Jan-Erik Berdal

• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Olsen, Inge Christoffer; Rueegg, Corina Silvia; Rangberg, Anbjørg; Jonassen, Christine M; Omland, Torbjørn; Røsjø, Helge & Dalgard, Olav (2020). A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics. Nature Communications.  ISSN 2041-1723.  11:5284, s 1- 6 . doi: 10.1038/s41467-020-19056-6 Full text in Research Archive.
• Myhre, Peder Langeland; Prebensen, Christian; Strand, Heidi; Røysland, Ragnhild; Jonassen, Christine M.; Rangberg, Anbjørg; Sørensen, Vibecke; Søvik, Signe; Røsjø, Helge; Svensson, My Hanna Sofia; Berdal, Jan Erik & Omland, Torbjørn (2020). Growth Differentiation Factor-15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized with COVID-19. Circulation.  ISSN 0009-7322. . doi: 10.1161/CIRCULATIONAHA.120.050360
• Omland, Torbjørn; Prebensen, Christian; Røysland, Ragnhild; Søvik, Signe; Sørensen, Vibecke; Røsjø, Helge; Svensson, My Hanna Sofia; Berdal, Jan Erik & Myhre, Peder Langeland (2020). Established Cardiovascular Biomarkers Provide Limited Prognostic Information in Unselected Patients Hospitalized with COVID-19. Circulation.  ISSN 0009-7322.  19, s 1878- 1880 . doi: 10.1161/CIRCULATIONAHA.120.050089
• Prebensen, Christian; Myhre, Peder Langeland; Jonassen, Christine M; Rangberg, Anbjørg; Blomfeldt, Anita; Svensson, My Hanna Sofia; Omland, Torbjørn & Berdal, Jan Erik (2020). Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Plasma Is Associated With Intensive Care Unit Admission and Mortality in Patients Hospitalized With Coronavirus Disease 2019. Clinical Infectious Diseases.  ISSN 1058-4838. . doi: 10.1093/cid/ciaa1338
• Søvik, Signe; Bådstøløkken, Per Martin; Sørensen, Vibecke; Myhre, Peder Langeland; Prebensen, Christian; Omland, Torbjørn & Berdal, Jan Erik (2020). A single‐centre, prospective cohort study of COVID‐19 patients admitted to ICU for mechanical ventilatory support. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172. . doi: 10.1111/aas.13726 Full text in Research Archive.
• Berdal, Jan Erik; Follin-Arbelet, Benoit & Bjørnholt, Jørgen Vildershøj (2019). Experiences from multiplex PCR diagnostics of faeces in hospitalised patients: Clinical significance of Enteropathogenic Escherichia coli (EPEC) and culture negative campylobacter. BMC Infectious Diseases.  ISSN 1471-2334.  19(1) . doi: 10.1186/s12879-019-4271-1 Full text in Research Archive.
• Hesstvedt, Liv; Gaustad, Peter; Müller, Fredrik; Andersen, Cecilie Torp; Brunborg, Cathrine; Mylvaganam, Haima; Leiva, Rafael Alexander Mo; Berdal, Jan Erik; Ranheim, Trond Egil; Johnsen, Bjørn Odd; Falch, Birgit Margrethe; Grimnes, Gro; Skogen, Vegard; Haarr, Elisebet; Lyngøy, Anita Sandmo; Larssen, Kjersti Wik; Hannula, Raisa; Hansen, Bjørn Åsheim & Nordøy, Ingvild (2019). The impact of age on risk assessment, therapeutic practice and outcome in candidemia. Infectious Diseases.  ISSN 2374-4235.  51(6), s 425- 434 . doi: 10.1080/23744235.2019.1595709
• Albotins, Craig A.; Berdal, Jan Erik; Cascas, Fransisco; Corona, Pablo S.; Cuellar, Daniel; Ferrari, Matteo Carlo; Hendershot, Edward; Huang, Wei; Kuo, Feng-Chih; Malkani, Arthur; Reyes, Francisco; Rudelli, Sergio; Safir, Oleg; Seyler, Thorsten & Tan, Timothy L. (2018). Hip and Knee Section, Prevention, Antimicrobials (Systemic): Proceedings of International Consensus on Orthopedic Infections. Journal of Arthroplasty.  ISSN 0883-5403.  34(2), s S279- S288 . doi: 10.1016/j.arth.2018.09.012
• Morland, Mona; Haagensen, Rolf E; Dahl, Fredrik Andreas & Berdal, Jan Erik (2018). Epidemiologi og prognoser i en medisinsk overvåkningsavdeling. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  138(8), s 734- 739 . doi: 10.4045/tidsskr.17.0496
• Mohn, Kristin Greve Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M & Mjaaland, Siri (2015). Immune responses in acute and convalescent patients with mild, moderate and severe disease during the 2009 influenza pandemic in Norway. PLOS ONE.  ISSN 1932-6203.  10:e0143281(11) . doi: 10.1371/journal.pone.0143281 Full text in Research Archive. Show summary

  Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during the 2009 influenza pandemic and characterized humoral and cellular immune responses. Those included were either acute hospitalized or convalescent patients with different disease severities (mild, moderate or severe). In general, protective antibody responses increased with enhanced disease severity. In the acute patients, we found higher levels of TNF-α single-producing CD4+T-cells in the severely ill as compared to patients with moderate disease. Stimulation of peripheral blood mononuclear cells (PBMC) from a subset of acute patients with peptide T-cell epitopes showed significantly lower frequencies of influenza specific CD8+ compared with CD4+ IFN-γ T-cells in acute patients. Both T-cell subsets were predominantly directed against the envelope antigens (HA and NA). However, in the convalescent patients we found high levels of both CD4+ and CD8+ T-cells directed against conserved core antigens (NP, PA, PB, and M). The results indicate that the antigen targets recognized by the T-cell subsets may vary according to the phase of infection. The apparent low levels of cross-reactive CD8+ T-cells cells recognizing internal antigens in acute hospitalized patients suggest an important role for this T-cell subset in protective immunity against influenza. I

• Berdal, Jan Erik; Haagensen, Rolf E; Ranheim, Trond Egil & Bjørnholt, Jørgen (2014). Nosocomial candidemia; risk factors and prognosis revisited; 11 years experience from a Norwegian secondary hospital. PLOS ONE.  ISSN 1932-6203.  9(7) . doi: 10.1371/journal.pone.0103916 Full text in Research Archive.
• Berdal, Jan Erik; Mollnes, Tom Eirik; Wæhre, Torgun; Olstad, Ole Kristoffer; Halvorsen, Bente; Ueland, Thor; Laake, Jon Henrik; Furuseth, May T; Maagaard, Anne; Kjekshus, Harald; Aukrust, Pål & Jonassen, Christine M (2011). Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza. Journal of Infection.  ISSN 0163-4453.  63(4), s 308- 316 . doi: 10.1016/j.jinf.2011.07.004
• Berdal, Jan Erik; Stavem, Knut; Omland, Torbjørn; Hall, Christian & Smith, Erichsen Nils (2008). Prognostic merit of N-terminal-proBNP and N-terminal-proANP in mechanically ventilated critically ill patients. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  52, s 1265- 1272 . doi: 10.111/j.1399-6576.2008.01737.x
• Berdal, Jan Erik; Bjørnholt, Jørgen; Blomfeldt, Anita; Smith, Erichsen Nils & Bukholm, Geir (2007). Patterns and dynamics of airway colonisation in mechanically-ventilated patients. Clinical Microbiology and Infection (CMI).  ISSN 1198-743X.  13 . doi: 10.1111/j.1469-0691.2006.01678.x
• Berdal, Jan Erik; Smith, Erichsen Nils; Bjørnholt, Jørgen; Blomfeldt, Anita & Bukholm, Geir (2006). Does Pseudomonas aeruginosa colonization influence morbidity and mortality in the intensive care unit patient? Experience from an outbreak caused by contaminated oral swabs. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  50, s 1095- 1102
• Berdal, Jan Erik; Skråmm, Inge; Mowinckel, P.; Gulbrandsen, Pål & Bjørnholt, Jørgen (2005). Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections. Clinical Microbiology and Infection (CMI).  ISSN 1198-743X.  11, s 843- 845
• Simonsen, GS; Berdal, Jan Erik; Sundsfjord, A & Berild, D (2004). Simplified and not exact about antibiotics. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  124(18), s 2397
• Berdal, Jan Erik & Steinbakk, Martin (2003). Long-term antibiotic suppressive therapy for an infected thoracic aorta graft. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  (16), s 2260- 2262

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• Myhre, Peder L.; Prebensen, Christian; Jonassen, Christine Monceyron; Berdal, Jan Erik & Omland, Torbjørn (2021). Sars-cov-2 viremia is associated with inflammatory, but not cardiovascular biomarkers, in patients hospitalized for covid-19. Journal of the American Heart Association (JAHA).  ISSN 2047-9980.  10(9), s 1- 5 . doi: 10.1161/JAHA.120.019756
• Berdal, Jan Erik (2020). Management of Extracranial infections, In Terje Sundstrøm; Per-Olof Grände; Teemu Luoto; Christina Rosenlund; Johan Undén & Knut Gustav Wester (ed.),  Management of Severe Traumatic Brain Injury Evidence, Tricks, and Pitfalls.  Springer.  ISBN 978-3-030-39383-0.  Kapittel 67.  s 485 - 491
• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Inge Christoffer, Olsen; Rangberg, Anbjørg; Jonassen, Christine M.; Omland, Torbjørn; Røsjø, Helge & Dalgard, Olav (2020). Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial. Trials.  ISSN 1745-6215.  21 . doi: 10.1186/s13063-020-04420-0
• Berdal, Jan Erik (2017). Infeksjonmedisin. Klinisk undersøkelse og utredning, I:  Indremedisin I & II.  Forlag Vett & Viten.  ISBN 9788241207402.  38.  s 15 - 23
• Berdal, Jan Erik; Bukholm, Geir; Jonassen, Christine M & Müller, Fredrik (2012). Airway colonization pathogenesis and prognosis in mechanically ventilated patients. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 1323.

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