasmic region of syndecan-4, myoblast fusion and thus myotube formation was blocked, both in normal cells and in syndecan-4 knock down cells. Altogether this suggests that the cytoplasmic domain of syndecan-4 is important in regulation of myogenesis. The internalization of syndecan-4 from the plasma membrane during muscle differentiation and the nuclear localization of syndecan-4 in differentiated muscle cells may be part of this regulation, and is a novel aspect of syndecan biology which merits further studies.

• Berk, Jason M.; Simon, Dan N.; Jenkins-Houk, Clifton R.; Westerbeck, Jason W.; Grønning-Wang, Line Mariann & Carlson, Cathrine Rein [Show all 7 contributors for this article] (2014). The molecular basis of emerin-emerin and emerin-BAF interactions. Journal of Cell Science. ISSN 0021-9533. 127(18), p. 3956–3969. doi: 10.1242/jcs.148247.
• Wanichawan, Pimthanya; Lubelwana, Tandekile; Hodne, Kjetil; Aronsen, Jan Magnus; Lunde, Ida Gjervold & Dalhus, Bjørn [Show all 13 contributors for this article] (2014). Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure. Journal of Biological Chemistry. ISSN 0021-9258. 289(49), p. 33984–33998. doi: 10.1074/jbc.M114.602581.
• Aspelin, Trude; Eriksen, Morten; Ilebekk, Arnfinn; Cataliotti, Alessandro; Carlson, Cathrine Rein & Lyberg, Torstein (2014). ß-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and b2-adrenergic receptor in vivo. Thrombosis and Haemostasis. ISSN 0340-6245. 112(5), p. 951–959. doi: 10.1160/TH14-01-0059.
• Vistnes, Maria; Aronsen, Jan Magnus; Lunde, Ida Gjervold; Sjaastad, Ivar; Carlson, Cathrine Rein & Christensen, Geir Arve (2014). Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. PLOS ONE. ISSN 1932-6203. 9(3). doi: 10.1371/journal.pone.0089621.
• Herum, Kate Louise Møller; Lunde, Ida Gjervold; Skrbic, Biljana; Florholmen, Geir; Behmen, Dina & Sjaastad, Ivar [Show all 9 contributors for this article] (2013). Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 54, p. 73–81. doi: 10.1016/j.yjmcc.2012.11.006.

View all works in Cristin

• Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Melleby, Arne Olav & Carlson, Cathrine Rein (2023). Response by Aronsen et al to Letter Regarding Article, "Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure". Circulation. ISSN 0009-7322. 148(10), p. 857–858. doi: 10.1161/CIRCULATIONAHA.123.065884.
• Pejšková, Lucie; Rønning, Sissel Beate; Kent, Matthew Peter; Wold, Jens Petter; Mosleth, Ellen Færgestad & Høst, Vibeke [Show all 11 contributors for this article] (2023). Shedding of syndecans play a crucial role in the extensive remodelling of the extracellular matrix in skeletal muscle myopathy in chicken .
• Pejšková, Lucie; Rønning, Sissel Beate; Kent, Matthew Peter; Høst, Vibeke; Solberg, Nina & Kolset, Svein Olav [Show all 9 contributors for this article] (2023). Syndecans as potential regulators of the severe skeletal muscle myopathy .
• Tønnessen, Theis; Christensen, Geir; Carlson, Cathrine Rein; Skrbic, Biljana & Sjaastad, Ivar (2022). Calcineurin-NFAT dynamics corresponds to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement. Frontiers in Molecular Medicine for Cardiology. doi: 10.3389/fmmed.2022.980717.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Pisconti, Addolorate & Lunde, Marianne [Show all 11 contributors for this article] (2019). Extracellular Matrix remodeling and multiple signaling pathways are regulated by syndecan-4 during myogenesis.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Aronsen, Jan Magnus; Høst, Vibeke; Liland, Kristian Hovde & Stang, Espen [Show all 10 contributors for this article] (2017). Syndecan-4 is a skeletal muscle regenerator and is important for normal skeletal muscle fibre development.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Laver, Derek R; Myhre, Peder Langeland; Dalhus, Bjørn & Lunde, Per Kristian [Show all 14 contributors for this article] (2017). Secretoneurin is an Endogenous CaMKII Inhibitor That Attenuates Ca2+-Dependent Arrhythmogenesis. Circulation. ISSN 0009-7322. 136.
• Mathiesen, Sabrina Bech; Lunde, Marianne; Christensen, Geir Arve & Carlson, Cathrine Rein (2016). Mass spectrometry analysis of cytoplasmic binding partners of cardiac syndecan - 2.
• Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Wanichawan, Pimthanya; Lunde, Marianne; Martinsen, Marita & Sejersted, Ole M [Show all 7 contributors for this article] (2016). In vivo protein-protein interaction map of cardiac NCX1.
• Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Albert, Ingrid [Show all 13 contributors for this article] (2016). Physical coupling of PDE3A regulates SERCA2 activity in cardiomyocytes.
• Albert, Ingrid; Skogestad, Jonas; Carlson, Cathrine Rein; Lunde, Marianne; Marshall, Serena & Lunde, Per Kristian [Show all 8 contributors for this article] (2016). Development of PDE3A-SERCA2 disruptor agents for SERCA2 activation.
• Manotheepan, Ravinea; Danielsen, Tore Kristian; Saberniak, Jorg; Sadredini, Mani; Anderson, Mark e. & Carlson, Cathrine Rein [Show all 11 contributors for this article] (2016). Exercise training as anti-arrhythmic therapy in cathecholaminergic polymorphic ventricular tachycardia type 1.
• Mathiesen, Sabrina Bech; Lunde, Marianne; Christensen, Geir Arve & Carlson, Cathrine Rein (2016). Mass spectrometry analysis of cytoplasmic binding partners of cardiac syndecan-2.
• Wanichawan, Pimthanya; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita; Louch, William Edward & Sejersted, Ole M [Show all 7 contributors for this article] (2016). The N-terminal membrane occupation and recognition nexus (MORN) domains of junctophilin-2 bind to Na+/Ca2+ exchanger.
• Rønning, Sissel Beate; Pedersen, Mona Elisabeth & Carlson, Cathrine Rein (2016). Syndecan-4 in skeletal muscle development and regeneration.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Høst, Vibeke; Aronsen, Jan Magnus; Liland, Kristian Hovde & Stang, Espen [Show all 9 contributors for this article] (2016). Syndecan-4 is important for normal skeletal muscle fibre development .
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Hollung, Kristin; Pedersen, Mona Elisabeth; Stang, Espen & Kolset, Svein Olav [Show all 7 contributors for this article] (2015). Syndecan-4 in skeletal muscle development and regeneration.
• Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein (2015). The in vitro NCX1 interactome.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Johansen, Rune F.; Stridsberg, Mats & Jarstadmarken, Hilde [Show all 12 contributors for this article] (2015). Chromogranin A is a potent prognostic biomarker in acute heart failure, and its fragment catestatin regulates cardiomyocyte calcium homeostasis by CaMKII inhibition.
• Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Albert, Ingrid [Show all 12 contributors for this article] (2015). Physical coupling between SERCA2 and PDE3A regulates SERCA2 activity in cardiomyocytes.
• Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein (2015). Identification of the in vitro NCX1 interactome.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Dahl, Mai Britt; Sandbu, Ragnhild Askeland & Johansen, Rune F. [Show all 15 contributors for this article] (2015). Enhanced myocardial chromogranin A glycosylation in acute heart failure: reduced processing and potential impact on cardiomyocyte calcium homeostasis.
• Hafver, Tandekile Lubelwana; De Souza, Gustavo Antonio; Lunde, Marianne; Martinsen, Marita; Sejersted, Ole M & Carlson, Cathrine Rein (2015). Mapping the in vitro interactome of NCX1.
• Hafver, Tandekile Lubelwana; Hodne, Kjetil; Wanichawan, Pimthanya; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Per Kristian [Show all 12 contributors for this article] (2015). PP1 associated with cardiac NCX1 regulates exchange activity by dephosphorylating pSer-68-PLM.
• Wanichawan, Pimthanya; Hodne, Kjetil; Hafver, Tandekile Lubelwana; Lunde, Marianne; Martinsen, Marita & Louch, William Edward [Show all 8 contributors for this article] (2015). Development of a high affinity phospholemman binding peptide that reverses phosphorylated serine 68 phospholemman inhibition of the cardiac sodium-calcium exchanger 1.
• Børstad, Mira Halvorsen; Albert, Ingrid; Lunde, Marianne; Carlson, Cathrine Rein; Sjaastad, Ivar & Aronsen, Jan Magnus (2015). Molecular mechanisms for PDE3A mediated inhibition of SERCA2 activity.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Stang, Espen; Kolset, Svein Olav; Christensen, Geir Arve & Hollung, Kristin [Show all 7 contributors for this article] (2015). Syndecan-4 is important for skeletal muscle development.
• Marshall, Serena; Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B & Lunde, Per Kristian [Show all 13 contributors for this article] (2015). Dual PDE3A coupling to AKAP18 and SERCA2 Controls SERCA2 Activity in adult cardiomyocytes.
• Manotheepan, Ravinea; Danielsen, Tore Kristian; Sadredini, Mani Nikoo; Anderson, Mark e.; Carlson, Cathrine Rein & Lehnart, Stefan [Show all 8 contributors for this article] (2015). Exercise training reduced CaMKII-dependent arrhythmogenic Ca2+ release and prevents ventricular tachycardia in CPVT 1.
• Carlson, Cathrine Rein; Nygård, Ståle; Sirnes, Solveig; Jarstadmarken, Hilde; Martinsen, Marita & Lunde, Marianne [Show all 9 contributors for this article] (2015). A protein-protein interaction (PPI) map of cardiac syndecan-4.
• Albert, Ingrid; Børstad, Mira Halvorsen; Carlson, Cathrine Rein; Calejo, Anna; Skogestad, Jonas & Lunde, Marianne [Show all 10 contributors for this article] (2015). Development of SERCA2 activating agents.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Pedersen, Mona Elisabeth; Hollung, Kristin; Kolset, Svein Olav & Stang, Espen (2015). Syndecan-4 in skeletal muscle development and regeneration.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Edwards, Andrew; Landsverk, Ole J. B.; Johansen, Rune Forstrøm & Moe, Morten Kaare [Show all 12 contributors for this article] (2015). Secretoneurin,a novel endogenous CaMKII inhibitor, augments cardiomyocyte Calcium handling and inhibits arrhythmogenic Calcium release. Biophysical Journal. ISSN 0006-3495. 108, p. 340a–340a.
• Hodne, Kjetil; Wanichawan, Pimthanya; Lubelwana, Tandekile; Louch, William Edward; Lunde, Marianne & Mathisen, Marita [Show all 8 contributors for this article] (2015). Liberation of Pser68-Plm inhibition of NCX1 by an optimized anchoring disruptor peptide. Biophysical Journal. ISSN 0006-3495. 108, p. 434a–434a.
• Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne [Show all 12 contributors for this article] (2015). Anchoring onto NCX1 facilitates dephosphorylation of P-SER68-PLM. Biophysical Journal. ISSN 0006-3495. 108, p. 584a–584a.
• Pedersen, Mona Elisabeth; Rønning, Sissel Beate; Carlson, Cathrine Rein; Stang, Espen; Kolset, Svein Olav & Hollung, Kristin (2015). Syndecan-4 is important for skeletal muscle development.
• Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne [Show all 10 contributors for this article] (2014). Molecular analysis of PP1 anchoring to NCX1 macromolecular complex. Show summary

  Introduction: The cardiac Na+/Ca2+ exchanger 1 (NCX1) modulates excitation-contraction coupling and contributes to Ca2+ removal in cardiomyocytes. Altered expression and activity of NCX1 is linked to dysfunctional Ca2+ handling in chronic heart disease. Consequently, modulation of NCX1 activity has been proposed as a therapeutic target, but detailed understanding of NCX1 regulation is warranted. It has been shown that NCX1 exists in a macromolecular complex which would allow for regulation of its activity. NCX1 is also regulated by its accessory protein phospholemman (PLM) which inhibits NCX1 activity when phosphorylated at serine 68 (pSer68-PLM). Protein phosphatase 1 (PP1) dephosphorylates pSer68-PLM, and thus indirectly regulates NCX1 activity. Although no anchoring site is known, PP1 co-precipitates NCX1. We hypothesised that PP1 regulates NCX1 activity and that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer68-PLM dephosphorylation. We set out to identify PP1 binding sites to the pPLM-NCX1 complex and assess the biological function of the interaction. Methods and results: NCX1 co-precipitated PP1 and PLM in wild-type rat left ventricular lysates and PLM-NCX1 co transfected HEK 293 cells. NCX1 protein levels were upregulated, PP1/NCX1 protein levels were downregulated while pSer68-PLM/total PLM protein levels were upregulated in our pressure overload model. The proximity ligation assay showed that cardiac NCX1 and PP1 colocalize within <40nm in isolated cardiomyocytes. Bioinformatic analysis revealed three putative PP1 binding sites on NCX1. Overlay assays of NCX1 and PP1α showed that PP1α bound directly to the consensus sequence R/KVxF in CBD1 (calcium binding domain 1) in NCX1, which is preserved across isoforms. The reciprocal NCX1 binding site was identified within residues 235-260 in PP1α, a region which harbours the aspartic acid, leucine and arginine docking motif. Binding data were confirmed by immunoprecipitations, mutation analysis of NCX1-GFP and FLAG-HIS-PP1α deletion mutants expressed in HEK 293 cells and in pulldown assays using NCX1 biotinylated peptides. We have generated a peptide docking model of the R/KVxF motif bound close to the PP1α active site. Single and double mutations of residues in the docking motif confirmed the interaction. Biacore analysis indicated that the NCX1-PPIα binding is strong. In competition assay using NCX1, PP1 and PLM co transfected HEK cells a NCX1 peptide disruptor was able to displace the interaction, p<0.05, indicating that PP1 dephosphorylates pSer68-PLM when anchored to NCX1. Conclusion: The R/KVxF motif in CBD1 of NCX1 facilitates PP1 anchoring to NCX1 and is directly and functionally required for pSer68-PLM dephosphorylation.

• Hafver, Tandekile Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne [Show all 10 contributors for this article] (2014). Molecular analysis of the pPLM-NCX1-PP1 complex. Show summary

  Introduction: The cardiac Na+/Ca2+ exchanger (NCX1) is an ion transporting membrane protein which modulates excitation-contraction coupling and contributes to Ca2+ removal in cardiomyocytes. Altered expression and activity of NCX1 has been linked to dysfunctional Ca2+ handling in chronic heart disease. Consequently, modulation of NCX1 activity has been proposed as a therapeutic target, but detailed understanding of NCX1 regulation is warranted. In the rat heart, NCX1 exists in a macromolecular complex comprising of kinases, phosphatases, anchoring and adaptor proteins, which enables fine tuning of signals which converge on NCX1. NCX1 is also regulated by its accessory protein phospholemman (PLM). When phosphorylated at Serine 68 by PKA and PKC, PLM binds to and inhibits NCX1 activity. It has been shown that phospho Serine 68-PLM (pSer68-PLM) is dephosphorylated by protein phosphatase 1 (PP1) and furthermore PP1 co-precipitate with NCX1, however, no anchoring site is known. We hypothesised that PP1 regulates NCX1 activity and that a direct and functional NCX1-PP1 interaction is a prerequisite for pSer68-PLM dephosphorylation. We set out to identify PP1 binding sites to the pPLM-NCX1 complex and assess the biological function of the interaction. Methods and results: We have shown that NCX1 exists in a macromolecular complex with PP1 and PLM in wild-type rat left ventricular lysates and in transfected HEK cells. The proximity ligation assay was used to show that cardiac NCX1 and PP1 colocalize within <40nm in isolated cardiomyocytes. Bioinformatic analysis revealed three putative PP1 binding sites on NCX1. Overlay assays of NCX1 and PP1α showed that PP1α bound directly to the consensus sequence R/KVxF in CBD1 (calcium binding region 1) in NCX1, which is preserved across isoforms. The reciprocal NCX1 binding site was identified within residues 235-260 in PP1, a region which harbours the aspartic acid (Asp), leucine (Leu) and arginine (Arg) docking motif. Immunoprecipitations and mutation analysis of NCX1-GFP and FLAG-HIS-PP1α deletion mutants expressed in HEK 293 cells confirmed this interaction. A peptide docking model of the R/KVxF motif bound to the PP1α active site showed that the Asp 242 and Leu 243, identified from the PP1α overlay, make contact with the Valine (Val) and Phenylalanine (Phe) in the R/KVxF motif. Single and double mutations of Asp 242, Leu 243 and Arg 257 confirmed the interaction. Biacore analysis also showed that recombinant NCX1 cytoplasmic part bound to GST-PP1α recombinant protein. Conclusion: PP1 anchored directly to NCX1 through an R/KVxF motif in CBD1, whereas NCX1 bound to a DL motif within residues 235-260 in PP1. The biological role of the R/KVxF motif in PLM and NCX1 regulation is currently being assessed.

• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Stridsberg, Mats; Høiseth, Arne Didrik & Brynildsen, Jon [Show all 10 contributors for this article] (2014). Chromogranin A is a potent risk marker in acute heart failure and directly associated with cardiomyocyTe Ca2+ handling. European Heart Journal. ISSN 0195-668X. 35, p. 328–328.
• Hafver, Lubelwana; Wanichawan, Pimthanya; Hodne, Kjetil; Aronsen, Jan Magnus; Dalhus, Bjørn & Lunde, Marianne [Show all 10 contributors for this article] (2014). Molecular analysis of the phospho-PLM-NCX1-PP1 complex.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Kurola, Jouni & Johansen, Rune Forstrøm [Show all 18 contributors for this article] (2014). Secretoneurin provides independent prognostic information in patients with heart failure and cardiac arrest, and has a direct inhibitory effect on diastolic Ca2+ leak and arrhythmogenic Ca2+ waves via CaMKII inhibition. Circulation Research. ISSN 0009-7330. 115.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Louch, William Edward; Høiseth, Arne Didrick; Brynildsen, Jon & Stridsberg, Mats [Show all 9 contributors for this article] (2014). Chromogranin A directly modifies cardiomyocyte Ca2+ homeostasis via CaMKII inhibition and is a strong prognostic biomarker in acute heart failure.
• Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Lunde, Per Kristian [Show all 10 contributors for this article] (2014). Hypokalemia induce CA2+ waves by lowering NKA alpha 2 activity in rat ventricular cardiomyocytes.
• Aronsen, Jan Magnus; Skogestad, Jonas; Hougen, Karina; Lunde, Marianne; Lothe, Gustav B & Lunde, Per Kristian [Show all 10 contributors for this article] (2014). Physical coupling of PDE3A to SERCA2 regulates SERCA2 activity in cardiomyoyctes.
• Hodne, Kjetil; Wanichawan, Pimthanya; Hafver, Tandekile Lubelwana; Aronsen, Jan Magnus; Lunde, Ida Gjervold & Lunde, Marianne [Show all 12 contributors for this article] (2014). Identification and functional role of calpain cleavage site in Na+-Ca2+ exchanger 1 (NCX1). Biophysical Journal. ISSN 0006-3495. 106.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth (2014). Syndecan-4 is involved in regulation of muscle differentiation at multiple stages and by different mechanisms.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth (2014). Syndecan-4 in muscel development.
• Rønning, Sissel Beate; Carlson, Cathrine Rein; Kolset, Svein Olav; Stang, Espen; Hollung, Kristin & Pedersen, Mona Elisabeth (2014). The cell surface proteoglycan syndecan 4 is important for in vitro muscle cell differentiation.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune Forstrøm & Moe, Morten Kaare [Show all 10 contributors for this article] (2013). Secretoneurin regulates cardiomyocyte calcium homeostasis via CaMKII inhibition and is a potent marker of mortality in patients with acute heart failure. European Heart Journal. ISSN 0195-668X. 34, p. 6–7.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold [Show all 10 contributors for this article] (2013). Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold [Show all 10 contributors for this article] (2013). Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis. Circulation. ISSN 0009-7322. 128.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten Carsten [Show all 14 contributors for this article] (2013). Secretoneurin regulates cardiomyocyte calcium homeostasis via CaMKIIinhibition and is a potent marker of mortality in patients with acute heart failure.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten [Show all 10 contributors for this article] (2013). Secretoneurin regulates cardiomyocyte calcium homeostasis CaMKIIinhibition and is a potent marker of mortality in patients with acute heart failure.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune forstrom & Moe, Morten [Show all 14 contributors for this article] (2013). Secretoneurin is a novel endogenous CaMKII inhibitor that regulates cardiomyocyte calcium handling and is closely associated with mortality in patients with acute heart failure. Circulation. ISSN 0009-7322. 128.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Johansen, Rune Forstrom & Moe, Morten [Show all 14 contributors for this article] (2013). 32. Secretoneurin is a novel endogenous CaMKII inhibitor that regulates cardiomyocyte calcium handling and is closely associated with mortality in patients with acute heart failure.
• Wanichawan, Pimthanya; Lunde, Ida Gjervold; Aronsen, Jan Magnus; Austbø, Bjørg; Lunde, Marianne & Tønnessen, Theis [Show all 9 contributors for this article] (2013). Calpain mediates proteolysis of the cardiac Na+- Ca2+ exchanger 1(NCX1) in failing hearts through its catalytic site (IIb) and domain III.
• Lunde, Ida Gjervold; Skrbic, Biljana; Tønnessen, Theis; Kvaløy, Heidi; Enger, Ulla Helene & Dahl, Christen Peder [Show all 9 contributors for this article] (2013). Clinical and Experimental Aortic Stenosis; Attenuation of Activated Pro-Hypertrophic NFAT Transcription Factor Isoforms by Relief of Pressure Overload. Circulation. ISSN 0009-7322. 128.
• Aspelin, Trude; Eriksen, Morten; Carlson, Cathrine Rein; Ilebekk, Arnfinn & Lyberg, Torstein (2013). Bradykinin enhances nerve-induced cardiac tPA release possibly by transactivation of the β2-adrenergic receptor.
• Aspelin, Trude; Eriksen, Morten; Ilebekk, Arnfinn; Carlson, Cathrine Rein & Lyberg, Torstein (2013). Heterodimerization of bradykinin receptor-2 (BK2R) and B-adrenergic receptor-2 (B2AR) with physiological consequences on cardiact tPA release in vivo.
• Wanichawan, Pimthanya; Hafver, Tandekile; Aronsen, Jan Magnus; Lunde, Ida Gjervold; Lunde, Marianne & Kvaløy, Heidi [Show all 10 contributors for this article] (2013). Modulation of the Sodium-calcium Exchanger 1 (NCX1) by Calpain; Molecular Interactions and Identification of a Calpain Cleavage Site. Circulation. ISSN 0009-7322. 128.
• Lunde, Ida Gjervold; Skrbic, Biljana; Tønnessen, Theis; Dahl, Christen Peder; Kvaløy, Heidi & Enger, Ulla Helene [Show all 9 contributors for this article] (2013). Clinical and experimental aortic stenosis; attenuation of activated pro-hypertrophic NFAT transcription factor isoforms during reverse remodeling.
• Grønland, Mari Therese; Eijsink, Vincent; Dalhus, Bjørn; Bjørås, Magnar & Carlson, Cathrine Rein (2015). Human CaMKIId mutanter – proteinekspresjon, rensing, krystallisering og analyse av SN-peptid binding. NMBU,IKBM.

View all works in Cristin