Drude Merete Fugelseth

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Phone +47-22850545
Mobile phone +47-41478650
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Visiting address Kirkeveien 166 Bygg 9 None 0450 OSLO
Postal address Postboks 4956 Nydalen 0424 OSLO
Professor II/Consultant at Dept of Neonatal Intensive Care, Oslo University Hospital Ullevål

Academic Interests.

Main topics of interest are neonatology with focus on the newborn circulation, myocardial function and ventilation.

The research has been concentrated about myocardial function and circulation in healthy and sick term and preterm newborns. The transitional phase from fetal to newborn circulation is a vulnerable period for the newborn baby and has been of main interest.

As a leader of the research group "NeoCHIBS" (Neonatal Circulation, Heart, Infection and Brain Study Group), there are ongoing projects covering newer modalities for studying the myocardial function (Tissue Doppler Imaging),  macro- and microcirculation (ultrasound, laser Doppler, video microscopy and spectroscopy), studies of the cerebral circulation and MR in neonates treated with therapeutic hypothermia after birth asphyxia, and studies of spesific GBS-antibodies in mothers and the transmition to the baby.

The main aim of the circulatory studies is developing better methods for monitoring the sick newborn baby for improving supportive circulatory treatments.

Our research group is cooperating with several other departments within Oslo University Hospital, as well as other institutions and health regions in Norway and institutions in other countries.

Courses taught

  • Medical students in 9th semester with special focus on neonatology

Background

  • 2011-2014 Deputy Head of Institute for Clinical Medicine, Faculty of Medicine, University of Oslo and Professor/consultant Dept. of Neonatal Intensive Care, Oslo University Hospital, Ullevål
  • 2007 Professor in Neonatology at University of Oslo
  • 2000 Doctor Medicinae, University of Oslo (Thesis: Ductus Venosus “Arantii” in the Newborn. “The forgotten vessel in neonatologi?” An ultrasonographic study.)
  • 1993 Consultant in Neonatology and Paediatric Cardiology, Oslo University Hospital
  • 1991 Spesialization in Paediatrics and Neonatology
  • 1981 MD University of Oslo
  • 1975 Educational Research, University of Oslo
  • 1972 Physiotherapist, National School of Physiotherapy

Awards

  • The director award of excellent research 2003

Collaboration

  • St. Michaels Hospital, University of Bristol, UK, Dept. of Biomedical Engineering, Linköping University, Linköping, Sweden, Dept. of Physiology, Temple University, Philadelphia PA, USA, Novartis Vaccines and Diagnostics, Siena, Italia, Dept. of Cardiothoracic Surgery, Oslo University Hospital, Ullevål, Oslo, Institute of Circulation and Medical Imaging, Norwegian Institute of Science and Technology, Trondheim, Dept. of Electronics and Telecommunications, Norwegian University of Science and Technology, St. Olavs Hospital, Trondheim, Dept. of Paediatrics, Vestfold Hospital Trust, Vestfold Hospital, Tønsberg, Department of Paediatrics, Sunnmore Public Health Enterprice, Aalesund, Norway

Publications

  • Heier, Martin; Nygaard, Cathrine Skorpen; Brunborg, Cathrine; Seljeflot, Ingebjørg; MARGEIRSDOTTIR, HANNA DIS; Hanssen, Kristian Folkvord; Fugelseth, Drude & Dahl-Jørgensen, Knut (2018). Preserved endothelial function in young adults with type 1 diabetes. PLOS ONE.  ISSN 1932-6203.  13:e0206523(10), s 1- 8 . doi: 10.1371/journal.pone.0206523
  • Nestaas, Eirik; Fugelseth, Drude & Eriksen, Beate Horsberg (2018). Assessment of Systemic Blood Flow and Myocardial Function in the Neonatal Period Using Ultrasound, In Richard A. Polin (ed.),  Hemodynamics and Cardiology.  Elsevier.  ISBN 9780323533669.  11.
  • Brunvand, Leif; Heier, Martin; Brunborg, Cathrine; Hanssen, Kristian Folkvord; Fugelseth, Drude; STENSÆTH, KNUT HAAKON; Dahl-Jørgensen, Knut & MARGEIRSDOTTIR, HANNA DIS (2017). Advanced glycation end products in children with type 1 diabetes and early reduced diastolic heart function. BMC Cardiovascular Disorders.  ISSN 1471-2261.  17(133) . doi: 10.1186/s12872-017-0551-0 Full text in Research Archive.
  • Skranes, Janne Helen; Løhaugen, Gro; Schumacher, Eva Margrethe; Osredkar, Damjan; Server, Andrés; Cowan, Frances Mary; Stiris, Tom; Fugelseth, Drude & Thoresen, Marianne (2017). Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age. Journal of Pediatrics.  ISSN 0022-3476.  187, s 34- 42 . doi: 10.1016/j.jpeds.2017.04.041
  • Brunvand, Leif; Fugelseth, Drude; STENSÆTH, KNUT-HAAKON; Dahl-Jørgensen, Knut & MARGEIRSDOTTIR, HANNA DIS (2016). Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study. BMC Cardiovascular Disorders.  ISSN 1471-2261.  16(103) . doi: 10.1186/s12872-016-0288-1
  • Fredly, Siv; Fugelseth, Drude; Nygaard, Cathrine Skorpen; Salerud, Gøran; Stiris, Tom & Kvernebo, Knut (2016). Noninvasive assessments of oxygen delivery from the microcirculation to skin in hypothermia-treated asphyxiated newborn infants. Pediatric Research.  ISSN 0031-3998.  79, s 902- 906 . doi: 10.1038/pr.2016.16
  • Fredly, Siv; Nygaard, Cathrine Skorpen; Skranes, Janne Helen; Stiris, Tom & Fugelseth, Drude (2016). Cooling effect on skin microcirculation in asphyxiated newborn infants with increased C-reactive protein. Neonatology.  ISSN 1661-7800.  110(4), s 270- 276 . doi: 10.1159/000446763
  • Nestaas, Eirik; Støylen, Asbjørn & Fugelseth, Drude (2016). Speckle tracking using gray-scale information from tissue Doppler recordings versus regular gray-scale recordings in term neonates. Ultrasound in Medicine and Biology.  ISSN 0301-5629.  42(11), s 2599- 2605 . doi: 10.1016/j.ultrasmedbio.2016.06.003
  • Brigtsen, Anne Karin; Dedi, Lumnije; Melby, Kjetil K.; Holberg-Petersen, Mona; Radtke, Andreas; Lyng, Randi Valsø; Andresen, Lise Lima; Jacobsen, Anne Flem; Fugelseth, Drude & Whitelaw, Andrew (2015). Comparison of PCR and serotyping of Group B Streptococcus in pregnant women: The Oslo GBS-study. Journal of Microbiological Methods.  ISSN 0167-7012.  108, s 31- 35 . doi: 10.1016/j.mimet.2014.11.001
  • Brigtsen, Anne Karin; Jacobsen, Anne Flem; Dedi, Lumnije; Melby, Kjetil K.; Fugelseth, Drude & Whitelaw, Andrew (2015). Maternal colonization with Group B streptococcus is associated with an increased rate of infants transferred to the neonatal intensive care unit. Neonatology.  ISSN 1661-7800.  108, s 157- 163 . doi: 10.1159/000434716
  • Fredly, Siv; Fugelseth, Drude; Wester, Torjus; Häggblad, Erik & Kvernebo, Knut (2015). Skin microcirculation in healthy term newborn infants-assessment of morphology, perfusion and oxygenation. Clinical Hemorheology and Microcirculation.  ISSN 1386-0291.  59(4), s 309- 322 . doi: 10.3233/CH-131764
  • Helmer, Caroline; Skranes, Janne Helen; Liestøl, Knut & Fugelseth, Drude (2015). Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels. Acta Paediatrica.  ISSN 0803-5253.  104(9), s e378- e383 . doi: 10.1111/apa.13055
  • Skranes, Janne Helen; Cowan, Frances; Stiris, Tom; Fugelseth, Drude; Thoresen, Marianne & SERVER, ANDRES (2015). Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth. Acta Paediatrica.  ISSN 0803-5253.  104(8), s 752- 758 . doi: 10.1111/apa.13016
  • Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2014). Myocardial function in term and preterm infants. Influence of heart size, gestational age and postnatal maturation. Early Human Development.  ISSN 0378-3782.  90(7), s 359- 364 . doi: 10.1016/j.earlhumdev.2014.04.010 Show summary
  • Lee, Anja; Nestaas, Eirik; Liestøl, Knut; Brunvand, Leif; Lindemann, Rolf & Fugelseth, Drude (2014). Tissue Doppler imaging in very preterm infants during the first 24 h of life: an observational study. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  99(1), s F64- F69 . doi: 10.1136/archdischild-2013-304197
  • Nestaas, Eirik; Fugelseth, Drude & Støylen, Asbjørn (2014). Automated, Objective and Expert-Independent Assessment of the Analyzability of Strain and Strain Rate in Tissue Doppler Images in Term Neonates by Analysis of Beat-to-Beat Variation. Ultrasound in Medicine and Biology.  ISSN 0301-5629.  40(3), s 637- 642 . doi: 10.1016/j.ultrasmedbio.2013.10.026
  • Nestaas, Eirik; Skranes, Janne Helen; Støylen, Asbjørn; Brunvand, Leif & Fugelseth, Drude (2014). The myocardial function during and after whole-body therapeutic hypothermia for hypoxic–ischemic encephalopathy, a cohort study. Early Human Development.  ISSN 0378-3782.  90(5), s 247- 252 . doi: 10.1016/j.earlhumdev.2014.01.014
  • Skranes, Janne Helen; Elstad, Maja; Thoresen, Marianne; Cowan, Frances; Stiris, Tom & Fugelseth, Drude (2014). Hypothermia Makes Cerebral Resistance Index a Poor Prognostic Tool in Encephalopathic Newborns. Neonatology.  ISSN 1661-7800.  106(1), s 17- 23 . doi: 10.1159/000358229
  • Eriksen, Beate Horsberg; Husebekk, Anne; Fugelseth, Drude; Salberg, Karen Reistad & Lindemann, Rolf (2013). Et nyfødt barn med petekkier. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(7), s 761- 764 . doi: 10.4045/tidsskr.12.1009
  • Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2013). Longitudinal assessment of atrioventricular annulus excursion by grey-scale m-mode and colour tissue Doppler imaging in premature infants. Early Human Development.  ISSN 0378-3782.  89(12), s 977- 982 . doi: 10.1016/j.earlhumdev.2013.09.006
  • Eriksen, Beate Horsberg; Nestaas, Eirik; Hole, Torstein; Liestøl, Knut; Støylen, Asbjørn & Fugelseth, Drude (2013). Myocardial function in premature infants: a longitudinal observational study. BMJ Open.  ISSN 2044-6055.  3(3) . doi: 10.1136/bmjopen-2012-002441 Full text in Research Archive.
  • Henrichsen, Thore Andre; Lindenskov, Paal Helge H.; Shaffer, Thomas H.; Løkke, Ruth J.; Fugelseth, Drude & Lindemann, Rolf (2012). Perfluorodecalin lavage of a longstanding lung atelectasis in a child with spinal muscle atrophy. Pediatric Pulmonology.  ISSN 8755-6863.  47(4), s 415- 419 . doi: 10.1002/ppul.21565
  • Nestaas, Eirik; Støylen, Asbjørn & Fugelseth, Drude (2012). Myocardial performance assessment in neonates by one-segment strain and strain rate analysis by tissue Doppler - a quality improvement cohort study. BMJ Open.  ISSN 2044-6055.  2(4) . doi: 10.1136/bmjopen-2012-001636 Full text in Research Archive.
  • Fugelseth, Drude; RAMSTAD, HEIDI; Kvehaugen, Anne Stine; Nestaas, Eirik; Støylen, Asbjørn & Staff, Anne Cathrine (2011). Myocardial function in offspring 5-8 years after pregnancy complicated by preeclampsia. Early Human Development.  ISSN 0378-3782.  87(8), s 531- 535 . doi: 10.1016/j.earlhumdev.2011.04.006
  • Kvehaugen, Anne Stine; Dechend, R; Ramstad, HB; Troisi, R; Fugelseth, Drude & Staff, Anne Cathrine (2011). Endothelial Function and Circulating Biomarkers Are Disturbed in Women and Children After Preeclampsia. Hypertension.  ISSN 0194-911X.  58(1), s 63- 69 . doi: 10.1161/HYPERTENSIONAHA.111.172387
  • Nestaas, Eirik; Støylen, Asbjørn; Brunvand, Leif & Fugelseth, Drude (2011). Longitudinal strain and strain rate by tissue Doppler are more sensitive indices than fractional shortening for assessing the reduced myocardial function in asphyxiated neonates. Cardiology in the Young.  ISSN 1047-9511.  21(1), s 1- 7 . doi: 10.1017/S1047951109991314
  • Lee, Anja; Liestøl, Knut; Nestaas, Eirik; Brunvand, Leif; Lindemann, Rolf & Fugelseth, Drude (2010). Superior vena cava flow: feasibility and reliability of the off-line analyses. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  95(2), s F121- F125 . doi: 10.1136/adc.2009.176883
  • Bakkeheim, E; Bergerud, U. E.; Schmidt-Melbye, AC; Akkok, CA; Liestøl, Knut; Fugelseth, Drude & Lindemann, Rolf (2009). Maternal IgG anti-A and anti-B titres predict outcome in ABO-incompatibility in the neonate. Acta Paediatrica.  ISSN 0803-5253.  98(12), s 1896- 1901 . doi: 10.1111/j.1651-2227.2009.01478.x
  • Fredly, Siv; Aksnes, Gunnar; Viddal, Kai O; Lindemann, Rolf & Fugelseth, Drude (2009). The outcome in newborns with congenital diaphragmatic hernia in a Norwegian region. Acta Paediatrica.  ISSN 0803-5253.  98(1), s 107- 111 . doi: 10.1111/j.1651-2227.2008.01024.x
  • Lee, Anja; Liestøl, Knut; Nestaas, Eirik; Brunvand, Leif; Lindemann, Rolf & Fugelseth, Drude (2009). Superior vena cava flow - feasibility and reliability of the off-line analyses. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998. . doi: 10.1136/adc.2009.176883
  • Nestaas, E; Stoylen, A; Støylen, Asbjørn; Brunvand, L & Fugelseth, D (2009). Tissue Doppler Derived Longitudinal Strain and Strain Rate During the First 3 Days of Life in Healthy Term Neonates. Pediatric Research.  ISSN 0031-3998.  65(3), s 357- 362
  • Nestaas, Eirik; Støylen, Asbjørn & Fugelseth, Drude (2008). Optimal types of probe, and tissue Doppler frame rates, for use during tissue Doppler recording and off-line analysis of strain and strain rate in neonates at term. Cardiology in the Young.  ISSN 1047-9511.  18(5), s 502- 511 . doi: 10.1017/S1047951108002655
  • Lindemann, Rolf; Rajka, Thomas; Henrichsen, Thore Andre; Vinorum, Ole Georg; De Lange, Charlotte; Erichsen, Aage & Fugelseth, Drude Merete (2007). Bronchioalveolar lavage with perfluorochemical liquid during conventional ventilation. Pediatric Critical Care Medicine.  ISSN 1529-7535.  8 . doi: 10.1097/01.PCC.0000282757.25347.6C
  • Nestaas, Eirik; Støylen, Asbjørn; Sandvik, Leif; Brunvand, Leif & Fugelseth, Drude (2007). FEASIBILITY AND RELIABILITY OF STRAIN AND STRAIN RATE MEASUREMENT IN NEONATES BY OPTIMIZING THE ANALYSIS PARAMETERS SETTINGS. Ultrasound in Medicine and Biology.  ISSN 0301-5629.  33(2), s 270- 278
  • Nestaas, Eirik; Støylen, Asbjørn; Sandvik, Leiv; Brunvand, Leif & Fugelseth, Drude (2007). Feasibility and reliability of strain and strain rate measurement in neonates by optimizing the analysis parameters settings. Ultrasound in Medicine and Biology.  ISSN 0301-5629.  33(2), s 270- 278 . doi: 10.1016/j.ultrasmedbio.2006.08.006
  • Børke, Wenche Bakken; Edvardsen, Thor; Fugelseth, Drude Merete; Lenes, K; Ihlen, Halfdan; Saugstad, Ola Didrik & Thaulow, Erik (2006). Reduced left ventricular function in hypoxemic newborn pigs: a strain Doppler echocardiographic study. Pediatric Research.  ISSN 0031-3998.  59(5), s 630- 635
  • Fugelseth, Drude Merete; Børke, Wenche Bakken; Lenes, K; Matthews, Iren; Saugstad, Ola Didrik & Thaulow, Erik (2005). Restoration of cardiopulmonary function with 21% versus 100% oxygen after hypoxaemia in newborn pigs. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  90, s 229- 234 . doi: 10.1136 Show summary
  • Fugelseth, Drude; Satas, Saulius; Steen, PA & Thoresen, Marianne (2003). Cardiac output, pulmonary artery pressure, and patent ductus arteriosus during therapeutic cooling after global hypoxia-ischaemia. Archives of Disease in Childhood: Fetal and Neonatal Edition.  ISSN 1359-2998.  88(3), s F223- F228

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  • Kynø, Nina Margrethe; Fugelseth, Drude & Hanssen, Ingrid (2018). Når felles språk med helsepersonell mangler; mødres opplevelser på nyfødtintensiv avdeling.
  • Fugelseth, Drude (2017). Measuring superior vena cava flow as part of echocardiography examinations performed by neonatologists. Acta Paediatrica.  ISSN 0803-5253.  106(1), s 5- 6 . doi: 10.1111/apa.13604
  • Wood, Thomas Ragnar; Skranes, Janne Helen; Falck, Mari; Lohaugen, GC; Stiris, Tom; Loberg, EM; Fugelseth, Drude & Thoresen, Marianne (2016). Core Temperature After Neonatal Hypoxia-Ischaemia Predicts Long-term Cerebral Injury.
  • Skranes, Janne Helen; Cowan, Frances; Stiris, Tom; Fugelseth, Drude; Thoresen, Marianne & SERVER, ANDRES (2014). Cerebral MRI on Days 4 and 11 in Encephalopathic Neonates Treated With Hypothermia.
  • Fugelseth, Drude & Kutzsche, Stefan (2013). Ensuring safe neonatal care for newborn babies. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  133(3), s 270- 271 . doi: 10.4045/tidsskr.12.1222
  • Skranes, Janne Helen; Thoresen, Marianne; Stiris, Tom; Cowan, Frances; Server, Andres Alonso; Fugelseth, Drude & Elstad, Maja (2013). Changes in Cerebral Resistance Index (RI) after rewarming from day three of cooling predicts good but not poor outcome in infants undergoing therapeutic hypothermia.
  • Brigtsen, Anne Karin; Dedi, Lumnije; Melby, Kjetil K.; Fugelseth, Drude; Flem-Jacobsen, Anne & Lindemann, Rolf (2012). High Prevalence of Group B Streptococcus Serotype IX in the Norwegian Population.
  • Eriksen, Beate Horsberg; Nestaas, Eirik & Fugelseth, Drude (2012). Functional echocardiography and cerebral blood doppler velocity measurements: Repeated examinations for clinical assessment in moderately preterm infants. Journal of Maternal-Fetal & Neonatal Medicine.  ISSN 1476-7058.  25 . doi: 10.3109/14767058.2012.667977
  • Bakkeheim, Egil; Bergerud, U. E.; Schmidt-Melbye, Anne-Christine; Akkok, CA; Liestøl, Knut; Fugelseth, Drude & Lindemann, Rolf (2010). Maternal IgG Anti-A and Anti-B Titres Predict Outcome in ABO-Incompatibility in the Neonate EDITORIAL COMMENT. Obstetrical and Gynecological Survey.  ISSN 0029-7828.  65(3), s 160- 162
  • Nestaas, Eirik & Fugelseth, Drude (2010). Longitudinal strain and strain rate by tissue Doppler in term neonates. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 985.
  • Fugelseth, Drude (2009). Kapittel 25: Resuscitering av nyfødte. Kapittel 27: Respirasjonssvikt og respirasjonsunderstøttende behandling av nyfødte. Kapittel 28: Sirkulasjonssvikt hos nyfødte - "sjokk" Kapittel 29: Hjerte og kretsløp i nyfødtperioden, I: Bente Silnes Tandberg & Solfrid Steinnes (red.),  Nyfødtsykepleie, bind I.  Cappelen Damm AS.  ISBN 978-82-02-25392-9.  kapittel 25, 27, 28 og 29.  s 117 - 176
  • Lindemann, Rolf; Myhre, Mia Cathrine; Bakken, Mari; Rustad, Cecilie; Fugelseth, Drude & Woldseth, Berit (2008). Et nyfødt barn med hyperventilasjon. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  128(13-14), s 1535- 1536
  • Fugelseth, Drude Merete; Børke, Wenche Bakken; Lenes, Kjetil; Matthews, Iren; Saugstad, Ola Didrik & Thaulow, Erik (2004). Reversal of pulmonary hypertension and restoration of cardiac output in hypoxemic newborn pigs.

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Published Apr. 13, 2011 2:53 PM - Last modified May 28, 2015 1:32 PM