Academic interests
- Cardiac imaging
- Cardiac biomarkers
- Cardiovascular heamodynamics
- Translational cardiovascular research
Courses taught
- https://www.uio.no/studier/emner/medisin/med/MED6800/index.html
- https://www.uio.no/studier/emner/medisin/med/MED3300/index.html
Education
- 2005: M.D. (Cand. Med.), Faculty of Medicine, University of Oslo
- 2013: Ph.D., Faculty of Medicine, University of Oslo, Norway. Thesis: “Cardioprotective Mechanisms in Ischemia-Reperfusion Injury and Heart Failure”
- 2016: Board certified in Internal Medicine
- 2018: Board certified in Cardiology
Positions held
- 2016-t.d.: Senior Consultant, Dept. of Cardiology, Oslo University Hospital, Ullevål,
- 2021-t.d.: Associate Professor, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
- 2019-2021: Head of section for Resident Fellows, Dept. of Cardiology, Oslo University Hospital, Ullevål
- 2008-2016: Resident Fellow, Østfold Hospital Trust and Akershus University Hospital
- 2005-2008: Ph.D. Fellow, Institute for Surgical Research / Dept. of Cardiology, Oslo University Hospital, Rikshospitalet
Publications
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Rutkovskiy, Arkady; Sagave, Julia Fritzi; Czibik, Gabor Tamas; Baysa, Anton; Zihlavnikova, Katarina & Hillestad, Vigdis
[Show all 14 contributors for this article]
(2017).
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans.
Scandinavian Journal of Clinical and Laboratory Investigation.
ISSN 0036-5513.
77(5),
p. 321–331.
doi:
10.1080/00365513.2017.1318447.
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Gravning, Jørgen A.; Askevold, Erik Tandberg; Nymo, Ståle Haugset; Ueland, Thor; Wikstrand, John & McMurray, John J.V.
[Show all 9 contributors for this article]
(2014).
Prognostic effect of high-sensitive troponin t assessment in elderly patients with chronic heart failure results from the CORONA Trial.
Circulation: Heart Failure.
ISSN 1941-3289.
7(1),
p. 96–103.
doi:
10.1161/CIRCHEARTFAILURE.113.000450.
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Gravning, Jørgen A.; Ahmed, Muhammad Shakil; von Lueder, Thomas Gero; Edvardsen, Thor & Attramadal, Håvard
(2013).
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon pressure-overload.
International Journal of Cardiology.
ISSN 0167-5273.
168(3),
p. 2049–2056.
doi:
10.1016/j.ijcard.2013.01.165.
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Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor & Moe, Ingvild Tronstad
[Show all 13 contributors for this article]
(2013).
Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes.
Molecular Pharmacology.
ISSN 0026-895X.
84(3),
p. 372–383.
doi:
10.1124/mol.113.087312.
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Bilbija, Dusan; Gravning, Jørgen A.; Haugen, Fred; Attramadal, Håvard & Valen, Guro
(2012).
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle.
Life Sciences.
ISSN 0024-3205.
91(17-18),
p. 828–836.
doi:
10.1016/j.lfs.2012.08.014.
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von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil & Krobert, Kurt Allen
[Show all 11 contributors for this article]
(2012).
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload.
American Journal of Physiology. Heart and Circulatory Physiology.
ISSN 0363-6135.
303(1),
p. H66–H74.
doi:
10.1152/ajpheart.00724.2011.
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Gravning, Jørgen A.; Ørn, Stein; Kaasbøll, Ole Jørgen; Martinov, Vladimir Nikolkaev; Manhenke, Cord A & Dickstein, Kenneth
[Show all 9 contributors for this article]
(2012).
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction.
PLOS ONE.
ISSN 1932-6203.
7(12).
doi:
10.1371/journal.pone.0052120.
Show summary
Aims: Myocardial CCN2/CTGF is induced in heart failure of various etiologies. However, its role in the pathophysiology of left ventricular (LV) remodeling after myocardial infarction (MI) remains unresolved. The current study explores the role of CTGF in infarct healing and LV remodeling in an animal model and in patients admitted for acute ST-elevation MI.
Methods and Results: Transgenic mice with cardiac-restricted overexpression of CTGF (Tg-CTGF) and non-transgenic
littermate controls (NLC) were subjected to permanent ligation of the left anterior descending coronary artery. Despite similar infarct size (area of infarction relative to area at risk) 24 hours after ligation of the coronary artery in Tg-CTGF and NLC mice, Tg-CTGF mice disclosed smaller area of scar tissue, smaller increase of cardiac hypertrophy, and less LV dilatation and deterioration of LV function 4 weeks after MI. Tg-CTGF mice also revealed substantially reduced mortality after MI. Remote/peri-infarct tissue of Tg-CTGF mice contained reduced numbers of leucocytes, macrophages, and cells undergoing apoptosis as compared with NLC mice. In a cohort of patients with acute ST-elevation MI (n = 42) admitted to hospital for percutaneous coronary intervention (PCI) serum-CTGF levels (s-CTGF) were monitored and related to infarct size and LV function assessed by cardiac MRI. Increase in s-CTGF levels after MI was associated with reduced infarct size and improved LV ejection fraction one year after MI, as well as attenuated levels of CRP and GDF-15.
Conclusion: Increased myocardial CTGF activities after MI are associated with attenuation of LV remodeling and improved
LV function mediated by attenuation of inflammatory responses and inhibition of apoptosis.
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Czibik, Gabor Tamas; Gravning, Jørgen A.; Martinov, Vladimir Nikolkaev; Ishaq, Bushra; Knudsen, Eirunn & Attramadal, Håvard
[Show all 7 contributors for this article]
(2011).
Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo.
Life Sciences.
ISSN 0024-3205.
88(11-12),
p. 543–550.
doi:
10.1016/j.lfs.2011.01.006.
Show summary
Aims: Gene therapy of a peripheral organ to protect the heart is clinically attractive. The transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha) transactivates cardioprotective genes. We investigated if remote delivery of DNA encoding for HIF-1 alpha is protective against myocardial ischemia-reperfusion injury in vivo.
Main methods: DNA encoding for human HIF-1 alpha was delivered to quadriceps muscles of mice. One week later myocardial infarction was induced and four weeks later its size was measured. Echocardiography and in vivo pressure-volume analysis was performed. Coronary vascularization was evaluated through plastic casting. HL-1 cells, transfected with either HIF-1 alpha or HMOX-1 or administered bilirubin or the carbon monoxide (CO) donor CORM-2, were subjected to lipopolysacharide (LPS)-induced cell death to compare the efficacy of treatments.
Key findings: After four weeks of reperfusion post infarction, animals pretreated with HIF-1 alpha showed reduced infarct size and left ventricular remodeling (p<0.05, respectively). Fractional shortening was preserved in mice pretreated with HIF-1 alpha (p<0.05). Invasive hemodynamic parameters indicated preserved left ventricular function after HIF-1 alpha (p<0.05), which also induced coronary vascularization (p<0.05). HIF-1 alpha downstream target heme oxygenase 1 (HMOX-1) was upregulated in skeletal muscle, while serum bilirubin was increased. Transfection of HL-1 cells with HIF-1 alpha or HMOX-1 and administration of bilirubin or CORM-2 comparably salvaged cells from lipopolysacharide (LPS)-induced cell death (all p<0.05).
Significance: HIF-1 alpha gene delivery to skeletal muscle preceding myocardial ischemia reduced infarct size and postischemic remodeling accompanied by an improved cardiac function and vascularization. Similar to HIF-1 alpha, HMOX-1, bilirubin and CO were protective against LPS-induced injury. This observation may have clinical potential. (C) 2011 Elsevier Inc. All rights reserved.
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Ahmed, Muhammad Shakil; Gravning, Jørgen A.; Martinov, Vladimir Nikolkaev; von Lueder, Thomas Gero; Edvardsen, Thor & Czibik, Gabor Tamas
[Show all 11 contributors for this article]
(2011).
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury.
American Journal of Physiology. Heart and Circulatory Physiology.
ISSN 0363-6135.
300(4),
p. H1291–H1302.
doi:
10.1152/ajpheart.00604.2010.
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Vinge, Leif Erik; von Lueder, Thomas Gero; Aasum, E; Qvigstad, Eirik; Gravning, Jørgen Amundsen & How, OJ
[Show all 17 contributors for this article]
(2008).
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 uncovers distinct functions of GRK3 in regulation of cardiac contractility and growth - GRK3 controls cardiac alpha(1)-adrenergic receptor responsiveness.
Journal of Biological Chemistry.
ISSN 0021-9258.
283.
doi:
10.1074/jbc.M708912200.
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Gravning, Jørgen A.; Vege, Åshild & Kjekshus, John
(2006).
Plutselig uventet dødsfall etter perkutan koronar intervensjon.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
24(126),
p. 2111–2113.
View all works in Cristin
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Gravning, Jørgen A.
(2013).
Pulmonal hypertensjon i frakkelommen.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
133.
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Gravning, Jørgen A.
(2013).
Sensitive eller vanlige troponinanalyser ved koronare stenoser?
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
133.
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Gravning, Jørgen A.; Askevold, Erik Tandberg; Nymo, Ståle Haugset; Ueland, Thor; Wergeland, Ragnhild & Wikstrand, J
[Show all 9 contributors for this article]
(2012).
Prognostic impact of high-sensitive troponin T assessment in chronic heart failure and interaction with statin therapy. Results from CORONA.
European Heart Journal.
ISSN 0195-668X.
33,
p. 644–645.
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Bergestuen, Deidi Ann; Gravning, Jørgen A.; Haugaa, Kristina; Sahakyan, Laura G.; Aakhus, Svend & Carlsen, Espen
[Show all 10 contributors for this article]
(2010).
Plasma CCN2/Connective Tissue Growth Factor is Associated with Right Ventricular Dysfunction in Patients with Neuroendocrine Tumors.
Neuroendocrinology.
ISSN 0028-3835.
92(1),
p. 19–19.
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Gravning, Jørgen Amundsen; Attramadal, Håvard; Martinov, VN & Ahmed, MS
(2009).
CCN2/CTGF, Connective Tissue Growth Factor, Prevents Heart Failure and Improves Survival After Myocardial Infarction.
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Gravning, Jørgen Amundsen; Ahmed, MS; Qvigstad, E; Sagave, JF; Krobert, KA & Edvardsen, Thor
[Show all 10 contributors for this article]
(2009).
CCN2/CTGF - Connective Tissue Growth Factor - Reduces ?-Adrenergic Receptor Responsiveness and Catecholamine-Induced Cardiotoxicity by Upregulation of Cardiac Myocyte G Protein-Coupled Receptor Kinase-5.
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Gravning, Jørgen A.; Attramadal, Håvard; Martinov, Vladimir Nikolkaev & Ahmed, Muhammad Shakil
(2009).
CCN2/CTGF, Connective Tissue Growth Factor, Prevents Heart Failure and Improves Survival After Myocardial Infarction.
Circulation.
ISSN 0009-7322.
120(18),
p. S719–S719.
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Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Sagave, Julia Fritzi; Krobert, Kurt Allen & Edvardsen, Thor
[Show all 10 contributors for this article]
(2009).
CCN2/CTGF - Connective Tissue Growth Factor - Reduces beta-Adrenergic Receptor Responsiveness and Catecholamine-Induced Cardiotoxicity by Upregulation of Cardiac Myocyte G Protein-Coupled Receptor Kinase-5.
Circulation.
ISSN 0009-7322.
120(18),
p. S720–S720.
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Gravning, Jørgen Amundsen & Kjekshus, John
(2008).
The perfect biomarker in acute coronary syndrome: a challenge for diagnosis, prognosis, and treatment.
European Heart Journal.
ISSN 0195-668X.
29(23),
p. 2827–2828.
doi:
10.1093/eurheartj/ehn489.
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Gravning, Jørgen Amundsen; Ahmed, Muhammad Shakil; Qvigstad, Erik; Sagave, Julia Fritzi; Krobert, Kurt Allen & Edvardsen, Thor
[Show all 10 contributors for this article]
(2008).
Connective tissue growth factor (CTGF/CCN2) desensitizes myocardial beta-adrenergic receptor signaling and inhibits isoproterenol induced hypertrophy.
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Gravning, Jørgen A.; von Lueder, Thomas Gero; Edvardsen, Thor; Vinge, Leif Erik; How, OJ & Ahmed, Shakil Muhammed
[Show all 9 contributors for this article]
(2007).
Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload.
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Ahmed, Muhammad Shakil; von Lueder, Thomas Gero; Gravning, Jørgen A.; Edvardsen, Thor; Smiseth, Otto A. & Attramadal, Håvard
(2007).
Connective tissue growth factor inhibits myocardial growth, stimulates fibrosis, but preserves myocardial function in chronic pressure overload.
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Gravning, Jørgen A.; Ahmed, Shakil Muhammed; Martinov, V; von Lueder, Thomas Gero; Czibik, Gabor Tamas & Edvardsen, Thor
[Show all 9 contributors for this article]
(2007).
Novel cardioprotective role of connective tissue growth factor in ischemia/reperfusion injury and heart failure.
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Gravning, Jørgen A.; von Lueder, Thomas Gero; Edvardsen, Thor; How, OJ; Aasum, E & Ahmed, Muhammad Shakil
[Show all 11 contributors for this article]
(2006).
Inhibition of G Protein-Couples Receptor Kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload.
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Gravning, Jørgen A. & Attramadal, Håvard
(2013).
Cardioprotective Mechanisms in Ischemia-Reperfusion Injury and Heart Failure - Experimental and Clinical Studies Dissecting the Functional Effects of Connective Tissue Growth Factor (CTGF/CCN2) in the Heart.
Unipub forlag.
ISSN 978-82-8264-421-1.
View all works in Cristin
Published
Feb. 2, 2021 8:37 AM
- Last modified
Dec. 7, 2023 1:04 PM
