Christian Hall

• Ibsen, Jørgen; Hov, Maren Ranhoff; Holodinsky, Jessalyn Kathryn; Kaasa, Per Olav; Pripp, Are Hugo & Lund, Christian G. [Show all 7 contributors for this article] (2026). Rural Computed Tomography - a model for access to rapid stroke care in sparsely populated areas? BMC Health Services Research. 26(1). doi: 10.1186/s12913-026-14307-6. Full text in Research Archive Show summary

  Background Patients living in rural districts may have limited access to acute stroke treatment due to long transport times to hospital facilities with radiology and revascularization therapy. This study simulates the utility of transferring acute diagnostics and treatment into rural areas by deployment of rural Computed Tomography (CT) services. Methods In Hallingdal county, Norway, a CT and thrombolytic station is operated in a local medical centre. We hypothetically deployed similar stations in rural Norway to explore the impact of such model of prehospital rural acute stroke treatment on ambulance transport times and patient outcomes after ischemic stroke. In addition, we described consequent changes in transport strategy for patients with suspected Large Vessel Occlusion (LVO) stroke. Results Significant reductions in hypothetical transport times were obtained after deployment of 30 rural CT stations. The part of the Norwegian population not eligible for thrombolysis within the recommended time window due to long transport time decreased from 11% to 1% (p< 0.001). By simulation of 1000 ischemic strokes, the estimated odds ratio for good outcome judged by modified Rankin Scale after thrombolysis for the rural population increased from 1.37 to 1.61 (p < 0.001). When LVO stroke was suspected, rural CT stations slightly increased the geographical area in which patients would receive local thrombolysis before transport to endovascular treatment. Conclusions Deployment of rural CT stations may facilitate rapid triage and early thrombolysis for patients with acute ischemic stroke living furthest away from hospital and this concept may be applicable to other health care systems worldwide. However, further research is needed to confirm its utility in the clinical setting.

• Enge, Katrine; Ulimoen, Sara Reinvik; Enger, Steve; Onarheim, Sophia; Olufsen, Mona & Pripp, Are Hugo [Show all 10 contributors for this article] (2025). Effects of diltiazem and metoprolol on levels of high-sensitivity troponin I in patients with permanent atrial fibrillation: a randomized trial. BMC Cardiovascular Disorders. 25(1). doi: 10.1186/s12872-025-04574-2. Full text in Research Archive Show summary

  Background High-sensitive (hs-) cardiac troponin assays provide prognostic information in atrial fibrillation (AF) patients. Few studies have explored the impact of long-term rate control therapy on levels of troponin in AF patients without coronary heart disease and heart failure. This substudy of the RATe control in Atrial Fibrillation (RATAF) II study aimed to compare the effects of six months’ treatment with diltiazem and metoprolol on hs-troponin I (TnI) levels both at rest and during exercise testing in patients with permanent AF. Methods This was a parallel-group, randomized, investigator-blinded clinical trial. The cohort consisted of 93 patients (28 women, mean age 71 ± 7 years) with symptomatic, permanent AF with preserved left ventricular systolic function and no coronary heart disease. Participants were randomized in a 1:1 ratio to receive either diltiazem 360 mg (n = 49) or metoprolol 100 mg (n = 44) once daily for six months. Blood tests were drawn at rest and during peak exercise testing at baseline, one month and six months’ treatment. This research has been supported by grants from the South-Eastern Norway Regional Health Authority and Vestre Viken Hospital Trust. Results Six months’ treatment with diltiazem and metoprolol significantly lowered the heart rate at rest and peak exercise. Both treatment groups exhibited a decrease in hs-TnI levels at rest (diltiazem p = 0.008, metoprolol p = 0.03) and peak exercise (diltiazem p < 0.001, metoprolol p = 0.004) at six months compared to baseline levels, with no significant differences observed between the groups. Conclusions In patients with permanent AF, six months of rate control therapy with diltiazem or metoprolol lowered levels of hs-TnI. Further research is warranted to determine whether this reduction translates into an improved prognosis.

• Ibsen, Jørgen; Hov, Maren Ranhoff; Varmdal, Torunn; Lund, Christian & Hall, Christian (2025). Transport time as a potential limiting factor for thrombolytic treatment of stroke in Norway. BMC Health Services Research. 25(1). doi: 10.1186/s12913-025-12503-4. Full text in Research Archive Show summary

  Background Rapid diagnosis and treatment of stroke is important for good outcome. In some cases, patients with ischemic stroke arrive at hospital too late for reperfusion therapy. This may be the case especially in rural areas where time spent during transport may delay or even preclude thrombolytic treatment after hospital arrival. We aimed to estimate the extent and clinical relevance of this problem in the Norwegian population. Methods We collected data for all reported acute ischemic strokes for the years 2017 and 2018. Transport times from home to hospital were calculated from geographical data and related to frequency of thrombolysis, thrombectomy and clinical outcome after 3 months. Results The frequency of reperfusion therapy decreased significantly as transport time increased. Six percent (564) of 9 428 patients were classified as having a prolonged time in transport. In this group, frequency of intravenous thrombolysis was 10,5% as opposed to 28,2% when prolonged transport was not present. Thrombectomy was performed in 2.1% versus 4.9% in the two groups respectively. We did not find a statistically significant difference between the two groups with regard to clinical outcome as judged by the modified Rankin Scale. Conclusion In the years 2017 and 2018 a relatively small group of Norwegian patients with prolonged time in transport was disfavored concerning access to reperfusion therapy for ischemic stroke. In such cases a prehospital solution for diagnostic work up and treatment might improve access to acute stroke treatment.

• Enge, Katrine; Tveit, Arnljot; Enger, Steve; Onarheim, Sophia; Pripp, Are Hugo & Rønningen, Peter Selmer [Show all 14 contributors for this article] (2024). Diltiazem reduces levels of NT-proBNP and improves symptoms compared with metoprolol in patients with permanent atrial fibrillation. European Heart Journal (EHJ) - Cardiovascular Pharmacotherapy. ISSN 2055-6837. 10(6), p. 515–525. doi: 10.1093/ehjcvp/pvae032. Full text in Research Archive
• Ibsen, Jørgen; Hov, Maren Ranhoff; Tokerud, Gunn Eli; Fuglum, Julia; Krogstad, Marianne Linnerud & Stugaard, Marie [Show all 9 contributors for this article] (2024). Prehospital computed tomography in a rural district for rapid diagnosis and treatment of stroke. European Stroke Journal. ISSN 2396-9873. doi: 10.1177/23969873241267084. Full text in Research Archive Show summary

  Background: Early diagnosis and triage of patients with ischemic stroke is essential for rapid reperfusion therapy. The prehospital delay may be substantial and patients from rural districts often arrive at their local hospital too late for disability-preventing thrombolytic therapy due to prolonged transport times. Methods: Hallingdal District Medical Centre (HDMC) is located in a rural area of Norway and is equipped with a computed tomography (CT) scanner. We established emergency pathways of CT imaging and thrombolytic treatment of patients with acute ischemic stroke at HDMC. During office hours these pathways were managed by a radiographer and a general physician supported by videoconference from the Primary Stroke Centre. Outside office hours we remotely controlled the CT exam and supported telestroke guided paramedics handling and examining the patients. With a primary aim of demonstrating the feasibility of this de novo concept we enrolled patients in the period 2017–2021 into a comparative cohort observational study. We compared patients treated at HDMC (the Rural CT group) to patients from two other rural regions in Norway with similar distances to their local hospital but without access to a rural CT scanner (the Reference group). Results: A total of 86 patients were included in the Rural CT group (mean age 74, 52% male, 43% stroke mimics), and 69 patients were included in the Reference group (mean age 70, 42% male, 28% stroke mimics). Median time from onset of symptoms to completed CT examination was 93 min in the Rural CT group as compared to 240 min in the Reference group (p < 0.05). In patients receiving intravenous thrombolysis time from onset of symptoms to treatment was median 124 min in the Rural CT group and 213 min in the Reference group, p < 0.05. The frequency of thrombolysis for ischemic stroke did not significantly differ between the two groups. Conclusion: Combining prehospital rural CT examination with telestroke guided diagnosis and thrombolytic treatment by paramedics may facilitate earlier initiation of thrombolysis for patients with ischemic stroke.

• Gleditsch, Jostein; Halvorsen, Bjørn Arild; Bratis, Konstantinos; Alvim, Astrid; Jordal, Anders & Fjeld, Jan Gunnar [Show all 10 contributors for this article] (2023). Accuracy of stress perfusion cardiac magnetic resonance imaging in a district hospital. Acta Radiologica Open. 12(2). doi: 10.1177/20584601231157018. Full text in Research Archive Show summary

  Background The European Society of Cardiology has published updated guidelines regarding pathways for diagnosis and management of obstructive coronary artery disease (CAD). Non-invasive functional assessment, for example, by stress perfusion cardiac magnetic resonance (stress pCMR) is recommended in patients with intermediate pretest probability of disease. Previous pCMR studies were mainly performed in high volume university hospitals with experienced radiologists or cardiologists interpreting the images. Purpose The aim of the present study was to evaluate the feasibility of establishing a stress pCMR imaging service in a district hospital. Material and Methods One hundred and thirteen patients with intermediate pretest probability of CAD referred for single-photon emission computed tomography (SPECT) at the regional hospital also underwent adenosine stress pCMR locally. The diagnostic analysis was compared to that of an experienced cardiac magnetic resonance (CMR) center serving as a reference. Results Inter-rater agreement between local readers and the reference reader was substantial to perfect for late gadolinium enhancement (LGE) (weighted kappa = 0.76 and 0.82), but only fair to moderate for pCMR ( k = 0.34 and 0.51). No improvement in agreement between reference reader and local reader during the study was demonstrated. Conclusion CMR is feasible in patients with intermediate pretest probability of obstructive CAD in the setting of a district hospital. However, as opposed to infarct detection with LGE, the interpretation of stress pCMR was more challenging. To establish this method, we suggest obtaining experience in close collaboration with a reference CMR center.

• Leosdottir, Margret; Willenheimer, Ronnie; Hall, Christian; Tjora, Solve; Malm, Johan & Melander, Olle [Show all 7 contributors for this article] (2011). Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 45(5), p. 294–300. doi: 10.3109/14017431.2011.581763. Full text in Research Archive
• Magnusson, M; Jovinge, S; Rydberg, E; Dahlof, B; Hall, Christian & Nielsen, OW [Show all 8 contributors for this article] (2009). Natriuretic peptides as indicators of cardiac remodeling in hypertensive patients. Blood Pressure. ISSN 0803-7051. 18(4), p. 196–203. doi: 10.1080/08037050903083298. Full text in Research Archive
• Berdal, Jan Erik; Stavem, Knut; Omland, Torbjørn; Hall, Christian & Smith, Erichsen Nils (2008). Prognostic merit of N-terminal-proBNP and N-terminal-proANP in mechanically ventilated critically ill patients. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 52, p. 1265–1272. Full text in Research Archive
• Omland, Torbjørn; Sabatine, MS; Jablonski, KA; Rice, MM; Hsia, J & Wergeland, R [Show all 12 contributors for this article] (2007). Prognostic value of B-Type natriuretic peptides in patients with stable coronary artery disease - The PEACE trial. Journal of the American College of Cardiology. ISSN 0735-1097. 50(3), p. 205–214. doi: 10.1016/j.jacc.2007.03.038. Full text in Research Archive
• Larsen, Alf Inge; Dickstein, Kenneth; Ahmadi, Seyed Nasser; Ahmadi, Seyed Nasser; Aarsland, Torbjørn & Kvaløy, Jan Terje [Show all 8 contributors for this article] (2006). The effect of altering haemodynamics on the plasma concentrations of natriuretic peptides in heart failure. European Journal of Heart Failure. ISSN 1388-9842. 8(6), p. 628–633. doi: 10.1016/j.ejheart.2005.11.018. Full text in Research Archive
• Halvorsen, Bente; Wæhre, Torgun; Schulz, Hanne; Clausen, Ole Petter; Thusen, JH Von der & Muller, Fredrik [Show all 13 contributors for this article] (2005). Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms. Journal of Lipid Research. ISSN 0022-2275. 46. Full text in Research Archive
• Hall, Christian (2005). NT-PROBNP: The Mechanism Behind the Marker. Journal of Cardiac Failure. ISSN 1071-9164. 11(5), p. S81–S83. Full text in Research Archive
• Yan, RT; White, M.; Yan, AT; Yusuf, S.; Rouleau, J.L. & Maggioni, AP [Show all 12 contributors for this article] (2005). Usefulness of temporal changes in neurohormones as markers of ventricular remodeling and prognosis in patients with left ventricular systolic dysfunction and heart failure receiving either candesartan or enalapril or both. American Journal of Cardiology. ISSN 0002-9149. 96, p. 698–704. Full text in Research Archive
• Stanton, E; Hansen, M; Wijeysundera, HC; Kupchak, P; Hall, Christian & Rouleau, JL (2005). A direct comparison of the natriuretic peptides and their relationship to survival in chronic heart failure of a presumed non-ischaemic origin. European Journal of Heart Failure. ISSN 1388-9842. 7. Full text in Research Archive
• Larsen, AI; Gjesdal, K; Hall, Christian; Aukrust, Pål; Aarsland, T & Dickstein, K (2004). Effect of exercise training in patients with heart failure: a pilot study on autonomous balance assessed by heart rate variability. Journal of Cardiovascular Risk. ISSN 1350-6277. 11, p. 162–167. Full text in Research Archive
• Hopkins, William E; Chen, Zengyi; Fukagawa, Naomi K; Hall, Christian; Knot, Harm J & LeWinter, Martin M (2004). Increased atrial and brain natriuretic peptides in adults with cyanotic congenital heart disease - Enhanced understanding of the relationship between hypoxia and natriuretic peptide secretion. Circulation. ISSN 0009-7322. 109(23), p. 2872–2877. Full text in Research Archive
• Sabatine, Marc S; Morrow, David A; Lemos, James A De; Omland, Torbjørn; Desai, Milind Y & Tanasijevic, Milenko [Show all 9 contributors for this article] (2004). Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. Journal of the American College of Cardiology. ISSN 0735-1097. 44(10), p. 1988–1995. Full text in Research Archive
• Hole, Torstein; Hall, Christian & Skjærpe, Terje (2004). N-terminal proatrial natriuretic peptide predicts two-year remodelling in patients with acute transmural myocardial infarction. European Heart Journal. ISSN 0195-668X. 25(5), p. 416–423. Full text in Research Archive
• Hall, Christian (2004). Essential biochemistry and physiology of (NT-pro)BNP. European Journal of Heart Failure. ISSN 1388-9842. 6(3), p. 257–260. Full text in Research Archive
• Larsen, Alf Inge; Gjesdal, Clara Gram; Hall, C.; Aukrust, P.; Aarsland, T. & Dickstein, Kenneth (2004). Effect of exercise training in patients with heart failure: a pilot study on autonomic balance assessed by heart rate variability. Journal of Cardiovascular Risk. ISSN 1350-6277. 11(2), p. 162–167. Full text in Research Archive Show summary

  BACKGROUND: Heart rate variability (HRV) is decreased in patients with congestive heart failure (CHF) and is a prognostic marker in this disease. Exercise training is now regarded as an important part of the treatment of patients with CHF, but the effect on HRV and the association between this effect and the effect on neurohormones are not well assessed. METHODS: Heart rate recording was performed in 12 patients with CHF (mean age 67+/-8 years) with CHF NYHA functional class III, before and after 12 weeks of exercise training. The association with exercise capacity and serum levels of atrial natriuretic peptide was assessed. We also evaluated the correlation between HRV and survival at follow-up 87 months later. RESULTS: At baseline there was a significant correlation between mean heart rate and work performed during max cycle test (r=0.650, P=0.022) and the HRV parameter standard deviation normal to normal (SDNN) (r=0.678, P=0.015). After exercise training there was a significant increase in work performed (30.3+/-14.2 versus 38.1+/-14.1 kJ), 6-min walk test (502+/-88 versus 552+/-59 m, P=0.006) and SDNN (117.3+/-40.7 versus 128.6+/-42.3 ms, P=0.028). At 87 months of follow-up, there was a borderline significant difference between survivors and non-survivors. Only the survivors had a significant increase in SDNN after exercise training. CONCLUSION: This pilot study demonstrates an improvement with regard to parameters for HRV after exercise training in patients with CHF. The study suggests that the positive effect of exercise training in patients with CHF involves an attenuation of the reduced HRV response, and that this improvement might have prognostic significance

• Scholz, Hanne; Aukrust, Pål; Damås, Jan Kristian; Tonstad, Serena; Sagen, Ellen Lund & Kolset, Svein Olav [Show all 9 contributors for this article] (2004). 8-isoprostane increases scavenger receptor A and matrix metalloproteinase activity in THP-1 macrophages, resulting in long-lived foam cells. European Journal of Clinical Investigation. ISSN 0014-2972. 34(7), p. 451–458. Full text in Research Archive
• Wijeysundera, HC; Hansen, MS; Stanton, E; Cropp, AS & Hall, Christian (2003). Neurohormones and oxidative stress in nonischemic cardiomyopathy: relationship to survival and the effect of treatment with amlodipine. American Heart Journal. ISSN 0002-8703. 146, p. 291–297. Full text in Research Archive
• Larsen, Alf Inge; Hall, Christian; Aukrust, Pål; Aarsland, Torbjørn; Faris, Peter & Dickstein, Kenneth (2003). Prognostic usefulness of an increase of N-terminal proatrial natriuretic peptide during exercise in patients with chronic heart failure. American Journal of Cardiology. ISSN 0002-9149. 92(1), p. 91–94. Full text in Research Archive
• Hall, Christian; Ihlen, Halfdan; Bonarjee, Vernon; Dickstein, Kenneth & Kjekshus, John (2003). N-terminal proatrial natriuretic peptide in primary care: relation to echocardiographic indices of cardiac function in mild to moderate cardiac disease. International Journal of Cardiology. ISSN 0167-5273. 89, p. 197–205. Full text in Research Archive
• Qi, Wei; Mathisen, Per; Kjekshus, John; Simonsen, S; Bjørnerheim, Reidar & Hall, Christian [Show all 7 contributors for this article] (2002). The effect of aortic valve replacement on T-terminal natriuretic propeptides in patients with aortic stenosis. Clinical Cardiology. ISSN 0160-9289. 25, p. 174–180. Full text in Research Archive
• Persson, H.; Andréassen, K.; Kahan, T.; Eriksson, S.V.; Tidgren, B. & Hjemdahl, P. [Show all 8 contributors for this article] (2002). Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists. European Journal of Heart Failure. ISSN 1388-9842. 4, p. 73–82. Full text in Research Archive
• Qi, Wei; Mathisen, Per; Kjekshus, John; Simonsen, Svein; Endresen, Knut & Bjørnerheim, Reidar [Show all 7 contributors for this article] (2002). The effect of aortic valve replacement on N-terminal natriuretic propeptides in patients with aortic stenosis. Clinical Cardiology. ISSN 0160-9289. 25, p. 174–180. Full text in Research Archive
• Sheth, Tej; Parker, Tom; Block, Alan & Hall, Christian (2002). Comparison of the effects of omapatrilat and lisinopril on circulating neurohormones and cytokines in patients with chronic heart failure. American Journal of Cardiology. ISSN 0002-9149. 90(5), p. 496–500. Full text in Research Archive
• McDowell, G.; Patterson, C.; Maguire, S.; Shaw, C. A.; Nicholls, D.P. & Hall, Christian (2002). Variability of Nt-proANP and C-ANP. European Journal of Clinical Investigation. ISSN 0014-2972. 32, p. 545–548. Full text in Research Archive
• Johnson, Wendy; Omland, Torbjørn; Hall, Christian; Lucas, Caroline; Myking, Ole Langeland & Collins, Caroline [Show all 9 contributors for this article] (2002). Neurohormonal activation rapidly decreases after intravenous therapy with diuretics and vasodilators for class IV heart failure. Journal of the American College of Cardiology. ISSN 0735-1097. 15, p. 1623–1629. Full text in Research Archive
• Otterstad, Jan Erik; Sutton, M. G. St John; Frøland, Gisle; Holme, Ingar; Skjærpe, T. & Hall, Christian (2002). Prognostic value of two-dimensional echocardiography and N-terminal proatrial natriuretic peptide following an acute myocardial infarction. European Heart Journal. ISSN 0195-668X. 23, p. 73–82. Full text in Research Archive
• Sheth, Tej; Parker, Tom; Block, Alan; Hall, Christian; Adam, A. & Pfeffer, M.A. [Show all 9 contributors for this article] (2002). Comparison of the effects of omapatrilat and lisinopril on circulating neurohormones and cytokines in patients with chronic heart failure. American Journal of Cardiology. ISSN 0002-9149. 90, p. 496–500. Full text in Research Archive
• Hall, Christian & Stokke, Oddvar (2002). Natriuretiske hjertepeptider som markører for hjertesykdom. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 29(122), p. 2784–2786. Full text in Research Archive
• Omland, Torbjørn; Lemos, J. A. de; Morrow, D A.; Antman, E M.; Cannon, C.P. & Hall, Christian [Show all 7 contributors for this article] (2002). Prognostic value of N-terminal pro-atrial and pro-brain natriuretic peptide in patients with acute coronary syndromes. American Journal of Cardiology. ISSN 0002-9149. 89, p. 463–465. Full text in Research Archive
• Smith, Jørgen A.; Bruusgaard, D.; Bodd, E. & Hall, Christian (2001). Relations between medical history, clinical findings and plasma N-terminal proatrial natriuretic peptide in patients in primary health care. European Journal of Heart Failure. ISSN 1388-9842. 3, p. 307–313. Full text in Research Archive
• Sigurdsson, A; Eriksson, S.V.; Hall, Christian; Kahan, T. & Swedberg, Karl (2001). Early neurohormonal effects of trandolapril in patients with left ventricular dysfunction and a recent acute myocardial infarction: a double-blind, randomized, placebo-controlled multicentre study. European Journal of Heart Failure. ISSN 1388-9842. 3, p. 69–78. Full text in Research Archive
• Hall, Christian (2001). Natriuretiske hjertepeptider - klare for den diagnostiske rutinen? Klinisk Biokemi i Norden. ISSN 1101-2013. 1, p. 9–13. Full text in Research Archive
• Holmström, Henrik Alf B.; Hall, Christian & Thaulow, Erik (2001). Plasma levels of natriuretic peptides and hemodynamic assessment of patent ductus arteriosus in preterm infants. Acta Paediatrica. ISSN 0803-5253. 90, p. 184–191. Full text in Research Archive
• Lemos, J A De; Morrow, D A.; Bentley, J H.; Omland, Torbjørn; Sabatine, M S. & McCabe, C H. [Show all 9 contributors for this article] (2001). The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. New England Journal of Medicine. ISSN 0028-4793. 345, p. 1014–1021. Full text in Research Archive
• Schulz, Hanne; Langvik, T. A.; Sagen, Ellen Lund; Smith, Jørgen A.; Ahmadi, N. & Hall, Christian (2001). Radioimmunoassay for N- terminal probrain natriuretic peptide in human plasma. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 61, p. 33–42. Full text in Research Archive
• Metry, G.; Hall, Christian; Wikström, B.; Källskog, V.; Hansell, P. & Danielsen, Bo (2001). Fluid balance in patients with chronic renal failure assessed with N-terminal proatrial natriuretic peptide, atrial natriuretic peptide and ultrasonography. Acta Physiologica Scandinavica. ISSN 0001-6772. 171, p. 117–122. Full text in Research Archive
• White, M.; Rouleau, J.L.; Hall, Christian; Arnold, M.; Harel, F. & Sirois, P. [Show all 12 contributors for this article] (2001). Changes in vasoconstrictive hormones, natriuretic peptides, and left ventricular remodeling soon after anterior myocardial infarction. American Heart Journal. ISSN 0002-8703. 142, p. 1056–1065. Full text in Research Archive
• Hall, Kirsten Sundby; Wiklund, T.; Erikstein, Bjørn; Holte, H.; Kvalheim, Gunnar & Sommer, Hilde Heen [Show all 10 contributors for this article] (2001). Effects of dose-intensive chemotherapy and radiotherapy on serum n-terminal proatrial natriuretic peptide in high-risk breast cancer patients. Breast Cancer Research and Treatment. ISSN 0167-6806. 67, p. 235–244. Full text in Research Archive
• Hystad, Marit Elise; Geiran, Odd; Attramadal, Håvard; Spurkland, Anne; Vege, Åshild & Simonsen, S [Show all 7 contributors for this article] (2001). Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure. Acta Physiologica Scandinavica. ISSN 0001-6772. 171(4), p. 395–403. Full text in Research Archive Show summary

  Abstract: The purpose of this study was to examine the regional cardiac mRNA expression and concentration of brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) in relation to the circulating peptide concentrations in patients with chronic heart failure (CHF). The myocardial mRNA levels and peptide concentrations of BNP and ANP were analysed in seven different regions of the heart from patients undergoing cardiac transplantation. Autopsy samples from individuals without known cardiovascular disease were used as controls. The plasma levels of natriuretic peptides and their N-terminal propeptides, Nt-proBNP and Nt-proANP, were measured in the CHF patients and healthy volunteers. In the autopsy specimens, the atrial regions appeared to contain the highest peptide levels for BNP as well as ANP, the atrioventricular ratio being 12-262 and 72-637-fold, respectively. In the CHF patients there was a relative shift towards the ventricle for BNP, reducing the atrioventricular ratio to 6-16-fold. The circulating concentrations of BNP/Nt-proBNP in the CHF patients correlated closely to the BNP mRNA expression in most myocardial regions including the left ventricle (r = 0.72, P < 0.001). For circulating concentrations of ANP/Nt-proANP, such correlation were limited to the left atrium free wall (r = .66, P < 0.002). Thus, of the two natriuretic peptides, BNP/Nt-proBNP may be a better reflector of left ventricular overload.

• Qi, Wei; Mathisen, Per; Kjekshus, John; Simonsen, Svein; Bjørnerheim, Reidar & Endresen, Knut [Show all 7 contributors for this article] (2001). Natriuretic peptides in patients with aortic stenosis. American Heart Journal. ISSN 0002-8703. 42, p. 725–732. Full text in Research Archive
• Hystad, Marit Elise; Øie, Erik; Grøgaard, Haakon Kiil; Kuusnemi, K.; Voulteenah, O. & Attramadal, Håvard [Show all 7 contributors for this article] (2001). Gene expression of natriuretic peptides and their reseptors type -A and -C after myocardinal infarction in rat. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 61, p. 139–150. Full text in Research Archive
• Holmstrøm, Henrik; Hall, Christian & Thaulow, Erik (2001). Plasma levels of natriuretic peptides and hemodynamic assessment of patent ductus arteriosus in preterm infants. Acta Paediatrica. ISSN 0803-5253. 90(2), p. 184–91. Full text in Research Archive
• Qi, Wei; Kjekshus, Harald; Klinge, Randi Furseth; Kjekshus, John & Hall, Christian (2000). Cardiac natriuretic peptides and continuously monitored atrial pressure during chronic rapid pacing in pigs. Acta Physiologica Scandinavica. ISSN 0001-6772. 169, p. 95–102. Full text in Research Archive
• Qi, Wei; Kjekshus, John & Hall, Christian (2000). Differential responses of plasma atrial and brain natriuretic peptides to acute alteration in atrial pressure in pigs. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 60, p. 55–64. Full text in Research Archive
• Gullestad, Lars; Jørgensen, Bjørn; Bjurø, T.; Pernow, J.; Lundberg, J.M. & Dota, C-D. [Show all 9 contributors for this article] (2000). Postexercise ischemia is associated with increased neuropeptide Y in patients with coronary artery disease. Circulation. ISSN 0009-7322. 102, p. 987–993. Full text in Research Archive
• Holmström, Henrik Alf B.; Hall, Christian; Stokke, Oddvar & Thaulow, Erik (2000). Plasma levels of N-terminal proatrial natriuretic peptide in children are dependent on renal function and age. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 60, p. 149–159. Full text in Research Archive
• Andersson, B. & Hall, Christian (2000). N-terminal proatrial natriuretic peptide and prognosis in patients with heart failure and preserved systolic function. Journal of Cardiac Failure. ISSN 1071-9164. 6, p. 208–213. Full text in Research Archive
• Hystad, Marit Elise; Klinge, Randi Furseth; Spurkland, Anne; Attramadal, Håvard & Hall, Christian (2000). Contrasting cardiac regional responses of A-type and B-type natriuretic peptide to experimental chronic heart failure. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 60, p. 299–310. Full text in Research Archive
• Moe, G W.; Rouleau, J.L.; Charbonneau, L.; Proulx, G.; Arnold, J M. & Hall, Christian [Show all 10 contributors for this article] (2000). Neurohormonal activation in severe heart failure: relations to patient death and the effect of treatment with flosequinan. American Heart Journal. ISSN 0002-8703. 139, p. 587–595. Full text in Research Archive
• Holmstrøm, Henrik; Hall, Christian; Stokke, Oddvar & Thaulow, Erik (2000). Plasma levels of N-terminal proatrial natriuretic peptide in children are dependent on renal function and age. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 60(2), p. 149–59. Full text in Research Archive
• Qi, Wei; Kjekshus, John & Hall, Christian (2000). Differential responses of plasma atrial and brain natriuretic peptides to acute alternation in atrial pressure in pigs. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 60, p. 50–64. Full text in Research Archive
• Otterstad, Jan Erik; Hall, Christian; Graving, B.; Skjerpe, T. & Holme, Ingar (1999). Ekkokardiografiske funn, pro-ANF og behandling ved akutt hjerteinfarkt uten manifest hjertesvikt. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 119, p. 2802–2805. Full text in Research Archive
• Holmström, Henrik Alf B.; Hall, Christian; Stokke, Oddvar; Lindberg, Harald L. & Thaulow, Erik (1999). Måling av N-terminal proatrial natriuretisk faktor hos barn. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 119, p. 2838–2841. Full text in Research Archive
• Wijbenga, J.A.M.; Balk, A.H.M.M.; Boomsma, F. & Hall, Christian (1999). Cardiac peptides differ in their response to exercise. Implications for patients with heart failure in clinical practice. European Heart Journal. ISSN 0195-668X. 20, p. 1424–1428. Full text in Research Archive
• Goldstein, Sidney; Kennedy, H.L.; Hall, Christian; Anderson, J.L.; Gheorghiade, M. & Gottlieb, S.S. [Show all 10 contributors for this article] (1999). Metoprolol CR/XL in patients with heart failure: A pilot study examining the tolerability, safety, and effect on left ventricular ejection fraction. American Heart Journal. ISSN 0002-8703. 138(6), p. 1158–1165. Full text in Research Archive
• Klinge, Randi Furseth; Jørgensen, Bjørn; Thaulow, Erik; Sirnes, Per A. & Hall, Christian (1999). N-terminal proatrial natriuretic peptide in angina pectoris: impact of revascularization by angioplasty. International Journal of Cardiology. ISSN 0167-5273. 68, p. 1–8. Full text in Research Archive
• Holmström, Henrik Alf B.; Hall, Christian; Stokke, Oddvar; Lindberg, Harald L. & Thaulow, Erik (1999). Elevation of atrial natriuretic peptide prohormone. Hemodynamic background of the elevation of N-terminal natriuretic peptide prohormone in children with congenital heart disease. Cardiology in the Young. ISSN 1047-9511. 9, p. 141–149. Full text in Research Archive
• Holmstrøm, Henrik; Hall, Christian; Stokke, Oddvar; Lindberg, Harald L & Thaulow, Erik (1999). Measurements of N-terminal proatrial natriuretic factor in children. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 119(19), p. 2838–41. Full text in Research Archive
• Holmstrøm, Henrik; Hall, Christian; Stokke, Oddvar; Lindberg, Harald L & Thaulow, Erik (1999). Elevation of atrial natriuretic peptide prohormone. Hemodynamic background of the elevation of N-terminal natriuretic peptide prohormone in children with congenital heart disease. Cardiology in the Young. ISSN 1047-9511. 9(2), p. 141–9. Full text in Research Archive
• Dahle, M.G.; Simonsen, Svein; Hall, Christian & Kjekshus, John (1998). Power of plasma N-terminal proatrial natriuretic factor to determine haemodynamics in patients with cardiac disease: relation to serum creatinine. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 58, p. 395–404. Full text in Research Archive
• Klinge, Randi Furseth; Hystad, Marit Elise; Kjekshus, John; Karlberg, B.E.; Djøseland, Ole & Aakvaag, A. [Show all 7 contributors for this article] (1998). An experimental study of cardiac natriuretic peptides as markers of development of congestive heart failure. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 58, p. 683–692. Full text in Research Archive
• Hornestam, B.; Hall, Christian; Held, P.; Carlsson, T.; Falk, L. & Karlsson, B W. [Show all 8 contributors for this article] (1998). N- terminal proANF in acute atrial fibrillationa biochemical marker of atrial pressures but not a predictor for conversion to sinus rhythm. Digitalis in Acute Atrial Fibrillation (DAAF) Trial group. American Heart Journal. ISSN 0002-8703. 135, p. 1040–1047. Full text in Research Archive
• Jørgensen, Bjørn; Ueland, Thor & Hall, Christian (1998). Prolonged ischemia after exercise is associated with elevated levels of neuropeptide Y in patients with angina pectoris. European Heart Journal. ISSN 0195-668X. 19, p. 280–280. Full text in Research Archive

View all works in NVA

• Leosdottir, M; Willenheimer, R; Hall, Christian; Tjora, S; Malm, Johan & Melander, O [Show all 8 contributors for this article] (2009). Gender differences in the association between NT proBNP and glucometabolic disturbances in a population-based cohort. Cardiology. ISSN 0008-6312. 113, p. 48–48. Full text in Research Archive
• Schulz, Hanne; Yndestad, Arne; Aukrust, Pål; Hall, Christian & Halvorsen, Bente (2002). 8-iso-prostaglandin F2a stimulates interleukin-8 expression in human THP-1 derived macrophages. Full text in Research Archive
• Hall, Christian (2002). Biochemistry, pathophysiology and potential use of N-terminal B-type natriuretic peptide. Full text in Research Archive
• Schulz, Hanne; Halvorsen, Bente & Hall, Christian (2001). 8-iso-Prostaglandin F2alpha reduces productin of TIMP-1 in human macrophages (THP-1 cells). A potential role of 8-iso-prostaglandin F2alpha in plaque rupture. Full text in Research Archive
• Hall, Christian (2001). Synthesis, secretion and molecular forms of NT-proBNP. NT-proBNP: Achievements and Gaps. Full text in Research Archive
• White, M.; McKelvie, R S.; Hall, Christian; Maggioni, A.; Latini, R. & Masson, S. [Show all 10 contributors for this article] (2001). Predictive value of natriuretic peptides and endothelin-1 for LV remodelling in response to candesartan and enalapril: the RESOLVD neurohumoral ancillary study. Full text in Research Archive
• Omland, Torbjørn; Lemos, J A De; Morrow, D A.; Antman, E M.; Cannon, C.P. & Hall, Christian [Show all 7 contributors for this article] (2001). N-terminal pro-brain natriuretic peptide is an independent predictor of survival in patients with non-ST-segment elevation acute coronary syndromes: a TIMI 11B substudy. Full text in Research Archive
• Alehagen, Urban; Eriksson, H.; Hall, Christian & Dahlström, U. (2001). B-type natriuretic peptides as markers of left ventricular function in the elderly. Full text in Research Archive
• Hall, Christian (2001). The value of natriuretic peptides for the management of heart failure: current state of play. European Journal of Heart Failure. ISSN 1388-9842. 3, p. 395–397. Full text in Research Archive
• Hall, Christian (2001). Natriuretiske peptider - klare for rutinen? Bioingeniøren. ISSN 0801-6828. 8, p. 6–8. Full text in Research Archive
• Hall, Christian (2000). Natriuretic peptides as markers of cardiac function. Full text in Research Archive
• Hall, Christian (2000). Prognostisk betydning av N-terminal pro-ANF og ekkokardiografiske funn ved inklusjon. Full text in Research Archive
• Hall, Christian (2000). Diagnostic use of natriuretic peptides. Full text in Research Archive
• Otterstad, Jan Erik; Holme, Ingar; Skjærpe, T.; Hall, Christian & Sutton, M. G. St John (2000). Prognostic impact of changes in left ventricular volumes and N-terminal proANP 3 months following an acute myocardial infarction. Full text in Research Archive
• Hall, Christian (2000). Natriuretic peptides in clinical practice. European Heart Journal. ISSN 0195-668X. 21, p. 337–337. Full text in Research Archive
• Hall, Christian (1999). Natriuretic peptides as markers of cardiac disease. Full text in Research Archive
• Hall, Christian; Segal, R.; Sharma, D.; Klinger, G.H.; Velivis, M. & Pitt, B. (1999). Neurohormonal profile following long-term treatment of heart failure patients with Losartan or Captopril - ELITE study. Full text in Research Archive
• Hall, Christian; Rouleau, J.L.; White, M.; McKelvie, R S.; Maggioni, A. & Latini, R. [Show all 7 contributors for this article] (1999). Metoprolol in chronic heart failure: natriuretic peptides involved in mechanism of action? Full text in Research Archive
• Hall, Christian (1999). Importance in diagnosis and treatment of heart failure. Full text in Research Archive
• Omland, Torbjørn; Johnsen, Wenche; Collins, C.; Hall, Christian & Stevenson, L.W. (1999). Intravenøs vasodilatator og diuretisk behandling fører til redusert neurohormonell aktivering hos pasienter med klasse IV hjertesvikt. Full text in Research Archive
• Hall, Christian (1999). Kulturkollisjon med Forskningsrådet. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. Full text in Research Archive
• Hall, Christian (1998). Natriuretic peptide as diagnostics of congestive heart failure. Full text in Research Archive
• Hall, Christian (1998). Natriuretic peptides as markers of cardiac disease - where do we go from here? Full text in Research Archive
• White, M.; Pfeffer, M.A.; Arnold, M.; Ajani, U.; Hall, Christian & Rouleau, J.L. (1998). Neurohumoural activation and left ventricular remodelling early post-anterior myocardial infarctionthe HEART neurohumoural ancillary study. Full text in Research Archive
• Hall, Christian (1998). Clinical use of BNP and ANP determinations in heart failure. Full text in Research Archive
• Hall, Christian (1998). Hvordan prioritere internt? Universitas. Full text in Research Archive
• Hall, Christian (1998). Ti bud for universitetsledelse. Dagbladet. ISSN 0805-3766. Full text in Research Archive
• Hall, Christian (1998). Om rektorrollen. Universitas. Full text in Research Archive
• Hall, Christian (1998). Hva vil vi med universitetene? Dagbladet. ISSN 0805-3766. Full text in Research Archive
• Hall, Christian (1998). Skal UiO betale for senteret? Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116. Full text in Research Archive
• Ibsen, Jørgen; Hall, Christian; Lund, Christian; Hov, Maren Ranhoff & Stugaard, Marie (2026). Rural Computed Tomography and thrombolytic treatment for ischemic stroke. Universitetet i Oslo. ISSN 9788234808678. Full text in Research Archive Show summary

  Acute stroke affects approximately 10.000 Norwegians annually. Early thrombolytic treatment of patients with ischemic stroke significantly improves prognosis, however treatment is time dependent and should in most patients be administered within 4.5 hours from onset of symptoms. To exclude cerebral haemorrhage, a rapid Computed Tomography (CT) scan of the brain must be performed. Stroke patients from rural areas in Norway may have a long transport time to hospital and arrive too late for treatment. The primary aim of this thesis was to examine the rationale, feasibility and potential utility of a rural CT station in prehospital stroke diagnosis and treatment. Data from the Norwegian Stroke Registry demonstrate a significant inverse relationship between transport time in ambulance and frequency of reperfusion therapy. Alternative models such as Mobile Stroke Units have been tested to reduce the prehospital time delay. In the thesis Rural computed tomography and thrombolytic treatment for ischemic stroke Ibsen et al. explores effects of a decentralized CT and thrombolytic service in Hallingdal, Norway. During daytime, the service is operated by a local radiographer and a general practitioner. Out of office hours, the CT scanner is remotely controlled from Ringerike Hospital and trained paramedics are supervised over video link to perform diagnosis and treatment. In a clinical study, treated patients received thrombolysis 89 minutes earlier than patients from a similar rural district without a rural CT station. In collaboration with the Norwegian Mapping Authority, we hypothetically deployed similar CT stations as in Hallingdal into rural areas in Norway. The deployment resulted in a significant reduction in transport times and an increased odds ratio for good outcome in case of ischemic stroke. Such deployment may be feasible due to utilization of telemedicine and paramedics already on-call, however cost-benefit analyses are up to now not performed.

View all works in NVA