Kristine Vaage Hatlen

• Hatlen, Kristine Vaage; Lensnes, Therese Margrethe Lysell; Henriksen, Christine; Berg, Tore Julsrud; Nermoen, Ingrid & Lundin, Knut (2024). Suboptimal adherence to a gluten-free diet in adults with both type 1 diabetes and celiac disease using urinary gluten immunogenic peptide measurement. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 60(1), p. 28–36. doi: 10.1080/00365521.2024.2442688. Full text in Research Archive Show summary

  Objectives Concurrent type 1 diabetes (T1D) and celiac disease (CeD) pose challenges in insulin dosage adjustments and gluten-free dietary adherence. Urine testing for gluten immunogenic peptides (GIP) is a new method to detect gluten exposure within the last 3–12 h. Our aims were to compare gluten-free dietary adherence between T1D + CeD and CeD individuals and evaluate urinary GIP testing in an outpatient setting. Materials and methods This observational cross-sectional study included three adult groups: (1) T1D and CeD, (2) CeD only, and (3) T1D only. T1D participants were recruited from outpatient clinics, the CeD group via social media. One urine sample (12 pm–7 pm) was analyzed using a qualitative immunographic GIP test. CeD participants completed ‘Celiac Dietary Adherence Test’ (CDAT) and ‘Celiac Symptom Index’ (CSI) questionnaires. IgA anti-transglutaminase 2 (IgA-TG2) and IgG anti-deamidated gliadin (IgG-DGP) serology were also analyzed. Results 197 participants, mean (SD) age 43 (15) years, were included. Female percentages were: CeD: 90%, T1D + CeD: 64%, and T1D: 47%. Positive urinary GIP was found in 15% (14/96) of T1D + CeD and 0% (0/50) of CeD (p = 0.002). As expected, most T1D only participants had positive urinary GIP (86%, 44/51). CDAT and CSI scores did not differ between T1D + CeD and CeD groups. Positive IgA-TG2 and/or IgG-DGP levels were found in 12% of T1D + CeD and 6% of CeD participants (p = 0.38). Conclusions A single GIP urine test revealed higher gluten exposure in T1D + CeD versus CeD only, questioning dietary adherence in this population. Urinary GIP tests can be useful for clinical follow-up.

• Hatlen, Kristine Vaage; Sharma, Archana & Nermoen, Ingrid (2020). Servere ketoacidosis in a patient taking an SLGT2 inhibitorfor diabetes. Tidsskrift for Den norske legeforening (Tidsskriftet). ISSN 0029-2001. 140(12), p. 1–4. doi: 10.4045/tidsskr.19.0826. Full text in Research Archive

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• Sharma, Archana & Hatlen, Kristine Vaage (2022). SGLT2-hemmere ved akutte innleggelser og operasjoner. Indremedisineren. ISSN 1891-1617. 04, p. 16–19. Full text in Research Archive
• Nermoen, Ingrid; Sharma, Archana & Hatlen, Kristine Vaage (2022). SGLT2-hemmere ved akutte innleggelser og operasjoner. Indremedisineren. ISSN 1891-1617. 4, p. 16–19. Full text in Research Archive

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