Guttorm Haraldsen

Professor II
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Research Interests

  • Inflammation, anigogenesis, tissue repair, vascular and cytokine biology

Employment and Professional Experience

  • MD University of Bonn 1989
  • PhD University of Oslo 1997
  • Author of more than 65 research articles (published or in press) including papers in Nature (30.9, 1*), Immunity (20.6, 1), J Exp Med (14.5, 4), Gastroenterology (12.9, 1), Blood (10.6, 5), PNAS (9.4, 1), Trends Immunol (8.8, 2), ATVB (7.2, 1), Am J Transplant (6.4, 1), Am J Pathol (5.7, 7), J Immunol (5.6, 4) and J. Biol. Chem (5.3, 1). *journal impact factor, number of papers
  • Cited more than 2800 times, averag. citations per paper: 39.15, H-index: 30 (ISI, JUN 2014)
  • Research Director, Division of Diagnostics and Intervention, Oslo University Hospital, 2010-current
  • Research Director, Division of Pathology, Rikshospitalet University Hospital 2005-2009
  • Biobank coordinator/Senior Scientist, Rikshospitalet 2005
  • Senior Scientist, Department of Pathology, Rikshospitalet 2002-2004
  • Visiting Scientist, Novartis Research Institute, Vienna 2001-2002
  • Scientist, Inst. of Pathology, University of Oslo 2000-2002
  • Postdoctoral Fellow, Inst. of Pathology, University of Oslo
  • Postdoctoral Fellow, Dept of Pathology (head, prof. E.C. Butcher, MD), Stanford University, Stanford, CA, 1997-1998
  • Research Fellow, Inst. of Pathology (head, prof. P. Brandtzaeg, PhD), Univ. of Oslo, 1992-1997

Awards and Honors

  • Professor Kreyberg’s prize of Experimental Pathology 2005-2008 to Dag Kristian Skovseth for his PhD Thesis (supervisor: Guttorm Haraldsen)
  • Career Investigator, Research Council of Norway 2000-2005
  • Odd Fellow Medical Award 1999, 2000, 2001

Collaborations

  • Ralph Adams, Max-Planck Institut, Münster
  • Martin Knöfler, University of Vienna
  • Kim Midwood, Oxford University
  • Tatiana Petrova, Helsinki University
  • Stefan Pflanz, Merck Research Labs (former DNAX), Palo Alto
  • Pål Aukrust, OUS
  • Alexandre Corthay, OUS
  • Bjørn Dahlhus, OUS
  • Zlatko Dembic, Oralbiologi, UiO
  • Jon Florholmen, UNN
  • Pål-Dag Line, OUS
  • Kjetil Taskén, Bioteknologisenteret
  • Morten Vatn, OUS/Ahus

Publications

  • La Cour Poulsen, Lars; Edelmann, Reidunn Jetne; Krüger, Stig; Diéguez-Hurtado, Rodrigo; Shah, Akshay; Stav-Noraas, Tor Espen; Renzi, Anastasia; Szymanska, Monika; Wang, Junbai; Ehling, Manuel; Benedito, Rui; Kasprzycka, Monika; Bækkevold, Espen Sønderaal; Sundnes, Olav; Midwood, Kim S.; Scott, Helge; Collas, Philippe; Siebel, Christian W.; Adams, Ralf H.; Haraldsen, Guttorm; Sundlisæter, Eirik & Hol, Johanna (2018). Inhibition of endothelial NOTCH1 signaling attenuates inflammation by reducing cytokine-mediated histone acetylation at inflammatory enhancers. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  38(4), s 854- 869 . doi: 10.1161/ATVBAHA.117.310388
  • Pihlstrøm, Hege; Gatti, Francesca; Hammarström, Clara Louise; Eide, Ivar Anders; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Svensson, My Hanna Sofia; Midtvedt, Karsten; Mjøen, Geir; Dahle, Dag Olav; Hartmann, Anders & Holdaas, Hallvard (2017). Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study. Transplant International.  ISSN 0934-0874.  30(8), s 827- 840 . doi: 10.1111/tri.12973
  • Stav-Noraas, Tor Espen; Edelmann, Reidunn Jetne; La Cour Poulsen, Lars; Sundnes, Olav; Phung, Danh; Kuchler, Axel Matthias; Müller, Fredrik; Kamen, Amine A.; Haraldsen, Guttorm; Kaarbø, Mari & Hol, Johanna (2017). Endothelial IL-33 expression is augmented by adenoviral activation of the DNA damage machinery. Journal of Immunology.  ISSN 0022-1767.  198(8), s 3318- 3325 . doi: 10.4049/jimmunol.1600054 Full text in Research Archive.
  • Cantelmo, Anna Rita; Conradi, Lena-Christin; Brajic, Aleksandra; Goveia, Jermaina; Kalucka, Joanna; Pircher, Andreas; Chaturvedi, Pallavi; Hol, Johanna; Thienpont, Bernard; Teuwen, Laure-Anne; Schoors, Sandra; Boeckx, Bram; Vriens, Joris; Kuchnio, Anna; Veys, Koen; Cruys, Bert; Finotto, Lise; Treps, Lucas; Stav-Noraas, Tor Espen; Bifari, Francesco; Stapor, Peter; Decimo, Ilaria; Kampen, Kim; De Bock, Katrien; Haraldsen, Guttorm; Schoonjans, Luc; Rabelink, Ton; Eelen, Guy; Ghesquière, Bart; Rehman, Jalees; Lambrechts, Diether; Malik, Asrar B.; Dewerchin, Mieke & Carmeliet, Peter (2016). Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. Cancer Cell.  ISSN 1535-6108.  30(6), s 968- 985 . doi: 10.1016/j.ccell.2016.10.006
  • Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm & Florholmen, Jon (2016). Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep35403 Full text in Research Archive.
  • Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research.  ISSN 0008-5472.  76(23), s 6864- 6876 . doi: 10.1158/0008-5472.CAN-16-1219
  • Pihlstrøm, Hege; Mjøen, Geir; Mucha, S; Haraldsen, Guttorm; Franke, A; Jardine, A; Fellström, Bengt; Holdaas, Hallvard & Melum, Espen (2016). Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study. American Journal of Transplantation.  ISSN 1600-6135.  17(2), s 528- 533 . doi: 10.1111/ajt.13995
  • Kasprzycka, Monika; Hammarström, Clara Louise & Haraldsen, Guttorm (2015). Tenascins in fibrotic disorders-from bench to bedside. Cell Adhesion & Migration.  ISSN 1933-6918.  9(1-2), s 83- 89 . doi: 10.4161/19336918.2014.994901
  • Schrumpf, Elisabeth; Tan, Corey; Karlsen, Tom Hemming; Sponheim, Jon; Björkström, Niklas K.; Sundnes, Olav; Alfsnes, Kristian; Kaser, Arthur; Jefferson, Douglas M.; Ueno, Yoshiyuki; Eide, Tor Jacob; Haraldsen, Guttorm; Zeissig, Sebastian; Exley, Mark A.; Blumberg, Richard S. & Melum, Espen (2015). The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology.  ISSN 0270-9139.  62(4), s 1249- 1259 . doi: 10.1002/hep.27840
  • Sundnes, Olav; Pietka, Wojciech; Loos, Tamara; Sponheim, Jon; Rankin, Andrew L.; Pflanz, Stefan; Bertelsen, Vibeke; Sitek, Jan Cezary; Hol, Johanna; Haraldsen, Guttorm & Khnykin, Denis (2015). Epidermal expression and regulation of interleukin-33 during homeostasis and inflammation: Strong species differences. Journal of Investigative Dermatology.  ISSN 0022-202X.  135(7), s 1771- 1780 . doi: 10.1038/jid.2015.85
  • Øynebråten, Inger; Barois, Nicolas; Bergeland, Trygve; Kuchler, Axel Matthias; Bakke, Oddmund & Haraldsen, Guttorm (2015). Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells. Scientific Reports.  ISSN 2045-2322.  5:9261 . doi: 10.1038/srep09261 Full text in Research Archive.
  • Pandya, Abhilash D.; Leergaard, Trygve Brauns; Dissen, Erik; Haraldsen, Guttorm & Spurkland, Anne (2014). Expression of the T cell-specific adapter protein in human tissues. Scandinavian Journal of Immunology.  ISSN 0300-9475.  80(3), s 169- 179 . doi: 10.1111/sji.12199
  • Skårn, Magne Nordang; Noordhuis, Paul; Wang, Mengyu; Veuger, Maria Johanna; Kresse, Stine Henrichson; Egeland, Eivind Valen; Micci, Francesca; Namløs, Heidi Maria; Håkelien, Anne-Mari; Olafsrud, Solveig Mjelstad; Lorenz, Susanne; Haraldsen, Guttorm; Kvalheim, Gunnar; Meza, Leonardo Zepeda & Myklebost, Ola (2014). Generation and characterization of an immortalized human mesenchymal stromal cell line. Stem Cells and Development.  ISSN 1547-3287.  23(19), s 2377- 2389 . doi: 10.1089/scd.2013.0599
  • Tveita, Anders; Schjesvold, Fredrik Hellem; Sundnes, Olav; Haabeth, Ole Audun; Haraldsen, Guttorm & Bogen, Bjarne (2014). Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatiallyrestricted and fails to prevent escape of antigen-negative cells. European Journal of Immunology.  ISSN 0014-2980.  44(9), s 2625- 2637 . doi: 10.1002/eji.201444659
  • Pollheimer, Jürgen; Bodin, Johanna; Sundnes, Olav; Bekkeheien, Reidunn C; Skånland, Sigrid Strand; Sponheim, Jon; Brox, Mari Johanna; Sundlisæter, Eirik; Loos, Tamara; Vatn, Morten H; Kasprzycka, Monika; Wang, Junbai; Kuchler, Axel Matthias; Tasken, Kjetil; Haraldsen, Guttorm & Hol, Johanna (2013). Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  33(2), s e47- e55 . doi: 10.1161/ATVBAHA.112.253427
  • Hol, Johanna; Otterdal, Kari; Breland, Unni Mathilde; Stang, Espen; Pedersen, Turid Margrethe; Hagelsteen, Kathrine; Ranheim, Trine; Kasprzycka, Monika; Halvorsen, Bente; Haraldsen, Guttorm & Aukrust, Pål (2012). Statins Affect the Presentation of Endothelial Chemokines by Targeting to Multivesicular Bodies. PLoS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0040673
  • Sundlisæter, Eirik; Bekkeheien, Reidunn C; Hol, Johanna; Sponheim, Jon; Kuchler, Axel Matthias; Weiss, Miriam; Udalova, Irina A.; Midwood, Kim S.; Kasprzycka, Monika & Haraldsen, Guttorm (2012). The Alarmin IL-33 Is a Notch Target in Quiescent Endothelial Cells. American Journal of Pathology.  ISSN 0002-9440.  181(3), s 1099- 1111 . doi: 10.1016/j.ajpath.2012.06.003
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1239
  • Pollheimer, Jürgen; Haslinger, Peter; Fock, Valerie; Prast, Johanna; Saleh, Leila; Biadasiewicz, Katarzyna; Bekkeheien, Reidunn C; Haraldsen, Guttorm; Haider, Sandra; Hirtenlehner-Ferber, Kora & Knöfler, Martin (2011). Endostatin Suppresses IGF-II-Mediated Signaling and Invasion of Human Extravillous Trophoblasts. Endocrinology.  ISSN 0013-7227.  152(11), s 4431- 4442 . doi: 10.1210/en.2011-1196
  • Hol, Johanna; Wilhelmsen, Linn & Haraldsen, Guttorm (2010). The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies. Journal of Leukocyte Biology.  ISSN 0741-5400.  87(3), s 501- 508 . doi: 10.1189/jlb.0809532
  • Mikalsen, Bjørg; Fosby, Bjarte; Wang, Jacob Edward; Hammarstrom, C; Brundvold, Hilde; Lundström, Marlene; Kasprzycka, Monika; Scott, Helge; Line, Pål Dag & Haraldsen, Guttorm (2010). Genome-Wide Transcription Profile of Endothelial Cells After Cardiac Transplantation in the Rat. American Journal of Transplantation.  ISSN 1600-6135.  10(7), s 1534- 1544 . doi: 10.1111/j.1600-6143.2010.03157.x
  • Norrmén, C.; Vandevelde, Wouter; Ny, Annelii; Saharinen, Pipsa; Gentile, M.; Haraldsen, Guttorm; Puolakkainen, P.; Lukanidin, E.; Dewerchin, M.; Alitalo, Kari & Petrova, T.V. (2010). Liprin beta 1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood.  ISSN 0006-4971.  115(4), s 906- 909 . doi: 10.1182/blood-2009-03-212274
  • Sponheim, Jon; Pollheimer, Jürgen; Olsen, Trine; Balogh, Eva Johanna; Hammarström, Clara; Loos, Tamara; Kasprzycka, Monika; Sørensen, Dag Reidar; Nilsen, Hogne Røed; Kuchler, Axel Matthias; Vatn, Morten H & Haraldsen, Guttorm (2010). Inflammatory Bowel Disease-Associated Interleukin-33 Is Preferentially Expressed in Ulceration-Associated Myofibroblasts. American Journal of Pathology.  ISSN 0002-9440.  177(6), s 2804- 2815 . doi: 10.2353/ajpath.2010.100378
  • Etokebe, Godfrey; Kuchler, Axel Matthias; Haraldsen, Guttorm; Landin, Maria Augusta Dos S Silva; Osmundsen, Harald & Dembic, Zlatko (2009). Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds. Archives of Oral Biology.  ISSN 0003-9969.  54(11), s 1002- 1007 . doi: 10.1016/j.archoralbio.2009.08.005
  • Haraldsen, Guttorm; Balogh, Eva Johanna; Pollheimer, Jürgen; Sponheim, Jon & Kuchler, Axel Matthias (2009). Interleukin-33-cytokine of dual function or novel alarmin?. Trends in immunology.  ISSN 1471-4906.  30(5), s 227- 233 . doi: 10.1016/j.it.2009.03.003
  • Hol, Johanna; Kuchler, Axel Matthias; Dalhus, Bjørn; Johansen, Finn Eirik; Haraldsen, Guttorm & Øynebråten, Inger (2009). Molecular Requirements for Sorting of the Chemokine Interleukin-8/CXCL8 to Endothelial Weibel-Palade Bodies. Journal of Biological Chemistry.  ISSN 0021-9258.  284(35), s 23532- 23539 . doi: 10.1074/jbc.M900874200
  • Breland, Unni Mathilde; Halvorsen, Bente; Hol, Johanna; Øie, Erik; Paulsson-Berne, G; Yndestad, Arne; Smith, Camilla; Otterdal, Kari; Hedin, U; Wæhre, Torgun; Sandberg, Wiggo Johan; Frøland, Stig Sophus; Haraldsen, Guttorm; Gullestad, Lars; Damås, Jan Kristian; Hansson, GK & Aukrust, Pål (2008). A potential role of the CXC chemokine GRO alpha in atherosclerosis and plaque destabilization - Downregulatory effects of statins. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  28 . doi: 10.1161/ATVBAHA.108.162305
  • Kuchler, Axel Matthias; Pollheimer, Jürgen; Balogh, Eva Johanna; Sponheim, Jon; Manley, Linda; Sørensen, Dag Reidar; De Angelis, Paula; Scott, Helge & Haraldsen, Guttorm (2008). Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. American Journal of Pathology.  ISSN 0002-9440.  173, s 1229- 1242 . doi: 10.2353/ajpath.2008.080014
  • Sæthre, Marit; Schneider, MKJ; Lambris, JD; Magotti, P; Haraldsen, Guttorm; Seebach, JD & Mollnes, Tom Eirik (2008). Cytokine secretion depends on Gal alpha(1,3)Gal expression in a pig-to-human whole blood model. Journal of Immunology.  ISSN 0022-1767.  180, s 6346- 6353
  • Skovseth, Dag Kristian; Kuchler, Axel Matthias & Haraldsen, Guttorm (2007). The HUVEC/Matrigel assay: an in vivo assay of human angiogenesis suitable for drug validation. Methods in molecular biology.  ISSN 1064-3745.  360, s 253- 268
  • Sæthre, Marit; Lea, Tor; Borgen, Merethe S.; Fiane, Arnt E.; Michaelsen, Terje Einar; Thorsby, Erik; Haraldsen, Guttorm & Mollnes, Tom E. (2006). Human complement-activating immunoglobulin (Ig)G3 antibodies are essential for porcine endothelial cell activation. Xenotransplantation.  ISSN 0908-665X.  13(3), s 215- 223 . doi: 10.1111/j.1399-3089.2006.00289x Show summary
  • Carlsen, Hege Synnøve; Haraldsen, Guttorm; Brandtzæg, Per & Bækkevold, Espen Sønderaal (2005). Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules. Blood.  ISSN 0006-4971.  106, s 444- 446
  • Fiane, Arnt E; Ueland, Thor; Simonsen, Svein; Scott, Helge; Endresen, Knut; Gullestad, Lars; Geiran, Odd; Haraldsen, Guttorm; Heggelund, Lars; Andreassen, Arne K.; Wergeland, Ragnhild; Frøland, Stig Sophus; Aukrust, Pål & Mollnes, Tom Eirik (2005). Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation. European Heart Journal.  ISSN 0195-668X.  26(16), s 1660- 1665
  • Qiao, Shuo-Wang; Piper, J; Haraldsen, Guttorm; Øynebråten, Inger; Fleckenstein, Burkhard; Molberg, Øyvind; Khosla, C & Sollid, Ludvig Magne (2005). Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology.  ISSN 0022-1767.  174, s 1657- 1663
  • Skovseth, Dag Kristian; Veuger, Maria Johanna; Sørensen, Dag Reidar; De Angelis, Paula & Haraldsen, Guttorm (2005). Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis and perivascular cell recruitment in vivo. Blood.  ISSN 0006-4971.  105, s 1044- 1051
  • Øynebråten, Inger; Barois, Nicolas; Hagelsteen, Kathrine; Johansen, Finn Eirik; Bakke, Oddmund & Haraldsen, Guttorm (2005). Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol. Journal of Immunology.  ISSN 0022-1767.  175(8), s 5358- 5369 Show summary
  • Bækkevold, Espen Sønderaal; Wurbel, M-A; Kivisäkk, P; Wain, CM; Power, CA; Haraldsen, Guttorm & Campbell, JJ (2005). A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations. Journal of Experimental Medicine.  ISSN 0022-1007.  201, s 1045- 1051
  • Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde; Hofgaard, Peter Olaf; Haraldsen, Guttorm & Bogen, Bjarne (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity.  ISSN 1074-7613.  22, s 371- 383
  • Øynebråten, Inger; Barois, Nicolas; Hagelsteen, Kathrine; Johansen, Finn Eirik; Bakke, Oddmund & Haraldsen, Guttorm (2005). Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol. Journal of Immunology.  ISSN 0022-1767.  175(8), s 5358- 5369 Show summary
  • Lacorre, D-A; Bækkevold, Espen S.; Garrido, I; Brandtzæg, Per; Haraldsen, Guttorm; Amalric, F & Girard, J-P (2004). Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment. Blood.  ISSN 0006-4971.  103, s 4164- 4172
  • Øynebråten, Inger; Oynebraten, Inger; Bakke, Oddmund; Brandtzæg, Per; Johansen, Finn Erik & Haraldsen, Guttorm (2004). Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood.  ISSN 0006-4971.  104(2), s 314- 320 Show summary
  • Bækkevold, Espen S.; Roussigné, M; Yamanaka, Takeshi; Johansen, Finn Eirik; Jahnsen, Frode Lars; Amalric, F; Brandtzæg, Per; Erard, M; Haraldsen, Guttorm & Girard, J.P. (2003). Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. American Journal of Pathology.  ISSN 0002-9440.  163, s 69- 79
  • Chi, J-T; Chang, HY; Haraldsen, Guttorm; Jahnsen, Frode Lars; Troyanskaya, OG; Chang, DS; Wang, Z; Rockson, SG; Rijn, M Van de; Botstein, David & Brown, P. O (2003). Endothelial cell diversity revealed by global expression profiling. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  100, s 10623- 10628
  • Carlsen, Hege Synnøve; Bækkevold, Espen S.; Johansen, Finn Eirik; Haraldsen, Guttorm & Brandtzæg, Per (2002). B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut.  ISSN 0017-5749.  51, s 364- 371
  • Farstad, Inger Nina; Malavasi, F.; Haraldsen, Guttorm; Huitfeldt, Henrik & Brandtzæg, Per (2002). CD38 is a marker of human lacteals. Virchows Archiv.  ISSN 0945-6317.  441, s 605- 613
  • Skovseth, Dag Kristian; Sørensen, Dag R. & Haraldsen, Guttorm (2002). Vascular morphogenesis and differentiation following adoptive transfer of human endothelial cells to immunodeficient mice. American Journal of Pathology.  ISSN 0002-9440.
  • Skovseth, Dag Kristian; Yamamoto, Takeshi; Brandtzæg, Per; Butcher, Eugene & Haraldsen, Guttorm (2002). Vascular morphogenesis and differentiation following adoptive transfer of human endothelial cells to immunodeficient mice. American Journal of Pathology.  ISSN 0002-9440.  160, s 1629- 1637
  • Sæthre, Marit; Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik; Platt, Jeffrey L. & Mollnes, Tom Eirik (2002). Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 and IgM anti-Gal antibodies. Xenotransplantation.  ISSN 0908-665X.  9, s 350- 358
  • Bækkevold, Espen S.; Yamamoto, Takeshi; Palframan, R.T.; Carlsen, Hege Synnøve; Reinholt, Finn P.; Andrian, U. H. von; Brandtzæg, Per & Haraldsen, Guttorm (2001). The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. Journal of Experimental Medicine.  ISSN 0022-1007.  193(9), s 1105- 1112 Show summary
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation.  ISSN 0041-1337.  72, s 1967- 1973 Show summary
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation.  ISSN 0041-1337.  72, s 1967- 1973 Show summary
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation.  ISSN 0041-1337.
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik & Mollnes, Tom Eirik (2001). C1 inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells. Transplantation Proceedings.  ISSN 0041-1345.  (33), s 789- 790
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik & Mollnes, Tom Eirik (2001). C1-inhibitor attenuates human serum induced E-selectin expression of pig aortic endothelial cells. Transplantation Proceedings.  ISSN 0041-1345.  33, s 789- 790 Show summary
  • Kunkel, Eric; Campbell, James; Haraldsen, Guttorm; Pan, Junliang; Boisvert, Judie; Roberts, Arthur; Ebert, Ellen; Vierra, Mark; Goodmn, Stuart; Genovese, Mark; Wardlaw, Andy; Greenberg, Harry; Parker, Christina; Butcher, Eugene; Andrew, David & Agace, William (2000). Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Journal of Experimental Medicine.  ISSN 0022-1007.  s 761- 767
  • Sindre, Hilde; Haraldsen, Guttorm; Beck, Solveig; Hestad, Kjetil; Kvale, Dag; Brandtzæg, Per; Degre, Miklos & Rollag, Halvor (2000). Human intestinal endothelium shows high susceptibility to cytomegalovirus and altered expression of adhesion molecules after infection. Scandinavian Journal of Immunology.  ISSN 0300-9475.  51, s 354- 360
  • Sindre, Hilde; Haraldsen, Guttorm; Beck, Solveig; Hestad, Kjetil; Kvale, Dag; Brandtzæg, Per; Degre, Miklos & Rollag, Halvor (2000). Human intestinal endothelium shows high susceptibility to cytomegalovirus and altered expression of adhesion molecules after infection. Scandinavian Journal of Immunology.  ISSN 0300-9475.  51, s 354- 360
  • Bækkevold, Espen S.; Jahnsen, Frode Lars; Johansen, Finn Eirik; Bakke, Oddmund; Gaudernack, Gustav; Brandtzæg, Per & Haraldsen, Guttorm (1999). Culture characterization of differentiated high endothelial venule cells from human tonsils. Laboratory Investigation.  ISSN 0023-6837.  79(3), s 327- 336 Show summary
  • Girard, J.P.; Bækkevold, Espen S.; Yamamoto, Takeshi; Haraldsen, Guttorm; Brandtzæg, Per & Amalric, F (1999). Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization. American Journal of Pathology.  ISSN 0002-9440.  155(6), s 2043- 2055 Show summary
  • Brandtzæg, Per; Farstad, Inger Nina; Haraldsen, Guttorm & Jahnsen, Frode Lars (1998). Cellular and molecular mechanisms for induction of mucosal immunity. Karger biobehavioral medicine series.  ISSN 0254-5373.  92, s 93- 108
  • Haraldsen, Guttorm; Sollid, Ludvig Magne; Bakke, Oddmund; Farstad, Inger Nina; Kvale, Dag; Molberg, Øyvind; Norstein, J.; Stang, Espen & Brandtzæg, Per (1998). Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells. Gastroenterology.  ISSN 0016-5085.  114, s 649- 656
  • Haraldsen, Guttorm; Sollid, Ludvig Magne; Bakke, Oddmund; Farstad, Inger Nina; Kvale, Dag; Molberg, Øyvind; Norstein, J.; Stang, P. & Brandtzæg, Per (1998). MHC class II-dependent antigen presentation by human intestinal endothelial cells. Gastroenterology.  ISSN 0016-5085.  114, s 649- 656
  • Nilsen, Ellen M.; Johansen, Finn Eirik; Jahnsen, Frode Lars; Lundin, Knut E. A.; Scholz, Tim; Brandtzæg, Per & Haraldsen, Guttorm (1998). Cytokine profiles of cultured microvascular endothelial cells from the human intestine. Gut.  ISSN 0017-5749.  42, s 635- 642
  • Utgaard, J. O.; Jahnsen, Frode Lars; Bakka, Arne; Brandtzæg, Per & Haraldsen, Guttorm (1998). Rapid secretion of prestored interleukin-8 from microvascular endothelial cells. Journal of Experimental Medicine.  ISSN 0022-1007.  188, s 1751- 1756
  • Brandtzæg, Per; Berstad, Audun Elnæs; Farstad, Inger Nina; Haraldsen, Guttorm; Helgeland, Lars; Jahnsen, Frode Lars; Johansen, Finn Eirik; Natvig, Inger Backer; Nilsen, Ellen M. & Rugtveit, Jarle (1997). A major adaptive defence mechanism. Behring-Institute-Mitteilungen.  ISSN 0301-0457.  98, s 1- 23
  • Brandtzæg, Per; Berstad, Audun Elnæs; Farstad, Inger Nina; Haraldsen, Guttorm; Helgeland, Lars; Jahnsen, Frode Lars; Johansen, Finn Eirik; Natvig, Inger Backer; Nilsen, Ellen M. & Rugtveit, Jarle (1997). Mucosal immunity ¿ a major adaptive defence mechanism. Behring-Institute-Mitteilungen.  ISSN 0301-0457.  98, s 1- 23
  • Brandtzæg, Per; Farstad, Inger Nina; Haraldsen, Guttorm & Jahnsen, Frode Lars (1997). Cellular and molecular mechanisms for induction of mucosal immunity. Karger biobehavioral medicine series.  ISSN 0254-5373.  92, s 93- 108
  • Brandtzæg, Per; Haraldsen, Guttorm & Rugtveit, Jarle (1997). Immunopathological mechanisms in inflammatory bowel disease, In Herzog B Hadziselimovic F & B Herzog (ed.),  Inflammatory Bowel Diseases and Chronic Recurrent Abdominal Pain.  Kluwer Academic Publishers, London.  s 15 - 51
  • Brandtzæg, Per; Haraldsen, Guttorm & Rugtveit, Jarle (1997). Immunopathology of human inflammatory bowel disease. Springer Seminars in Immunopathology.  ISSN 0344-4325.  18, s 555- 589
  • Brandtzæg, Per; Jahnsen, Frode Lars; Farstad, Inger Nina & Haraldsen, Guttorm (1997). Mucosal immunology of the upper airways: an overview. Annals of the New York Academy of Sciences.  ISSN 0077-8923.  830, s 1- 18

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  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi.  February
  • Haraldsen, Guttorm (2013). Interleukin-33 drives a proinflammatory endothelial activation that selectively targets non-quiescent cells. The FASEB Journal.  ISSN 0892-6638.  27
  • Schjesvold, Fredrik Hellem; Tveita, Anders; Sundnes, Olav; Haraldsen, Guttorm & Bogen, Bjarne (2013). CD4+T cell-mediated protection against tumors: no bystander killing. Journal of Immunology.  ISSN 0022-1767.  190
  • Sundnes, Olav; Khnykin, Denis & Haraldsen, Guttorm (2013). Cellular expression of the alarmin IL-33 in acute skin inflammation. Journal of Investigative Dermatology.  ISSN 0022-202X.  133, s S52- S52
  • Haraldsen, Guttorm; Jetne, Reidunn; Hol, Johanna; Sponheim, Jon; Kuchler, Axel Matthias; Kasprzycka, Monika & Sundlisæter, Eirik (2012). The Alarmin Interleukin-33 is a Notch Target in Quiescent Endothelial Cells. Journal of Immunology.  ISSN 0022-1767.  188
  • Sponheim, Jon; Haraldsen, Guttorm; Vatn, Morten H & Torsvik, Harald (2012). Inerleukin-33 in inflammation and wound repair : an experimental study with special reference to endothelial cells and myofibroblats. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 1329.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). A cancer-protective role of inflammation. Cytokine.  ISSN 1043-4666.  56(1), s 101- 101 . doi: 10.1016/j.cyto.2011.07.392
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(6), s 603- 603
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 384- 384
  • Mikalsen, Bjørg & Haraldsen, Guttorm (2011). Genome-wide endothelial cell activation profiles and matricellular protein expression after solid organ transplantation. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. No. 1067.
  • Sundlisæter, Eirik; Bekkeheien, Reidunn C; Hol, Johanna; Sponheim, Jon; Kuchler, Axel Matthias; Kasprzycka, Monika & Haraldsen, Guttorm (2011). The Putative Alarmin IL-33 is Induced and Maintained in Resting Endothelial Cells by Notch Ligand DLL4. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 366- 366
  • Hol, Johanna & Haraldsen, Guttorm (2010). Sorting, storage and secretion of neutrophil-recruiting CXC chemokines from endothelial cells. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 997.
  • Sponheim, Jon; Pollheimer, Jürgen; Olsen, Trine; Balogh, Johanna; Hammarström, Clara; Loos, Tamara; Kasprzycka, Monika; Sørensen, Dag Reidar; Nilsen, Hogne Røed; Kuchler, Axel Matthias; Vatn, Morten & Haraldsen, Guttorm (2010). Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Wound Repair and Regeneration.  ISSN 1067-1927.  18(6), s A94- A94
  • Hol, Johanna; Kuchler, Axel Matthias; Johansen, Finn Eirik; Haraldsen, Guttorm & Øynebråten, Inger (2008). Molecular requirements for sorting of IL-8/CXCL8 to endothelial Weibel Palade bodies. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 228- 229
  • Josefsen, Dag; Kuechler, A; Wang, Mari; Haraldsen, Guttorm & Kvalheim, Gunnar (2008). Human bone marrow mononuclear cells, CD34+cells and CD133+cells do not form vascular structures in vivo. Bone Marrow Transplantation.  ISSN 0268-3369.  41, s S130- S130
  • Mikalsen, Bjørg; Lundström, Marlene; Fosby, Bjarte; Hammarstrom, C; Bjaerke, H; Wang, J; Kasprzycka, Monika; Scott, Helge; Line, Pål Dag & Haraldsen, Guttorm (2008). Genome-wide transcription profiles of endothelial cells during cardiac allograft rejection. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 220- 221
  • Westgaard, Arne; Carlsen, Hege Synnøve; Bækkevold, Espen S.; Haraldsen, Guttorm; Bergan, Anstein Bjørnar & Brandtzæg, Per (2002). "B-cell attracting chemokine 1" (CXCL13): Mulig patogenetisk rolle i inflammatorisk tarmsykdom?. Show summary
  • Bækkevold, Espen S.; Yamamoto, Takeshi; Carlsen, Hege Synnøve; Brandtzæg, Per & Haraldsen, Guttorm (2001). Transcytosis of the CC chemokine ELC/CCL19 in human high endothelial venules.
  • Bækkevold, Espen S.; Yamamoto, Takeshi; Palframan, R.T.; Carlsen, Hege Synnøve; Reinholt, Finn P.; Andrian, U. H. von; Brandtzæg, Per & Haraldsen, Guttorm (2001). The CCR7-ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment.
  • Sæthre, Marit; Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik; Platt, Jeffrey L. & Mollnes, Tom Eirik (2001). Human serum-induced porcine endothelial cell E-selectin expression is associated with Ig3 anti-gal antibodies.
  • Sæthre, Marit; Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik; Platt, Jeffrey L. & Mollnes, Tom Eirik (2001). Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 anti-Gal antibodies.
  • Sæthre, Marit; Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik; Platt, Jeffrey L. & Mollnes, Tom Eirik (2001). Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 anti-Gal antibodies. Show summary
  • Sæthre, Marit; Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Thorsby, Erik; Platt, Jeffrey L. & Mollnes, Tom Eirik (2001). Human serum-induced porcine endothelial cell E-selectin expression is associated with IgG3 anti-Gal antibodies. Show summary
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells is totally complement mediated: Evidence for a role of complement in delayed xenograft rejection.
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells is totally complement mediated: Evidence for a role of complement in delayed xenograft rejection.
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Fung, M.; Thorsby, Erik & Mollnes, Tom Eirik (2001). Human serum-induced E-selectin expression on porcine aortic endothelial cells is totally complement mediated: evidence for a role of complement in delayed xenograft rejection.
  • Bækkevold, Espen S.; Yamamoto, Takeshi; Brandtzæg, Per & Haraldsen, Guttorm (2000). Transcytosis of the CC chemokine ELC/MIP-3beta in human high endothelial venules.
  • Skovseth, Dag Kristian; Butcher, Eugene; Brandtzæg, Per & Haraldsen, Guttorm (2000). Capillary morpho-genesis and differentiation following adoptive transfer of human endothelial cells to immunodeficient mice.
  • Sølvik, Una Ørvim; Haraldsen, Guttorm; Fiane, Arnt E.; Boretti, Eva; Lambris, J.D.; Thorsby, Erik & Mollnes, Tom Eirik (2000). Complement inhibition reduces human serum induced type II activation of porcine endothelial cells.
  • Øynebråten, Inger; Johansen, Finn Eirik; Brandtzæg, Per & Haraldsen, Guttorm (2000). An efficient and convenient method for high transfection efficency in cultured endothelial cells.

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Published Apr. 13, 2011 2:54 PM - Last modified Nov. 8, 2016 2:54 PM