Sindre Lee-Ødegård

Image of Sindre Lee-Ødegård
Norwegian version of this page
Room Bygg 98
Username
Visiting address ‎Aker sykehus
Postal address Postboks 4959 Nydalen OUS HF Aker sykehus 0424 Oslo

Academic interests
Diabetes, clinical and mechanistic studies
Insulin resistance and metabolic syndrome
Physical activity and nutrition
Biostatistics and bioinformatics in multi-omics

Background
Exercise physiologist in 2008
MD in 2019
PhD in 2020
Clinical work at the Department of Endocrinology, Aker Hospital / Oslo University Hospital
Research at the Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Aker Hospital / Oslo University Hospital

Honors
Novo Nordisk Fonden Excellence Emerging Grant 2023
Helse Sør-Øst åpent prosjekt, co-PI 2023
Diabetesforbundets forskningspris 2021

Collaborations
Oslo Diabetes Research Centre (Several Groups)
Prof. Andrea Hevener, UCLA
Prof. Christian Drevon, Dep. of nutrition, University of Oslo
Prof. Frode Norheim, Dep. of nutrition, University of Oslo
Prof. Truls Råstad, Dep. of sport sciences, NIH

Tags: Diabetes and hormones, Exercise, Nutrition, Biostatistics, Bioinformatics

Publications

  • Linares-Pineda, Teresa M.; Fragoso Bargas, Nicolas; Picón, María José; Molina-Vega, Maria; Jenum, Anne Karen & Sletner, Line [Show all 14 contributors for this article] (2024). DNA methylation risk score for type 2 diabetes is associated with gestational diabetes. Cardiovascular Diabetology. ISSN 1475-2840. 23(1). doi: 10.1186/s12933-024-02151-z.
  • Opsahl, J. O.; Fragoso-Bargas, N.; Lee, Y.; Carlsen, E. Ø.; Lekanova, N. & Qvigstad, E. [Show all 13 contributors for this article] (2024). Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain. International Journal of Obesity. ISSN 0307-0565. p. 1–10. doi: 10.1038/s41366-024-01458-x. Full text in Research Archive
  • Olsen, Thomas; Stolt, Emma Theresia Kjelland; Øvrebø, Bente; Elshorbagy, Amany; Tore, Elena C. & Lee-Ødegård, Sindre [Show all 20 contributors for this article] (2024). Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. Journal of Translational Medicine. ISSN 1479-5876. 22(1). doi: 10.1186/s12967-023-04833-w.
  • Jersin, Regine Åsen; Tallapragada, Divya Sri; Skartveit, Linn; Bjune, Mona Synnøve; Muniandy, Maheswary & Lee-Ødegård, Sindre [Show all 16 contributors for this article] (2023). Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 108(9), p. 2217–2229. doi: 10.1210/clinem/dgad148. Full text in Research Archive
  • Moore, Timothy M.; Lee-Ødegård, Sindre; Olsen, Thomas; Morselli, Marco; Strumwasser, Alexander R. & Lin, Amanda J. [Show all 40 contributors for this article] (2023). Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice. Cell reports. ISSN 2211-1247. 42(5). doi: 10.1016/j.celrep.2023.112499. Full text in Research Archive
  • Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre & Opsahl, Julia Onsrud [Show all 13 contributors for this article] (2023). Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes. Epigenomics. ISSN 1750-1911. 15(1), p. 39–52. doi: 10.2217/epi-2022-0427. Full text in Research Archive
  • Fragoso-Bargas, Nicolas; Elliott, Hannah R.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line & Jenum, Anne Karen [Show all 12 contributors for this article] (2022). Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study. Diabetes. ISSN 0012-1797. 72(3), p. 415–426. doi: 10.2337/db22-0504.
  • Sommer, Christine; Vangberg, Kjersti G; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre & Høgestøl, Ingvild Kristine [Show all 11 contributors for this article] (2022). Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 108(5), p. 1110–1119. doi: 10.1210/clinem/dgac699. Full text in Research Archive
  • Elshorbagy, Amany; Bastani, Nasser Ezzatkhah; Lee-Ødegård, Sindre; Øvrebø, Bente; Haj Yasein, Nadia & Svendsen, Karianne [Show all 10 contributors for this article] (2022). The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression. Amino Acids. ISSN 0939-4451. doi: 10.1007/s00726-022-03229-2. Full text in Research Archive
  • Sharma, Archana; Lee-Ødegård, Sindre; Qvigstad, Elisabeth; Sommer, Christine; Sattar, Naveed & Gill, Jason M.R. [Show all 10 contributors for this article] (2022). β-Cell Function, Hepatic Insulin Clearance, and Insulin Sensitivity in South Asian and Nordic Women After Gestational Diabetes Mellitus. Diabetes. ISSN 0012-1797. 71(12), p. 2530–2538. doi: 10.2337/db22-0622. Full text in Research Archive
  • Lee-Ødegård, Sindre; Ueland, Thor; Thorsby, Per Medbøe; Aukrust, Pål; Michelsen, Annika Elisabet & Halvorsen, Bente [Show all 8 contributors for this article] (2022). Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes. BMC Endocrine Disorders. ISSN 1472-6823. 22. doi: 10.1186/s12902-022-01127-y. Full text in Research Archive
  • Bjerkreim, Betty Ann; Hammerstad, Sara Salehi; Gulseth, Hanne Løvdal; Berg, Tore Julsrud; Lee-Ødegård, Sindre & Eriksen, Erik Fink (2022). Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover Trial. Journal of Thyroid Research. ISSN 2090-8067. 2022. doi: 10.1155/2022/6423023. Full text in Research Archive
  • Doncheva, Atanaska Ivanova; Romero, Silvana Angelica Troncoso; Ramirez-Garrastacho, Manuel; Lee-Ødegård, Sindre; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Show all 11 contributors for this article] (2022). Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight. Acta Physiologica. ISSN 1748-1708. 236(4). doi: 10.1111/apha.13862. Full text in Research Archive
  • Lee-Ødegård, Sindre; Olsen, Thomas; Norheim, Frode Amador; Drevon, Christian A & Birkeland, Kåre Inge (2022). Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance. Metabolites. ISSN 2218-1989. 12(3)(208). doi: 10.3390/metabo12030208. Full text in Research Archive
  • Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre & Qvigstad, Elisabeth [Show all 15 contributors for this article] (2021). Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes. PLOS ONE. ISSN 1932-6203. 16(8), p. 1–15. doi: 10.1371/journal.pone.0256158. Full text in Research Archive
  • Bjerkreim, Betty Ann; Hammerstad, Sara Salehi; Gulseth, Hanne Løvdal; Berg, Tore Julsrud; Lee-Ødegård, Sindre & Rangberg, Anbjørg [Show all 12 contributors for this article] (2021). Effect of Liothyronine Treatment on Quality of Life in Female Hypothyroid Patients With Residual Symptoms on Levothyroxine Therapy: A Randomized Crossover Study. Frontiers in Endocrinology. ISSN 1664-2392. 13, p. 1–11. doi: 10.3389/fendo.2022.816566. Full text in Research Archive
  • Bleskestad, Kristiane Birkeland; Nordheim, Espen; Lindahl, Jørn Petter Hanto; Midtvedt, Karsten; Pihlstrøm, Hege K. & Horneland, Rune [Show all 10 contributors for this article] (2021). Insulin secretion and action after pancreas transplantation. A retrospective single-center study. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 81(5), p. 365–370. doi: 10.1080/00365513.2021.1926535. Full text in Research Archive
  • Tallay, Elias; Lindberg, Sondre K.; Lee-Ødegård, Sindre; Bjordal, Jonas; Fraser, Alexander Nilsskog & Madsen, Jan Erik [Show all 7 contributors for this article] (2021). External validity in a multicenter randomized clinical trial of proximal humeral fractures: the DelPhi trial. European Journal of Orthopaedic Surgery & Traumatology (EJOST). ISSN 1633-8065. doi: 10.1007/s00590-021-02982-6.
  • Lee, Yunsung; Jacobsen, Kristine Løkås; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian & Lyle, Robert [Show all 19 contributors for this article] (2020). Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics. ISSN 1471-2164. 21(1). doi: 10.1186/s12864-020-07168-8. Full text in Research Archive
  • Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas & Refsum, Helga [Show all 9 contributors for this article] (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia. ISSN 0012-186X. 64, p. 410–423. doi: 10.1007/s00125-020-05296-0. Full text in Research Archive
  • Zhou, Zhenqi; Moore, Timothy M.; Drew, Brian G.; Ribas, Vicent; Wanagat, Jonathan & Civelek, Mete [Show all 31 contributors for this article] (2020). Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine. ISSN 1946-6234. 12(555). doi: 10.1126/SCITRANSLMED.AAX8096. Full text in Research Archive
  • Hansen, Anne-Marte; Wium, Cecilie; Lee-Ødegård, Sindre; Tierney, Audrey C.; McCarthy, Danielle & Roche, Helen M. [Show all 9 contributors for this article] (2020). Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 80(4), p. 282–290. doi: 10.1080/00365513.2020.1730433. Full text in Research Archive
  • Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne & Hjorth, Marit [Show all 11 contributors for this article] (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine. ISSN 1479-5876. 18(122). doi: 10.1186/s12967-020-02288-x. Full text in Research Archive
  • Lee-Ødegård, Sindre; Kolset, Svein Olav; Birkeland, Kåre I.; Drevon, Christian A & Reine, Trine M. (2019). Acute exercise increases syndecan-1 and -4 serum concentrations. Glycoconjugate Journal. ISSN 0282-0080. 36(2), p. 113–125. doi: 10.1007/s10719-019-09869-z. Full text in Research Archive
  • Blakstad, Elin Wahl; Korpela, Katri; Lee-Ødegård, Sindre; Nakstad, Britt; Moltu, Sissel & Strømmen, Kenneth [Show all 11 contributors for this article] (2019). Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants. Pediatric Research. ISSN 0031-3998. doi: 10.1038/s41390-019-0412-x.
  • Lee-Ødegård, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight. Diabetologia. ISSN 0012-186X. 62(6), p. 1048–1064. doi: 10.1007/s00125-019-4866-5. Full text in Research Archive
  • Lee-Ødegård, Sindre; Olsen, Thomas; Vinknes, Kathrine; Refsum, Helga; Gulseth, Hanne Løvdal & Birkeland, Kåre I. [Show all 7 contributors for this article] (2019). Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients. ISSN 2072-6643. 11(1). doi: 10.3390/nu11010010. Full text in Research Archive
  • Moore, Timothy M.; Zhou, Zhenqi; Cohn, Whitaker; Norheim, Frode; Lin, Amanda J. & Kalajian, Nareg [Show all 23 contributors for this article] (2018). The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Molecular Metabolism. ISSN 2212-8778. 21, p. 51–67. doi: 10.1016/j.molmet.2018.11.012. Full text in Research Archive
  • Lee-Ødegård, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael & Gundersen, Thomas Erik [Show all 9 contributors for this article] (2018). Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports. ISSN 2045-2322. 8:6531, p. 1–12. doi: 10.1038/s41598-018-24976-x. Full text in Research Archive
  • Pourteymour, Shirin; Hjorth, Marit; Lee-Ødegård, Sindre; Holen, Torgeir; Langleite, Torgrim Mikal & Jensen, Jørgen [Show all 9 contributors for this article] (2017). Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise. Physiological Reports. ISSN 2051-817X. 5:e13459(19), p. 1–14. doi: 10.14814/phy2.13459. Full text in Research Archive
  • Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen & Tangen, Daniel S. [Show all 12 contributors for this article] (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5). doi: 10.14814/phy2.13183. Full text in Research Archive
  • Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre & Jensen, Jørgen [Show all 9 contributors for this article] (2017). Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines. Molecular Metabolism. ISSN 2212-8778. 6(4), p. 352–365. doi: 10.1016/j.molmet.2017.01.007. Full text in Research Archive
  • Lee, Sindre; Norheim, Frode; Langleite, Torgrim Mikal; NORENG, HANS JØRGEN; Storås, Tryggve & Afman, Lydia A. [Show all 18 contributors for this article] (2016). Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging. Physiological Reports. ISSN 2051-817X. 4(21). doi: 10.14814/phy2.13019.
  • Hjorth, Marit; Pourteymour, Shirin; Goergens, S W; Langleite, Torgrim Mikal; Lee, Sindre & Holen, Torgeir [Show all 11 contributors for this article] (2016). Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells. Acta Physiologica. ISSN 1748-1708. 217(1), p. 45–60. doi: 10.1111/apha.12631.
  • Görgens, Sven W.; Hjorth, Marit; Eckardt, Kristin; Wichert, Stefan; Norheim, Frode & Holen, Torgeir [Show all 16 contributors for this article] (2016). The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation. Acta Physiologica. ISSN 1748-1708. 216(3), p. 330–345. doi: 10.1111/apha.12579.
  • Pourteymour, Shirin; Lee, Sindre; Langleite, Torgrim Mikal; Eckardt, Kristin; Hjorth, Marit & Bindesbøll, Christian [Show all 11 contributors for this article] (2015). Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiological Reports. ISSN 2051-817X. 3:e12481(8), p. 1–15. doi: 10.14814/phy2.12481.
  • Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre & Holen, Torgeir [Show all 13 contributors for this article] (2015). The effect of acute and long-term physical activity on extracelluar Matrix and serglycin in huuman skeletal muscle. Physiological Reports. ISSN 2051-817X. 3:e12473(8), p. 1–19. doi: 10.14814/phy2.12473.
  • Albrecht, Elke; Norheim, Frode; Thiede, Bernd; Holen, Torgeir; Ohashi, Tomoo & Schering, Lisa [Show all 12 contributors for this article] (2015). Irisin - A myth rather than an exercise-inducible myokine. Scientific Reports. ISSN 2045-2322. 5. doi: 10.1038/srep08889.
  • Albrecht, Elke; norheim, frode; Thiede, Bernd; Lee, Sindre; Holen, Torgeir & Ohashi,, Tomoo [Show all 12 contributors for this article] (2015). Irisin – a myth rather than an exercise-inducible myokine. Scientific Reports. ISSN 2045-2322. doi: 10.1038/srep08889.
  • Kanzleiter, Timo; Rath, Michaela; Görgens, Sven W.; Jensen, Jørgen; Tangen, Daniel S. & Kolnes, Anders Jensen [Show all 11 contributors for this article] (2014). The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 450(2), p. 1089–1094. doi: 10.1016/j.bbrc.2014.06.123.
  • Li, Yuchuan; Lee, Sindre; Langleite, Torgrim Mikal; Norheim, Frode; Pourteymour, Shirin & Jensen, Jørgen [Show all 13 contributors for this article] (2014). Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention. Physiological Reports. ISSN 2051-817X. 2(11). doi: 10.14814/phy2.12187.
  • Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir & Bindesbøll, Christian [Show all 13 contributors for this article] (2014). Regulation of angiopoietin-like protein 4 Production during and after exercise. Physiological Reports. ISSN 2051-817X. 2(8). doi: 10.14814/phy2.12109.

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  • Fragoso Bargas, Nicolas; Linares-Pineda, Teresa; Molina-Vega, María; Picón, María José; Jenum, Anne Karen & Sletner, Line [Show all 14 contributors for this article] (2023). Methylation risk score for gestational diabetes on DNA methylation patterns associated with type 2 diabetes.
  • Borgen, Tove Tveitan; Lee-Ødegård, Sindre; Eriksen, Barbara & Eriksen, Erik Fink (2023). Intermittent Dosing of Zoledronic acid Based on Bone Turnover Marker Assessment Reduces Vertebral and Non-Vertebral Fractures.
  • Borgen, Tove Tveitan; Lee-Ødegård, Sindre; Eriksen, Barbara & Eriksen, Erik Fink (2023). Long term treatment with i.v. Zoledronic acid with dosing based on bone turnover markers.
  • Elshorbagy, Amany; Bastani, Nasser Ezzatkhah; Lee-Ødegård, Sindre; Øvrebø, Bente; Haj Yasein, Nadia & Svendsen, Karianne [Show all 10 contributors for this article] (2023). Correction to: The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression (Amino Acids, (2022), 10.1007/s00726-022-03229-2). Amino Acids. ISSN 0939-4451. 55, p. 547–548. doi: 10.1007/s00726-023-03244-x.
  • Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; Oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Show all 12 contributors for this article] (2022). Epigenome-Wide Association Study of objectively measured physical activity in pregnancy.
  • Fragoso-Bargas, Nicolas; Lee-Ødegård, Sindre; Moen, Gunn-Helen Øiseth; oppsahl, JO; Sletner, Line & Jenum, Anne Karen [Show all 13 contributors for this article] (2022). Epigenome-Wide Association Study of objectively measured moderate physical activity in pregnan.
  • Lee-Ødegård, Sindre; Norheim, Frode Amador; Langleite, Torgrim Mikal; Gulseth, Hanne Løvdal; Birkeland, Kåre Inge & Drevon, Christian A (2022). Correction to: Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight (Diabetologia, (2019), 62, 6, (1048-1064), 10.1007/s00125-019-4866-5). Diabetologia. ISSN 0012-186X. doi: 10.1007/s00125-022-05841-z.
  • Lee-Ødegård, Sindre; Norheim, Frode Amador; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Aker, Andreas Helge Mikael & Gundersen, Thomas Erik [Show all 9 contributors for this article] (2018). Author Correction: Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-26061-9.
  • Eckardt, Kristin; Pourteymour, Shirin; Hjorth, Marit; Lee, Sindre; Langleite, Torgrim Mikal & Holen, Torgeir [Show all 9 contributors for this article] (2016). Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise.
  • Eckardt, Kristin; Lee, Sindre; Langleite, Torgrim Mikal; Holen, Torgeir; Jensen, Jørgen & Birkeland, Kåre I. [Show all 7 contributors for this article] (2015). Stearoyl-CoA desaturase and its regulation in human skeletal muscle by exercise.

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Published Feb. 5, 2020 3:08 PM - Last modified July 28, 2023 10:34 PM

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