Hilde Loge Nilsen

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Visiting address Akershus University Hospital Sykehusveien 25 Epigen B2 1478 Lørenskog Norway
Postal address Akershus universitetssykehus 1478 Lørenskog

Academic Interests

Mechanisms of DNA and RNA quality control in human disease.

Positions held

  • 2013 - present:  Professor Department of Clinical Molecular Biology
  • 2009 - 2013:  Assistant Director, Biotechnology Centre of Oslo.
  • 2006 - present:  Problem-based learning supervisor, Medical Faculty, University of Oslo.
  • 2004 - 2013:  Group leader, “DNA Repair”, Biotechnology Centre of Oslo.

Education

  • 2000 - 2004:  Post doctoral fellow, Cancer Research UK.
  • 2000:  Dr. ing. from the Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Research Interests

We are interested in the quality control mechanisms that maintain function of DNA and RNA throughout the lifetime of cells and organisms.

DNA repair enzymes remove damaged or inappropriate bases from DNA. Historically, studies of DNA repair has been motivated by the need for these mechanisms in order to prevent mutations - changes in the genetic code. Studies of DNA repair is therefore important in order to understand how cancer develops and how cancer can be treated. In recent years it has become clear that DNA repair enzymes have many important functions in cells other than to prevent mutations, most importantly in neurobiology to prevent neurodegenerative diseases. We have also recently demonstrated that some DNA repair proteins also contribute to RNA quality control. 

Aims:

  • To study whether DNA damage and mutations may act as a driver of tumorigenesis
  • To study how DNA repair mechanisms protect us from premature aging and age-related neurodegenerative diseases
  • To study how DNA repair proteins contribute to RNA quality Control

Research achievements

  • We have revealed mutation signatures associated with failure to repair uracil via the Base Excision repair pathway (Alsøe et al., 2017)
  • We have uncovered a mechanism by which failure to repair nuclear DNA can lead to progressive mitochondrial dysfunction and neurodegeneration (Fang et al., 2014; Fang et al 2016)
  • We have demonstrated that the DNA repair enzyme SMUG1 removes damaged bases from RNA and contribute to RNA quality control (Jobert et al., 2013)
  • We have identified a novel mechanism for induction of autophagy by the chemotherapeutic agent 5-fluorouracil (Erdelyi et al., 2011; SenGupta 2013)
  • We have described transcriptomic and proteomic changes that compensate for the lack of DNA repair in C. elegans and contribute to maintain normal lifespan (Fensgård et al, 2010; Skjeldam et al., 2010; Arczewska et al., 2012; Lans et al 2013; Kassahun et al., 2017)
  • We demonstrated that DNA repair enzymes act to initiate cellular signaling cascades leading to activation of apoptosis (Dengg et al., 2006)
Tags: DNA repair, DNA damage, Cancer, Neurodegeneration, Ageing

Publications

Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix; Lirussi, Lisa; Sengupta, Tanima; Tekin, Nuriye Basdag; Jobert, Laure; Alexandrov, Ludmil B.; Galashevskaya, Anastasia; Rada, Cristina; Sandve, Geir Kjetil; Rognes, Torbjørn; Krokan, Hans Einar & Nilsen, Hilde Loge (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG. Scientific Reports.  ISSN 2045-2322.  7(1) . doi:10.1038/s41598-017-07314-5

Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina; Lu, Huiming; Shamanna, Raghavendra A.; Kalyanasundaram, Sumana; Bollineni, Ravi Chand; Wilson, Mark A.; Iser, Wendy B.; Wollman, Bradley N.; Morevati, Marya; Li, Jun; Kerr, Jesse S.; Lu, Qiping; Waltz, Tyler B.; Tian, Jane; Sinclair, David A.; Mattson, Mark P.; Nilsen, Hilde & Bohr, Vilhelm A. (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism.  ISSN 1550-4131. 24(4), s 566- 581 . doi: 10.1016/j.cmet.2016.09.004

Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg; Bjørås, Magnar & Nilsen, Hilde (2013). The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell.  ISSN 1097-2765.  49(2), s 339- 345 . doi:10.1016/j.molcel.2012.11.010

Sengupta, Tanima; Torgersen, Maria Lyngaas; Kassahun, Henok; Vellai, Tibor; Simonsen, Anne & Nilsen, Hilde (2013). The Base Excision Repair AP-endonucleases functions in the same pathways as Mismatch Repair for Activation of Checkpoint Mediated Autophagy. Nature Communications.  ISSN 2041-1723. 4, s 2674 . doi: 10.1038/ncomms3674

Nilsen, Hilde; Rosewell, I.; Robins, P.; Skjelbred, Camilla; Andersen, Sonja; Slupphaug, Geir; Krokan, Hans Einar; Lindahl, T. & Barnes, D.E. (2000). ) Ung-deficient mice reveal a primary role of the uracil-DNA glycosylase enzyme during DNA replication.Molecular Cell.  ISSN 1097-2765.  s 1059- 1065

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  • Vatn, Simen Svendsen; Lindstrøm, Jonas Christoffer; Moen, Aina Elisabeth Fossum; Brackmann, Stephan Andreas; Tannæs, Tone Møller & Olbjørn, Christine [Show all 19 contributors for this article] (2022). Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort. Clinical and Experimental Gastroenterology. ISSN 1178-7023. 15, p. 5–25. doi: 10.2147/CEG.S343468.
  • Xie, Chenglong; Zhuang, Xu-Xu; Niu, Zhangming; Ai, Ruixue; Lautrup, Sofie Hindkjær & Zheng, Shuangjia [Show all 29 contributors for this article] (2022). Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nature Biomedical Engineering. ISSN 2157-846X. 6(1), p. 76–93. doi: 10.1038/s41551-021-00819-5.
  • Palikaras, Konstantinos; Sengupta, Tanima; Nilsen, Hilde & Tavernarakis, Nektarios (2022). Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson's disease. STAR Protocols. ISSN 2666-1667. 3(2). doi: 10.1016/j.xpro.2022.101264.
  • Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T & Kroustallaki, Pinelopi [Show all 15 contributors for this article] (2022). NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length. Biochemistry and Biophysics Reports. ISSN 2405-5808. 29. doi: 10.1016/j.bbrep.2022.101211.
  • Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar & Kirpekar, Finn [Show all 10 contributors for this article] (2021). Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.762032. Full text in Research Archive
  • Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Show all 30 contributors for this article] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, p. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023. Full text in Research Archive
  • SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Qin Ying; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo & Achanta, Kavya [Show all 14 contributors for this article] (2021). Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell reports. ISSN 2211-1247. 36(10), p. 1–44. doi: 10.1016/j.celrep.2021.109668. Full text in Research Archive
  • Følling, Ivar; Wennerström, Anna Berit; Eide, Tor Jacob & Nilsen, Hilde Loge (2021). Phaeochromocytomas overexpress insulin transcript and produce insulin. Endocrine Connections. ISSN 2049-3614. 10(8), p. 815–824. doi: 10.1530/EC-21-0269. Full text in Research Archive
  • Gupta, Swapnil; You, Panpan; Sengupta, Tanima; Nilsen, Hilde & Sharma, Kulbhushan (2021). Crosstalk between Different DNA repair pathways contributes to neurodegenerative diseases. Biology (Basel). ISSN 2079-7737. 10(2). doi: 10.3390/biology10020163. Full text in Research Archive
  • Bordin, Diana Lilian; Lirussi, Lisa & Nilsen, Hilde (2021). Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation. DNA Repair. ISSN 1568-7864. 99, p. 1–11. doi: 10.1016/j.dnarep.2021.103051.
  • Lirussi, Lisa; Demir, Özlem; You, Panpan; Sarno, Antonio; Amaro, Rommie E. & Nilsen, Hilde (2021). RNA metabolism guided by RNA modifications: The role of SMUG1 in rRNA quality control. Biomolecules. ISSN 2218-273X. 11(1), p. 1–22. doi: 10.3390/biom11010076. Full text in Research Archive
  • Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Vitelli, Valeria; Celius, Elisabeth Gulowsen & Luders, Torben [Show all 10 contributors for this article] (2020). CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. doi: 10.1177/2055217320978511. Full text in Research Archive
  • Aman, Yahyah; Frank, Johannes; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming & Yang, Guang [Show all 13 contributors for this article] (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development. ISSN 0047-6374. 185, p. 1–11. doi: 10.1016/j.mad.2019.111194. Full text in Research Archive
  • Safavi, Shiva; Larouche, Ariane; Zahn, Astrid; Patenaude, Anne-Marie; Domanska, Diana Ewa & Dionne, Kiersten [Show all 17 contributors for this article] (2020). The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer. ISSN 2632-8674. 2(3). doi: 10.1093/narcan/zcaa019. Full text in Research Archive
  • Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie & Aman, Yahyah [Show all 18 contributors for this article] (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 186, p. 1–6. doi: 10.1016/j.mad.2020.111208. Full text in Research Archive
  • Fang, Fei; Nilsen, Hilde; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2019). NO-age in Norway. Translational Medicine of Aging. ISSN 2468-5011. 3, p. 37–39. doi: 10.1016/j.tma.2019.04.001.
  • Fang, Evandro Fei; Hou, Yujun; Hindkjær Lautrup, Sofie; Jensen, Martin Borch; Yang, Beimeng & Sengupta, Tanima [Show all 29 contributors for this article] (2019). NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nature Communications. ISSN 2041-1723. 10:5284, p. 1–18. doi: 10.1038/s41467-019-13172-8. Full text in Research Archive
  • Malt, Eva Albertsen; Juhasz, Katalin; Frengen, Anna Brzozowska; Wangensteen, Urd Teresia; Emilsen, Nina Merete & Hansen, Børre [Show all 8 contributors for this article] (2019). Neuropsychiatric phenotype in relation to gene variants in the hemizygous allele in 3q29 deletion carriers: A case series. Molecular Genetics & Genomic Medicine. ISSN 2324-9269. 7(9). doi: 10.1002/mgg3.889. Full text in Research Archive
  • Zheleva, Angelina; Gómez-Orte, Eva; Sáenz-Narciso, Beatriz; Ezcurra, Begoña; Kassahun, Henok & de Toro, María [Show all 10 contributors for this article] (2019). Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. PLoS Genetics. ISSN 1553-7390. 15:e1008338(9), p. 1–33. doi: 10.1371/journal.pgen.1008338. Full text in Research Archive
  • Serebrenik, Artur A.; Starrett, Gabriel J.; Leenen, Sterre; Jarvis, Matthew C.; Shaban, Nadine M. & Salamango, Daniel J. [Show all 9 contributors for this article] (2019). The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), p. 22158–22163. doi: 10.1073/pnas.1904024116.
  • Lirussi, Lisa & Nilsen, Hilde (2019). Telomere maintenance: regulating hTERC fate through RNA modifications. Molecular and Cellular Oncology (MCO). ISSN 2372-3556. 6:1670489(6), p. 1–3. doi: 10.1080/23723556.2019.1670489. Full text in Research Archive
  • Kroustallaki, Pinelopi; Lirussi, Lisa; Carracedo Huroz, Sergio; You, Panpan; Esbensen, Qin Ying & Götz, Alexandra [Show all 11 contributors for this article] (2019). SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell reports. ISSN 2211-1247. doi: 10.1016/j.celrep.2019.07.040. Full text in Research Archive
  • Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S. & Yang, Beimeng [Show all 20 contributors for this article] (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience. ISSN 1097-6256. 22(3), p. 401–412. doi: 10.1038/s41593-018-0332-9. Full text in Research Archive
  • Nguyen, Chinh BKrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes & Nilsen, Hilde Loge [Show all 7 contributors for this article] (2019). Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome. Brain, Behavior, and Immunity. ISSN 0889-1591. 76, p. 82–96. doi: 10.1016/j.bbi.2018.11.008. Full text in Research Archive
  • Arczewska, Katarzyna D.; Stachurska, Anna; Wojewódzka, Maria; Karpińska, Kamila; Kruszewski, Marcin & Nilsen, Hilde Loge [Show all 7 contributors for this article] (2018). hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells. DNA Repair. ISSN 1568-7864. 69, p. 53–62. doi: 10.1016/j.dnarep.2018.07.006.
  • Torgovnick, Alessandro; Schiavi, Alfonso; Shaik, Anjumara; Kassahun, Henok; Maglioni, Silvia & Rea, Shane L [Show all 12 contributors for this article] (2018). BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. EMBO Reports. ISSN 1469-221X. 19(12). doi: 10.15252/embr.201845856.
  • Kassahun, Henok; Sengupta, Tanima; Schiavi, Alfonso; Maglioni, Silvia; Skjeldam, Hanne Kim & Arczewska, Katarzyna [Show all 11 contributors for this article] (2018). Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair. ISSN 1568-7864. 61, p. 46–55. doi: 10.1016/j.dnarep.2017.11.009. Full text in Research Archive
  • Fang, Evandro Fei; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D. & Kerr, Jesse S. [Show all 14 contributors for this article] (2017). In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. Journal of Visualized Experiments. ISSN 1940-087X. 2017(129). doi: 10.3791/56301.
  • Fang, Evandro Fei; Waltz, Tyler B.; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S. & Morevati, Marya [Show all 20 contributors for this article] (2017). Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/srep46208. Full text in Research Archive
  • Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna & Nilsen, Hilde Loge [Show all 8 contributors for this article] (2017). Mitophagy in neurodegeneration and aging. Neurochemistry International. ISSN 0197-0186. 109, p. 202–209. doi: 10.1016/j.neuint.2017.02.007. Full text in Research Archive
  • Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge & Ivanauskiene, Kristina [Show all 13 contributors for this article] (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185708. Full text in Research Archive
  • Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Show all 16 contributors for this article] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-07314-5. Full text in Research Archive
  • Nguyen, Chinh Bkrong Thi Thuy; Alsøe, Lene; Lindvall, Jessica Margareta; Sulheim, Dag; Fagermoen, Frode Even & Winger, Anette [Show all 9 contributors for this article] (2017). Whole blood gene expression in adolescent chronic fatigue syndrome: An exploratory cross-sectional study suggesting altered B cell differentiation and survival. Journal of Translational Medicine. ISSN 1479-5876. 15. doi: 10.1186/s12967-017-1201-0. Full text in Research Archive
  • Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja & Neurauter, Christine Gran [Show all 15 contributors for this article] (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/s41598-017-04472-4. Full text in Research Archive
  • Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei & Iyama, Teruaki [Show all 22 contributors for this article] (2016). Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 113(44), p. 12502–12507. doi: 10.1073/pnas.1610198113.
  • Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina & Lu, Huiming [Show all 22 contributors for this article] (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. ISSN 1550-4131. 24(4), p. 566–581. doi: 10.1016/j.cmet.2016.09.004.
  • Fang, Evandro E; Wollman, B; Kassahun, Henok; Nilsen, Hilde; Scheibye-Knudsen, Morten & Bohr, Vilhelm A (2015). Nuclear DNA repair Proteins in Mitochondrial Health and Aging. Gerontology and geriatric medicine. ISSN 2333-7214. 1, p. 1–2.
  • Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima & Nilsen, Hilde [Show all 9 contributors for this article] (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell. ISSN 0092-8674. 157(4). doi: 10.1016/j.cell.2014.03.026.
  • Jobert, Laure & Nilsen, Hilde (2014). Regulatory mechanisms of RNA function: Emerging roles of DNA repair enzymes. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71(13), p. 2451–2465. doi: 10.1007/s00018-014-1562-y.
  • Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg & Bjørås, Magnar [Show all 7 contributors for this article] (2013). The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell. ISSN 1097-2765. 49(2), p. 339–345. doi: 10.1016/j.molcel.2012.11.010.
  • Sengupta, Tanima; Torgersen, Maria Lyngaas; Kassahun, Henok; Vellai, Tibor; Simonsen, Anne & Nilsen, Hilde (2013). The Base Excision Repair AP-endonucleases functions in the same pathways as Mismatch Repair for Activation of Checkpoint Mediated Autophagy. Nature Communications. ISSN 2041-1723. 4. doi: 10.1038/ncomms3674.
  • Forthun, Rakel Brendsdal; Sengupta, Tanima; Skjeldam, Hanne Kim; Lindvall, Jessica Margareta; Mccormack, Emmet Martin & Gjertsen, Bjørn Tore [Show all 7 contributors for this article] (2012). Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLOS ONE. ISSN 1932-6203. 7(11). doi: 10.1371/journal.pone.0048992. Full text in Research Archive
  • Tomazella, Gisele Guicardi; Kassahun, Henok; Nilsen, Hilde & Thiede, Bernd (2012). Quantitative Proteome Analysis Reveals RNA Processing Factors As Modulators of Ionizing Radiation-Induced Apoptosis in the C. elegans Germline. Journal of Proteome Research. ISSN 1535-3893. 11(8), p. 4277–4288. doi: 10.1021/pr300386z.
  • Erdélyi, Péter; Borsos, Éva; Takács-Vellai, Krisztina; Kovács, Tibor; Kovács, Attila L. & Sigmond, Tímea [Show all 15 contributors for this article] (2011). Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. Journal of Cell Science. ISSN 0021-9533. 124(9), p. 1510–1518. doi: 10.1242/jcs.080192.
  • Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Show all 7 contributors for this article] (2011). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. 10(2), p. 176–187. doi: 10.1016/j.dnarep.2010.10.009.
  • Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Show all 7 contributors for this article] (2010). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2010.10.009.
  • Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta & Nilsen, Hilde (2010). A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Aging. ISSN 1945-4589. Full text in Research Archive
  • Skjeldam, Hanne Kim; Kassahun, Henok; Fensgård, Øyvind; Sengupta, Tanima; Babaie, Eshrat & Lindvall, Jessica Margareta [Show all 8 contributors for this article] (2010). Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents. DNA Repair. ISSN 1568-7864. 9(8), p. 861–870. doi: 10.1016/j.dnarep.2010.04.009.
  • Zakaria, Chadi; Kassahun, Henok; Yang, Xiaoming; Labbé, Jean-Claude; Nilsen, Hilde & Ramotar, Dindial (2010). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. DNA Repair. ISSN 1568-7864. 9(2), p. 169–176. doi: 10.1016/j.dnarep.2009.11.007.
  • Nilsen, Hilde; Corneliussen, Henriette; Fensgård, Øyvind; Grallert, Beata & Boye, Erik (2009). Global transcriptional response after exposure of fission yeast cells to ultraviolet light. BMC Cell Biology. ISSN 1471-2121. 10.
  • Nilsen, Hilde; Kassahun, Henok; Zakaria, Chadi; Yang, Xiaoming; Labbe, Jean-Claude & Ramotar, Dindial (2009). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. Accepted for publication in DNA repair, DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2009.11.007.
  • Nilsen, Hilde; Arczewska, Katarzyna; Michalickova, Katerina & Donaldson, Ian Matthew (2008). The contribution of DNA base damage to human cancer is modulated by the base excision repair interaction network. Critical reviews in oncogenesis. ISSN 0893-9675. 14(4), p. 217–273.
  • Schmidt, Frank; Strozynski, Margarita Anna; Salus, Sandra Suzanne; Nilsen, Hilde & Thiede, Bernd (2007). Rapid determination of amino acid incorporation by stable isotope labeling with amino acids in cell culture (SILAC). Rapid Communications in Mass Spectrometry. ISSN 0951-4198. 21, p. 3919–3926. doi: 10.1002/rcm.3290.
  • Dengg, Marlene; Garcia-Muse, Tatiana; Gill, Stephen G.; Ashcroft, Neville; Boulton, Simon j. & Nilsen, Hilde (2006). Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Reports. ISSN 1469-221X. 7, p. 1046–1051. doi: 10.1038/sj.embor.7400782.
  • Andersen, Sonja Benedikte; Heine, T; Sneve, Ragnhild; Kønig, Imbritt; Krokan, Hans Einar & Epe, B [Show all 7 contributors for this article] (2005). Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis. ISSN 0143-3334. 26(3), p. 547–555. doi: 10.1093/carcin/bgh347.
  • Andersen, S; Ericsson, M; DAI, H; Peña-Diaz, J; Slupphaug, G & Nilsen, Hilde [Show all 8 contributors for this article] (2005). Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair. ISSN 1568-7864. 4(12), p. 1432–1441.
  • Nilsen, Hilde; An, Q & Lindahl, T (2005). Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene. ISSN 0950-9232. 24(18), p. 3063–3066.
  • Andersen, S; Heine, T; Sneve, Ragnhild; Konig, I; Krokan, HE & Epe, B [Show all 7 contributors for this article] (2005). Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis. ISSN 0143-3334. 26(3), p. 547–555.
  • Nilsen, Hilde; An, Q & Lindahl, T (2004). Mutation frequenceies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene. ISSN 0950-9232.
  • Nilsen, Hilde; Stamp, G; Andersen, Sonja; Hrivnak, G; Krokan, Hans Einar & Lindahl, T [Show all 7 contributors for this article] (2003). Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene. ISSN 0950-9232. 22, p. 5381–5386.
  • Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde & Skorpen, Frank [Show all 10 contributors for this article] (2002). hUNG2 is the major repair enzyme for removal of uracil from U:A matchers,U:G mismatches and U in single stranded DNA, with SMUG1 as a broad specificity backup. Journal of Biological Chemistry. ISSN 0021-9258. 18, p. 39926–39936.
  • Kvaløy, Kirsti; Nilsen, H.; Steinsbekk, Kristin; Nedal, Aina; Monterotti, Bruno & Akbari, Mansour [Show all 7 contributors for this article] (2001). Sequence variation in the human uracil-DNA glycosylase (UNG) gene. Mutation Research (DNA Repair). ISSN 0921-8777. 461(4), p. 325–338. doi: 10.1016/S0921-8777%2800%2900063-X%2C.

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  • Einevoll, Gaute & Nilsen, Hilde (2021). Podcast #43: Om å stoppe aldring. [Internet]. Podcast: Vett og vitenskap med Gaute Einevoll.
  • Bos, Steffan Daniel; Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Vitelli, Valeria & Celius, Elisabeth Gulowsen [Show all 10 contributors for this article] (2019). Differential gene expression analysis of CD8+ T cells from multiple sclerosis patients and healthy controls .
  • Hindkjær Lautrup, Sofie; Lou, Guofeng; Aman, Yahyah; Nilsen, Hilde; Tao, Jun & Fang, Evandro Fei (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International. ISSN 0197-0186. 129. doi: 10.1016/j.neuint.2019.104469.
  • Gudmundsrud, Ruben; Lautrup, Sofie; Nilsen, Hilde Loge; Bohr, Vilhelm & Fang, Fei (2018). Mitofagi i nevrodegenerasjon og aldring. BestPractice Norge. 109, p. 202–209. doi: 10.1016/j.neuint.2017.02.007.
  • Høyer, Helle; Tveten, Kristian; Røsby, Oddveig; Hilmarsen, Hilde T; Busk, Øyvind & Svendsen, Marit [Show all 12 contributors for this article] (2018). A novel AARS variant identified in three CMT2 families.
  • Alsøe, Lene; Wennerström, Anna Berit; Liu, Yan; Esbensen, Qin Ying; Bjørset, Randi & Penz, Christine [Show all 10 contributors for this article] (2018). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
  • Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Show all 16 contributors for this article] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1 .
  • Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Show all 10 contributors for this article] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
  • Sarno, Antonio; Alsøe, Lene; Carracedo, Sergio; Tekin, Nuriya Basdag; Gupta, Tanima Sen & Jobert, Laure [Show all 9 contributors for this article] (2016). UNG and SMUG1 complement each other in DNA uracil excision and DNA 5-hydroxymethyluracil originates from 5-hydroxymethylcytosine deamination in mice.
  • Nilsen, Hilde; Kroustallaki, Pinelopi; Alsøe, Lene; Huroz, Sergio C; Sarno, Antonio & Esbensen, Ying [Show all 11 contributors for this article] (2016). Telomere maintenance defects in mice deficient in SMUG1 uracil-DNA glycosylase.
  • Wyller, Vegard Bruun; Jacobsen, Kristine; Dahl, Mai Britt; Nilsen, Hilde; Proske, Simone & Horter, Thorsten [Show all 7 contributors for this article] (2016). Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy. International Journal of Cardiology. ISSN 0167-5273. 221, p. 376–378. doi: 10.1016/j.ijcard.2016.06.288.
  • Nilsen, Hilde (2013). Kan denne ormen avsløre at vitaminbruk er bortkastet. Aftenposten Innsikt. ISSN 1890-6931.
  • Nilsen, Hilde & Nickelsen, Trine (2013). Vitaminpiller kan skade kroppens eget forsvar. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926.
  • Nilsen, Hilde (2012). Liten orm gir mer effektiv kreftmedisin. Forskning.no. ISSN 1891-635X.
  • Nilsen, Hilde (2010). Om forsknings arbeider i Bioteknologisenteret. [TV]. NRK Østlandssendningen.
  • Nilsen, Hilde (2010). Liten orm hjelper oss til bedre liv. [Newspaper]. Aftenposten.
  • Nilsen, Hilde (2010). Liten orm avslører våre aldringsprosesser. [Newspaper]. Apollon.
  • Nilsen, Hilde (2010). DNA repair dependent signalling of cell death responses to 5-Fluorouracil.
  • Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
  • Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
  • Fensgård, Øyvind & Nilsen, Hilde (2010). DNA skader aldringsprosessen. NBS-nytt. ISSN 0801-3535. p. 9–13.
  • Fensgård, Øyvind; Lindvall, Jessica Margareta; Kassahun, Henok; Rognes, Torbjørn & Nilsen, Hilde (2009). Microarray analysis of BER mutants.
  • Nilsen, Hilde (2009). Uracil DNA glycosylase is required for apoptosis in response to 5-fluorouracil in C. elegans.
  • Nilsen, Hilde (2009). DNA repair modulates responses to chemotherapeutic agents.
  • Nilsen, Hilde (2009). Two-tiered response to loss of DNA damage in C. elegans.
  • Fensgård, Øyvind; Lindvall, Jessica; Kassahun, Henok; Rognes, Torbjørn & Nilsen, Hilde (2009). Microarray analysis of BER mutants.
  • Nilsen, Hilde & Dengg, Marlene (2006). Caenorhabditis elegans and the DNA damage response. NBS-nytt. ISSN 0801-3535. 30(3), p. 22–25.
  • Nilsen, Hilde (2005). Cellular responses to endogenous DNA damage.
  • Nilsen, Hilde (2005). Using C.elegans to study the DNA damage response”.
  • Nilsen, Hilde (2005). Using Caenorhabditis elegans to study cellular responses to endogenous DNA damage.
  • Nilsen, Hilde (2005). Genetic studies of repair of endogenous DNA damage.
  • Nilsen, Hilde (2005). Using C.elegans to study the DNA damage response.
  • Nilsen, Hilde (2004). The UNG uracil -NDA glycosylase- a region specific guardian of the genome.
  • Nilsen, Hilde (2004). The UNG uracil-DNA glycosylase- a region specific guardian of the genome.
  • Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R & Slupphaug, Geir [Show all 11 contributors for this article] (2002). "URACIL-DNAGLYCOSYLASE KNOCKOUT MICE-effects on lifespan and health. Characterisation of uracil removing activities in wild type and Ung deficient mice.".
  • Kavli, Bodil; Sundheim, Ottar; Akbari, Mansour; Otterlei, Marit; Nilsen, Hilde & Aas, Per Arne [Show all 8 contributors for this article] (2002). Substrate preference and enzyme kinetics reveal distinct properties of UNG2 and SMUG1 in cellular base-excision repair; hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches and U in single stranded DNA, with hSMUG1 as a broad specificity backup.
  • Andersen, Sonja; Nilsen, Hilde; Grøsvik, K; Kønig, I; Sneve, R & Slupphaug, Geir [Show all 7 contributors for this article] (2002). Uracil-DNA glycosylase knockout mice.
  • Fensgård, Øyvind & Nilsen, Hilde (2010). Global Genome Responses to DNA-Repair Deficiency Modulate Aging and Stress Response Pathways. Unipud. ISSN 978-82-8264-118-0.

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Published Sep. 4, 2013 12:57 PM - Last modified Jan. 2, 2018 2:59 PM