Hilde Loge Nilsen

• Wang, He-Ling; Siow, Richard; Schmauck-Medina, Tomas; Zhang, Jianying; Sandset, Per Morten & Filshie, Clare [Vis alle 38 forfattere av denne artikkelen] (2024). Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies. The journals of gerontology. Series A, Biological sciences and medical sciences. ISSN 1079-5006. 79(4). doi: 10.1093/gerona/glae029.
• Qian, Shuangjie; He, Haijun; Xiong, Xi; Ai, Ruixue; Wang, Wenwen & Zhu, Huimin [Vis alle 10 forfattere av denne artikkelen] (2023). Identification of mitophagy-associated proteins profile as potential plasma biomarkers of idiopathic Parkinson's disease. CNS Neuroscience & Therapeutics. ISSN 1755-5930. 00, s. 1–14. doi: 10.1111/cns.14532. Fulltekst i vitenarkiv
• Presterud, Rebecca; Deng, Wei Hai; Wennerström, Anna Berit; Burgers, Geertruida Aleida Wilhelmina; Gajera, Bharat & Mattsson, Kirsten G. [Vis alle 11 forfattere av denne artikkelen] (2023). Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia. Movement Disorders. ISSN 0885-3185. s. 1–11. doi: 10.1002/mds.29645. Fulltekst i vitenarkiv Vis sammendrag

  Background: Supplementation of nicotinamide riboside (NR) ameliorates neuropathology in animal models of ataxia telangiectasia (A-T). In humans, short-term NR supplementation showed benefits in neurological outcome. Objectives: The study aimed to investigate the safety and benefits of long-term NR supplementation in individuals with A-T. Methods: A single-arm, open-label clinical trial was performed in individuals with A-T, receiving NR over a period of 2 years. Biomarkers and clinical examinations were used to assess safety parameters. Standardized and validated neuromotor tests were used to monitor changes in neurological symptoms. Using generalized mixed models, test results were compared to expected disease progression based on historical data. Results: NAD+ concentrations increased rapidly in peripheral blood and stabilized at a higher level than baseline. NR supplementation was well tolerated for most participants. The total scores in the neuromotor test panels, as evaluated at the 18-month time point, improved for all but one participant, primarily driven by improvements in coordination subscores and eye movements. A comparison with historical data revealed that the progression of certain neuromotor symptoms was slower than anticipated. Conclusions: Long-term use of NR appears to be safe and well tolerated, and it improves motor coordination and eye movements in patients with A-T of all ages. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

• Durfee, Cameron; Temiz, Nuri Alpay; Levin-Klein, Rena; Argyris, Prokopios P.; Alsøe, Lene & Carracedo Huroz, Sergio [Vis alle 16 forfattere av denne artikkelen] (2023). Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases. Cell Reports Medicine. ISSN 2666-3791. 4(10), s. 1–26. doi: 10.1016/j.xcrm.2023.101211. Fulltekst i vitenarkiv
• Misceo, Doriana; Lirussi, Lisa; Strømme, Petter; Sumathipala, Dulika Sanjeewani; Guerin, Andrea & Wolf, Nicole I [Vis alle 14 forfattere av denne artikkelen] (2023). A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis. Brain. ISSN 0006-8950. 146(8), s. 3513–3527. doi: 10.1093/brain/awad086. Fulltekst i vitenarkiv
• Lirussi, Lisa & Nilsen, Hilde (2023). DNA Glycosylases Define the Outcome of Endogenous Base Modifications. International Journal of Molecular Sciences. ISSN 1661-6596. 24(12), s. 1–19. doi: 10.3390/ijms241210307. Fulltekst i vitenarkiv
• Lefol, Yohan Pierre; Korfage, Tom; Mjelle, Robin; Prebensen, Christian Haugland; Lüders, Torben & Müller, Bruno [Vis alle 13 forfattere av denne artikkelen] (2023). TiSA: TimeSeriesAnalysis - A pipeline for the analysis of longitudinal transcriptomics data. NAR Genomics and Bioinformatics. ISSN 2631-9268. 5(1). doi: 10.1093/nargab/lqad020. Fulltekst i vitenarkiv
• Sleiman, Ahmad; Lalanne, Kévin; Vianna, François; Perrot, Yann; Richaud, Myriam & Sengupta, Tanima [Vis alle 12 forfattere av denne artikkelen] (2023). Targeted Central Nervous System Irradiation with Proton Microbeam Induces Mitochondrial Changes in Caenorhabditis elegans. Biology (Basel). ISSN 2079-7737. 12(6). doi: 10.3390/biology12060839.
• Prebensen, Christian Haugland; Lefol, Yohan Pierre; Myhre, Peder Langeland; Lüders, Torben; Jonassen, Christine M & Blomfeldt, Anita [Vis alle 9 forfattere av denne artikkelen] (2023). Longitudinal whole blood transcriptomic analysis characterizes neutrophil activation and interferon signaling in moderate and severe COVID-19. Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-37606-y. Fulltekst i vitenarkiv
• Kalyanasundaram, Sumana; Lefol, Yohan Pierre; Gundersen, Sveinung; Rognes, Torbjørn; Alsøe, Lene & Nilsen, Hilde [Vis alle 9 forfattere av denne artikkelen] (2023). hGSuite HyperBrowser: A web-based toolkit for hierarchical metadata-informed analysis of genomic tracks. PLOS ONE. ISSN 1932-6203. 18(7). doi: 10.1371/journal.pone.0286330. Fulltekst i vitenarkiv
• Naranjo-Galindo, Francisco José; Ai, Ruixue; Fang, Evandro Fei; Nilsen, Hilde Loge & SenGupta, Tanima (2022). C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration. Frontiers in Aging. ISSN 2673-6217. 3. doi: 10.3389/fragi.2022.916118. Fulltekst i vitenarkiv
• Sengupta, Tanima; Lefol, Yohan Pierre; Lirussi, Lisa; Suaste Morales, Veronica; Lüders, Torben & Gupta, Swapnil [Vis alle 10 forfattere av denne artikkelen] (2022). Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Aging. ISSN 1945-4589. 14(21), s. 8661–8687. doi: 10.18632/aging.204375. Fulltekst i vitenarkiv
• Lirussi, Lisa; Ayyildiz, Dilara; Liu, Yan; Montaldo, Nicola Pietro; Carracedo Huroz, Sergio & Aure, Miriam Ragle [Vis alle 16 forfattere av denne artikkelen] (2022). A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours. Nucleic Acids Research (NAR). ISSN 0305-1048. 50(18), s. 10449–10468. doi: 10.1093/nar/gkac807. Fulltekst i vitenarkiv
• Akbari, Mansour; Nilsen, Hilde & Montaldo, Nicola Pietro (2022). Dynamic features of human mitochondrial DNA maintenance and transcription. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 10. doi: 10.3389/fcell.2022.984245. Fulltekst i vitenarkiv
• Carracedo Huroz, Sergio; Lirussi, Lisa; Alsøe, Lene; Segers, Filip; Wang, Changliang & Bartosova, Zdenka [Vis alle 21 forfattere av denne artikkelen] (2022). SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice. DNA Repair. ISSN 1568-7864. 120. doi: 10.1016/j.dnarep.2022.103410.
• Sumathipala, Dulika Sanjeewani; Strømme, Petter; Fattahi, Zohreh; Lüders, Torben; Sheng, Ying & Kahrizi, Kimia [Vis alle 20 forfattere av denne artikkelen] (2022). ZBTB11 dysfunction: Spectrum of brain abnormalities, biochemical signature and cellular consequences. Brain. ISSN 0006-8950. 145(7), s. 2602–2616. doi: 10.1093/brain/awac034. Fulltekst i vitenarkiv
• Høyer, Helle; Busk, Øyvind Løvold; Esbensen, Qin Ying; Røsby, Oddveig; Hilmarsen, Hilde Tveitan & Russell, Michael Bjørn [Vis alle 9 forfattere av denne artikkelen] (2022). Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation. BMC Neurology. ISSN 1471-2377. 22(1). doi: 10.1186/s12883-022-02828-6. Fulltekst i vitenarkiv Vis sammendrag

  Background: Aminoacyl tRNA-synthetases are ubiquitously-expressed enzymes that attach amino acids to their cognate tRNA molecules. Mutations in several genes encoding aminoacyl tRNA-synthetases, have been associated with peripheral neuropathy, i.e. AARS1, GARS1, HARS1, YARS1 and WARS1. The pathogenic mechanism underlying AARS1-related neuropathy is not known. Methods: From 2012 onward, all probands presenting at Telemark Hospital (Skien, Norway) with peripheral neuropathy were screened for variants in AARS1 using an "in-house" next-generation sequencing panel. DNA from patient's family members was examined by Sanger sequencing. Blood from affected family members and healthy controls were used for quantification of AARS1 mRNA and alanine. Proteomic analyses were conducted in peripheral blood mononuclear cells (PBMC) from four affected family members and five healthy controls. Results: Seventeen individuals in two Norwegian families affected by Charcot-Marie-Tooth disease (CMT) were characterized in this study. The heterozygous NM_001605.2:c.976C > T p.(Arg326Trp) AARS1 mutation was identified in ten affected family members. All living carriers had a mild to severe length-dependent sensorimotor neuropathy. Three deceased obligate carriers aged 74-98 were reported to be unaffected, but were not examined in the clinic. Proteomic studies in PBMC from four affected individuals suggest an effect on the immune system mediated by components of a systemic response to chronic injury and inflammation. Furthermore, altered expression of proteins linked to mitochondrial function/dysfunction was observed. Proteomic data are available via ProteomeXchange using identifier PXD023842. Conclusion: This study describes clinical and neurophysiological features linked to the p.(Arg326Trp) variant of AARS1 in CMT-affected members of two Norwegian families. Proteomic analyses based on of PBMC from four CMT-affected individuals suggest that involvement of inflammation and mitochondrial dysfunction might contribute to AARS1 variant-associated peripheral neuropathy.

• Vatn, Simen Svendsen; Lindstrøm, Jonas Christoffer; Moen, Aina Elisabeth Fossum; Brackmann, Stephan Andreas; Tannæs, Tone Møller & Olbjørn, Christine [Vis alle 19 forfattere av denne artikkelen] (2022). Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort. Clinical and Experimental Gastroenterology. ISSN 1178-7023. 15, s. 5–25. doi: 10.2147/CEG.S343468. Fulltekst i vitenarkiv
• Xie, Chenglong; Zhuang, Xu-Xu; Niu, Zhangming; Ai, Ruixue; Lautrup, Sofie Hindkjær & Zheng, Shuangjia [Vis alle 29 forfattere av denne artikkelen] (2022). Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nature Biomedical Engineering. ISSN 2157-846X. 6(1), s. 76–93. doi: 10.1038/s41551-021-00819-5. Fulltekst i vitenarkiv
• Karlsen, Tom Rune; Olsen, Maria Belland; Kong, Xiang Yi; Yang, Kuan; Quiles-Jiménez, Ana M T & Kroustallaki, Pinelopi [Vis alle 15 forfattere av denne artikkelen] (2022). NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length. Biochemistry and Biophysics Reports. ISSN 2405-5808. 29. doi: 10.1016/j.bbrep.2022.101211. Fulltekst i vitenarkiv
• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar & Kirpekar, Finn [Vis alle 10 forfattere av denne artikkelen] (2021). Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.762032. Fulltekst i vitenarkiv
• Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Vis alle 30 forfattere av denne artikkelen] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, s. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023. Fulltekst i vitenarkiv
• SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Qin Ying; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo & Achanta, Kavya [Vis alle 14 forfattere av denne artikkelen] (2021). Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell reports. ISSN 2211-1247. 36(10), s. 1–44. doi: 10.1016/j.celrep.2021.109668. Fulltekst i vitenarkiv
• Følling, Ivar; Wennerström, Anna Berit; Eide, Tor Jacob & Nilsen, Hilde Loge (2021). Phaeochromocytomas overexpress insulin transcript and produce insulin. Endocrine Connections. ISSN 2049-3614. 10(8), s. 815–824. doi: 10.1530/EC-21-0269. Fulltekst i vitenarkiv
• Gupta, Swapnil; You, Panpan; Sengupta, Tanima; Nilsen, Hilde & Sharma, Kulbhushan (2021). Crosstalk between Different DNA repair pathways contributes to neurodegenerative diseases. Biology (Basel). ISSN 2079-7737. 10(2). doi: 10.3390/biology10020163. Fulltekst i vitenarkiv
• Bordin, Diana Lilian; Lirussi, Lisa & Nilsen, Hilde (2021). Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation. DNA Repair. ISSN 1568-7864. 99, s. 1–11. doi: 10.1016/j.dnarep.2021.103051.
• Lirussi, Lisa; Demir, Özlem; You, Panpan; Sarno, Antonio; Amaro, Rommie E. & Nilsen, Hilde (2021). RNA metabolism guided by RNA modifications: The role of SMUG1 in rRNA quality control. Biomolecules. ISSN 2218-273X. 11(1), s. 1–22. doi: 10.3390/biom11010076. Fulltekst i vitenarkiv Vis sammendrag

  RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified RNA substrates and thereby contribute to RNA surveillance. Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that not only recognizes and removes uracil and oxidized pyrimidines from DNA but is also able to process modified RNA substrates. SMUG1 interacts with the pseudouridine synthase dyskerin (DKC1), an enzyme essential for the correct assembly of small nucleolar ribonucleoproteins (snRNPs) and ribosomal RNA (rRNA) processing. Here, we review rRNA modifications and RNA quality control mechanisms in general and discuss the specific function of SMUG1 in rRNA metabolism. Cells lacking SMUG1 have elevated levels of immature rRNA molecules and accumulation of 5-hydroxymethyluridine (5hmU) in mature rRNA. SMUG1 may be required for post-transcriptional regulation and quality control of rRNAs, partly by regulating rRNA and stability.

• Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Vitelli, Valeria; Celius, Elisabeth Gulowsen & Luders, Torben [Vis alle 10 forfattere av denne artikkelen] (2020). CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. doi: 10.1177/2055217320978511. Fulltekst i vitenarkiv
• Aman, Yahyah; Frank, Johannes; Lautrup, Sofie Hindkjær; Matysek, Adrian; Niu, Zhangming & Yang, Guang [Vis alle 13 forfattere av denne artikkelen] (2020). The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications. Mechanisms of Ageing and Development. ISSN 0047-6374. 185, s. 1–11. doi: 10.1016/j.mad.2019.111194. Fulltekst i vitenarkiv
• Safavi, Shiva; Larouche, Ariane; Zahn, Astrid; Patenaude, Anne-Marie; Domanska, Diana Ewa & Dionne, Kiersten [Vis alle 17 forfattere av denne artikkelen] (2020). The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. NAR Cancer. ISSN 2632-8674. 2(3). doi: 10.1093/narcan/zcaa019. Fulltekst i vitenarkiv
• Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie & Aman, Yahyah [Vis alle 18 forfattere av denne artikkelen] (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 186, s. 1–6. doi: 10.1016/j.mad.2020.111208. Fulltekst i vitenarkiv
• Fang, Fei; Hou, Y; Palikaras, Konstantinos; Adriaanse, BA; Kerr, SJ & Yang, B [Vis alle 19 forfattere av denne artikkelen] (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience. ISSN 1097-6256. 22(3), s. 401–412. doi: 10.1038/s41593-018-0332-9.
• Fang, Fei; Nilsen, Hilde; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2019). NO-age in Norway. Translational Medicine of Aging. ISSN 2468-5011. 3, s. 37–39. doi: 10.1016/j.tma.2019.04.001.
• Fang, Evandro Fei; Hou, Yujun; Hindkjær Lautrup, Sofie; Jensen, Martin Borch; Yang, Beimeng & Sengupta, Tanima [Vis alle 29 forfattere av denne artikkelen] (2019). NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nature Communications. ISSN 2041-1723. 10:5284, s. 1–18. doi: 10.1038/s41467-019-13172-8. Fulltekst i vitenarkiv
• Malt, Eva Albertsen; Juhasz, Katalin; Frengen, Anna Brzozowska; Wangensteen, Urd Teresia; Emilsen, Nina Merete & Hansen, Børre [Vis alle 8 forfattere av denne artikkelen] (2019). Neuropsychiatric phenotype in relation to gene variants in the hemizygous allele in 3q29 deletion carriers: A case series. Molecular Genetics & Genomic Medicine. ISSN 2324-9269. 7(9). doi: 10.1002/mgg3.889. Fulltekst i vitenarkiv Vis sammendrag

  Background: Genetic risk variants in the hemizygous allele may influence neuropsychiatric manifestations and clinical course in 3q29 deletion carriers. Methods: In‐depth phenotypic assessment in two deletion carriers included medical records, medical, genetic, psychiatric and neuropsychological evaluations, brain MRI scan and EEG. Blood samples were analyzed for copy number variations, and deep sequencing of the affected 3q29 region was performed in patients and seven first‐degree relatives. Risk variants were identified through bioinformatic analysis. Results: One deletion carrier was diagnosed with learning difficulties and childhood autism, the other with mild intellectual disability and schizophrenia. EEG abnormalities in childhood normalized in adulthood in both. Cognitive abilities improved during adolescence in one deletion carrier. Both had microcytic, hypochromic erythrocytes and suffered from chronic pain and fatigue. Molecular and bioinformatic analyses identified risk variants in the hemizygous allele that were not present in the homozygous state in relatives in genes involved in cilia function and insulin action in the autistic individual and in synaptic function and neurosteroid transport in the subject with schizophrenia. Conclusion: 3q29 deletion carriers may undergo developmental phenotypic transition and need regular medical follow‐up. Identified risk variants in the remaining hemizygous allele should be explored further in autism and schizophrenia research.

• Zheleva, Angelina; Gómez-Orte, Eva; Sáenz-Narciso, Beatriz; Ezcurra, Begoña; Kassahun, Henok & de Toro, María [Vis alle 10 forfattere av denne artikkelen] (2019). Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. PLoS Genetics. ISSN 1553-7390. 15:e1008338(9), s. 1–33. doi: 10.1371/journal.pgen.1008338. Fulltekst i vitenarkiv
• Serebrenik, Artur A.; Starrett, Gabriel J.; Leenen, Sterre; Jarvis, Matthew C.; Shaban, Nadine M. & Salamango, Daniel J. [Vis alle 9 forfattere av denne artikkelen] (2019). The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 116(44), s. 22158–22163. doi: 10.1073/pnas.1904024116.
• Lirussi, Lisa & Nilsen, Hilde (2019). Telomere maintenance: regulating hTERC fate through RNA modifications. Molecular and Cellular Oncology (MCO). ISSN 2372-3556. 6:1670489(6), s. 1–3. doi: 10.1080/23723556.2019.1670489. Fulltekst i vitenarkiv
• Kroustallaki, Pinelopi; Lirussi, Lisa; Carracedo Huroz, Sergio; You, Panpan; Esbensen, Qin Ying & Götz, Alexandra [Vis alle 11 forfattere av denne artikkelen] (2019). SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell reports. ISSN 2211-1247. doi: 10.1016/j.celrep.2019.07.040. Fulltekst i vitenarkiv
• Fang, Evandro Fei; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A.; Kerr, Jesse S. & Yang, Beimeng [Vis alle 20 forfattere av denne artikkelen] (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature Neuroscience. ISSN 1097-6256. 22(3), s. 401–412. doi: 10.1038/s41593-018-0332-9. Fulltekst i vitenarkiv
• Nguyen, Chinh BKrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes & Nilsen, Hilde Loge [Vis alle 7 forfattere av denne artikkelen] (2019). Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome. Brain, Behavior, and Immunity. ISSN 0889-1591. 76, s. 82–96. doi: 10.1016/j.bbi.2018.11.008. Fulltekst i vitenarkiv Vis sammendrag

  Background Chronic Fatigue Syndrome (CFS) is one of the most important causes of disability among adolescents while limited knowledge exists on genetic determinants underlying disease pathophysiology. Methods We analyzed deregulated immune-gene modules using Pathifier software on whole blood gene expression data (29 CFS patients, 18 controls). Deconvolution of immune cell subtypes based on gene expression profile was performed using CIBERSORT. Supervised consensus clustering on pathway deregulation score (PDS) was used to define CFS subgroups. Associations between PDS and immune, neuroendocrine/autonomic and clinical markers were examined. The impact of plasma norepinephrine level on clinical markers over time was assessed in a larger cohort (91 patients). Results A group of 29 immune-gene sets was shown to differ patients from controls and detect subgroups within CFS. Group 1P (high PDS, low norepinephrine, low naïve CD4+ composition) had strong association with levels of serum C-reactive protein and Transforming Growth Factor-beta. Group 2P (low PDS, high norepinephrine, high naïve CD4+ composition) had strong associations with neuroendocrine/autonomic markers. The corresponding plasma norepinephrine level delineated 91 patients into two subgroups with significant differences in fatigue score. Conclusion We identified 29 immune-gene sets linked to plasma norepinephrine level that could delineate CFS subgroups. Plasma norepinephrine stratification revealed that lower levels of norepinephrine were associated with higher fatigue. Our data suggests potential involvement of neuro-immune dysregulation and genetic stratification in CFS.

• Arczewska, Katarzyna D.; Stachurska, Anna; Wojewódzka, Maria; Karpińska, Kamila; Kruszewski, Marcin & Nilsen, Hilde Loge [Vis alle 7 forfattere av denne artikkelen] (2018). hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells. DNA Repair. ISSN 1568-7864. 69, s. 53–62. doi: 10.1016/j.dnarep.2018.07.006.
• Torgovnick, Alessandro; Schiavi, Alfonso; Shaik, Anjumara; Kassahun, Henok; Maglioni, Silvia & Rea, Shane L [Vis alle 12 forfattere av denne artikkelen] (2018). BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. EMBO Reports. ISSN 1469-221X. 19(12). doi: 10.15252/embr.201845856.
• Kassahun, Henok; Sengupta, Tanima; Schiavi, Alfonso; Maglioni, Silvia; Skjeldam, Hanne Kim & Arczewska, Katarzyna [Vis alle 11 forfattere av denne artikkelen] (2018). Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair. ISSN 1568-7864. 61, s. 46–55. doi: 10.1016/j.dnarep.2017.11.009. Fulltekst i vitenarkiv
• Croteau, DL; Fang, Fei; Nilsen, Hilde & Bohr, Vilhelm A. (2017). NAD+ in DNA repair and mitochondrial maintenance. Cell Cycle. ISSN 1538-4101. 16(6), s. 491–492.
• Fang, Evandro Fei; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D. & Kerr, Jesse S. [Vis alle 14 forfattere av denne artikkelen] (2017). In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. Journal of Visualized Experiments. ISSN 1940-087X. 2017(129). doi: 10.3791/56301.
• Fang, Evandro Fei; Waltz, Tyler B.; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S. & Morevati, Marya [Vis alle 20 forfattere av denne artikkelen] (2017). Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/srep46208. Fulltekst i vitenarkiv
• Fivenson, Elayne M.; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna & Nilsen, Hilde Loge [Vis alle 8 forfattere av denne artikkelen] (2017). Mitophagy in neurodegeneration and aging. Neurochemistry International. ISSN 0197-0186. 109, s. 202–209. doi: 10.1016/j.neuint.2017.02.007. Fulltekst i vitenarkiv
• Holm, Kristine Lillebø; Syljuåsen, Randi G.; Hasvold, Grete; Alsøe, Lene; Nilsen, Hilde Loge & Ivanauskiene, Kristina [Vis alle 13 forfattere av denne artikkelen] (2017). TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185708. Fulltekst i vitenarkiv
• Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Vis alle 16 forfattere av denne artikkelen] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-07314-5. Fulltekst i vitenarkiv
• Nguyen, Chinh Bkrong Thi Thuy; Alsøe, Lene; Lindvall, Jessica Margareta; Sulheim, Dag; Fagermoen, Frode Even & Winger, Anette [Vis alle 9 forfattere av denne artikkelen] (2017). Whole blood gene expression in adolescent chronic fatigue syndrome: An exploratory cross-sectional study suggesting altered B cell differentiation and survival. Journal of Translational Medicine. ISSN 1479-5876. 15. doi: 10.1186/s12967-017-1201-0. Fulltekst i vitenarkiv Vis sammendrag

  Background Chronic fatigue syndrome (CFS) is a prevalent and disabling condition affecting adolescents. The pathophysiology is poorly understood, but immune alterations might be an important component. This study compared whole blood gene expression in adolescent CFS patients and healthy controls, and explored associations between gene expression and neuroendocrine markers, immune markers and clinical markers within the CFS group. Methods CFS patients (12–18 years old) were recruited nation-wide to a single referral center as part of the NorCAPITAL project. A broad case definition of CFS was applied, requiring 3 months of unexplained, disabling chronic/relapsing fatigue of new onset, whereas no accompanying symptoms were necessary. Healthy controls having comparable distribution of gender and age were recruited from local schools. Whole blood samples were subjected to RNA sequencing. Immune markers were blood leukocyte counts, plasma cytokines, serum C-reactive protein and immunoglobulins. Neuroendocrine markers encompassed plasma and urine levels of catecholamines and cortisol, as well as heart rate variability indices. Clinical markers consisted of questionnaire scores for symptoms of post-exertional malaise, inflammation, fatigue, depression and trait anxiety, as well as activity recordings. Results A total of 29 CFS patients and 18 healthy controls were included. We identified 176 genes as differentially expressed in patients compared to controls, adjusting for age and gender factors. Gene set enrichment analyses suggested impairment of B cell differentiation and survival, as well as enhancement of innate antiviral responses and inflammation in the CFS group. A pattern of co-expression could be identified, and this pattern, as well as single gene transcripts, was significantly associated with indices of autonomic nervous activity, plasma cortisol, and blood monocyte and eosinophil counts. Also, an association with symptoms of post-exertional malaise was demonstrated. Conclusion Adolescent CFS is characterized by differential gene expression pattern in whole blood suggestive of impaired B cell differentiation and survival, and enhanced innate antiviral responses and inflammation. This expression pattern is associated with neuroendocrine markers of altered HPA axis and autonomic nervous activity, and with symptoms of post-exertional malaise.

• Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja & Neurauter, Christine Gran [Vis alle 15 forfattere av denne artikkelen] (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/s41598-017-04472-4. Fulltekst i vitenarkiv
• Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei & Iyama, Teruaki [Vis alle 22 forfattere av denne artikkelen] (2016). Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 113(44), s. 12502–12507. doi: 10.1073/pnas.1610198113.
• Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L.; Scheibye-Knudsen, Morten; Marosi, Krisztina & Lu, Huiming [Vis alle 22 forfattere av denne artikkelen] (2016). NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. ISSN 1550-4131. 24(4), s. 566–581. doi: 10.1016/j.cmet.2016.09.004.
• Fang, Fei; Wollman, BN; Kassahun, H & Nilsen, Hilde (2015). Nuclear DNA Repair proteins in mitochondrial health and aging. HSOA Journal of Gerontology and Geriatric Medicine. ISSN 2381-8662. 1.
• Fang, Evandro E; Wollman, B; Kassahun, Henok; Nilsen, Hilde; Scheibye-Knudsen, Morten & Bohr, Vilhelm A (2015). Nuclear DNA repair Proteins in Mitochondrial Health and Aging. Gerontology and geriatric medicine. ISSN 2333-7214. 1, s. 1–2.
• Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; Sengupta, Tanima & Nilsen, Hilde [Vis alle 9 forfattere av denne artikkelen] (2014). Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction. Cell. ISSN 0092-8674. 157(4). doi: 10.1016/j.cell.2014.03.026. Vis sammendrag

  Mitochondrial dysfunction is a common feature in neurodegeneration and aging.We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA-deficient cells show defective mitophagy with excessive cleavage of PINK1 and increased mitochondrial membrane potential. The mitochondrial abnormalities appear to be caused by decreased activation of the NAD+-SIRT1-PGC-1a axis triggered by hyperactivation of the DNA damage sensor PARP- 1. This phenotype is rescued by PARP-1 inhibition or by supplementation with NAD+ precursors that also rescue the lifespan defect in xpa-1 nematodes. Importantly, this pathogenesis appears common to ataxia-telangiectasia and Cockayne syndrome, two other DNA repair disorders with neurodegeneration, but absent in XPC, a DNA repair disorder without neurodegeneration. Our findings reveal a nuclearmitochondrial crosstalk that is critical for the maintenance of mitochondrial health.

• Jobert, Laure & Nilsen, Hilde (2014). Regulatory mechanisms of RNA function: Emerging roles of DNA repair enzymes. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 71(13), s. 2451–2465. doi: 10.1007/s00018-014-1562-y.
• Jobert, Laure; Skjeldam, Hanne Kim; Dalhus, Bjørn; Galashevskaya, Anastasia; Vågbø, Cathrine Broberg & Bjørås, Magnar [Vis alle 7 forfattere av denne artikkelen] (2013). The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control. Molecular Cell. ISSN 1097-2765. 49(2), s. 339–345. doi: 10.1016/j.molcel.2012.11.010.
• Sengupta, Tanima; Torgersen, Maria Lyngaas; Kassahun, Henok; Vellai, Tibor; Simonsen, Anne & Nilsen, Hilde (2013). The Base Excision Repair AP-endonucleases functions in the same pathways as Mismatch Repair for Activation of Checkpoint Mediated Autophagy. Nature Communications. ISSN 2041-1723. 4. doi: 10.1038/ncomms3674.
• Forthun, Rakel Brendsdal; Sengupta, Tanima; Skjeldam, Hanne Kim; Lindvall, Jessica Margareta; Mccormack, Emmet Martin & Gjertsen, Bjørn Tore [Vis alle 7 forfattere av denne artikkelen] (2012). Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLOS ONE. ISSN 1932-6203. 7(11). doi: 10.1371/journal.pone.0048992. Fulltekst i vitenarkiv
• Tomazella, Gisele Guicardi; Kassahun, Henok; Nilsen, Hilde & Thiede, Bernd (2012). Quantitative Proteome Analysis Reveals RNA Processing Factors As Modulators of Ionizing Radiation-Induced Apoptosis in the C. elegans Germline. Journal of Proteome Research. ISSN 1535-3893. 11(8), s. 4277–4288. doi: 10.1021/pr300386z.
• Erdélyi, Péter; Borsos, Éva; Takács-Vellai, Krisztina; Kovács, Tibor; Kovács, Attila L. & Sigmond, Tímea [Vis alle 15 forfattere av denne artikkelen] (2011). Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. Journal of Cell Science. ISSN 0021-9533. 124(9), s. 1510–1518. doi: 10.1242/jcs.080192.
• Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Vis alle 7 forfattere av denne artikkelen] (2011). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. 10(2), s. 176–187. doi: 10.1016/j.dnarep.2010.10.009.
• Arczewska, Katarzyna; Baumeier, Christian; Kassahun, Henok; Sengupta, Tanima; Bjørås, Magnar & Kuśmierek, Jarosław T. [Vis alle 7 forfattere av denne artikkelen] (2010). Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2010.10.009.
• Fensgård, Øyvind; Kassahun, Henok; Izabela Agnieszka, Bombik; Rognes, Torbjørn; Lindvall, Jessica Margareta & Nilsen, Hilde (2010). A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Aging. ISSN 1945-4589. Fulltekst i vitenarkiv Vis sammendrag

  Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response to persistent transcription-blocking DNA damage, although the relevant lesions have not been identified. Here we show that loss of NTH-1, the only Base Excision Repair (BER) enzyme known to initiate repair of oxidative DNA damage inC. elegans, restores normal lifespan of the short-lived NER deficient xpa-1 mutant. Loss of NTH-1 leads to oxidative stress and global expression profile changes that involve upregulation of genes responding to endogenous stress and downregulation of ILS. A similar, but more extensive, transcriptomic shift is observed in the xpa-1 mutant whereas loss of both NTH-1 and XPA-1 elicits a different profile with downregulation of Aurora-B and Polo-like kinase 1 signaling networks as well as DNA repair and DNA damage response genes. The restoration of normal lifespan and absence oxidative stress responses in nth-1;xpa-1 indicate that BER contributes to generate transcription blocking lesions from oxidative DNA damage. Hence, our data strongly suggests that the DNA lesions relevant for aging are repair intermediates resulting from aberrant or attempted processing by BER of lesions normally repaired by NER.

• Skjeldam, Hanne Kim; Kassahun, Henok; Fensgård, Øyvind; Sengupta, Tanima; Babaie, Eshrat & Lindvall, Jessica Margareta [Vis alle 8 forfattere av denne artikkelen] (2010). Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents. DNA Repair. ISSN 1568-7864. 9(8), s. 861–870. doi: 10.1016/j.dnarep.2010.04.009. Vis sammendrag

  The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only known UDG. C. elegans could therefore become a valuable model organism for studies of the genetic interaction networks involving base excision repair (BER). As a first step towards characterization of BER in C. elegans, we show that the UNG-1 protein is an active uracil-DNA glycosylase. We demonstrate that an ung-1 mutant has reduced ability to repair uracil-containing DNA but that an alternative Ugi-inhibited activity is present in ung-1 nuclear extracts. Finally, we demonstrate that ung-1 mutants show altered levels of apoptotic cell corpses formed in response to DNA damaging agents. Increased apoptosis in the ung-1 mutant in response to ionizing radiation (IR) suggests that UNG-1 contributes to repair of IR-induced DNA base damage in vivo. Following treatment with paraquat however, the apoptotic corpse-formation was reduced. Gene expression profiling suggests that this phenotype is a consequence of compensatory transcriptomic shifts that modulate oxidative stress responses in the mutant and not an effect of reduced DNA damage signaling.

• Zakaria, Chadi; Kassahun, Henok; Yang, Xiaoming; Labbé, Jean-Claude; Nilsen, Hilde & Ramotar, Dindial (2010). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. DNA Repair. ISSN 1568-7864. 9(2), s. 169–176. doi: 10.1016/j.dnarep.2009.11.007.
• Nilsen, Hilde; Corneliussen, Henriette; Fensgård, Øyvind; Grallert, Beata & Boye, Erik (2009). Global transcriptional response after exposure of fission yeast cells to ultraviolet light. BMC Cell Biology. ISSN 1471-2121. 10.
• Nilsen, Hilde; Kassahun, Henok; Zakaria, Chadi; Yang, Xiaoming; Labbe, Jean-Claude & Ramotar, Dindial (2009). Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability. Accepted for publication in DNA repair, DNA Repair. ISSN 1568-7864. doi: 10.1016/j.dnarep.2009.11.007.

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• Prebensen, Christian Haugland; Lefol, Yohan Pierre; Myhre, Peder Langeland; Lüders, Torben; Jonassen, Christine M & Blomfeldt, Anita [Vis alle 9 forfattere av denne artikkelen] (2023). Author Correction: Longitudinal whole blood transcriptomic analysis characterizes neutrophil activation and interferon signaling in moderate and severe COVID-19 (Scientific Reports, (2023), 13, 1, (10368), 10.1038/s41598-023-37606-y). Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-39872-2.
• Tasken, Kjetil; Russnes, Hege Elisabeth Giercksky; Aas, Eline; Bjørge, Line; Blix, Egil Støre & Ahlquist, Terje C. [Vis alle 116 forfattere av denne artikkelen] (2022). A national precision cancer medicine implementation initiative for Norway. Nature Medicine. ISSN 1078-8956. 28(5), s. 885–887. doi: 10.1038/s41591-022-01777-4.
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne & Berg, Thomas [Vis alle 53 forfattere av denne artikkelen] (2022). Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway (Journal of Translational Medicine, (2022), 20, 1, (225), 10.1186/s12967-022-03432-5). Journal of Translational Medicine. ISSN 1479-5876. 20(1). doi: 10.1186/s12967-022-03518-0.
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne & Berg, Thomas [Vis alle 53 forfattere av denne artikkelen] (2022). Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. Journal of Translational Medicine. ISSN 1479-5876. 20(1), s. 1–11. doi: 10.1186/s12967-022-03432-5. Fulltekst i vitenarkiv Vis sammendrag

  Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed attention has arisen due to recent advancements in cancer diagnostics including access to high-throughput sequencing of tumour tissue. Targeted therapies interfering with cancer specific pathways have been developed and approved for subgroups of patients. These drugs might just as well be efficient in other diagnostic subgroups, not investigated in pharma-led clinical studies, but their potential use on new indications is never explored due to limited number of patients. Methods In this national, investigator-initiated, prospective, open-label, non-randomized combined basket- and umbrella-trial, patients are enrolled in multiple parallel cohorts. Each cohort is defined by the patient’s tumour type, molecular profile of the tumour, and study drug. Treatment outcome in each cohort is monitored by using a Simon two-stage-like ‘admissible’ monitoring plan to identify evidence of clinical activity. All drugs available in IMPRESS-Norway have regulatory approval and are funded by pharmaceutical companies. Molecular diagnostics are funded by the public health care system.

• Palikaras, Konstantinos; Sengupta, Tanima; Nilsen, Hilde & Tavernarakis, Nektarios (2022). Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson's disease. STAR Protocols. ISSN 2666-1667. 3(2). doi: 10.1016/j.xpro.2022.101264.
• Safavi, Shiva; Larouche, Ariane; Zahn, Astrid; Patenaude, Anne-Marie; Domanska, Diana & Dionne, Kiersten [Vis alle 17 forfattere av denne artikkelen] (2021). Erratum: The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID (NAR Cancer (2020) 2:3 (zcaa019) DOI: 10.1093/narcan/zcaa019). NAR Cancer. ISSN 2632-8674. 3(1). doi: 10.1093/NARCAN/ZCAA045.
• Einevoll, Gaute & Nilsen, Hilde (2021). Podcast #43: Om å stoppe aldring. [Internett]. Podcast: Vett og vitenskap med Gaute Einevoll.
• Bos, Steffan Daniel; Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Vitelli, Valeria & Celius, Elisabeth Gulowsen [Vis alle 10 forfattere av denne artikkelen] (2019). Differential gene expression analysis of CD8+ T cells from multiple sclerosis patients and healthy controls .
• Hindkjær Lautrup, Sofie; Lou, Guofeng; Aman, Yahyah; Nilsen, Hilde; Tao, Jun & Fang, Evandro Fei (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International. ISSN 0197-0186. 129. doi: 10.1016/j.neuint.2019.104469.
• Gudmundsrud, Ruben; Lautrup, Sofie; Nilsen, Hilde Loge; Bohr, Vilhelm & Fang, Fei (2018). Mitofagi i nevrodegenerasjon og aldring. BestPractice Norge. 109, s. 202–209. doi: 10.1016/j.neuint.2017.02.007.
• Høyer, Helle; Tveten, Kristian; Røsby, Oddveig; Hilmarsen, Hilde T; Busk, Øyvind & Svendsen, Marit [Vis alle 12 forfattere av denne artikkelen] (2018). A novel AARS variant identified in three CMT2 families.
• Alsøe, Lene; Wennerström, Anna Berit; Liu, Yan; Esbensen, Qin Ying; Bjørset, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2018). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
• Alsøe, Lene; Sarno, Antonio; Carracedo Huroz, Sergio; Domanska, Diana Ewa; Dingler, Felix & Lirussi, Lisa [Vis alle 16 forfattere av denne artikkelen] (2017). Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1 .
• Alsøe, Lene; Wennerstrøm, Anna; Liu, Yan; Esbensen, Qin Ying; Bjørseth, Randi & Penz, Christine [Vis alle 10 forfattere av denne artikkelen] (2017). Do APOBEC proteins contribute to genomic instability in colitis-associated colorectal cancer? .
• Sarno, Antonio; Alsøe, Lene; Carracedo, Sergio; Tekin, Nuriya Basdag; Gupta, Tanima Sen & Jobert, Laure [Vis alle 9 forfattere av denne artikkelen] (2016). UNG and SMUG1 complement each other in DNA uracil excision and DNA 5-hydroxymethyluracil originates from 5-hydroxymethylcytosine deamination in mice.
• Nilsen, Hilde; Kroustallaki, Pinelopi; Alsøe, Lene; Huroz, Sergio C; Sarno, Antonio & Esbensen, Ying [Vis alle 11 forfattere av denne artikkelen] (2016). Telomere maintenance defects in mice deficient in SMUG1 uracil-DNA glycosylase.
• Wyller, Vegard Bruun; Jacobsen, Kristine; Dahl, Mai Britt; Nilsen, Hilde; Proske, Simone & Horter, Thorsten [Vis alle 7 forfattere av denne artikkelen] (2016). Interferon gamma may improve cardiac function in Friedreich's ataxia cardiomyopathy. International Journal of Cardiology. ISSN 0167-5273. 221, s. 376–378. doi: 10.1016/j.ijcard.2016.06.288.
• Nilsen, Hilde (2013). Kan denne ormen avsløre at vitaminbruk er bortkastet. Aftenposten Innsikt. ISSN 1890-6931.
• Nilsen, Hilde & Nickelsen, Trine (2013). Vitaminpiller kan skade kroppens eget forsvar. Apollon : Forskningsmagasin for Universitetet i Oslo. ISSN 0803-6926.
• Nilsen, Hilde (2012). Liten orm gir mer effektiv kreftmedisin. Forskning.no. ISSN 1891-635X.
• Nilsen, Hilde (2010). Om forsknings arbeider i Bioteknologisenteret. [TV]. NRK Østlandssendningen.
• Nilsen, Hilde (2010). Liten orm hjelper oss til bedre liv. [Avis]. Aftenposten.
• Nilsen, Hilde (2010). Liten orm avslører våre aldringsprosesser. [Avis]. Apollon.
• Nilsen, Hilde (2010). DNA repair dependent signalling of cell death responses to 5-Fluorouracil.
• Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
• Nilsen, Hilde (2010). A two-tiered compensatory response to loss of DNA repair modulated aging and stress-response pathways.
• Fensgård, Øyvind & Nilsen, Hilde (2010). DNA skader aldringsprosessen. NBS-nytt. ISSN 0801-3535. s. 9–13.
• Fensgård, Øyvind; Lindvall, Jessica Margareta; Kassahun, Henok; Rognes, Torbjørn & Nilsen, Hilde (2009). Microarray analysis of BER mutants.
• Nilsen, Hilde (2009). Uracil DNA glycosylase is required for apoptosis in response to 5-fluorouracil in C. elegans.
• Fensgård, Øyvind & Nilsen, Hilde (2010). Global Genome Responses to DNA-Repair Deficiency Modulate Aging and Stress Response Pathways. Unipud. ISSN 978-82-8264-118-0.

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