Nicola Pietro Montaldo

• Bordin, Diana Lilian; Grooms, Kayla Mae; Montaldo, Nicola Pietro; Fordyce Martin, Sarah L.; Sætrom, Pål & Samson, Leona D. [Show all 8 contributors for this article] (2024). Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory. DNA Repair. ISSN 1568-7864. 135. doi: 10.1016/j.dnarep.2024.103632.
• Glærum, Ingvild Lynneberg; Dunville, Keagan; Moan, Kristian Magnus; Krause, Maike; Montaldo, Nicola Pietro & Kirikae, Hinaco [Show all 10 contributors for this article] (2024). Postnatal persistence of hippocampal Cajal-Retzius cells has a critical role in the establishment of the hippocampal circuit. Development. ISSN 0950-1991. 151(1). doi: 10.1242/dev.202236.
• Loevenich, Simon; Montaldo, Nicola Pietro; Wickenhagen, Arthur; Sherstova, Tatyana; van Loon, Barbara & Boyartchuk, Victor [Show all 7 contributors for this article] (2023). Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens. Frontiers in Immunology. ISSN 1664-3224. 14. doi: 10.3389/fimmu.2023.1173605. Full text in Research Archive
• Lirussi, Lisa; Ayyildiz, Dilara; Liu, Yan; Montaldo, Nicola Pietro; Carracedo Huroz, Sergio & Aure, Miriam Ragle [Show all 16 contributors for this article] (2022). A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours. Nucleic Acids Research (NAR). ISSN 0305-1048. 50(18), p. 10449–10468. doi: 10.1093/nar/gkac807. Full text in Research Archive
• Akbari, Mansour; Nilsen, Hilde & Montaldo, Nicola Pietro (2022). Dynamic features of human mitochondrial DNA maintenance and transcription. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 10. doi: 10.3389/fcell.2022.984245. Full text in Research Archive
• Aprigliano, Rossana; Aksu, Merdane Ezgi; Bradamante, Stefano; Mihaljevic, Boris; Wang, Wei & Rian, Kristin [Show all 19 contributors for this article] (2021). Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities. Cell Reports Medicine. ISSN 2666-3791. 2(4). doi: 10.1016/j.xcrm.2021.100240. Full text in Research Archive Show summary

  Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), the disease mechanisms common to these syndromes remain unknown. In this work, we identify p53 signaling as the central process altered in HUWE1-promoted XLID syndromes. By focusing on Juberg-Marsidi syndrome (JMS), one of the severest XLIDs, we show that increased p53 signaling results from p53 accumulation caused by HUWE1 p.G4310R destabilization. This further alters cell-cycle progression and proliferation in JMS cells. Modeling of JMS neurodevelopment reveals majorly impaired neural differentiation accompanied by increased p53 signaling. The neural differentiation defects can be successfully rescued by reducing p53 levels and restoring the expression of p53 target genes, in particular CDKN1A/p21. In summary, our findings suggest that increased p53 signaling underlies HUWE1-promoted syndromes and impairs XLID JMS neural differentiation.

• Rolinski, Milosz; Montaldo, Nicola Pietro; Aksu, Merdane Ezgi; Martin, Sarah Fordyce; Brambilla, Alessandro & Kunath, Nicolas [Show all 13 contributors for this article] (2021). Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Research (NAR). ISSN 0305-1048. 49(3), p. 1470–1484. doi: 10.1093/nar/gkaa1289. Full text in Research Archive
• Montaldo, Nicola Pietro; Bordin, Diana Lilian; Brambilla, Alessandro; Rösinger, Marcel; Martin, Sarah Fordyce & Bjørås, Karine Øian [Show all 16 contributors for this article] (2019). Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-13394-w. Full text in Research Archive

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• Anthonsen, Marit Walbye; Boyartchuk, Victor; Loevenich, Simon; van Loon, Barbara; Montaldo, Nicola Pietro & Sherstova, Tatyana (2019). Human metapneumovirus impairs antibacterial transcription by introducing H3K27 trimethylation at the IL1B promoter.

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