Frode Vartdal

Professor Emeritus - Department of Immunology

Norwegian version of this page

Email frode.vartdal@medisin.uio.no

Mobile phone +47 99700152

Username

Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo

Postal address OUS HF Rikshospitalet Postboks 4950 Nydalen 0424 Oslo

Other affiliations Institute of Basic Medical Sciences

Press photo Download business card

Main goal

The Deputy Deans and I aim to improve the quality of research and teaching at the faculty. A key task for us in order to achieve this goal, is to enable our co-workers to develop both themselves and their fields of expertise.

Academic interests

My main area of research has been within the fields of neuroimmunology and transplantational immunology, with a focus on B-lymfocytes, bone marrow cells, multiple sclerosis and T-lymfocytes.

Background

Elected Dean at The Faculty of Medicine 2011 - 2014.

Head of Institute of Clinical Medicine (2010)
Head of Faculty Division Rikshospitalet (2006 - 2009)
Specialist in Immunology and Transfusion Medicine
Professor of Immunology since 1990
MD in 1975, PhD in 1984 at University of Oslo

I have published more than 100 articles and supervised eight PhD candidates.

Since 1978 I have worked at Rikshospitalet in various positions, among other things as Research Fellow, Head of Department and Head of Clinic. I have been member of numerous adjudication committees evaluating PhD dissertations and academic positions.

Positions held

Member of The Novo Nordic Foundation (2000 - 2009)
President of The Norwegian Society for Immunology (1999 - 2002)
Member of EU Expert Committee on Biomedical Research (1989 - 1992)

Tags: Management, Immunology, Multiple sclerosis, Central nervous system, Autoimmunity, Transplantion immunology

Tomescu-Baciu, Alina; Johansen, Jorunn; Holmøy, Trygve; Greiff, Victor; Stensland, Maria; De Souza, Gustavo Antonio; Vartdal, Frode & Lossius, Peter Andreas Vold (2019). Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis. Journal of Neuroimmunology. ISSN 0165-5728. 333:576966, s 1- 7 . doi: 10.1016/j.jneuroim.2019.576966 Full text in Research Archive. Show summary
In multiple sclerosis (MS), B cells are trafficking across the blood-brain barrier, but it is not known how this relates to the synthesis of oligoclonal IgG. We used quantitative mass spectrometry of oligoclonal bands and high-throughput sequencing of immunoglobulin heavy-chain variable transcripts to study the longitudinal B cell response in the cerebrospinal fluid (CSF) and blood of two MS patients. Twenty of 22 (91%) and 25 of 28 (89%) of oligoclonal band peptides persisted in samples collected 18 months apart, in spite of a dynamic exchange across the blood-CSF barrier of B lineage cells connecting to oligoclonal IgG.
Høglund, Rune Alexander; Polak, Justyna; Vartdal, Frode; Holmøy, Trygve & Lossius, Peter Andreas Vold (2018). B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate. Multiple Sclerosis and Related Disorders. ISSN 2211-0348. 26, s 90- 95 . doi: 10.1016/j.msard.2018.08.032 Full text in Research Archive.
Tomescu-Baciu, Alina; Vartdal, Frode; Holmøy, Trygve; Vedeler, Christian A. & Lossius, Peter Andreas Vold (2018). G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis. Annals of clinical and translational neurology. ISSN 2328-9503. 5(10), s 1303- 1309 . doi: 10.1002/acn3.642 Full text in Research Archive.
Lossius, Peter Andreas Vold; Tomescu-Baciu, Alina; Holmøy, Trygve; Vedeler, Christian A.; Røsjø, Egil Rørvik; Lorentzen, Åslaug Rudjord; Casetta, Ilaria & Vartdal, Frode (2017). Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis. Annals of clinical and translational neurology. ISSN 2328-9503. 4(10), s 756- 761 . doi: 10.1002/acn3.451 Full text in Research Archive.
Lossius, Peter Andreas Vold; Johansen, Jorunn; Vartdal, Frode & Holmøy, Trygve (2016). High-throughput sequencing of immune repertoires in multiple sclerosis. Annals of clinical and translational neurology. ISSN 2328-9503. 3(4), s 295- 306 . doi: 10.1002/acn3.295 Full text in Research Archive.
Johansen, Jorunn; Vartdal, Frode; Desmarais, Cindy; Tutturen, Astrid Elisabeth Voorham; De Souza, Gustavo Antonio; Lossius, Peter Andreas Vold & Holmøy, Trygve (2015). Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome. Clinical Immunology. ISSN 1521-6616. 160(2), s 211- 225 . doi: 10.1016/j.clim.2015.06.001
Lossius, Peter Andreas Vold; Johansen, Jorunn; Vartdal, Frode; Robins, Harlan; Saltyte Benth, Jurate; Holmøy, Trygve & Olweus, Johanna (2014). High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells. European Journal of Immunology. ISSN 0014-2980. 44(11), s 3439- 3452 . doi: 10.1002/eji.201444662
Vold, Lossius Peter Andreas; Johansen, Jorunn; Torkildsen, Øivind; Vartdal, Frode & Holmøy, Trygve (2012). Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation. Viruses. ISSN 1999-4915. 4(12), s 3701- 3730 . doi: 10.3390/v4123701

View all works in Cristin

Vartdal, Frode (2018). Gratulerer med studievalget!. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(12)
Vartdal, Frode (2014). I samsvar med lova. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(3), s 267- 267 . doi: 10.4045/tidsskr.14.0078

View all works in Cristin

Published Apr. 13, 2011 2:34 PM - Last modified Jan. 7, 2019 8:46 AM

Research groups

Neuroimmunology