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Soili Marianne Lehto

Image of Soili Marianne Lehto
Visiting address Sykehusveien 25 1474 Nordbyhagen
Postal address Akershus universitetssykehus 1478 Lørenskog

My research group, Psychobiology, focuses on characterising how psychological phenomena and the physiology of the human body interact, and discovering new ways to modify these interactions. Our goals are to identify mechanisms for common mental health disorders such as depression, and to use this knowledge to develop and optimise treatments. We work with different populations ranging from healthy volunteers to individuals affected by mental health disorders.

Academic and Professional Degrees

  • Special Competence in Medical Education, Finnish Medical Association, Finland, 2013
  • Clinical Specialist in Psychiatry, University of Eastern Finland, Finland, 2012
  • Ph.D., University of Kuopio, Finland, 2009
  • M.D., University of Kuopio, Finland, 2006

Major Positions and Appointments

  • Head of Department, Department of Mental Health, Institute of Clinical Medicine, University of Oslo, 2025– present
  • Professor, Institute of Clinical Medicine, University of Oslo, 2020– present
  • Research professor, Akershus University Hospital, 2020– present
  • Research Director, University of Helsinki, 2018–2020
  • Title of Docent in Biological Psychiatry, University of Helsinki, 2017–present
  • University Researcher, University of Helsinki, 2016–2017
  • Professor in Psychiatry (acting), University of Eastern Finland, 2016
  • Visiting academic, University of Oxford, 2014–2015
  • Professor in Psychiatry (acting), University of Eastern Finland, 2013–2014
  • Clinical lecturer in Psychiatry, University of Eastern Finland, 2010–2013
  • Title of Docent in Experimental Psychiatry, University of Eastern Finland, 2010– present

Major Positions of Trust

  • EU COST Action Management Group Member: Representative for Norway. CA22114 - Maternal Perinatal Stress and Adverse Outcomes in the Offspring: Maximising infants´ development (TREASURE). 2023–2027.
  • Associate editor. Nordic Journal of Psychiatry. 2019–present.
  • The National Committee of Medical Research Ethics in Finland, deputy member, 2018–2022
  • Ethics adviser. Horizon 2020 Innovative Training Networks project “ChildBrain: Advancing brain research in children’s developmental neurocognitive disorders" (Marie Skłodowska-Curie Actions (MSCA) Innovative Training Networks (ITN), H2020-MSCA-ITN-2014). 2014–2017.
  • Invited grant review panel member for international research funding calls (e.g., European Research Council. ERC Advanced Grant Call). 2013–present

Major Research Interests

  • Novel modelling approaches that allow better characterisation of the complex biopsychosocial interactions underlying disease processes in mood disorders.
  • Development and optimisation of treatment applications based on novel disease mechanisms identified for mood disorders.

Collaboration

  • In order to achieve our goals, my group collaborates with several institutions both nationally and internationally, including the Central Institute of Mental Health in Mannheim, King’s College London, University of Bern, University of Kent, University of Tampere and University of Eastern Finland.

Publications

  • Sarnola, Katriina M; Välitalo, Hanna; Kraav, Siiri Liisi; Therman, Sebastian; Kurkinen, Karoliina & Ruuska, Sami Matti [Show all 10 contributors for this article] (2026). The Change in Trait Resilience Predicts the Alleviation of Transdiagnostic Depressive Symptoms in Outpatient Adolescents: The Mediating Role of the Change in Psychological Inflexibility/Experiential Avoidance. Clinical Psychology and Psychotherapy. ISSN 1063-3995. 33(2), p. 1–11. doi: 10.1002/cpp.70268. Full text in Research Archive
  • Laurila, Joanna; Masar, Johanna; Tuppurainen, Marjo; Lehto, Soili Marianne; Hantunen, Sari & Keski-Nisula, Leea (2026). Higher Risk of Gestational Diabetes in Women With a Greater Variety of Sleep Disturbances. Journal of Pregnancy. ISSN 2090-2727. 2026(1). doi: 10.1155/jp/4604151. Full text in Research Archive
  • Airaksinen, Ville; Pesonen, Maiju; Bernhardsen, Guro Pauck; Chortatos, Arthur; Keski-Nisula, Leea & Backman, Katri [Show all 9 contributors for this article] (2026). Do prenatal affective symptoms have an impact on the infant oral microbial exposure? Results from the Kuopio Birth Cohort Study. Journal of Affective Disorders. ISSN 0165-0327. 408. doi: 10.1016/j.jad.2026.121828. Full text in Research Archive
  • Mikola, Tuomas; Lehto, Soili Marianne; Tolmunen, Tommi; Honkalampi, Kirsi; Valkonen-Korhonen, Minna & Laukkanen, Virpi [Show all 9 contributors for this article] (2026). Effect of a six-month vitamin D supplementation on depressive symptoms in patients with major depressive episode (DepFuD): a double-blinded randomised controlled trial. Journal of Affective Disorders. ISSN 0165-0327. 406. doi: 10.1016/j.jad.2026.121709. Full text in Research Archive
  • Bernhardsen, Guro Pauck; Pesonen, Maiju; Keski-Nisula, Leea; Nordeng, Hedvig Marie Egeland & Lehto, Soili Marianne (2025). Trajectories of Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Perinatal Outcomes: A Longitudinal Register Study. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 133(1), p. 83–94. doi: 10.1111/1471-0528.18337. Full text in Research Archive
  • Mikkonen, Ulla; Tusa, Nina; Sinikallio, Sanna; Lehto, Soili Marianne; Ruusunen, Anu & Kautiainen, Hannu [Show all 7 contributors for this article] (2025). The relationship between self-care preparedness and quality of life in a 3-year-follow-up: a study in primary health care. Family Practice. ISSN 0263-2136. 42(1). doi: 10.1093/fampra/cmae069. Full text in Research Archive
  • Honkalampi, Kirsi; Kraav, Siiri-Liisi; Kerr, Philippe; Juster, Robert-Paul; Virtanen, Marianna & Hintsa, Taina [Show all 8 contributors for this article] (2024). Associations of allostatic load with sociodemographic factors, depressive symptoms, lifestyle, and health characteristics in a large general population-based sample. Journal of Affective Disorders. ISSN 0165-0327. 350, p. 784–791. doi: 10.1016/j.jad.2024.01.189. Full text in Research Archive
  • Kärkkäinen, Olli; Tolmunen, Tommi; Kivimäki, Petri; Kurkinen, Karoliina; Ali-Sisto, Toni & Mäntyselkä, Pekka [Show all 12 contributors for this article] (2024). Alcohol use-associated alterations in the circulating metabolite profile in the general population and in individuals with major depressive disorder. Alcohol. ISSN 0741-8329. 120, p. 161–167. doi: 10.1016/j.alcohol.2024.01.005. Full text in Research Archive
  • Bernhardsen, Guro Pauck; Thomas, Owen Matthew Truscott; Mäntyselkä, Pekka; Niskanen, Leo; Vanhala, Mauno & Koponen, Hannu [Show all 7 contributors for this article] (2024). Metabolites and depressive symptoms: Network- and longitudinal analyses from the Finnish Depression and Metabolic Syndrome in Adults (FDMSA) Study. Journal of Affective Disorders. ISSN 0165-0327. 347, p. 199–209. doi: 10.1016/j.jad.2023.11.070. Full text in Research Archive
  • Varheenmaa, Markus; Lehto, Soili Marianne; Rizzo, Patrizia; Steinhausen, Hans-Christoph; Drechsler, Renate & Brem, Anna-Katharine (2024). Facial emotion recognition in children with attention deficit hyperactivity disorder. Nordic Journal of Psychiatry. ISSN 0803-9488. 78(7), p. 634–643. doi: 10.1080/08039488.2024.2403589. Full text in Research Archive
  • Chortatos, Arthur; Vittersø, Axel; Uusitalo, Lauri; Lehtonen, Marko; Huotari, Johanna & Auriola, Seppo [Show all 10 contributors for this article] (2024). Associations of gestational anxiety and depression with neonatal hair steroid levels. Psychoneuroendocrinology. ISSN 0306-4530. 172. doi: 10.1016/j.psyneuen.2024.107260. Full text in Research Archive
  • Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili Marianne; Luoma, Ilona; Kraav, Siiri-Liisi & Kivimäki, Petri [Show all 8 contributors for this article] (2024). An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence. Translational Psychiatry. 14(1). doi: 10.1038/s41398-024-03163-9. Full text in Research Archive
  • Korkmaz, Asli; Bernhardsen, Guro Pauck; Cirit, Burcu; Suzer, Gayem Koprucu; Kayan, Hale & Biçmen, Hülya [Show all 11 contributors for this article] (2024). Sudarshan Kriya Yoga Breathing and a Meditation Program for Burnout Among Physicians: A Randomized Clinical Trial. JAMA Network Open. 7(1). doi: 10.1001/jamanetworkopen.2023.53978. Full text in Research Archive
  • Mikola, T.; Lehto, Soili Marianne; Honkalampi, K.; Valkonen-Korhonen, M.; Koivumaa-Honkanen, H. & Tolmunen, T. [Show all 9 contributors for this article] (2024). A follow-up study with a double-blinded, randomized controlled vitamin D supplementation trial in patients with major depressive episode (DepFuD): A study protocol and baseline characteristics. Food Science & Nutrition. doi: 10.1002/fsn3.4417. Full text in Research Archive
  • Musakka, Emma-Reetta; Ylilauri, Maija Paula Tuulia; Jalanka, Jonna; Karvonen, Anne Maarit; Täubel, Martin & Hantunen, Sari [Show all 11 contributors for this article] (2024). Maternal exercise during pregnancy is associated with reduced risk of asthma in the child: A prospective birth cohort study. Med. ISSN 2666-6359. doi: 10.1016/j.medj.2024.09.003. Full text in Research Archive
  • Chortatos, Arthur; Pesonen, Maiju; Thomas, Owen Matthew Truscott; Toffol, Elena; Airaksinen, Ville & Musakka, Emma [Show all 12 contributors for this article] (2024). Microbial exposure at birth and the development of behavioral temperament during the first three years of childhood. Development and Psychopathology. ISSN 0954-5794. doi: 10.1017/S0954579424001676. Full text in Research Archive
  • Savard, Josephine; Bernhardsen, Guro Pauck; Mykkänen, Anu; Keski-Nisula, Leea & Lehto, Soili Marianne (2024). The association between gestational diabetes and fear of childbirth: a longitudinal register study. BMC Pregnancy and Childbirth. 24. doi: 10.1186/s12884-024-07022-9. Full text in Research Archive
  • Ali-Sisto, Toni; Tolmunen, Tommi; Kraav, Siiri-Liisi; Mäntyselkä, Pekka; Valkonen-Korhonen, Minna & Honkalampi, Kirsi [Show all 9 contributors for this article] (2023). Serum levels of carnosine may be associated with the duration of MDD episodes. Journal of Affective Disorders. ISSN 0165-0327. 320, p. 647–655. doi: 10.1016/j.jad.2022.09.092. Full text in Research Archive
  • Mikkonen, Ulla; Voutilainen, Ari; Mikola, Tuomas; Roponen, Johanna; Rajapolvi, Sanna & Lehto, Soili Marianne [Show all 8 contributors for this article] (2023). The effects of motivational self-care promotion on depressive symptoms among adults with type 2 diabetes: A systematic review and meta-analysis. Preventive Medicine Reports. 36. doi: 10.1016/j.pmedr.2023.102431. Full text in Research Archive
  • Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili Marianne; Luoma, Ilona; Kraav, Siiri-Liisi & Kivimäki, Petri [Show all 10 contributors for this article] (2023). The associations between metabolic profiles and sexual and physical abuse in depressed adolescent psychiatric outpatients: an exploratory pilot study. European Journal of Psychotraumatology. 14(1). doi: 10.1080/20008066.2023.2191396. Full text in Research Archive
  • Kananen, Anniina; Bernhardsen, Guro Pauck; Lehto, Soili Marianne; Huuskonen, Pasi; Kokki, Hannu & Keski-Nisula, Leea (2023). Quetiapine and other antipsychotic medications during pregnancy: a 15-year follow-up of a university hospital birth register. Nordic Journal of Psychiatry. ISSN 0803-9488. 77(7), p. 651–660. doi: 10.1080/08039488.2023.2205852. Full text in Research Archive
  • Airaksinen, Ville; Ruohomäki, Aleksi; Hantunen, Sari; Keski-Nisula, Leea; Luojus, Maria Katariina & Pekkanen, Juha [Show all 10 contributors for this article] (2022). Longitudinal Analyses of Diet Quality and Maternal Depressive Symptoms During Pregnancy: The Kuopio Birth Cohort Study. Journal of the Academy of Nutrition and Dietetics. ISSN 2212-2672. 123(1), p. 77–86.e4. doi: 10.1016/j.jand.2022.05.018. Full text in Research Archive
  • Mikola, Tuomas; Marx, Wolfgang; Lane, Melissa M.; Hockey, Meghan; Loughman, Amy & Rajapolvi, Sanna [Show all 12 contributors for this article] (2022). The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials. Critical reviews in food science and nutrition. ISSN 1040-8398. doi: 10.1080/10408398.2022.2096560. Full text in Research Archive
  • Honkalampi, Kirsi; Jokela, Markus; Lehto, Soili Marianne; Kivimäki, Mika & Virtanen, Marianna (2022). Association between alexithymia and substance use: A systematic review and meta-analysis. Scandinavian Journal of Psychology. ISSN 0036-5564. 63(5), p. 427–438. doi: 10.1111/sjop.12821. Full text in Research Archive
  • Kurkinen, Karoliina; Kärkkäinen, Olli; Lehto, Soili Marianne; Luoma, Ilona; Kraav, Siiri-Liisi & Nieminen, Anni I. [Show all 9 contributors for this article] (2021). One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study. Journal of Affective Disorders Reports. 6, p. 1–9. doi: 10.1016/j.jadr.2021.100261. Full text in Research Archive
  • Kaipainen, Aku L; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna-Kaisa & Paterno, Jussi J. [Show all 15 contributors for this article] (2021). Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: a literature review and validation of contemporary findings. Acta Neurochirurgica. ISSN 0001-6268. 163, p. 3353–3368. doi: 10.1007/s00701-021-04940-x. Full text in Research Archive
  • Kraav, Siiri-Liisi; Lehto, Soili Marianne; Kauhanen, Jussi; Hantunen, Sari & Tolmunen, Tommi (2021). Loneliness and social isolation increase cancer incidence in a cohort of Finnish middle-aged men. A longitudinal study. Psychiatry Research. ISSN 0165-1781. 299. doi: 10.1016/j.psychres.2021.113868. Full text in Research Archive
  • Kraav, Siiri-Liisi; Lehto, Soili Marianne; Junttila, Niina; Ruusunen, Anu; Kauhanen, Jussi & Hantunen, Sari [Show all 7 contributors for this article] (2021). Depression and loneliness may have a direct connection without mediating factors. Nordic Journal of Psychiatry. ISSN 0803-9488. 75(7), p. 553–557. doi: 10.1080/08039488.2021.1894231. Full text in Research Archive
  • Ruohomäki, Aleksi; Toffol, Elena; Airaksinen, Ville; Backman, Katri; Voutilainen, Raimo & Hantunen, Sari [Show all 16 contributors for this article] (2021). The impact of postpartum depressive symptoms on self-reported infant health and analgesic consumption at the age of 12 months: A prospective cohort study. Journal of Psychiatric Research. ISSN 0022-3956. 136, p. 388–397. doi: 10.1016/j.jpsychires.2021.02.036. Full text in Research Archive
  • Honkalampi, Kirsi; Virtanen, Marianna; Hintsa, Taina; Ruusunen, Anu; Mäntyselkä, Pekka & Ali-Sisto, Toni [Show all 11 contributors for this article] (2021). Comparison of the level of allostatic load between patients with major depression and the general population. Journal of Psychosomatic Research. ISSN 0022-3999. 143, p. 1–7. doi: 10.1016/j.jpsychores.2021.110389. Full text in Research Archive
  • Upadhyaya, Subina; Tolmunen, Tommi; Elomaa, Antti-Pekka; Ruohomäki, Aleksi; Kraav, Siiri-Liisi & Kauhanen, Laura [Show all 9 contributors for this article] (2020). Parental alcohol problems, parental divorce, and type II diabetes in adulthood: a longitudinal prospective cohort study in middle-aged men. Psychosomatic Medicine. ISSN 0033-3174. 82(9), p. 817–822. doi: 10.1097/PSY.0000000000000865. Full text in Research Archive
  • Kraav, Siiri-Liisi; Awoyemi, Olutosin; Junttila, Niina; Vornanen, Riitta; Kauhanen, Jussi & Toikko, Timo [Show all 9 contributors for this article] (2020). The effects of loneliness and social isolation on all-cause, injury, cancer, and CVD mortality in a cohort of middle-aged Finnish men. A prospective study. Aging & Mental Health. ISSN 1360-7863. p. 1–11. doi: 10.1080/13607863.2020.1830945. Full text in Research Archive

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  • Varheenmaa, Markus; Wikgren, Jan; Thomas, Owen Matthew Truscott; Kortteenniemi, Aaron; Brem, Anna-Katharine & Lehto, Soili Marianne (2021). Modulation of impulsive behaviours using transcranial random noise stimulation. Brain Stimulation. ISSN 1935-861X. 15(1), p. 32–34. doi: 10.1016/j.brs.2021.11.002. Full text in Research Archive
  • Lehto, Soili Marianne (2021). Research Into Early Immune System Activity and Later Psychological Distress: Promises and Challenges Ahead. Biological Psychiatry. ISSN 0006-3223. Full text in Research Archive
  • Kraav, Siiri-Liisi; Tolmunen, Tommi; Kauhanen, Jussi & Lehto, Soili Marianne (2021). The difference in chronic inflammation between individuals with officially documented and self-reported adverse childhood experiences is maintained until older middle-age. Psychological Medicine. ISSN 0033-2917. Full text in Research Archive

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Published Sep. 14, 2020 11:40 AM - Last modified Apr. 28, 2026 8:05 AM

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