Jan Erik Berdal

• Mohn, Kristin Greve Isdahl; Cox, Rebecca Jane; Tunheim, Gro; Berdal, Jan Erik; Hauge, Anna G; Jul-Larsen, Åsne; Peters, Bjørn; Oftung, Fredrik; Jonassen, Christine M & Mjaaland, Siri (2015). Immune responses in acute and convalescent patients with mild, moderate and severe disease during the 2009 influenza pandemic in Norway. PLoS ONE.  ISSN 1932-6203.  10:e0143281(11) . doi: 10.1371/journal.pone.0143281 Full text in Research Archive. Show summary

  Increased understanding of immune responses influencing clinical severity during pandemic influenza infection is important for improved treatment and vaccine development. In this study we recruited 46 adult patients during the 2009 influenza pandemic and characterized humoral and cellular immune responses. Those included were either acute hospitalized or convalescent patients with different disease severities (mild, moderate or severe). In general, protective antibody responses increased with enhanced disease severity. In the acute patients, we found higher levels of TNF-α single-producing CD4+T-cells in the severely ill as compared to patients with moderate disease. Stimulation of peripheral blood mononuclear cells (PBMC) from a subset of acute patients with peptide T-cell epitopes showed significantly lower frequencies of influenza specific CD8+ compared with CD4+ IFN-γ T-cells in acute patients. Both T-cell subsets were predominantly directed against the envelope antigens (HA and NA). However, in the convalescent patients we found high levels of both CD4+ and CD8+ T-cells directed against conserved core antigens (NP, PA, PB, and M). The results indicate that the antigen targets recognized by the T-cell subsets may vary according to the phase of infection. The apparent low levels of cross-reactive CD8+ T-cells cells recognizing internal antigens in acute hospitalized patients suggest an important role for this T-cell subset in protective immunity against influenza. I

• Berdal, Jan Erik; Haagensen, Rolf E; Ranheim, Trond Egil & Bjørnholt, Jørgen (2014). Nosocomial candidemia; risk factors and prognosis revisited; 11 years experience from a Norwegian secondary hospital. PLoS ONE.  ISSN 1932-6203.  9(7) . doi: 10.1371/journal.pone.0103916 Full text in Research Archive.
• Berdal, Jan Erik; Mollnes, Tom Eirik; Wæhre, Torgun; Olstad, Ole Kristoffer; Halvorsen, Bente; Ueland, Thor; Laake, Jon Henrik; Furuseth, May T; Maagaard, Anne; Kjekshus, Harald; Aukrust, Pål & Jonassen, Christine M (2011). Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza. Journal of Infection.  ISSN 0163-4453.  63(4), s 308- 316 . doi: 10.1016/j.jinf.2011.07.004
• Berdal, Jan Erik; Stavem, Knut; Omland, Torbjørn; Hall, Christian & Smith, Erichsen Nils (2008). Prognostic merit of N-terminal-proBNP and N-terminal-proANP in mechanically ventilated critically ill patients. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  52, s 1265- 1272 . doi: 10.111/j.1399-6576.2008.01737.x
• Berdal, Jan Erik; Bjørnholt, Jørgen; Blomfeldt, Anita; Smith, Erichsen Nils & Bukholm, Geir (2007). Patterns and dynamics of airway colonisation in mechanically-ventilated patients. Clinical Microbiology and Infection.  ISSN 1198-743X.  13 . doi: 10.1111/j.1469-0691.2006.01678.x
• Berdal, Jan Erik; Smith, Erichsen Nils; Bjørnholt, Jørgen; Blomfeldt, Anita & Bukholm, Geir (2006). Does Pseudomonas aeruginosa colonization influence morbidity and mortality in the intensive care unit patient? Experience from an outbreak caused by contaminated oral swabs. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  50, s 1095- 1102
• Berdal, Jan Erik; Skråmm, Inge; Mowinckel, P.; Gulbrandsen, Pål & Bjørnholt, Jørgen (2005). Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections. Clinical Microbiology and Infection.  ISSN 1198-743X.  11, s 843- 845
• Simonsen, GS; Berdal, Jan Erik; Sundsfjord, A & Berild, D (2004). Simplified and not exact about antibiotics. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  124(18), s 2397
• Berdal, Jan Erik & Steinbakk, Martin (2003). Long-term antibiotic suppressive therapy for an infected thoracic aorta graft. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  (16), s 2260- 2262

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• Berdal, Jan Erik; Bukholm, Geir; Jonassen, Christine M & Müller, Fredrik (2012). Airway colonization pathogenesis and prognosis in mechanically ventilated patients. Series of dissertations submitted to the Faculty of Medicine, University of Oslo. 1323.

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