Erlend Bremertun Smeland

• Spasevska, Ivana; Sharma, Ankush; Steen, Chloe Beate; Josefsson, Sarah Elisabet; Blaker, Yngvild Nuvin & Kolstad, Arne [Show all 26 contributors for this article] (2023). Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma. Blood Advances. ISSN 2473-9529. 7(23), p. 7216–7230. doi: 10.1182/bloodadvances.2023010158. Full text in Research Archive
• Casey, Nicholas Paul; Klee, Clara Helena; Bøthun, Anne Fåne; Caulier, Benjamin William; Graczyk-Jarzynka, Agnieszka & Krawczyk, Marta [Show all 17 contributors for this article] (2023). Efficient chimeric antigen receptor targeting of a central epitope of CD22. Journal of Biological Chemistry. ISSN 0021-9258. 299(7). doi: 10.1016/j.jbc.2023.104883. Full text in Research Archive
• Isaksen, Kathrine Thuestad; Galleberg, Renate Berget; Mastroianni, Maria Adele; Rinde, Marit; Rusten, Leiv Sindre & Barzenje, Dlawer Abdulla [Show all 15 contributors for this article] (2023). The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy. Haematologica. ISSN 0390-6078. 108(9), p. 2454–2466. doi: 10.3324/haematol.2022.282289. Full text in Research Archive Show summary

  The International prognostic Index (IPI) is the most widely used clinical prediction model for diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP), but may be suboptimal in older patients. We aimed to develop and externally validate a clinical prediction model for older, RCHOP- treated DLBCL patients by examining geriatric assessment and lymphoma-related parameters in real-world cohorts. A population-based training set of 365 R-CHOP-treated DLBCL patients ≥70 years was identified through the Cancer Registry of Norway. The external test set consisted of a population-based cohort of 193 patients. Data on candidate predictors were retrieved from the Cancer Registry and through review of clinical records. Cox regression models for 2-year overall survival were used for model selection. Activities of daily living, the Charlson Comorbidity Index, age, sex, albumin, stage, Eastern Cooperative Oncology Group performance status and lactate dehydrogenase level were identified as independent predictors and combined into a Geriatric Prognostic Index (GPI). The GPI demonstrated good discrimination (optimismcorrected C-index 0.752), and identified low-, intermediate- and high-risk groups with significantly different survivals (2- year overall survival, 94%, 65%, and 25%, respectively). At external validation, the continuous and grouped GPI demonstrated good discrimination (C-index 0.727 and 0.710, respectively) and the GPI groups had significantly different survivals (2-year overall survival 95%, 65%, and 44%, respectively). Both the continuous and grouped GPI showed better discrimination than the IPI, revised-IPI and National Comprehensive Cancer Network (NCCN)-IPI (C-index 0.621, 0.583, and 0.670, respectively). In conclusion, we have developed and externally validated a GPI for older DLBCL patients treated with R-CHOP that outperformed the IPI, revised-IPI and NCCN-IPI. A web-based calculator is available at https://wide.shinyapps. io/GPIcalculator/.

• Huse, Kanutte; Bai, Baoyan; Hilden, Vera Irene; Bollum, Lise Kristin; Våtsveen, Thea Kristin & Munthe, Ludvig Andre [Show all 10 contributors for this article] (2022). Mechanism of CD79A and CD79B support for IgM+ B cell fitness through B cell receptor surface expression. Journal of Immunology. ISSN 0022-1767. 209(10), p. 2042–2053. doi: 10.4049/jimmunol.2200144. Show summary

  he BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of CD79A and CD79B. Upon cognate Ag recognition, the receptor initiates important signals for B cell development and function. The receptor also conveys Ag-independent survival signals termed tonic signaling. Although the requirement of a CD79A/CD79B heterodimer for BCR complex assembly and surface expression is well established based on mice models, few studies have investigated this in human mature B cells. In this study, we found that human tonsillar B cells with high surface expression of IgM or IgG had potentiated BCR signaling compared with BCRlow cells, and high IgM expression in germinal center B cells was associated with reduced apoptosis. We explored the mechanism for IgM surface expression by CRISPR/Cas9-induced deletion of CD79A or CD79B in four B lymphoma cell lines. Deletion of either CD79 protein caused loss of surface IgM in all cell lines and reduced fitness in three. From two cell lines, we generated stable CD79A or CD79B knockout clones and demonstrated that loss of CD79A or CD79B caused a block in N-glycan maturation and accumulation of immature proteins, compatible with retention of BCR components in the endoplasmic reticulum. Rescue experiments with CD79B wild-type restored surface expression of CD79A and IgM with mature glycosylation, whereas a naturally occurring CD79B G137S mutant disrupting CD79A/CD79B heterodimerization did not. Our study highlights that CD79A and CD79B are required for surface IgM expression in human B cells and illuminates the importance of the IgM expression level for signaling and fitness.

• Oksvold, Morten Pedersen; Berglund, Ulrika Warpman; Gad, Helge; Bai, Baoyan; Stokke, Trond & Rein, Idun Dale [Show all 14 contributors for this article] (2021). Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-85613-8. Full text in Research Archive
• Ramis-Zaldivar, Joan Enric; Gonzalez-Farre, Blanca; Nicolae, Alina; Pack, Svetlana; Clot, Guillem & Nadeu, Ferran [Show all 26 contributors for this article] (2021). MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma. Haematologica. ISSN 0390-6078. 106(10), p. 2682–2693. doi: 10.3324/haematol.2020.271957. Full text in Research Archive
• Isaksen, Kathrine Thuestad; Mastroianni, Maria Adele; Rinde, Marit; Rusten, Leiv Sindre; Barzenje, Dlawer Abdulla & Ramslien, Lloyd Frode [Show all 13 contributors for this article] (2021). A simplified frailty score predicts survival and can aid treatment-intensity decisions in older patients with DLBCL. Blood Advances. ISSN 2473-9529. 5(22), p. 4771–4782. doi: 10.1182/bloodadvances.2021004777. Full text in Research Archive Show summary

  Diffuse large B-cell lymphoma (DLBCL) patients have a median age of 70 years. Yet, empirical knowledge on treatment for older patients is limited as they are frequently excluded from clinical trials. We aimed to construct a simplified frailty score and examine survival and treatment-related mortality (TRM) according to frailty status and treatment intensity in an older, real-world DLBCL population. All patients ≥70 years diagnosed with DLBCL 2006-2016 in south-eastern Norway (n=784) were included retrospectively, and divided into a training (n=522) and validation cohort (n=262). We constructed and validated a frailty score based on geriatric assessment variables, and examined survival and TRM according to frailty status and treatment. The frailty score identified three frailty groups with distinct survival and TRM, independent of established prognostic factors (2-year overall survival (OS) fit 82%, unfit 47%, frail 14%, P80%) was associated with better survival than attenuated R-CHOP (2-year OS 86% vs 70%, P=0.012), also in adjusted analysis. For unfit and frail patients, full-dose R-CHOP was not superior to attenuated R-CHOP, while an anthracycline-free regimen was associated with poorer survival in adjusted analyses. A simplified frailty score identified unfit and frail patients with higher risk of death and TRM, which can aid treatment intensity decisions in older DLBCL patients. In this study, fit patients benefit from full-dose R-CHOP, while unfit and frail patients have no benefit of full-dose R-CHOP over R-miniCHOP. An online calculator for assessment of the frailty score is available at https://wide.shinyapps.io/app-frailty/

• Köksal, Hakan; Dillard, Pierre; Juzeniene, Asta; Kvalheim, Gunnar; Smeland, Erlend B. & Myklebust, June Helen [Show all 8 contributors for this article] (2021). Combinatorial CAR design improves target restriction. Journal of Biological Chemistry. ISSN 0021-9258. 296:100116, p. 1–13. doi: 10.1074/jbc.RA120.016234. Full text in Research Archive
• Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild & Johannessen, Bjarne [Show all 24 contributors for this article] (2020). Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. ISSN 2473-9529. 4(9), p. 1859–1866. doi: 10.1182/bloodadvances.2019001325. Show summary

  • Diagnostic and relapse diffuse large B-cell lymphoma (DLBCL) biopsies reveal increased mutational burden/loss of heterozygosity in HLA-A. • Serially sampled tumor biopsies provide insight into therapeutic targets and evolutionary divergence in relapsed/refractory DLBCL.

• Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian & Wahlin, Björn Engelbrekt [Show all 14 contributors for this article] (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica. ISSN 0390-6078. 104(10), p. 460–464. doi: 10.3324/haematol.2018.209080. Full text in Research Archive
• Köksal, Hakan; Dillard, Pierre; Josefsson, Sarah Elisabet; Maggadottir, Solrun Melkorka; Pollmann, Sylvie Mireille & Fåne, Anne [Show all 16 contributors for this article] (2019). Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma. Blood Advances. ISSN 2473-9529. 3(8), p. 1230–1243. doi: 10.1182/bloodadvances.2018029678. Full text in Research Archive
• Josefsson, Sarah Elisabet; Beiske, Klaus; Blaker, Yngvild Nuvin; Førsund, Mette S; Holte, Harald & Østenstad, Bjørn [Show all 15 contributors for this article] (2019). TIGIT and PD-1 mark intratumoral T cells with reduced effector function in B-cell non-Hodgkin lymphoma. Cancer immunology research. ISSN 2326-6066. 7(3), p. 355–362. doi: 10.1158/2326-6066.CIR-18-0351. Full text in Research Archive
• Huse, Kanutte; Wogsland, Cara Ellen; Polikowsky, Hannah G.; Diggins, Kirsten E.; Smeland, Erlend B & Myklebust, June [Show all 7 contributors for this article] (2019). Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Cytometry Part A. ISSN 1552-4922. 95(4), p. 442–449. doi: 10.1002/cyto.a.23737.
• Mottok, Anja; Wright, George; Rosenwald, Andreas; Ott, German; Ramsower, Colleen & Campo, Elias [Show all 25 contributors for this article] (2018). Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Blood. ISSN 0006-4971. 132(22), p. 2401–2405. doi: 10.1182/blood-2018-05-851154.
• Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin & Myklebust, June [Show all 13 contributors for this article] (2018). The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology. ISSN 0007-1048. p. 1–10. doi: 10.1111/bjh.15518.
• Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian & Bai, Baoyan [Show all 14 contributors for this article] (2018). Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. ISSN 1756-8722. 11:23, p. 1–12. doi: 10.1186/s13045-018-0561-0. Full text in Research Archive
• Scott, David W.; Abrisqueta, Pau; Wright, George W.; Slack, Graham W.; Mottok, Anja & Villa, Diego [Show all 31 contributors for this article] (2017). New molecular assay for the proliferation signature in mantle cell lymphoma applicable to formalin-fixed paraffin-embedded biopsies. Journal of Clinical Oncology. ISSN 0732-183X. 35(15), p. 1668–1677. doi: 10.1200/JCO.2016.70.7901.
• Bollum, Lise Kristin; Huse, Kanutte; Oksvold, Morten Pedersen; Bai, Baoyan; Hilden, Vera Irene & Forfang, Lise [Show all 10 contributors for this article] (2017). BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLOS ONE. ISSN 1932-6203. 12(5). doi: 10.1371/journal.pone.0177188. Full text in Research Archive
• Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela & Steen, Chloe Beate [Show all 13 contributors for this article] (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research. ISSN 1078-0432. 24(4), p. 870–881. doi: 10.1158/1078-0432.CCR-17-2337. Full text in Research Archive
• Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus & Østenstad, Bjørn [Show all 13 contributors for this article] (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology. ISSN 0007-1048. 175(1), p. 102–114. doi: 10.1111/bjh.14201.
• Riihijärvi, Sari; Fiskvik, Idun Hege; Taskinen, Minna; Vajavaara, Heli; Tikkala, Maria & Yri, Olav Erich [Show all 11 contributors for this article] (2015). Prognostic influence of macrophages in patients with diffuse large B-Cell lymphoma: A correlative study from a nordic phase ii trial. Haematologica. ISSN 0390-6078. 100(2), p. 238–245. doi: 10.3324/haematol.2014.113472.
• Wise, Jillian Frances; Nakken, Sigve; Vodak, Daniel; Trøen, Gunhild; Lingjærde, Ole Christian & Meza-Zepeda, Leonardo A [Show all 12 contributors for this article] (2015). Discovery of recurrent mutations associated with chemo-immunotherapy relapse in diffuse large B-cell lymphoma. Blood. ISSN 0006-4971. 126(23), p. 110–110. doi: 10.1182/blood.v126.23.110.110.
• Fiskvik, Idun Hege; Beiske, Klaus; Delabie, Jan; Yri, Olav Erich; Spetalen, Signe & Karjalainen-Lindsberg, Marja-Liisa [Show all 10 contributors for this article] (2015). Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma. Leukemia and Lymphoma. ISSN 1042-8194. 56(6), p. 1742–1749. doi: 10.3109/10428194.2014.970550.
• Blaker, Yngvild Nuvin; Brodtkorb, Marianne; Maddison, John; Hveem, Tarjei Sveinsgjerd; Nesheim, John Arne & Mohn, Hans Martin [Show all 13 contributors for this article] (2015). Computerized image analysis of the Ki-67 proliferation index in mantle cell lymphoma. Histopathology. ISSN 0309-0167. 67(1), p. 62–69. doi: 10.1111/his.12624.
• Oksvold, Morten Pedersen; Duyvestyn, Johanna M.; Dagger, Samantha A.; Taylor, Samuel J.; Forfang, Lise & Myklebust, June [Show all 8 contributors for this article] (2015). The targeting of human and mouse B lymphocytes by dasatinib. Experimental Hematology. ISSN 0301-472X. 43(5), p. 352–363.e4. doi: 10.1016/j.exphem.2015.01.008.
• Muppidi, Jagan R.; Schmitz, Roland; Green, Jesse A.; Xiao, Wenming; Larsen, Adrien B. & Braun, Sterling E. [Show all 24 contributors for this article] (2014). Loss of signalling via G α 13 in germinal centre B-cell-derived lymphoma. Nature. ISSN 0028-0836. 516(7530), p. 254–258. doi: 10.1038/nature13765.
• Blaker, Yngvild Nuvin; Eide, Marianne Brodtkorb; Liestøl, Knut; Lauritzsen, Grete Fossum; Kolstad, Arne & Fosså, Alexander [Show all 8 contributors for this article] (2014). High dose chemotherapy with autologous stem cell transplant for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era. Leukemia and Lymphoma. ISSN 1042-8194. 55(10), p. 2319–2327. doi: 10.3109/10428194.2013.871632.
• Scott, David W.; Wright, George W.; Williams, P.Mickey; Lih, Chih-Jian; Walsh, William & Jaffe, Elaine S. [Show all 24 contributors for this article] (2014). Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood. ISSN 0006-4971. 123(8), p. 1214–1217. doi: 10.1182/blood-2013-11-536433.
• Bethge, Nicole; Lothe, Ragnhild A; Honne, Hilde; Andresen, Kim; Trøen, Gunhild & Eknæs, Mette [Show all 11 contributors for this article] (2014). Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma. Epigenetics. ISSN 1559-2294. 9(3), p. 428–436. doi: 10.4161/epi.27554.
• Bethge, Nicole; Honne, Hilde; Andresen, Kim; Hilden, Vera Irene; Trøen, Gunhild & Liestøl, Knut [Show all 10 contributors for this article] (2014). A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma. PLOS ONE. ISSN 1932-6203. 9(9). doi: 10.1371/journal.pone.0104249.
• Oksvold, Morten Pedersen; Kullmann, Anette; Forfang, Lise; Kierulf, Bente; Li, Mu & Brech, Andreas [Show all 10 contributors for this article] (2014). Expression of B-Cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells. Clinical Therapeutics. ISSN 0149-2918. 36(6), p. 847–862.e1. doi: 10.1016/j.clinthera.2014.05.010.
• Yang, Yibin; Schmitz, Roland; Mitala, Joseph; Whiting, Amanda; Xiao, Wenming & Ceribelli, Michele [Show all 29 contributors for this article] (2014). Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discovery. ISSN 2159-8274. 4(4), p. 480–493. doi: 10.1158/2159-8290.CD-13-0915.
• Wahlin, Björn Engelbrekt; Sundström, Christer; Sander, Birgitta; Christensson, Birger; Jeppsson-Ahlberg, Åsa & Hjalmarsson, Eric [Show all 11 contributors for this article] (2014). Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy. Leukemia and Lymphoma. ISSN 1042-8194. 55(2), p. 288–295. doi: 10.3109/10428194.2013.802778.
• Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise & Hilden, Vera Irene [Show all 12 contributors for this article] (2014). Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood. ISSN 0006-4971. 123(7), p. 1051–1054. doi: 10.1182/blood-2013-07-512392.
• Bethge, Nicole; Honne, Hilde; Hilden, Vera Irene; Trøen, Gunhild; Eknæs, Mette & Liestøl, Knut [Show all 10 contributors for this article] (2013). Identification of Highly Methylated Genes across Various Types of B-Cell Non-Hodgkin Lymphoma. PLOS ONE. ISSN 1932-6203. 8(11). doi: 10.1371/journal.pone.0079602.
• Bödör, Csaba; Grossmann, Vera; Popov, Nikolay; Okosun, Jessica; O'Riain, Ciarán & Tan, King [Show all 34 contributors for this article] (2013). EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood. ISSN 0006-4971. 122(18), p. 3165–3168. doi: 10.1182/blood-2013-04-496893.
• Fiskvik, Idun Hege; Aamot, Hege Vangstein; Delabie, Jan; Smeland, Erlend B; Stokke, Trond & Heim, Sverre [Show all 7 contributors for this article] (2013). Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome. European Journal of Haematology. ISSN 0902-4441. 91(4), p. 332–338. doi: 10.1111/ejh.12171.
• Yri, Olav Erich; Ekstrøm, Per Olaf; Hilden, Vera Irene; Gaudernack, Gustav; Liestøl, Knut & Smeland, Erlend B [Show all 7 contributors for this article] (2013). Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab. Leukemia and Lymphoma. ISSN 1042-8194. 54(10), p. 2205–2214. doi: 10.3109/10428194.2013.774392.
• Schmitz, Roland; Young, Ryan M.; Ceribelli, Michele; Jhavar, Sameer; Xiao, Wenming & Zhang, Meili [Show all 42 contributors for this article] (2012). Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. ISSN 0028-0836. 490(7418), p. 116–120. doi: 10.1038/nature11378.
• Bakkebø, Maren; Huse, Kanutte; Hilden, Vera Irene; Forfang, Lise; Myklebust, June & Smeland, Erlend B [Show all 7 contributors for this article] (2012). SARA is dispensable for functional TGF-beta signaling. FEBS Letters. ISSN 0014-5793. 586(19), p. 3367–3372. doi: 10.1016/j.febslet.2012.07.027.
• Huse, Kanutte; Bakkebø, Maren; Waelchli, Sebastien; Oksvold, Morten Pedersen; Hilden, Vera Irene & Forfang, Lise [Show all 11 contributors for this article] (2012). Role of Smad Proteins in Resistance to BMP-Induced Growth Inhibition in B-Cell Lymphoma. PLOS ONE. ISSN 1932-6203. 7(10). doi: 10.1371/journal.pone.0046117. Full text in Research Archive
• Oksvold, Morten Pedersen; Pedersen, Nina Marie; Forfang, Lise & Smeland, Erlend B (2012). Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling. FEBS Letters. ISSN 0014-5793. 586(20), p. 3575–3581. doi: 10.1016/j.febslet.2012.08.022.
• Wahlin, Björn Engelbrekt; Yri, Olav Erich; Kimby, Eva; Holte, Harald; Delabie, Jan & Smeland, Erlend B [Show all 9 contributors for this article] (2012). Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. British Journal of Haematology. ISSN 0007-1048. 156(2), p. 225–233. doi: 10.1111/j.1365-2141.2011.08942.x.
• Yri, Olav Erich; Ekstrøm, Per Olaf; Hilden, Vera Irene; Gaudernack, Gustav; Liestøl, Knut & Smeland, Erlend B [Show all 7 contributors for this article] (2012). Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma. Leukemia and Lymphoma. ISSN 1042-8194. 53(10), p. 1934–1944. doi: 10.3109/10428194.2012.682307.
• Josefsen, Dag; Forfang, Lise; Dyrhaug, Marianne; Blystad, Anne Kirsti; Stokke, Trond & Smeland, Erlend B [Show all 7 contributors for this article] (2011). Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy. European Journal of Haematology. ISSN 0902-4441. 87(6), p. 494–502. doi: 10.1111/j.1600-0609.2011.01681.x.
• Huse, Kanutte; Bakkebø, Maren Kolltveit; Oksvold, Morten Pedersen; Forfang, Lise; Hilden, Vera Irene & Stokke, Trond [Show all 8 contributors for this article] (2011). Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: Differential effects of BMP-6 and BMP-7. European Journal of Immunology. ISSN 0014-2980. 41(11), p. 3135–3145. doi: 10.1002/eji.201141558.
• Malumbres, Raquel; Fresquet, Vicente; Roman-Gomez, Jose; Bobadilla, Miriam; Robles, Eloy F. & Altobelli, Giovanna G. [Show all 14 contributors for this article] (2011). LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome. Haematologica. ISSN 0390-6078. 96(7), p. 980–986. doi: 10.3324/haematol.2011.040568.
• Ngo, Vu N.; Young, Ryan M.; Schmitz, Roland; Jhavar, Sameer; Xiao, Wenming & Lim, Kian-Huat [Show all 31 contributors for this article] (2011). Oncogenically active MYD88 mutations in human lymphoma. Nature. ISSN 0028-0836. 470(7332), p. 115–U133. doi: 10.1038/nature09671.
• Bakkebø, Maren Kolltveit; Huse, Kanutte; Hilden, Vera Irene; Smeland, Erlend B & Oksvold, Morten Pedersen (2010). TGF-beta-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK. BMC Immunology. ISSN 1471-2172. 11. doi: 10.1186/1471-2172-11-57.
• Rui, Lixin; Emre, N. C. Tolga; Kruhlak, Michael J.; Chung, Hye-Jung; Steidl, Christian & Slack, Graham [Show all 35 contributors for this article] (2010). Cooperative Epigenetic Modulation by Cancer Amplicon Genes. Cancer Cell. ISSN 1535-6108. 18(6), p. 590–605. doi: 10.1016/j.ccr.2010.11.013.
• Eide, Marianne Brodtkorb; Liestøl, Knut; Lingjærde, Ole Christian; Hystad, Marit Elise; Kresse, Stine Henrichson & Meza, Leonardo Zepeda [Show all 12 contributors for this article] (2010). Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood. ISSN 0006-4971. 116(9), p. 1489–1497. doi: 10.1182/blood-2010-03-272278.
• Davis, RE; Ngo, VN; Lenz, Georg; Tolar, Pavel; Young, RM & Romesser, PB [Show all 37 contributors for this article] (2010). Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. ISSN 0028-0836. 463(7277), p. 88–92. doi: 10.1038/nature08638.
• Holte, Harald; Kvaløy, Stein Olav; Delabie, Jan; Trøen, Gunhild & Smeland, Erlend B (2009). Molekylær diagnostikk av maligne lymfomer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 129(22), p. 2352–2356.
• O'Riain, C; O'Shea, DM; Yang, Y; Le Dieu, R; Gribben, JG & Summers, K [Show all 27 contributors for this article] (2009). Array-based DNA methylation profiling in follicular lymphoma. Leukemia. ISSN 0887-6924. 23(10), p. 1858–1866. doi: 10.1038/leu.2009.114.
• O'Shea, D; O'Riain, C; Taylor, C; Waters, R; Carlotti, E & MacDougall, F [Show all 20 contributors for this article] (2008). The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival. Blood. ISSN 0006-4971. 112, p. 3126–3129. doi: 10.1182/blood-2008-05-154013.
• Lenz, G; Wright, G; Dave, SS; Xiao, W; Powell, J & Zhao, H [Show all 50 contributors for this article] (2008). Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine. ISSN 0028-4793. 359(22), p. 2313–2323.
• Lenz, Georg; Davis, RE; Ngo, VN; Lam, L; George, TC & Wright, GW [Show all 22 contributors for this article] (2008). Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. ISSN 0036-8075. 319(5870), p. 1676–1679. doi: 10.1126/science.1153629.
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• Sivertsen, Einar; Huse, K; Hystad, ME; Kersten, C; Smeland, Erlend B & Myklebust, JH (2007). Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat TAg cells. European Journal of Immunology. ISSN 0014-2980. 37, p. 2937–2948. doi: 10.1002/eji.200636759.
• Sivertsen, Einar; Huse, Kanutte; Hystad, Marit Elise; Kersten, Christian; Smeland, Erlend B & Myklebust, June (2007). Inhibitory effects and target genes of bone morphogenetic protein 6 in Jurkat Tag cells. European Journal of Immunology. ISSN 0014-2980. 37(10), p. 2937–2948.
• Kersten, Christian; Dosen, Guri; Myklebust, June; Sivertsen, Einar; Hystad, Marit Elise & Smeland, Erlend B [Show all 7 contributors for this article] (2006). BMP-6 inhibits human bone marrow B lymphopoiesis - Upregulation of Id1 and Id3. Experimental Hematology. ISSN 0301-472X. 34(1), p. 72–81. doi: 10.1016/j.exphem.2005.09.010.
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• Sivertsen, EA; Hystad, ME; Gufzkow, Kristine B.; Dosen, G; Smeland, Erlend B & Blomhoff, Heidi Kiil [Show all 7 contributors for this article] (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. British Journal of Haematology. ISSN 0007-1048. 135, p. 117–128.
• Sivertsen, Einar Andreas; Hystad, Marit Elise; Gutzkow, Kristine B; Døsen, Guri; Smeland, Erlend B & Blomhoff, Heidi Kiil [Show all 7 contributors for this article] (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. British Journal of Haematology. ISSN 0007-1048. 135(1), p. 117–128.
• Torlakovic, Emina; Malecka, A; Aasheim, HC; Tierens, Anne; Nesland, Jahn M & Smeland, Erlend B [Show all 9 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: Identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. 206, p. 312–319.
• Kersten, Christian; Sivertsen, Einar; Hystad, Marit Elise; Forfang, Lise; Smeland, Erlend B & Myklebust, June (2005). BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. BMC Immunology. ISSN 1471-2172. 6. doi: 10.1186/1471-2172-6-9.
• Bea, Silvia; Zettl, A; Wright, George; Salaverria, I; Jahn, Philipp & Moreno, Victor [Show all 12 contributors for this article] (2005). Diffuse large B-cell lymphoma subgrups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood. ISSN 0006-4971. 106(9), p. 3183–3190. doi: 10.1182/blood-2005-04-1399.
• Torlakovic, Emina; Malecka, Agnieszka Maria; Myklebust, June Helen; Tierens, Anne; Åsheim, Hans-Christian & Smeland, Erlend B. [Show all 8 contributors for this article] (2005). PU.1 protein expression has a positive linear association with protein expression of germinal centre B cell genes including BCL-6, CD10, CD20 and CD22: identification of PU.1 putative binding sites in the BCL-6 promotor. Journal of Pathology. ISSN 0022-3417. doi: 10.1002/path.1777.
• Fosså, Alexander; Berner, Aasmund; Fosså, Sophie Dorothea; Hernes, Eivor; Gaudernack, Gustav & Smeland, Erlend B (2004). NY-ESO-1 proteine expression and humoral immune responses in prostate cancer. The Prostate. ISSN 0270-4137. 59(4), p. 440–447.
• Fosså, Alexander; Alsøe, Lene; Crameri, R; Berner, Aasmund; Hernes, Eivor & Funderud, Steinar [Show all 8 contributors for this article] (2004). Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, p. 431–438.
• Kersten, Christian; Delabie, Jan; Gaudernack, Gustav; Smeland, Erlend B & Fosså, Alexander (2004). Analysis of the autoantibody repertoire in Burkitt's lymphoma patients: frequent response against the transcription factor ATF-2. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53(12), p. 1119–1126. doi: 10.1007/s00262-004-0558-0.
• Dave, Sandeep S; Wright, George; Tan, Bruce; Rosenwald, Andreas; Gascoyne, Randy D & Chan, Wing C [Show all 22 contributors for this article] (2004). Survival following diagnosis of follicular lymphoma is predicted by molecular features of non-malignant tumor-infiltrating immune cells. New England Journal of Medicine. ISSN 0028-4793. 351(21), p. 2159–2169.
• Rosenwald, A.; Wright, Georg Henrik von; Wiestner, A; Chan, W.C.; Connors, J.M. & Campo, w [Show all 10 contributors for this article] (2003). The proliferation gene signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. ISSN 1535-6108. 3(2), p. 185–197.
• Rosenwald, A.; Wright, Georg Henrik von; Leroy, K; Gaulard, P; Yu, Xing-Qing & Gascoyne, R.D. [Show all 15 contributors for this article] (2003). Molecular diagnosis of primary mediastinal b cell lympho,a identifies a clinically favourable subgroup of diffuse large B cell lymphoma related to Hodgkin's lymhoma. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 198(6), p. 851–862.
• Rosenwald, Andreas; Wright, George; Wiestner, Adrian; Chan, Wing C; Connors, Joseph M & Campo, Elias [Show all 13 contributors for this article] (2003). The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. ISSN 1535-6108. 3(2), p. 185–197.
• Rosenwald, A.; Wright, George; Leroy, Karen; Xin, Yu; Smeland, Erlend B & Kvaløy, Stein [Show all 8 contributors for this article] (2003). Molecular diagnosis of primary mediastinal B-cell lymphoma identifies a clincally favorable subgroup of diffuse large B-cell lymphoma related to Hodgkin lymphoma. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 198(6), p. 851–862.
• Smeland, Erlend B; Holte, Harald & Delabie, Jan (2003). Molecular diagnosis of primary mediastinal B-cell lymphoma related to Hodgin lymphoma. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 198(6), p. 851–862.
• Smeland, Erlend B; Kvaløy, Stein; Holte, Harald & Delabie, Jan (2003). The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. ISSN 1535-6108. 3(2), p. 185–197.
• Josefsen, Dag & Smeland, Erlend B (2002). Retinoic receptors and apoptosis of human CD34 positive hematopoietic progenitor cells, Modern Trends in Skin Pharmacology. Molecular and Clinicl Aspects. D. Tsambaos and H. Merck. p. 117–128.
• Wang, Jacob Edward; Delabie, Jan; Aasheim, Hans-Christian; Smeland, Erlend B & Myklebost, Ola (2002). Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. Bioinformatics. ISSN 1367-4803. 3(1).
• Rosenwald, A.; Smeland, Erlend B; Kvaløy, Stein; Delabie, Jan; Holte, Hege Ruge & Krajci, Peter [Show all 7 contributors for this article] (2002). The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New England Journal of Medicine. ISSN 0028-4793. 346(25), p. 1937–1947.
• Myklebust, June Helene; Blomhoff, Heidi Kiil; Rusten, Leiv & Smeland, Erlend B (2002). Activation of phosphatidylinosol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34+ hematopoietic progenitor cells. Experimental Hematology. ISSN 0301-472X. 30, p. 990–1000.
• Rosenwald, A.; Wright, Georg Henrik von; Chan, W.C.; Connors, J.M.; Campo, E. & Risher, R. [Show all 10 contributors for this article] (2002). The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. New England Journal of Medicine. ISSN 0028-4793. 346(25), p. 1937–1947.
• Myklebust, June Helene; Blomhoff, Heidi Kiil; Rusten, Leiv; Stokke, Trond & Smeland, Erlend B (2002). Activation of PI3K but not p38 or ERK is regulated for EPO-induced erythropoiesis form CD34+ hematopoietic cells. Experimental Hematology. ISSN 0301-472X. 30, p. 990–1000.
• Wang, Junbai; Delabie, Jan; Åsheim, Hans-Christian; Smeland, Erlend B. & Myklebost, Ola (2002). Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. BMC Bioinformatics. ISSN 1471-2105. doi: 10.1186/1471-2105-3-36.
• Wang, Junbai; Delabie, Jan; aasheim, Hans-Christian; Smeland, Erlend B & Myklebost, Ola (2002). Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study. BMC Bioinformatics. ISSN 1471-2105.
• Smeland, Erlend B & Funderud, Steinar (2001). Anders Jahres medisinske priser 2001. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 121, p. 2751–2752.
• Lyngstadaas, Anita & Smeland, Erlend B (2001). Genterapi - status og anbefalinger for norsk medisin. Den norske tannlegeforenings tidende. ISSN 0029-2303. 111(4), p. 10–16.
• Hovig, Eivind; Myklebost, Ola; Aamdal, Steinar & Smeland, Erlend B (2001). Genterapi ved kreft. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 121(4), p. 482–488.
• Stokke, Trond; D'Angelis, Paula; Smedshammer, L.; Galteland, Eivind; Steen, Harald & Smeland, Erlend B [Show all 7 contributors for this article] (2001). Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell Non-Hodgkin's lymphoma. British Journal of Cancer. ISSN 0007-0920. 85, p. 1900–1913.

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• Bai, Baoyan; Vodák, Daniel; Nakken, Sigve; Wise, Jillian; Blaker, Yngvild Nuvin & Lingjærde, Ole Christian [Show all 18 contributors for this article] (2019). Deep profiling of genetic aberrations and clonal evolution in follicular lymphoma. Blood. ISSN 0006-4971. 134(1), p. 20–20. doi: 10.1182/blood-2019-128403.
• Malecka, Agnieszka Maria; Tierens, Anne; Østlie, Ingunn; Schmitz, Roland; Trøen, Gunhild & Spetalen, Signe [Show all 10 contributors for this article] (2015). Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell. Haematologica. ISSN 0390-6078. 100(10), p. e415–e418. doi: 10.3324/haematol.2015.126656.
• Wahlin, Björn Engelbrekt; Sundström, Christer; Holte, Harald; Sander, Birgitta; Østenstad, Bjørn & Brown, Peter de Nully [Show all 10 contributors for this article] (2011). Increasing Grades of Follicular Lymphoma Correlate with Better Prognosis in Patients Treated with Rituximab. Blood. ISSN 0006-4971. 118(21), p. 713–713.
• Yri, Olav Erich; Hilden, Vera Irene; Smeland, Erlend B; Gaudernack, Gustav; Liestøl, Knut & Ekstrøm, Per Olaf [Show all 7 contributors for this article] (2011). GENETIC POLYMORPHISMS INFLUENCE THE RISK OF HODGKIN'S LYMPHOMA. Annals of Oncology. ISSN 0923-7534. 22, p. 138–138.
• Smeland, Erlend B; Vartdal, Frode & Wisløff, Finn Georg B (2010). Tett samarbeid, men ikke overstyring. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(6), p. 590–591.
• Smeland, Erlend B; Vartdal, Frode & Wisløff, Finn Georg B (2010). Ledelse og akademisk kompetanse. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(6).
• Huse, Kanutte; Bakkebø, Maren; Forfang, Lise; Hilden, Vera Irene; Smeland, Erlend B & Myklebust, June (2010). Bone Morphogenetic Proteins Inhibit CD40L-and IL-21-Induced Ig Production In Human B Cells: Differential Effects of BMP-6 and BMP-7. Blood. ISSN 0006-4971. 116(21), p. 729–729.
• Sivertsen, Einar & Smeland, Erlend B (2007). Characterization of signaling pathways in normal and malignant hematopoietic cells by microarray technologies. Unipub forlag. ISSN 978-82-8072-426-7.
• Kersten, Christian & Smeland, Erlend B (2007). Studies of tumor associated antigens and BMP-6 signalling in normal and neoplastic B cells. Unipub forlag. ISSN 82-8072-409-5.
• Kyte, Jon A; Gaudernack, Gustav; Smeland, Erlend B & Funderud, Steinar (2007). Immuno-gene therapy of cancer with tumor-mRNA transfected dendritic cells. Unipub forlag. ISSN 978-82-8072-418-2.

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