Ivar Anders Eide

• Chan, Wai Joe; Svensson, My Hanna Sofia; Tannæs, Tone Møller; Waldum-Grevbo, Bård; Jenssen, Trond Geir & Eide, Ivar Anders (2022). Associations of Serum Uromodulin and Urinary Epidermal Growth Factor with Measured Glomerular Filtration Rate and Interstitial Fibrosis in Kidney Transplantation. American Journal of Nephrology. ISSN 0250-8095. 53(2-3), p. 108–117. doi: 10.1159/000521757. Full text in Research Archive Show summary

  Introduction: Noninvasive biomarkers that reflect tubular health and allow early recognition of accelerated graft fibrosis development are warranted. Serum uromodulin (sUmod) and urinary epidermal growth factor (uEGF) originate from kidney tubules and may reflect functional nephron mass. The aim of this study was to investigate the associations between sUmod and uEGF with measured glomerular filtration rate (mGFR) and kidney allograft interstitial fibrosis percentage (IF%) score. Methods: sUmod and uEGF measurements, mGFR by iohexol-clearance and kidney allograft biopsies were obtained from kidney transplant recipients (KTRs) included in the Omega-3 fatty acids in Renal Transplantation (ORENTRA) trial at 8 weeks (baseline) and at 1 year after transplantation (end of study). Associations were analyzed with univariable and multivariable linear regression. Results: Ninety patients at baseline and 48 patients at end of study had complete study variable assessments. uEGF normalized to urinary creatinine (uEGF/Cr) was associated with mGFR both at baseline (standardized β-coefficient [Std. β-coeff] = 0.457 [p = <0.001]) and at end of study (Std. β-coeff = 0.637 [p = <0.001]). sUmod was only associated with mGFR at end of study (Std. β-coeff = 0.443 [p = 0.002]). uEGF/Cr, sUmod, and mGFR were associated with graft IF% score both at baseline (Std. β-coeff = −0.349 [p = 0.001], −0.274 [p = 0.009] and −0.289 [p = 0.006], respectively) and at end of study (Std. β-coeff = −0.365 [p = 0.011], −0.347 [p = 0.016] and −0.405 [p = 0.004], respectively). The results remained largely unchanged in multivariable analysis. Conclusion: uEGF/Cr and sUmod were associated with mGFR and graft IF% score. Our results indicate a possible role of uEGF/Cr and sUmod in the follow-up of KTRs.

• Chan, Joe; Eide, Ivar A.; Tannæs, Tone Møller; Waldum-Grevbo, Bård; Jenssen, Trond & Svensson, My Hanna Sofia (2021). Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial. Kidney Medicine. 3(6), p. 1041–1049. doi: 10.1016/j.xkme.2021.07.010. Full text in Research Archive
• Jørgensen, Hanne Skou; Eide, Ivar Anders; Jenssen, Trond; Åsberg, Anders; Bollerslev, Jens & Godang, Kristin [Show all 9 contributors for this article] (2021). Marine n-3 polyunsaturated fatty acids and bone mineral density in kidney transplant recipients: A randomized, placebo-controlled trial. Nutrients. ISSN 2072-6643. 13(7). doi: 10.3390/nu13072361. Full text in Research Archive
• Chan, Wai Joe; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Schmidt, Erik B. & Eide, Ivar Anders (2020). Marine n-3 fatty acid consumption in a Norwegian renal transplant cohort: Comparison of a food frequency questionnaire with plasma phospholipid marine n-3 levels. PLOS ONE. ISSN 1932-6203. 15:e0244089(12), p. 1–14. doi: 10.1371/journal.pone.0244089. Full text in Research Archive
• Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca & Hammarström, Clara Louise [Show all 15 contributors for this article] (2020). Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLOS ONE. ISSN 1932-6203. 15:e0243759(12), p. 1–14. doi: 10.1371/journal.pone.0243759. Full text in Research Archive
• Chandra, Anupam; Røsjø, Helge; Svensson, My Hanna Sofia; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 14 contributors for this article] (2020). Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study. European Journal of Clinical Nutrition. ISSN 0954-3007. doi: 10.1038/s41430-020-0641-4. Full text in Research Archive
• Chandra, Anupam; Lyngbakken, Magnus; Eide, Ivar Anders; Røsjø, Helge; Vigen, Thea & Ihle-Hansen, Håkon [Show all 13 contributors for this article] (2020). Plasma trans fatty acid levels, cardiovascular risk factors and lifestyle: Results from the Akershus cardiac examination 1950 study. Nutrients. ISSN 2072-6643. 12(5). doi: 10.3390/nu12051419. Full text in Research Archive
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 13 contributors for this article] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02007-3.
• Lilleberg, Hanne Sether; Cichosz, Simon Lebech; Svensson, My Hanna Sofia; Christensen, Jeppe Hagstrup; Fleischer, Jesper & Eide, Ivar Anders [Show all 7 contributors for this article] (2019). The effect of marine n-3 polyunsaturated fatty acids on heart rate variability in renal transplant recipients: A randomized controlled trial. Nutrients. ISSN 2072-6643. 11:2847(12), p. 1–11. doi: 10.3390/nu11122847. Full text in Research Archive
• Chandra, Anupam; Midtvedt, Karsten; Åsberg, Anders & Eide, Ivar Anders (2019). Immunosuppression and Reproductive Health After Kidney Transplantation. Transplantation. ISSN 0041-1337. 103(11). doi: 10.1097/TP.0000000000002903.
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 13 contributors for this article] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. p. 1–11. doi: 10.1007/s00394-019-02007-3. Full text in Research Archive
• Eide, Ivar Anders; Rashidi, Forough; Lønning, Kjersti; Oldereid, Nan Birgitte; Reisæter, Anna Varberg & Åsberg, Anders [Show all 7 contributors for this article] (2019). Contraceptive Choices and Counseling in Norwegian Female Renal Transplant Recipients. Transplantation Proceedings. ISSN 0041-1345. 51(2), p. 470–474. doi: 10.1016/j.transproceed.2019.01.068.
• Eide, Ivar Anders; Reinholt, Finn P.; Jenssen, Trond Geir; Hartmann, Anders; Schmidt, Erik B. & Åsberg, Anders [Show all 9 contributors for this article] (2019). Effects of marine n-3 fatty acid supplementation in renal transplantation: A randomized controlled trial. American Journal of Transplantation. ISSN 1600-6135. 19, p. 790–800. doi: 10.1111/ajt.15080.
• Lilleberg, Hanne Sether; Eide, Ivar Anders; Geitung, Jonn Terje & Svensson, My Hanna Sofia (2018). Akutt glomerulonefritt utløst av parvovirus B19. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(17), p. 1–3. doi: 10.4045/tidsskr.18.0043.
• Chandra, Anupam; Svensson, My Hanna Sofia; Åsberg, Anders; Schmidt, Erik Berg; Bjerve, Kristian S & Jenssen, Trond Geir [Show all 9 contributors for this article] (2018). Trans-fatty acids and survival in renal transplantation. Journal of renal nutrition. ISSN 1051-2276. 29(3), p. 169–180. doi: 10.1053/j.jrn.2018.08.003. Full text in Research Archive
• Skaare, Helga; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Åsberg, Anders; Schmidt, Erik Berg & Chandra, Anupam [Show all 10 contributors for this article] (2018). Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation. Journal of renal nutrition. ISSN 1051-2276. 28(5), p. 333–339. doi: 10.1053/j.jrn.2018.02.008. Full text in Research Archive
• Eide, Ivar Anders; Dörje, Christina; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Hammarström, Clara Louise & Scott, Helge [Show all 13 contributors for this article] (2018). Development of Kidney Transplant Fibrosis Is Inversely Associated With Plasma Marine Fatty Acid Level. Journal of renal nutrition. ISSN 1051-2276. 28(2), p. 118–124. doi: 10.1053/j.jrn.2017.09.001.
• Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders & Jenssen, Trond Geir [Show all 8 contributors for this article] (2017). Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients. Progress in transplantation. ISSN 1526-9248. 27(4), p. 386–391. doi: 10.1177/1526924817732020. Full text in Research Archive
• Pihlstrøm, Hege; Gatti, Francesca; Hammarström, Clara Louise; Eide, Ivar Anders; Kasprzycka, Monika & Wang, Junbai [Show all 13 contributors for this article] (2017). Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study. Transplant International. ISSN 0934-0874. 30(8), p. 827–840. doi: 10.1111/tri.12973.
• Eide, Ivar Anders; Strøm Halden, Thea Anine; Hartmann, Anders; Dahle, Dag Olav; Åsberg, Anders & Jenssen, Trond Geir (2017). Associations Between Posttransplantation Diabetes Mellitus and Renal Graft Survival. Transplantation. ISSN 0041-1337. 101(6), p. 1282–1289. doi: 10.1097/TP.0000000000001259. Show summary

  BACKGROUND: Previous reports indicate that posttransplantation diabetes mellitus (PTDM) is associated with overall renal graft loss, but not death-censored graft loss. METHODS: In this single-center retrospective cohort study of 2749 adult Norwegian renal transplant recipients, transplanted between 1999 and 2011, we estimated overall and death-censored renal graft loss hazard ratios in patients diagnosed with PTDM, impaired glucose tolerance and diabetes before transplantation, using multivariable Cox proportional hazard regression analysis. RESULTS: A total of 893 renal grafts were lost during the study period, either due to recipient death (n = 540) or death-censored graft loss (n = 353). When the observational time started at time of transplantation, diabetes before transplantation was associated with both overall and death-censored graft loss. Pretransplantation diabetes was also associated with a steeper decline in renal graft function, a higher risk of acute rejections and more renal grafts lost due to acute rejection. In patients with a functional renal graft 1 year after transplantation, PTDM was associated with overall graft loss (hazard ratio, 1.46; 95% confidence interval, 1.13-1.88; P < 0.001), but not death-censored graft loss (hazard ratio, 1.25; 95% confidence interval, 0.80-1.96; P = 0.33). We found no significant associations between PTDM and change in renal function during the first 5 years or acute rejection risk during the first year after renal transplantation. Impaired glucose tolerance was not associated with either overall or death-censored graft loss. CONCLUSIONS: The present study confirms previous findings of an increased risk of overall but not death-censored renal graft loss in renal transplant recipients with PTDM. Longstanding diabetes might increase the risk of acute rejections.

• Eide, Ivar Anders; Åsberg, Anders; Svensson, My Hanna Sofia; Ueland, Thor; Mollnes, Tom Eirik & Hartmann, Anders [Show all 12 contributors for this article] (2017). Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Journal of renal nutrition. ISSN 1051-2276. 27(3), p. 161–168. doi: 10.1053/j.jrn.2016.09.008. Show summary

  OBJECTIVE: Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential anti-inflammatory effects and might improve long-term outcomes after renal transplantation. We assessed associations between plasma phospholipid levels of marine n-3 PUFAs and plasma inflammatory biomarkers 10 weeks after renal transplantation. DESIGN: Cross-sectional single-center study. SUBJECTS: A study population of 861 renal transplant recipients transplanted at Oslo University Hospital between 2007 and 2011. METHODS AND MAIN OUTCOME MEASURE: Plasma phospholipid fatty acids were determined by gas chromatography. Marine n-3 PUFA levels were defined as the sum of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid levels in weight percentage of total plasma phospholipid fatty acids. Plasma inflammatory biomarkers were measured by enzyme immunoassays. We used multivariable linear regression analysis to assess associations between levels of marine n-3 PUFAs and inflammatory biomarkers in plasma. RESULTS: Plasma marine n-3 PUFA levels were inversely associated with plasma levels of proinflammatory biomarkers soluble tumor necrosis factor receptor 1 (standardized regression coefficient -0.11, P < .001) and interleukin-6 (standardized regression coefficient -0.09, P = .01). In contrast, there was no association between plasma levels of marine n-3 PUFAs and the anti-inflammatory mediator interleukin-10. CONCLUSIONS: In this renal transplant cohort, inverse associations between plasma levels of marine n-3 PUFAs and markers of inflammation were demonstrated.

• Eide, Ivar Anders; Dahle, Dag Olav; Svensson, My Hanna Sofia; Hartmann, Anders; Åsberg, Anders & Bjerve, Kristian S [Show all 11 contributors for this article] (2016). Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients. European Journal of Clinical Nutrition. ISSN 0954-3007. 70(7), p. 824–830. doi: 10.1038/ejcn.2016.14.
• Eide, Ivar Anders; Strøm Halden, Thea Anine; Hartmann, Anders; Åsberg, Anders; Dahle, Dag Olav & Reisæter, Anna Varberg [Show all 7 contributors for this article] (2016). Mortality risk in post-transplantation diabetes mellitus based on glucose and HbA1c diagnostic criteria. Transplant International. ISSN 0934-0874. 29(5), p. 568–578. doi: 10.1111/tri.12757.
• Jørgensen, Hanne Skou; Eide, Ivar Anders; Hartmann, Anders; Åsberg, Anders; Christensen, Jeppe H. & Schmidt, Erik B. [Show all 9 contributors for this article] (2016). Plasma n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Renal Transplant Recipients. Journal of renal nutrition. ISSN 1051-2276. 26(3), p. 196–203. doi: 10.1053/j.jrn.2015.11.007.
• Eide, Ivar Anders; Jenssen, Trond Geir; Hartmann, Anders; Diep, Lien My; Dahle, Dag Olav & Reisæter, Anna Varberg [Show all 10 contributors for this article] (2016). Plasma levels of marine n-3 polyunsaturated fatty acids and renal allograft survival. Nephrology, Dialysis and Transplantation. ISSN 0931-0509. 31(1), p. 160–167. doi: 10.1093/ndt/gfv339.
• Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin & Eide, Ivar Anders [Show all 8 contributors for this article] (2015). Visceral fat is better related to impaired glucose metabolism than body mass index after kidney transplantation. Transplant International. ISSN 0934-0874. 28(10), p. 1162–1171. doi: 10.1111/tri.12606.
• Dahle, Dag Olav; Eide, Ivar Anders; Åsberg, Anders; Leivestad, Torbjørn; Holdaas, Hallvard & Jenssen, Trond Geir [Show all 10 contributors for this article] (2015). Aortic stiffness in a mortality risk calculator for kidney transplant recipients. Transplantation. ISSN 0041-1337. 99(8), p. 1730–1737. doi: 10.1097/TP.0000000000000660.
• Eide, Ivar Anders; Jenssen, Trond Geir; Hartmann, Anders; Diep, Lien My; Dahle, Dag Olav & Reisæter, Anna Varberg [Show all 10 contributors for this article] (2015). The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation. American Society of Nephrology. Clinical Journal. ISSN 1555-9041. 10(7), p. 1246–1256. doi: 10.2215/CJN.11931214.
• Eide, Ivar Anders; Strøm Halden, Thea Anine; Hartmann, Anders; Åsberg, Anders; Dahle, Dag Olav & Reisæter, Anna Varberg [Show all 7 contributors for this article] (2015). Limitations of hemoglobin A1c for the diagnosis of posttransplant diabetes mellitus. Transplantation. ISSN 0041-1337. 99(3), p. 629–635. doi: 10.1097/TP.0000000000000376.
• Lindahl, Jørn Petter Hanto; Reinholt, Finn P.; Eide, Ivar Anders; Hartmann, Anders; Midtvedt, Karsten & Holdaas, Hallvard [Show all 13 contributors for this article] (2014). In patients with type 1 diabetes simultaneous pancreas and kidney transplantation preserves long-term kidney graft ultrastructure and function better than transplantation of kidney alone. Diabetologia. ISSN 0012-186X. doi: 10.1007/s00125-014-3353-2.
• Dahle, Dag Olav; Jenssen, Trond Geir; Holdaas, Hallvard; Åsberg, Anders; Soveri, Inga & Holme, Ingar Morten K [Show all 12 contributors for this article] (2014). Uric acid and clinical correlates of endothelial function in kidney transplant recipients. Clinical Transplantation. ISSN 0902-0063. 28(10), p. 1167–1176. doi: 10.1111/ctr.12435.

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• Robertsen, Ida; Åsberg, Anders; Jenssen, Trond Geir; Gence, Berfin; Vethe, Nils Tore & Midtvedt, Karsten [Show all 8 contributors for this article] (2021). Increased systemic exposure of once-daily tacrolimus in renal transplant recipients on marine omega-3 fatty acid supplementation. Transplant International. ISSN 0934-0874. doi: 10.1111/tri.13917.
• Chandra, Anupam; Midtvedt, Karsten; Åsberg, Anders & Eide, Ivar Anders (2020). The Authors’ Reply: Placental Pathology in Pregnancies After Kidney Transplantation. Transplantation. ISSN 0041-1337. 104(7), p. e216–e216. doi: 10.1097/TP.0000000000003120.
• Egeland, Erlend Johannessen; Hermann, Monica; Eide, Ivar Anders & Åsberg, Anders (2016). Høy takrolimus-konsentrasjon hos nyretransplanterte- en risikofaktor for akutt rejeksjon.
• Eide, Ivar Anders; Strøm Halden, Thea Anine & Jenssen, Trond Geir (2015). The authors' reply: HbA1c is insensitive at month 3 after kidney transplantation. Transplantation. ISSN 0041-1337. 99(5). doi: 10.1097/TP.0000000000000684.

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