Mercy Varghese

• Brønstad, Maria; Varghese, Mercy & Nielsen, Erik Waage (2018). Fatal propofol infusion syndrome in a young man with status epilepticus. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 62(5), p. 709–711. doi: 10.1111/aas.13106. Full text in Research Archive
• Hauvik, Linn Eva; Varghese, Mercy & Nielsen, Erik Waage (2018). Lactate gap: a diagnostic support in severe metabolic acidosis of unknown origin. Case Reports in Medicine. ISSN 1687-9627. 2018: 5238240, p. 1–4. doi: 10.1155/2018/5238240. Full text in Research Archive Show summary

  Ethylene glycol poisoning is a medical emergency. The metabolites glycolate and glyoxylate give metabolic acidosis. Because of similar structure, these metabolites are misinterpreted as lactate by many point-of-care blood gas analyzers. The falsely high lactate values can lead to misdiagnosis, inappropriate laparotomies, and delayed antidotal therapy. As laboratory analyzers measure plasma lactate only, the difference or the “lactate gap” aids in early diagnosis. We present a patient with severe metabolic acidosis and elevated lactate levels on the point-of-care analyzer. A lactate gap supported the diagnosis of ethylene glycol poisoning. Hemodialysis and fomepizole treatment could be started immediately.

• Varghese, Mercy; Jørgensen, Geir Torvik; Aune, Camilla; Bergan, Ragnhild; Norderval, Stig & Moland, Jarl (2016). Primary aortoduodenal fistula - A case report and a review of the literature. Annals of Vascular Surgery. ISSN 0890-5096. 34, p. 271.e1–271.e4. doi: 10.1016/j.avsg.2015.12.013. Full text in Research Archive
• Varghese, Mercy; Bruland, Øyvind; Wiedswang, Anne Marit; Lobmaier, Ingvild Victoria Koren; Røsok, Bård Ingvald & Benjamin, Robert [Show all 7 contributors for this article] (2016). Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature. Clinical Sarcoma Research. 6(2). doi: 10.1186/s13569-016-0042-6. Full text in Research Archive
• Fossdal, Guri; Vik-Mo, Einar O.; Sandberg, Cecilie; Varghese, Mercy; Kaarbø, Mari & Telmo, Emily Herrera [Show all 8 contributors for this article] (2012). Aqp 9 and Brain Tumour Stem Cells. Scientific World Journal. doi: 10.1100/2012/915176. Full text in Research Archive
• Ølstørn, Håvard; Varghese, Mercy; Murrell, Wayne; Moe, Morten Carsten & Langmoen, Iver Arne (2011). Predifferentiated Brain-Derived Adult Human Progenitor Cells Migrate Toward Ischemia After Transplantation to the Adult Rat Brain. Neurosurgery. ISSN 0148-396X. 68(1), p. 213–222. doi: 10.1227/NEU.0b013e3181fd2c11. Full text in Research Archive
• Vik-Mo, Einar O.; Sandberg, Cecilie; Ølstørn, Håvard; Varghese, Mercy; Brandal, Petter & Ramm-Pettersen, Jon-Terje [Show all 8 contributors for this article] (2010). Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions. Neuro-Oncology. ISSN 1522-8517. 12(12), p. 1220–1230. doi: 10.1093/neuonc/noq102. Full text in Research Archive
• Varghese, Mercy; Ølstørn, Håvard; Murrell, Wayne & Langmoen, Iver Arne (2010). Exploring atypical locations of mammalian neural stem cells: the human filum terminale. Archives Italiennes de Biologie. ISSN 0003-9829. 148(2), p. 85–94. Full text in Research Archive
• Varghese, Mercy; Ølstørn, Håvard; Berg-Johnsen, Jon; Moe, Morten Carsten; Murrell, Wayne & Langmoen, Iver Arne (2009). Isolation of Human Multipotent Neural Progenitors from Adult Filum Terminale. Stem Cells and Development. ISSN 1547-3287. 18(4), p. 603–613. doi: 10.1089/scd.2008.0144. Full text in Research Archive
• Moe, Morten Carsten; Kolberg, RS; Sandberg, Cecilie; Vik-Mo, Einar O.; Olstorn, H & Varghese, Mercy [Show all 8 contributors for this article] (2009). A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain. Experimental Eye Research. ISSN 0014-4835. 88(1), p. 30–38. doi: 10.1016/j.exer.2008.09.020. Full text in Research Archive
• Varghese, Mercy; Ølstørn, Håvard; Sandberg, Cecilie; Vik-Mo, Einar O.; Noordhuis, Paul & Nistér, Monica [Show all 9 contributors for this article] (2008). A COMPARISON BETWEEN STEM CELLS FROM THE ADULT HUMAN BRAIN AND FROM BRAIN TUMORS. Neurosurgery. ISSN 0148-396X. 63(6), p. 1022–1033. doi: 10.1227/01.NEU.0000335792.85142.B0. Full text in Research Archive
• Westerlund, U; Svensson, M; Moe, Morten Carsten; Varghese, Mercy; Gustavsson, B. & Wallstedt, Lars [Show all 8 contributors for this article] (2005). Endoscopically harvested stem cells: a putative method in future autotransplantation. Neurosurgery. ISSN 0148-396X. 57(4), p. 779–784. Full text in Research Archive
• Moe, Morten Carstens; Westerlund, U; Varghese, Mercy; Berg-Johnsen, Jon; Svensson, M & Langmoen, Iver Arne (2005). Development of neuronal networks from single stem cells harvested from the adult human brain. Neurosurgery. ISSN 0148-396X. 56. Full text in Research Archive
• Moe, Morten Carstens; Varghese, Mercy; Danilov, AI; Westerlund, U; Ramm-Pettersen, J. & Brundin, L [Show all 9 contributors for this article] (2005). Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons. Brain. ISSN 0006-8950. 128. Full text in Research Archive
• Liu, C. Y.; Westerlund, U.; Svensson, Magnus; Moe, Morten Carstens; Varghese, Mercy & Berg-Johansen, John [Show all 9 contributors for this article] (2003). Artificial niches for human adult neural stem cells: Possibility for autologous transplantation therapy. Journal of Hematotherapy & Stem Cell Research. ISSN 1525-8165. 12, p. 689–699. Full text in Research Archive

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• Varghese, Mercy; Nymoen, Hanne Marte Gjertsen; Saxhaug, Cathrine; Krossnes, Bård Kronen; Hosainey, Sayied Abdol Mohieb & Meling, Torstein Ragnar [Show all 7 contributors for this article] (2016). Symptomatic spinal metastasis from intracranial glioblastoma multiforme – Two illustrative cases and a review of the literature. Acta Oncologica. ISSN 0284-186X. 55(9-10), p. 1236–1253. doi: 10.3109/0284186X.2016.1161824. Full text in Research Archive
• Varghese, Mercy (2008). Isolation and Characterization of Stem Cells from the Adult Human Central Nervous System and Brain Tumours. Universitetet i Oslo. Full text in Research Archive Show summary

  The central nervous system (CNS) was viewed as a static organ incapable of neurogenesis. The discovery of adult human neural stem cells (AHNSCs) capable of self-renewal, proliferation and multipotent differentiation opens new opportunities for stem cell-based treatment of CNS disorders, either by stimulating neurogenesis in vivo or transplanting AHNSCs. The main challenges facing clinical application include the limited availability of AHNSCs and their ability to develop into functional neurons. Recently, cells similar to AHNSCs known as tumour stem cells (TSCs) have been isolated from brain tumours. The TSC model proposes that TSCs drive glioma initiation and maintenance. Targeting TSCs may prove effective in cancer therapy. Given their intimate relation, we have investigated AHNSCs and TSCs.<br><br> We isolated AHNSCs from the ventricular wall of patients undergoing surgery for refractory epilepsy or hydrocephalus. AHNSCs exhibited self-renewal and proliferated into neurospheres. Furthermore, they exhibited multipotent differentiation into neurons, astrocytes and oligodendrocytes. Using electrophysiology, we showed that after 4 weeks neurons developed functional activity; they exhibited mature action potentials and communicated using GABAergic and glutamatergic synapses. We also demonstrated that AHNSCs isolated from the terminal end of the spinal cord, can develop into functional neurons. The functional differentiation of AHNSCs holds promise for the treatment of neurodegenerative CNS disorders.<br><br> We isolated TSCs from patients undergoing resections for low grade and high grade gliomas and compared them to AHNSCs. Given their similarities, we demonstrated several key differences including uncontrolled proliferation, precocious differentiation and tumour generation upon transplantation in vivo. Utilizing such differences may lead to effective therapies targeting TSCs whilst sparing resident AHNSCs. This may have a profound effect on the dismal prognosis of gliomas.

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