Jens Pahnke

Image of Jens Pahnke
Norwegian version of this page
Phone +47 23071466
Mobile phone +4747804637 +49 176 4560 9359
Room A2.M046
Visiting address Sognsvannsveien 20 Rikshospitalet Department of Pathology (PAT) 0372 Oslo
Postal address Postboks 4950 Nydalen 0424 OSLO

Pahnke Lab

Read more about my research, publications, CV, funding and more on my external pages

Scandinavian Neuropathological Society (SNS)

Read more on the SNS external pages


Tags:, ABC transporter, Alzheimer's disease, Pahnke, neurodegeneration, Parkinson's disease, mitochondria, Ageing, St.John's wort, Sideritis scardica, Huntington's disease, MRI, MRS, neuropathology, blood-brain barrier, mouse models, JPND, EU, treatment


  • Abelein, Axel; Chen, Gefei; Kitoka, Kristine; Alexis, Rihards; Oleskovs, Filips; Sarr, Médoune; Landreh, Michael; Pahnke, Jens; Nordling, Kerstin; Kronqvist, Nina; Jaudzems, Kristaps; Rising, Anna; Johansson, Jan & Biverstål, Henrik (2020). High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain. Scientific Reports.  ISSN 2045-2322.  10:235(1), s 1- 10 . doi: 10.1038/s41598-019-57143-x
  • Bascuñana, Pablo; Möhle, Luisa; Brackhan, Mirjam & Pahnke, Jens (2020). Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis. Drugs in R&D.  ISSN 1174-5886. . doi: 10.1007/s40268-020-00316-1
  • Borovkova, Mariia; Bykov, Alexander; Popov, Alexey; Pierangelo, Angelo; Novikova, Tatiana; Pahnke, Jens & Meglinski, Igor (2020). Evaluating β-amyloidosis progression in Alzheimer's disease with Mueller polarimetry. Biomedical Optics Express.  ISSN 2156-7085.  11(8), s 4509- 4519 . doi: 10.1364/BOE.396294
  • Borovkova, Mariia; Bykov, Alexander; Popov, Alexey; Pierangelo, Angelo; Novikova, Tatiana; Pahnke, Jens & Meglinski, Igor (2020). The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease. Proceedings of SPIE, the International Society for Optical Engineering.  ISSN 0277-786X.  11234:112340M, s 1- 6
  • Kolnes, Anders Jensen; Øystese, Kristin Astrid; Dahlberg, Daniel; Berg-Johnsen, Jon; Niehusmann, Pitt; Pahnke, Jens; Bollerslev, Jens & Jørgensen, Anders Palmstrøm (2020). Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma. Acta Neurochirurgica.  ISSN 0001-6268.  162(4), s 845- 852 . doi: 10.1007/s00701-019-04068-z
  • Möhle, Luisa; Schwarzová, Barbora; Krohn, Markus; Stefan, Sven Marcel & Pahnke, Jens (2020). Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol. Journal of pharmacological and toxicological methods.  ISSN 1056-8719.  104:106882, s 1- 11 . doi: 10.1016/j.vascn.2020.106882
  • Rai, Surya Prakash; Bascuñana, Pablo; Brackhan, Mirjam; Krohn, Markus; Möhle, Luisa; Paarmann, Kristin & Pahnke, Jens (2020). Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice. Journal of Alzheimer's Disease.  ISSN 1387-2877. . doi: 10.3233/JAD-200675
  • Rai, Surya Prakash; Krohn, Markus & Pahnke, Jens (2020). Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice. Journal of Alzheimer's Disease.  ISSN 1387-2877.  75(4), s 1301- 1317 . doi: 10.3233/JAD-200161
  • Zoufal, Viktoria; Mairinger, Severin; Brackhan, Mirjam; Krohn, Markus; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Wanek, Thomas; Tournier, Nicolas; Bauer, Martin; Pahnke, Jens & Langer, Oliver (2020). Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11 C-Metoclopramide PET. Journal of Nuclear Medicine.  ISSN 0161-5505.  61(7), s 1050- 1057 . doi: 10.2967/jnumed.119.237198
  • Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver & Pahnke, Jens (2019). Generation and characterization of an ABCC1 humanized mouse model (hABCC1(flx/flx) with knockout capability. Molecular Pharmacology.  ISSN 0026-895X.  96(2), s 138- 147 . doi: 10.1124/mol.119.115824 Full text in Research Archive.
  • Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar O.; Pahnke, Jens; Røysland, Kjetil; Hald, John K & Server, Andrés (2019). Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach. Neuroradiology.  ISSN 0028-3940.  61(5), s 545- 555 . doi: 10.1007/s00234-019-02173-5 Full text in Research Archive. Show summary
  • Zoufal, Viktoria; Mairinger, Severin; Krohn, Markus; Wanek, Thomas; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2019). Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  40(5), s 954- 965 . doi: 10.1177/0271678X19854541 Full text in Research Archive.
  • Ceafalan, Laura Cristina; Fertig, Tudor Emanuel; Gheorghe, Teodora Cristina; Hinescu, Mihail Eugen; Popescu, Bogdan Ovidiu; Pahnke, Jens & Gherghiceanu, Mihaela (2018). Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier. Journal of Cellular and Molecular Medicine.  ISSN 1582-1838.  23(2), s 819- 827 . doi: 10.1111/jcmm.13980 Full text in Research Archive.
  • Chee, Yuemin Celina; Pahnke, Jens; Bunte, Ralph; Adsool, Vikrant A; Madan, Babita & Virshup, David M (2018). Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. Developmental Cell.  ISSN 1534-5807.  46(6), s 681- 695.e5 . doi: 10.1016/j.devcel.2018.07.023 Full text in Research Archive.
  • Krohn, Markus; Wanek, Thomas; Menet, Marie-Claude; Noack, Andreas; Declèves, Xavier; Langer, Oliver; Löscher, Wolfgang & Pahnke, Jens (2018). Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches. European Journal of Microbiology and Immunology.  ISSN 2062-509X.  8(3), s 78- 86 . doi: 10.1556/1886.2018.00008 Full text in Research Archive.
  • Lamartinière, Yordenca; Boucau, Marie-Christine; Dehouck, Lucie; Krohn, Markus; Pahnke, Jens; Candela, Pietra; Gosselet, Fabien & Fenart, Laurence (2018). ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier. Journal of Alzheimer's Disease.  ISSN 1387-2877.  64(4), s 1195- 1211 . doi: 10.3233/JAD-170883
  • Latysheva, Anna; Emblem, Kyrre Eeg; Server, Andrés; Brandal, Petter; Meling, Torstein Ragnar; Pahnke, Jens & Hald, John K (2018). Survival associations using perfusion and diffusion magnetic resonance imaging in patients with histologic and genetic defined diffuse glioma World Health Organization grades II and III. Journal of computer assisted tomography.  ISSN 0363-8715.  42(5), s 807- 815 . doi: 10.1097/RCT.0000000000000742 Full text in Research Archive.
  • Leske, Henning; Rushing, Elisabeth; Budka, Herbert; Niehusmann, Pitt; Pahnke, Jens & Panagopoulos, Ioannis (2018). K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution. Acta Neuropathologica.  ISSN 0001-6322.  136, s 175- 176 . doi: 10.1007/s00401-018-1867-2
  • Mairinger, Severin; Zoufal, Viktoria; Wanek, Thomas; Traxl, Alexander; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Kuntner, Claudia; Pahnke, Jens; Müller, Markus & Langer, Oliver (2018). Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice. European Journal of Pharmaceutical Sciences.  ISSN 0928-0987.  115, s 212- 222 . doi: 10.1016/j.ejps.2018.01.034
  • Paarmann, Kristin; Prakash, Sanjeev; Krohn, Markus; Möhle, Luisa; Brackhan, Mirjam; Brüning, Thomas; Eiriz Delgado, Iván & Pahnke, Jens (2018). French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice. Phytomedicine.  ISSN 0944-7113.  57, s 39- 48 . doi: 10.1016/j.phymed.2018.11.033
  • Steffen, Johannes; Stenzel, Jan; Ibrahim, Saleh & Pahnke, Jens (2018). Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer's Disease. Journal of Alzheimer's Disease.  ISSN 1387-2877.  65(2), s 465- 474 . doi: 10.3233/JAD-180395 Full text in Research Archive.
  • Storck, Steffen E.; Hartz, Anika M.S.; Bernard, Jessica; Wolf, Andreas; Kachlmeier, André; Mahringer, Anne; Weggen, Sascha; Pahnke, Jens & Pietrzik, Claus U. (2018). The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain, behavior, and immunity.  ISSN 0889-1591.  73, s 21- 33 . doi: 10.1016/j.bbi.2018.07.017
  • Zoufal, Viktoria; Mairinger, Severin; Krohn, Markus; Wanek, Thomas; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Traxl, Alexander; Schuetz, John D; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2018). Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[(11)C]Methylpurine in Mice. Molecular Imaging and Biology.  ISSN 1536-1632.  s 1- 11 . doi: 10.1007/s11307-018-1230-y Full text in Research Archive.
  • Zoufal, Viktoria; Wanek, Thomas; Krohn, Markus; Mairinger, Severin; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Pekar, Thomas; Bauer, Martin; Pahnke, Jens & Langer, Oliver (2018). Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  40(1), s 150- 162 . doi: 10.1177/0271678X18806640
  • Aleksis, Rihards; Oleskovs, Filips; Jaudzems, Kristaps; Pahnke, Jens & Biverstål, Henrik (2017). Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity. Biochimie.  ISSN 0300-9084.  140, s 176- 192 . doi: 10.1016/j.biochi.2017.07.011
  • Sike, Adam; Wengenroth, Jonas; Upite, Jolanta; Brüning, Thomas; Eiriz Delgado, Iván; Santha, Petra; Biverstål, Henrik; Jansone, Baiba; Haugen, Håvard Jostein; Krohn, Markus & Pahnke, Jens (2017). Improved method for cannula fixation for long-term intracerebral brain infusion. Journal of Neuroscience Methods.  ISSN 0165-0270.  290, s 145- 150 . doi: 10.1016/j.jneumeth.2017.07.026
  • Steffen, Johannes; Krohn, Markus; Schwitlick, christina; Brüning, Thomas; Paarmann, Kristin; Pietrzik, Claus U; Biverstål, Henrik; Jansone, Baiba; Langer, Oliver & Pahnke, Jens (2017). Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.. Acta neuropathologica communications.  ISSN 2051-5960.  5(1) . doi: 10.1186/s40478-017-0448-2 Full text in Research Archive.
  • Möhle, Luisa; Israel, Nicole; Paarmann, Kristin; Krohn, Markus; Pietkiewicz, Sabine; Müller, Andreas; Lavrik, Inna N; Buguliskis, Jeffrey S; Schott, Björn H; Schlüter, Dirk; Gundelfinger, Eckart D; Montag, Dirk; Seifert, Ulrike; Pahnke, Jens & Dunay, Ildiko Rita (2016). Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta neuropathologica communications.  ISSN 2051-5960.  4 . doi: 10.1186/s40478-016-0293-8
  • Steffen, Johannes; Krohn, Markus; Paarmann, Kristin; Schwitlick, christina; Brüning, Thomas; Marreiros, Rita; Müller-Schiffmann, Andreas; Korth, Carsten; Braun, Katharina & Pahnke, Jens (2016). Revisiting rodent models: Octodon degus as Alzheimer's disease model?. Acta neuropathologica communications.  ISSN 2051-5960.  5(49) . doi: 10.1186/s40478-016-0363-y
  • Bernstein, Hans-Gert; Hildebrandt, Jens; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2016). Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula. Schizophrenia Research.  ISSN 0920-9964.  177(1-3), s 52- 58 . doi: 10.1016/j.schres.2016.02.036
  • Hofrichter, Jacqueline; Krohn, Markus; Schumacher, Toni; Lange, Cathleen; Feistel, Björn; Walbroel, Bernd & Pahnke, Jens (2016). Sideritis spp. extracts enhance memory and learning in Alzheimer's β-amyloidosis mouse models and aged C57Bl/6 mice. Journal of Alzheimer's Disease.  ISSN 1387-2877.  53(3), s 967- 980 . doi: 10.3233/JAD-160301
  • Marques, Fernanda; Sousa, Joao Carlos; Brito, Maria Alexandra; Pahnke, Jens; Santos, Cecilia; Correia-Neves, Margarida & Palha, Joana Almeida (2016). The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiology of Disease.  ISSN 0969-9961.  (107), s 32- 40 . doi: 10.1016/j.nbd.2016.08.011
  • Fröhlich, Christina; Zschiebsch, Katja; Gröger, Victoria; Paarmann, Kristin; Steffen, Johannes; Thurm, Christoph; Schropp, Eva-Maria; Brüning, Thomas; Gellerich, Frank; Radloff, Martin; Schwabe, Rainer; Lachmann, Ingolf; Krohn, Markus; Ibrahim, Saleh & Pahnke, Jens (2015). Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies. Molecular Neurobiology.  ISSN 0893-7648.  Published ahead of print . doi: 10.1007/s12035-015-9399-4 Show summary
  • Krohn, Markus; Bracke, Alexander; Avchalumov, Yosef; Schumacher, Toni; Hofrichter, Jacqueline; Paarmann, Kristin; Fröhlich, Christina; Lange, Cathleen; Brüning, Thomas; Von Bohlen und Halbach, Oliver & Pahnke, Jens (2015). Accumulation of murine amyloid-β mimics early Alzheimer's disease. Brain.  ISSN 0006-8950.  138(8), s 2370- 2382 . doi: 10.1093/brain/awv137
  • Apostolova, Ivayla; Niedzielska, Dagmara; Derlin, Thorsten; Koziolek, Eva J.; Amthauer, Holger; Salmen, Benedikt; Pahnke, Jens; Brenner, Winfried; Mautner, Victor F. & Buchert, Ralph (2015). Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: Towards a biomarker of neurologic deficits. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  35(8), s 1304- 1312 . doi: 10.1038/jcbfm.2015.43
  • Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; McMurray, Cynthia T.; Acevedo-Torres, Karina & Ayala-Peña, Sylvette (2015). Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease. PLoS Genetics.  ISSN 1553-7390.  11:e1005267(8) . doi: 10.1371/journal.pgen.1005267
  • Lill, Christina M.; Rengmark, Aina Sylvia Haugen; Pihlstrøm, Lasse; Fogh, Isabella; Shatunov, Aleksey; Sleiman, Patrick M.; Wang, Li-San; Liu, Tian; Lassen, Christina F.; Meissner, Esther; Alexopoulos, Panos; Calvo, Andrea; Chio, Adriano; Dizdar, Nil; Faltraco, Frank; Forsgren, Lars; Kirchheiner, Julia; Kurz, Alexander; Larsen, Jan Petter; Liebsch, Maria; Linder, Jan; Morrison, Karen E; Nissbrandt, Hans; Otto, Markus; Pahnke, Jens; Partch, Amanda; Restagno, Gabriella; Rujescu, Dan; Schnack, Cathrin; Shaw, Christopher E.; Shaw, Pamela J.; Tumani, Hayrettin; Tysnes, Ole-Bjørn; Valladares, Otto; Silani, Vincenzo; van den Berg, Leonard H.; Van Rheenen, Wouter; Veldink, Jan H.; Lindenberger, Ulman; Steinhagen-Thiessen, Elisabeth; Teipel, Stefan; Perneczky, Robert; Hakonarson, Hakon; Hampel, Harald; Von Arnim, Christine A.F.; Olsen, Jørgen H.; Van Deerlin, Vivianna M.; Al-Chalabi, Ammar; Toft, Mathias; Ritz, Beate & Bertram, Lars (2015). The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease. Alzheimer's & Dementia.  ISSN 1552-5260.  11(12), s 1407- 1416 . doi: 10.1016/j.jalz.2014.12.009
  • Wanek, Thomas; Römermann, Kerstin; Mairinger, Severin; Stanek, Johann; Sauberer, Michael; Filip, Thomas; Traxl, Alexander; Kuntner, Claudia; Pahnke, Jens; Bauer, Florian; Erker, Thomas; Löscher, Wolfgang; Müller, Markus & Langer, Oliver (2015). Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography. Molecular Pharmaceutics.  ISSN 1543-8384.  12(9), s 3214- 3225 . doi: 10.1021/acs.molpharmaceut.5b00168
  • Bernstein, Hans-Gert; Hölzl, Gloria; Dobrowolny, Henrik; Hildebrandt, Jens; Trubner, Kurt; Krohn, Markus; Bogerts, Bernhard & Pahnke, Jens (2014). Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. Mechanisms of Ageing and Development.  ISSN 0047-6374.  141, s 12- 21 . doi: 10.1016/j.mad.2014.08.003
  • Pahnke, Jens; Fröhlich, Christina; Paarmann, Kristin; Krohn, Markus; Bogdanovic, Nenad; Aarsland, Dag & Winblad, Bengt (2014). Cerebral ABC Transporter-common Mechanisms May Modulate Neurodegenerative Diseases and Depression in Elderly Subjects. Archives of Medical Research.  ISSN 0188-4409.  45(8), s 738- 743 . doi: 10.1016/j.arcmed.2014.10.010

View all works in Cristin

  • Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from Mediterranean countries and Balkan.
  • Moussavi, Nastaran; Azizullah, Hasina; Pahnke, Jens; Malterud, Karl Egil; Inngjerdingen, Kari Tvete & Wangensteen, Helle (2019). Greek mountain tea, a medicinal plant from the Mediterranean countries and Balkan..
  • Azizullah, Hasina; Pahnke, Jens; Moussavi, Nastaran; Malterud, Karl Egil & Wangensteen, Helle (2018). Gresk fjellte, en medisinplante fra middelhavslandene og Balkan.
  • Bernstein, Hans-Gert; Hildebrandt, J.; Dobrowolny, Henrik; Steiner, J.; Bogerts, Bernhard & Pahnke, Jens (2018). Corrigendum to 'Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula' [Schizophr. Res. 2016 Nov;177(1?3):52?58] (S0920996416300901) (10.1016/j.schres.2016.02.036)). Schizophrenia Research.  ISSN 0920-9964.  197, s 622- 623 . doi: 10.1016/j.schres.2018.03.036
  • Jansone, Baiba; Pahnke, Jens & Biverstål, Henrik (2017). Alcheimera slimības izpētes aktualitātes. Latvijas ārsts.  ISSN 1019-5068.  s 48- 53
  • Mairinger, Severin; Wanek, Thomas; Traxl, Alexander; Krohn, Markus; Stanek, Johann; Filip, Thomas; Sauberer, Michael; Kuntner, Claudia; Pahnke, Jens & Langer, Oliver (2016). 7-[11C]methyl-6-bromopurine, a PET tracer to measure brain Mrp1 function: radiosynthesis and first PET evaluation in mice. 32nd International Austrian Winter Symposium, Zell am See, the Netherlands. 20-23 January 2016. EJNMMI Research.  ISSN 2191-219X.  6(32) . doi: 10.1186/s13550-016-0168-9

View all works in Cristin

Published Oct. 31, 2014 3:12 PM - Last modified May 7, 2020 12:06 PM