Jan-Bjørn Osnes

Professor Emeritus - Department of Pharmacology
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Other affiliations Department of Pharmacy

Publications

  • Melsom, Elin Maria Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk; Osnes, Jan-Bjørn; Skomedal, Tor; Nikolaev, Viacheslav; Levy, Finn Olav & Krobert, Kurt Allen (2019). Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLOS ONE.  ISSN 1932-6203.  14:e021810(6), s 1- 19 . doi: 10.1371/journal.pone.0218110 Full text in Research Archive.
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology.  ISSN 0014-2999.  812, s 174- 183 . doi: 10.1016/j.ejphar.2017.07.014
  • Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  471(1), s 219- 225 . doi: 10.1016/j.bbrc.2016.01.132
  • Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  477(1), s 14- 19 . doi: 10.1016/j.bbrc.2016.05.138
  • Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE.  ISSN 1932-6203.  10(3) . doi: 10.1371/journal.pone.0115547 Full text in Research Archive.
  • Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(1), s 5- 14 . doi: 10.1007/s00210-013-0940-6
  • Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(12), s 1177- 1186 . doi: 10.1007/s00210-014-1036-7
  • Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine.  ISSN 1549-1277.  9:e0106608(9) . doi: 10.1371/journal.pone.0106608 Full text in Research Archive.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind; Lothe, Gustav B; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565. . doi: 10.1124/jpet.114.214882
  • Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(5), s 407- 417 . doi: 10.1007/s00210-013-0953-1
  • Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology.  ISSN 0007-1188.  171(23), s 5169- 5181 . doi: 10.1111/bph.12647
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor; Moe, Ingvild Tronstad; Hagelin, Else Marie Valbjørn; Sagave, Julia Fritzi; Valen, Guro; Levy, Finn Olav; Osnes, Jan-Bjørn; Skomedal, Tor & Attramadal, Håvard (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology.  ISSN 0026-895X.  84(3), s 372- 383 . doi: 10.1124/mol.113.087312
  • Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  56, s 129- 138 . doi: 10.1016/j.yjmcc.2012.11.015
  • Lei, Peng; Baysa, Anton; Nebb, Hilde Irene; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn; Yang, Zaiqing & Haugen, Fred (2013). Activation of liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury. Basic Research in Cardiology.  ISSN 0300-8428.  108 . doi: 10.1007/s00395-012-0323-z
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina; Ørstavik, Øivind; Sjaastad, Ivar; Christensen, Geir Arve; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology.  ISSN 0007-1188.  170(2), s 366- 379 . doi: 10.1111/bph.12282
  • Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar & Levy, Finn Olav (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0045489 Full text in Research Archive.
  • Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes; Osnes, Jan-Bjørn; Skomedal, Tor; Sandnes, Dagny Lise; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology.  ISSN 0014-2999.  686(1-3), s 66- 73 . doi: 10.1016/j.ejphar.2012.04.022
  • Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology.  ISSN 0300-8428.  107(5) . doi: 10.1007/s00395-012-0295-z
  • Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(1), s 54- 71 . doi: 10.1111/j.1476-5381.2010.00890.x
  • Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  384(6), s 543- 553 . doi: 10.1007/s00210-011-0670-6
  • Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(4), s 908- 916 . doi: 10.1111/j.1476-5381.2010.01097.x
  • Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR).  ISSN 0008-6363.  85(4), s 763- 772 . doi: 10.1093/cvr/cvp364
  • Ansteinsson, V; Refsnes, Magne; Skomedal, T; Osnes, JB; Schiander, I; Gutowska-Schiander, Iwona & Låg, Marit (2009). Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart. Cardiovascular Toxicology.  ISSN 1530-7905.  9(2), s 86- 94 . doi: 10.1007/s12012-009-9043-5
  • Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology.  ISSN 0007-1188.  156(4), s 575- 586 . doi: 10.1111/j.1476-5381.2009.00016.x
  • Hussain, Rizwan; Qvigstad, Erik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Krobert, Kurt Allen (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology.  ISSN 0007-1188.  156(4), s 575- 586 . doi: 10.1111/j.1750-3639.2009.00016.x Show summary
  • Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor; Olsen, IC; Sjaastad, Ivar; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure.  ISSN 1388-9842.  11(8), s 771- 778 . doi: 10.1093/eurjhf/hfp087
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar; Dahl, Christen Peder; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2008). 5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles. British Journal of Pharmacology.  ISSN 0007-1188.  155(7), s 1005- 1014 . doi: 10.1038/bjp.2008.339
  • Levy, Finn Olav; Qvigstad, Eirik; Krobert, Kurt Allen; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications. Neuropharmacology.  ISSN 0028-3908.  55(6), s 1066- 1071 . doi: 10.1016/j.neuropharm.2008.07.010
  • Riise, J; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Sandnes, Dagny Lise; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2008). Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation. Cardiovascular Research (CVR).  ISSN 0008-6363.  80(3), s 407- 415 . doi: 10.1093/cvr/cvn216
  • Totlandsdal, Annike Irene; Refsnes, Magne; Skomedal, Tor; Osnes, Jan-Bjørn; Schwarze, Per E & Låg, Marit (2008). Particle-induced cytokine responses in cardiac cell cultures-the effect of particles versus soluble mediators released by particle-exposed lung cells. Toxicological Sciences.  ISSN 1096-6080.  106(1), s 233- 241 . doi: 10.1093/toxsci/kfn162
  • Totlandsdal, Annike Irene; Skomedal, Tor; Låg, Marit; Osnes, Jan-Bjørn & Refsnes, Magne (2008). Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells. Toxicology.  ISSN 0300-483X.  247(1), s 23- 32 . doi: 10.1016/j.tox.2008.01.019
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn Fride; Gåsemyr, Jørund Inge & Natvig, Bent (2007). Is atenolol different from other adrenergic blockers?. BMC Clinical Pharmacology.  ISSN 1472-6904.  01.01.1904 07:04:00
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn; Gåsemyr, Jørund Inge & Natvig, Bent (2007). Does atenolol differ from other beta-adrenergic blockers?. BMC Clinical Pharmacology.  ISSN 1472-6904.  7(4) . doi: 10.1186/1472-6904-7-4
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Effects of treatment with a 5-HT4 receptor antagonist in heart failure. British Journal of Pharmacology.  ISSN 0007-1188.  150, s 143- 152 . doi: 10.1038/sj.bjp.0706966
  • Brattelid, Trond; Qvigstad, E; Birkeland, Jan Magne; Birkeland, Jon Arne; Swift, F; Bekkevold, SVS; Krobert, KA; Sejersted, Ole M.; Skomedal, T; Osnes, JB; Levy, F. & Sjaastad, I (2007). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  43, s 767- 779 . doi: 10.1016/j.yjmcc.2007.08.019
  • Brattelid, Trond; Tveit, Kristine; Birkeland, Jon Arne; Sjaastad, Ivar; Qvigstad, Eirik; Krobert, Kurt Allen; Rizwan, Hussain; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2007). Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure : A quantitative RT-PCR study and the question of normalisation. Basic Research in Cardiology.  ISSN 0300-8428.  102, s 198- 208 . doi: 10.1007/s00395-007-0648-1
  • Osnes, Jan-Bjørn & Aass, Halfdan (2007). Legemidler ved hjerte- og karsykdommer, I: Astri Vilberg (red.),  Norsk legemiddelhåndbok for helsepersonell 2007.  Foreningen for utgivelse av Norsk Legemiddelhåndbok.  ISBN 978-82-90732-09-2.  L8.  s 951 - 1036
  • Skomedal, Tor & Osnes, Jan-Bjørn (2007). Endring av anbefalt terapeutisk serumkonsentrasjonsområde for digoksin og digitoksin. Hjerteforum.  ISSN 0802-1465.  20(4), s 27- 31
  • Vinge, Leif Erik; Andressen, Kjetil Wessel; Attramadal, Toril; Andersen, Geir Øystein; Ahmed, Muhammad Shakil; Peppel, K; Koch, WJ; Freedman, NJ; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2007). Substrate specificities of G protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Molecular Pharmacology.  ISSN 0026-895X.  72, s 582- 591
  • Andersen, Geir Øystein; Øie, Erik; Vinge, Leif Erik; Yndestad, Arne; Attramadal, Håvard; Skomedal, Tor & Osnes, Jan-Bjørn (2006). Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts. Basic Research in Cardiology.  ISSN 0300-8428.  101(6), s 471- 478
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Molenaar, P.; Birkeland, Jon Arne; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Kaumann, Alberto Julio & Levy, Finn Olav (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure, In  Proceedings of the 25th European Section Meeting, International Society for Heart Research, Tromsø, Norway, June 21-25, 2005.  Medimond.  ISBN 88-7587-164-7.  Invited Lectures.  s 7 - 12 Show summary
  • Qvigstad, Eirik; Sjaastad, I; Bøkenes, Janny; Schiander, Iwona; Solberg, Line; Sejersted, Ole M; Osnes, Jan-Bjørn & Skomedal, Tor (2005). Carvedilol blockade of alpha(1)- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure. European Journal of Pharmacology.  ISSN 0014-2999.  516, s 51- 59
  • Kemi, Ole Johan; Haram, Per Magnus; Loennechen, Jan Pål; Osnes, Jan-Bjørn; Skomedal, Tor; Wisloff, U; Wisløff, Ulrik; Ellingsen, O & Ellingsen, Øyvind (2005). Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovascular Research (CVR).  ISSN 0008-6363.  67, s 161- 172
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Birkeland, Jon Arne; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure. Cardiovascular Research (CVR).  ISSN 0008-6363.  65 Show summary
  • Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Nunn, Caroline; Swift, Fredrik; Birkeland, Jon Arne; Krobert, Kurt Allen; Andersen, Geir Øystein; Sejersted, Ole M; Osnes, Jan-Bjørn; Levy, Finn Olav & Skomedal, Tor (2005). Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circulation Research.  ISSN 0009-7330.  97, s 268- 276
  • Brattelid, Trond; Qvigstad, Eirik; Lynham, J.A.; Molenaar, P.; Aass, H.; Geiran, Odd; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Kaumann, Alberto Julio (2004). Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  370(3), s 157- 166 . doi: 15365689 Show summary
  • Sandnes, Dagny Lise; Nilsen, Laila, Sortvik; Andersen, Geir Øystein; Viko, H.; Sjetnan, Anne E; Skomedal, Tor & Osnes, Jan-Bjørn (2004). Ca2+-Dependent elevation of inositol 1,4,5-trisphosphate level induced by freezing or homogenization of tissues and cells. Basic & Clinical Pharmacology.  ISSN 0891-2033.  95, s 288- 294
  • Andersen, Geir Øystein; Skomedal, Tor; Enger, Mette; Fidjeland, Astrid; Brattelid, Trond; Levy, Finn Olav & Osnes, Jan-Bjørn (2004). The alpha1-AR mediated activation of NKCC in rat cardiomyocytes involves ERK dependent phosphorylation of the cotransporter. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  286, s H1354- H1360
  • Beisvåg, Vidar; Falck, G; Loennechen, Jan P.; Qvigstad, Gunnar; Jynge, Per; Skomedal, Tor; Osnes, Jan-Bjørn; Sandvik, Arne K & Ellingsen, Øyvind (2003). Identification and regulation of the gastric H+/K+-ATPase in the rat heart. Acta Physiologica Scandinavica.  ISSN 0001-6772.  179, s 251- 262
  • Qvigstad, Erik; Osnes, Jan-Bjørn; Sandnes, Dagny Lise; Gutowska-Schiander, Iwona; Bøkenes, Janny; Sjaastad, Ivar & Skomedal, Tor (2003). Carvedilol blockade of rat myocardial alpha1-adrenoceptors. European Journal of Pharmacology.  ISSN 0014-2999.  481, s 83- 89
  • Sjaastad, Ivar; Gutowska-Schiander, Iwona; Sjetnan, Anne E; Qvigstad, Eirik; Bøkenes, Janny; Sandnes, Dagny Lise; Osnes, Jan-Bjørn; Sejersted, Ole M & Skomedal, Tor (2003). Increased contribution of alpha 1- versus beta-adrenoceptor-mediated inotropic response in rats with congestive heart failure. Acta Physiologica Scandinavica.  ISSN 0001-6772.  177, s 449- 458
  • Andersen, Geir Øystein; Qvigstad, Eirik; Schiander, Iwona; Aass, Halfdan; Osnes, Jan-Bjørn & Skomedal, Tor (2002). alpha-1-AR induced positive inotropic response in the heart is dependent on myosin light chain phosphorylation. American Journal of Physiology.  ISSN 0002-9513.  283, s h1471- h1480

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  • Osnes, Jan-Bjørn & Aass, H. (red.) (2004). Legemidler ved hjerte-karsykdommer. Foreningen for utgivelse av Norsk legemiddelhåndbok.  ISBN 82-90732-08-2.  75 s.

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  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eric & Levy, Finn Olav (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR).  ISSN 0008-6363.  93, s S18- S18 . doi: 10.1093/cvr/cvr332
  • Meier, Silja; Aronsen, Jan Magnus; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Enhancement of B1-adrenoceptor signaling by C-type natriuretic peptide through natriuretic peptide receptor B in normal and failing hearts: regulation by phosphodiesterases.
  • Melsom, CB; Hussain, Rizwan; Aronsen, Jan Magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2011). The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of "tonic" Gi activation.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
  • Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
  • Meier, Silja; Levy, Finn Olav; Skomedal, Tor; Qvigstad, Eirik & Osnes, Jan-Bjørn (2010). Cardiac tissue hypothyroidism and receptor functions in heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
  • Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
  • Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
  • Aursnes, Ivar & Osnes, Jan-Bjørn (2009). Atenolol Versus Other Beta-Adrenergic Blockers. Journal of the American College of Cardiology.  ISSN 0735-1097.  53(22), s 2101- 2102 . doi: 10.1016/j.jacc.2008.11.067
  • Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Sagave, Julia Fritzi; Krobert, Kurt Allen; Edvardsen, Thor; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2009). CCN2/CTGF - Connective Tissue Growth Factor - Reduces beta-Adrenergic Receptor Responsiveness and Catecholamine-Induced Cardiotoxicity by Upregulation of Cardiac Myocyte G Protein-Coupled Receptor Kinase-5. Circulation.  ISSN 0009-7322.  120(18), s S720- S720
  • Krobert, Kurt Allen; Hussain, Rizwan; Afzal, Faraz; Aronsen, Jon magnus; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor & Levy, Finn Olav (2009). Inreased Gi activity does not contribute to the reduced beta-adrenergic inotropic effect in failing rat ventricle but Gi acts as a tonic brake on basal adenylyl cyclase activity.
  • Eikemo, Hilde; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2008). Evidence for an unidentified kinase activity phosphorylating myosin light chain-2 in quiescent cardiomyocytes. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  44, s 782- 782 . doi: 10.1016/j.yjmcc.2008.02.170
  • Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry.  ISSN 0003-2697.  383(2), s 323- 325 . doi: 10.1016/j.ab.2008.09.011
  • Gravning, Jørgen Amundsen; Ahmed, Muhammad Shakil; Qvigstad, Erik; Sagave, Julia Fritzi; Krobert, Kurt Allen; Edvardsen, Thor; Valen, Guro; Skomedal, Tor; Osnes, Jan-Bjørn & Attramadal, Håvard (2008). Connective tissue growth factor (CTGF/CCN2) desensitizes myocardial beta-adrenergic receptor signaling and inhibits isoproterenol induced hypertrophy.
  • Kjekshus, John; Edvardsen, Thor; Gullestad, Lars; Koeber, L; Osnes, Jan-Bjørn; Qvigstad, Erik; Sjaastad, Ivar; Skomedal, Tor; Torp-Pedersen, C & Levy, Finn Olav (2008). The effect of Piboserod a 5-HT4-receptor antagonist on left ventricular function in patients with symptomatic heart failure.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 17- 17
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Aronsen, Jon magnus; Qvigstad, Eirik; Hougen, Karina; Birkeland, Jon Arne; Levy, Finn Olav; Osnes, Jan-Bjørn; Andersson, Kristin Brevik; Christensen, Geir Arve; Sejersted, Ole M; Skomedal, Tor & Sjaastad, Ivar (2007). Role of alpha-1-adrenergic signallling in Serca2 knockout mice.
  • Krobert, Kurt Allen; Hussain, Rizwan; Mørk, Halvor Kjeang; Qvigstad, Eirik; Sjaastad, Ivar; Osnes, Jan-Bjørn; Skomedal, Tor & Levy, Finn Olav (2007). cAMP-dependent inotropic effects are differentially regulated by muscarinic inhibition in failing rat ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S35- S35
  • Aursnes, Ivar Andreas; Osnes, Jan-Bjørn; Tvete, Ingunn; Gåsemyr, Jørund Inge & Natvig, Bent (2006). Er atenolol forskjellig fra andre beta-adrenerge blokkere? Bayesiansk analyse av publiserte data. Show summary
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2006). Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 75- 75
  • Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Qvigstad, Eirik; Moberg, Enrica Ratti; Krobert, Kurt Allen; Bjørnerheim, Reidar; Skomedal, Tor; Sejersted, Ole M; Osnes, Jan-Bjørn & Levy, Finn Olav (2006). Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 943- 944
  • Brattelid, Trond; Qvigstad, Eirik; Birkeland, Jon Arne; Swift, Fredrik; Bekkevold, Silje Veslemøy; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Sjaastad, Ivar (2006). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 74- 74
  • Brattelid, Trond; Qvigstad, Eirik; Birkeland, Jon Arne; Swift, Fredrik; Bekkevold, SVS; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Sjaastad, Ivar (2006). Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 944- 945
  • Eikemo, Hilde; Qvigstad, Eirik; Krobert, Kurt Allen; Nunn, Caroline; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2006). Kinetics of myosin light chain phosphorylation in the heart. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 994- 995
  • Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Nunn, Caroline; Swift, Fredrik; Birkeland, Jon Arne; Krobert, Kurt Allen; Andersen, Geir Øystein; Sejersted, Ole M; Osnes, Jan-Bjørn; Levy, Finn Olav & Skomedal, Tor (2006). Induction of functional serotonin 5-HT2A and 5-HT4 receptors in the acute failing cardiac ventricle. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 73- 73
  • Birkeland, Jon Arne; Qvigstad, Eirik; Sjaastad, Ivar; Brattelid, Trond; Krobert, Kurt Allen; Sejersted, Ole M; Ferrier, GR; Louch, W; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Induction of a 5-HT4 receptor-mediated inotropic response to serotonin in failing ventricular cardiomyocytes. Biophysical Journal.  ISSN 0006-3495.  88
  • Qvigstad, Eirik; Birkeland, Jon Arne; Sjaastad, Ivar; Brattelid, Trond; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Bjornerheim, Reidar; Sejersted, Ole M; Kaumann, Alberto Julio; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2005). Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  38, s 1041- 1041
  • Osnes, Jan-Bjørn; Andersen, Geir Øystein; Qvigstad, Eirik & Skomedal, Tor (2003). New aspects on differential molecular mechanisms of action of myocardial alpha 1-adrenoceptor stimulation.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Induction of 5-HT4 receptor mediated inotropic response to serotonin in failing ventricular myocardium.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Induction of serotonin receptors and inotropic effects in heart failure: a potential new neurohormonal target?.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Novel effect of serotonin (5-HT) in heart failure. A new therapeutic target.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Novel effect of serotonin (5-HT) in heart faiure. A new therapeutic agent?.
  • Qvigstad, Eirik; Brattelid, Trond; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Novel effects of serotonin in heart failure.
  • Tveit, Kristine; Brattelid, Trond; Qvigstad, Eirik; Sjaastad, Ivar; Krobert, Kurt Allen; Sejersted, Ole M; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2003). Regulation of serotonin receptor mRNA levels in heart failure.
  • Andersen, Geir Øystein; Skomedal, Tor; Øie, Erik; Vinge, L.E & Osnes, Jan-Bjørn (2002). Myocardial Na-K-2Cl cotransport regulation by alpha 1-adrenergic stimulation: Phosphorylation of cotransport protein.
  • Osnes, Jan-Bjørn (2002). Cyclic nucleotides: signaling molecules now among allies and rivals.
  • Osnes, Jan-Bjørn (2002). Effects and signalling pathways of G-coupled receptors in normal and failing hearts.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Osnes, Jan-Bjørn (2002). Neurohumoral receptor mediated effects and signalling pathways in normal and failing heart.
  • Osnes, Jan-Bjørn (2002). Neurohumorale inotrope mekanismer.
  • Osnes, Jan-Bjørn (2002). Nevro-humoral og medikamentell påvirkning på det sviktende hjertet.

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Published Sep. 19, 2014 9:26 AM - Last modified Sep. 19, 2014 9:26 AM