Jan-Bjørn Osnes

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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postal address Postboks 1057 Blindern 0316 Oslo

Publications

  • Melsom, Elin Maria Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk & Osnes, Jan-Bjørn [Show all 10 contributors for this article] (2019). Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLOS ONE. ISSN 1932-6203. 14:e021810(6), p. 1–19. doi: 10.1371/journal.pone.0218110. Full text in Research Archive
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Show all 10 contributors for this article] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, p. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
  • Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 477(1), p. 14–19. doi: 10.1016/j.bbrc.2016.05.138.
  • Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik & Skomedal, Tor [Show all 8 contributors for this article] (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 471(1), p. 219–225. doi: 10.1016/j.bbrc.2016.01.132.
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0115547. Full text in Research Archive
  • Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein & Levy, Finn Olav [Show all 9 contributors for this article] (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology. ISSN 0007-1188. 171(23), p. 5169–5181. doi: 10.1111/bph.12647.
  • Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine. ISSN 1549-1277. 9:e0106608(9). doi: 10.1371/journal.pone.0106608. Full text in Research Archive
  • Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar & Skomedal, Tor [Show all 9 contributors for this article] (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(12), p. 1177–1186. doi: 10.1007/s00210-014-1036-7.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind & Lothe, Gustav B [Show all 11 contributors for this article] (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. doi: 10.1124/jpet.114.214882.
  • Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar & Skomedal, Tor [Show all 9 contributors for this article] (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(5), p. 407–417. doi: 10.1007/s00210-013-0953-1.
  • Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 7 contributors for this article] (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(1), p. 5–14. doi: 10.1007/s00210-013-0940-6.
  • Lei, Peng; Baysa, Anton; Nebb, Hilde Irene; Valen, Guro; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2013). Activation of liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury. Basic Research in Cardiology. ISSN 0300-8428. 108. doi: 10.1007/s00395-012-0323-z.
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor & Moe, Ingvild Tronstad [Show all 13 contributors for this article] (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology. ISSN 0026-895X. 84(3), p. 372–383. doi: 10.1124/mol.113.087312.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina & Ørstavik, Øivind [Show all 12 contributors for this article] (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology. ISSN 0007-1188. 170(2), p. 366–379. doi: 10.1111/bph.12282.
  • Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 56, p. 129–138. doi: 10.1016/j.yjmcc.2012.11.015.
  • Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes & Osnes, Jan-Bjørn [Show all 10 contributors for this article] (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology. ISSN 0014-2999. 686(1-3), p. 66–73. doi: 10.1016/j.ejphar.2012.04.022.
  • Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology. ISSN 0300-8428. 107(5). doi: 10.1007/s00395-012-0295-z.
  • Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise & Birkeland, Jon Arne [Show all 10 contributors for this article] (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0045489. Full text in Research Archive
  • Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Show all 8 contributors for this article] (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 384(6), p. 543–553. doi: 10.1007/s00210-011-0670-6.
  • Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Show all 8 contributors for this article] (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(1), p. 54–71. doi: 10.1111/j.1476-5381.2010.00890.x.
  • Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Osnes, Jan-Bjørn [Show all 9 contributors for this article] (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(4), p. 908–916. doi: 10.1111/j.1476-5381.2010.01097.x.
  • Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina & Sjaastad, Ivar [Show all 9 contributors for this article] (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR). ISSN 0008-6363. 85(4), p. 763–772. doi: 10.1093/cvr/cvp364.
  • Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Show all 10 contributors for this article] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), p. 575–586. doi: 10.1111/j.1476-5381.2009.00016.x.
  • Ansteinsson, V; Refsnes, Magne; Skomedal, T; Osnes, JB; Gutowska-Schiander, Iwona & Schiander, I [Show all 7 contributors for this article] (2009). Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart. Cardiovascular Toxicology. ISSN 1530-7905. 9(2), p. 86–94. doi: 10.1007/s12012-009-9043-5.
  • Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor & Olsen, IC [Show all 11 contributors for this article] (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure. ISSN 1388-9842. 11(8), p. 771–778. doi: 10.1093/eurjhf/hfp087.
  • Hussain, Rizwan; Qvigstad, Erik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Show all 10 contributors for this article] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), p. 575–586. doi: 10.1111/j.1750-3639.2009.00016.x.
  • Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry. ISSN 0003-2697. 383(2), p. 323–325. doi: 10.1016/j.ab.2008.09.011.
  • Totlandsdal, Annike Irene; Refsnes, Magne; Skomedal, Tor; Osnes, Jan-Bjørn; Schwarze, Per E & Låg, Marit (2008). Particle-induced cytokine responses in cardiac cell cultures-the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicological Sciences. ISSN 1096-6080. 106(1), p. 233–241. doi: 10.1093/toxsci/kfn162.
  • Riise, J; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Sandnes, Dagny Lise; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2008). Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovascular Research (CVR). ISSN 0008-6363. 80(3), p. 407–415. doi: 10.1093/cvr/cvn216.
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Dahl, Christen Peder [Show all 10 contributors for this article] (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology. ISSN 0007-1188. 155(7), p. 1005–1014. doi: 10.1038/bjp.2008.339.
  • Levy, Finn Olav; Qvigstad, Eirik; Krobert, Kurt Allen; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications. Neuropharmacology. ISSN 0028-3908. 55(6), p. 1066–1071. doi: 10.1016/j.neuropharm.2008.07.010.
  • Totlandsdal, Annike Irene; Skomedal, Tor; Låg, Marit; Osnes, Jan-Bjørn & Refsnes, Magne (2008). Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells. Toxicology. ISSN 0300-483X. 247(1), p. 23–32. doi: 10.1016/j.tox.2008.01.019.
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn Fride; Gåsemyr, Jørund Inge & Natvig, Bent (2007). Is atenolol different from other adrenergic blockers? BMC Clinical Pharmacology. ISSN 1472-6904. 01.01.1904 07:04:00.
  • Osnes, Jan-Bjørn & Aass, Halfdan (2007). Legemidler ved hjerte- og karsykdommer. In Vilberg, Astri (Eds.), Norsk legemiddelhåndbok for helsepersonell 2007. Foreningen for utgivelse av Norsk Legemiddelhåndbok. ISSN 978-82-90732-09-2. p. 951–1036.
  • Skomedal, Tor & Osnes, Jan-Bjørn (2007). Endring av anbefalt terapeutisk serumkonsentrasjonsområde for digoksin og digitoksin. Hjerteforum. ISSN 0802-1465. 20(4), p. 27–31.
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn; Gåsemyr, Jørund Inge & Natvig, Bent (2007). Does atenolol differ from other beta-adrenergic blockers? BMC Clinical Pharmacology. ISSN 1472-6904. 7(4). doi: 10.1186/1472-6904-7-4.
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti & Krobert, Kurt Allen [Show all 11 contributors for this article] (2007). Effects of treatment with a 5-HT4 receptor antagonist in heart failure. British Journal of Pharmacology. ISSN 0007-1188. 150, p. 143–152. doi: 10.1038/sj.bjp.0706966.
  • Brattelid, Trond; Tveit, Kristine; Birkeland, Jon Arne; Sjaastad, Ivar; Qvigstad, Eirik & Krobert, Kurt Allen [Show all 10 contributors for this article] (2007). Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure : A quantitative RT-PCR study and the question of normalisation. Basic Research in Cardiology. ISSN 0300-8428. 102, p. 198–208. doi: 10.1007/s00395-007-0648-1.
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil & Peppel, K [Show all 12 contributors for this article] (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology. ISSN 0026-895X. 72, p. 582–591.
  • Brattelid, Trond; Qvigstad, E; Birkeland, Jan Magne; Birkeland, Jon Arne; Swift, F & Bekkevold, SVS [Show all 12 contributors for this article] (2007). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 43, p. 767–779. doi: 10.1016/j.yjmcc.2007.08.019.
  • Andersen, Geir Øystein; Øie, Erik; Vinge, Leif Erik; Yndestad, Arne; Attramadal, Håvard & Skomedal, Tor [Show all 7 contributors for this article] (2006). Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts. Basic Research in Cardiology. ISSN 0300-8428. 101(6), p. 471–478.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne & Andressen, Kjetil Wessel [Show all 12 contributors for this article] (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure, Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005. Medimond. ISSN 88-7587-164-7. p. 7–12.
  • Kemi, Ole Johan; Haram, Per Magnus; Loennechen, Jan Pål; Osnes, Jan-Bjørn; Wisloff, U & Skomedal, Tor [Show all 9 contributors for this article] (2005). Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovascular Research (CVR). ISSN 0008-6363. 67, p. 161–172.
  • Qvigstad, Eirik; Sjaastad, I; Bøkenes, Janny; Schiander, Iwona; Solberg, Line & Sejersted, Ole M [Show all 8 contributors for this article] (2005). Carvedilol blockade of alpha(1)- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure. European Journal of Pharmacology. ISSN 0014-2999. 516, p. 51–59.
  • Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Nunn, Caroline; Swift, Fredrik & Birkeland, Jon Arne [Show all 12 contributors for this article] (2005). Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circulation Research. ISSN 0009-7330. 97, p. 268–276.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen & Birkeland, Jon Arne [Show all 11 contributors for this article] (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovascular Research (CVR). ISSN 0008-6363. 65.
  • Andersen, Geir Øystein; Skomedal, Tor; Enger, Mette; Fidjeland, Astrid; Brattelid, Trond & Levy, Finn Olav [Show all 7 contributors for this article] (2004). The alpha1-AR mediated activation of NKCC in rat cardiomyocytes involves ERK dependent phosphorylation of the cotransporter. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 286, p. H1354–H1360.
  • Sandnes, Dagny Lise; Nilsen, Laila, Sortvik; Andersen, Geir Øystein; Viko, H.; Sjetnan, Anne E & Skomedal, Tor [Show all 7 contributors for this article] (2004). Ca2+-Dependent elevation of inositol 1,4,5-trisphosphate level induced by freezing or homogenization of tissues and cells. Basic & Clinical Pharmacology. ISSN 0891-2033. 95, p. 288–294.
  • Brattelid, Trond; Qvigstad, Eirik; Lynham, J.A.; Molenaar, P.; Aass, H. & Geiran, Odd [Show all 10 contributors for this article] (2004). Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 370(3), p. 157–166.
  • Qvigstad, Erik; Osnes, Jan-Bjørn; Sandnes, Dagny Lise; Gutowska-Schiander, Iwona; Bøkenes, Janny & Sjaastad, Ivar [Show all 7 contributors for this article] (2003). Carvedilol blockade of rat myocardial alpha1-adrenoceptors. European Journal of Pharmacology. ISSN 0014-2999. 481, p. 83–89.
  • Sjaastad, Ivar; Gutowska-Schiander, Iwona; Sjetnan, Anne E; Qvigstad, Eirik; Bøkenes, Janny & Sandnes, Dagny Lise [Show all 9 contributors for this article] (2003). Increased contribution of alpha 1- versus beta-adrenoceptor-mediated inotropic response in rats with congestive heart failure. Acta Physiologica Scandinavica. ISSN 0001-6772. 177, p. 449–458.
  • Beisvåg, Vidar; Falck, G; Loennechen, Jan P.; Qvigstad, Gunnar; Jynge, Per & Skomedal, Tor [Show all 9 contributors for this article] (2003). Identification and regulation of the gastric H+/K+-ATPase in the rat heart. Acta Physiologica Scandinavica. ISSN 0001-6772. 179, p. 251–262.
  • Andersen, Geir Øystein; Qvigstad, Eirik; Schiander, Iwona; Aass, Halfdan; Osnes, Jan-Bjørn & Skomedal, Tor (2002). alpha-1-AR induced positive inotropic response in the heart is dependent on myosin light chain phosphorylation. American Journal of Physiology. ISSN 0002-9513. 283, p. h1471–h1480.

View all works in Cristin

  • Osnes, Jan-Bjørn & Aass, H. (2004). Legemidler ved hjerte-karsykdommer. Foreningen for utgivelse av Norsk legemiddelhåndbok. ISBN 82-90732-08-2. 75 p.

View all works in Cristin

  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 9 contributors for this article] (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology. ISSN 2050-6511. 16, p. A66–A66. doi: 10.1186/2050-6511-16-S1-A66.
  • Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR). ISSN 0008-6363. 93, p. S18–S18. doi: 10.1093/cvr/cvr332.
  • Melsom, CB; Hussain, Rizwan; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2011). The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of "tonic" Gi activation.
  • Meier, Silja; Aronsen, Jan Magnus; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 7 contributors for this article] (2011). Enhancement of B1-adrenoceptor signaling by C-type natriuretic peptide through natriuretic peptide receptor B in normal and failing hearts: regulation by phosphodiesterases.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Show all 10 contributors for this article] (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Show all 10 contributors for this article] (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
  • Meier, Silja; Levy, Finn Olav; Skomedal, Tor; Qvigstad, Eirik & Osnes, Jan-Bjørn (2010). Cardiac tissue hypothyroidism and receptor functions in heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz & Sjaastad, Ivar [Show all 10 contributors for this article] (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
  • Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Show all 8 contributors for this article] (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
  • Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
  • Aursnes, Ivar & Osnes, Jan-Bjørn (2009). Atenolol Versus Other Beta-Adrenergic Blockers. Journal of the American College of Cardiology. ISSN 0735-1097. 53(22), p. 2101–2102. doi: 10.1016/j.jacc.2008.11.067.
  • Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Show all 8 contributors for this article] (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
  • Krobert, Kurt Allen; Hussain, Rizwan; Afzal, Faraz; Aronsen, Jon magnus; Sjaastad, Ivar & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2009). Inreased Gi activity does not contribute to the reduced beta-adrenergic inotropic effect in failing rat ventricle but Gi acts as a tonic brake on basal adenylyl cyclase activity.
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Sagave, Julia Fritzi; Krobert, Kurt Allen & Edvardsen, Thor [Show all 10 contributors for this article] (2009). CCN2/CTGF - Connective Tissue Growth Factor - Reduces beta-Adrenergic Receptor Responsiveness and Catecholamine-Induced Cardiotoxicity by Upregulation of Cardiac Myocyte G Protein-Coupled Receptor Kinase-5. Circulation. ISSN 0009-7322. 120(18), p. S720–S720.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz & Skomedal, Tor [Show all 9 contributors for this article] (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, p. 17–17.
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  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman & Sjaastad, Ivar [Show all 10 contributors for this article] (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42(6), p. S152–S152.
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  • Brattelid, Trond; Qvigstad, Eirik; Birkeland, Jon Arne; Swift, Fredrik; Bekkevold, SVS & Krobert, Kurt Allen [Show all 11 contributors for this article] (2006). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 40, p. 944–945.
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  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti & Krobert, Kurt Allen [Show all 11 contributors for this article] (2006). Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 40, p. 943–944.
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn; Gåsemyr, Jørund Inge & Natvig, Bent (2006). Er atenolol forskjellig fra andre beta-adrenerge blokkere? Bayesiansk analyse av publiserte data.
  • Birkeland, Jon Arne; Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Krobert, Kurt Allen & Sejersted, Ole M [Show all 11 contributors for this article] (2005). Induction of a 5-HT4 receptor-mediated inotropic response to serotonin in failing ventricular cardiomyocytes. Biophysical Journal. ISSN 0006-3495. 88.
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  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M & Skomedal, Tor [Show all 8 contributors for this article] (2003). Novel effect of serotonin (5-HT) in heart faiure. A new therapeutic agent?
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  • Osnes, Jan-Bjørn; Andersen, Geir Øystein; Qvigstad, Eirik & Skomedal, Tor (2003). New aspects on differential molecular mechanisms of action of myocardial alpha 1-adrenoceptor stimulation.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M & Skomedal, Tor [Show all 8 contributors for this article] (2003). Novel effects of serotonin in heart failure.
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  • Osnes, Jan-Bjørn (2002). Nevro-humoral og medikamentell påvirkning på det sviktende hjertet.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Osnes, Jan-Bjørn (2002). Effects and signalling pathways of G-coupled receptors in normal and failing hearts.
  • Osnes, Jan-Bjørn (2002). Cyclic nucleotides: signaling molecules now among allies and rivals.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Eikemo, Hilde; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Regulation of myosin light chain 2 phosphorylation in cardiac muscle and its possible role in contractile responses. Universitetet i Oslo. ISSN 978-82-8072-348-2.
  • Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Regulation of myosin light chain 2 phosphorylation in cardiac muscle and its possible role in contractile responses. Universitetet i Oslo.

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Published Sep. 19, 2014 9:26 AM - Last modified Sep. 19, 2014 9:26 AM