Sophie Dorothea Fosså

• Dahl, Alv A; Brennhovd, Bjørn; Fosså, Sophie Dorothea & Axcrona, Karol (2020). A cross-sectional study of current work ability after radical prostatectomy. BMC Urology.  ISSN 1471-2490.  20(1), s 1- 7 . doi: 10.1186/s12894-020-0579-9
• Ryalen, Pål Christie; Stensrud, Mats Julius; Fosså, Sophie Dorothea & Røysland, Kjetil (2020). Causal inference in continuous time: an example on prostate cancer therapy. Biostatistics.  ISSN 1465-4644.  21(1), s 172- 185 . doi: 10.1093/biostatistics/kxy036 Full text in Research Archive.
• Aksnessæther, Bjørg Yksnøy; Myklebust, Tor Åge; Solberg, Arne; Klepp, Olbjørn; Skovlund, Eva; Hoff, Solveig Roth; Fosså, Sophie Dorothea; Widmark, Anders & Lund, Jo-Åsmund (2019). Second Cancers in Patients With Locally Advanced Prostate Cancer Randomized to Lifelong Endocrine Treatment With or Without Radical Radiation Therapy: Long-Term Follow-up of the Scandinavian Prostate Cancer Group-7 Trial. International Journal of Radiation Oncology, Biology, Physics.  ISSN 0360-3016.  106(4), s 706- 714 . doi: 10.1016/j.ijrobp.2019.11.027 Full text in Research Archive.
• Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea; Grotmol, Tom; Haugnes, Hege Sagstuen & Rounge, Trine Ballestad (2019). Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome. Clinical Epigenetics.  ISSN 1868-7075.  11:179, s 1- 13 . doi: 10.1186/s13148-019-0764-4 Full text in Research Archive.
• Bøhn, Synne-Kristin Hoffart; Thorsen, Lene; Kiserud, Cecilie E.; Fosså, Sophie Dorothea; Lie, Hanne Cathrine; Loge, Jon Håvard; Wisløff, Torbjørn; Haugnes, Hege Sagstuen & Reinertsen, Kristin Valborg (2019). Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood. Acta Oncologica.  ISSN 0284-186X.  58(5), s 753- 762 . doi: 10.1080/0284186X.2018.1557344 Show summary

  Background: Chronic fatigue (CF) is scarcely explored among young adult cancer survivors (YACSs), and more knowledge is needed to develop targeted interventions for YACSs with CF. The present study aimed to investigate the prevalence of CF and associated factors in YACSs. Also, the change of fatigue with time was explored. Material and methods: The present cross-sectional study is part of a nation-wide population based survey of Norwegian survivors of cancer in childhood, adolescence, and young adulthood (The NOR-CAYACS study).YACSs diagnosed at the age of 19–39 years with breast cancer stage ≤ III (BC), colorectal cancer (CRC), non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia, or non-metastatic malignant melanoma (MM) were included 5–30 years after diagnosis. Survivors of MM treated with limited surgery were included as a reference group. CF was assessed by the Fatigue Questionnaire. Logistic regression analyses were performed to identify factors associated with CF. Results: In total, 1488 survivors completed the questionnaire (a response rate of 42%), of which 1088 were eligible for the present study. Overall, 25% reported CF. CF was significantly more prevalent among survivors of BC (29%) (p < .001), CRC (29%) (p = .001) and NHL (27%) (p = .003) than among survivors of MM (15%). CF was associated with systemic treatment combined with surgery and/or radiotherapy (p = .018), comorbidity (p = .038), pain (p = .002), numbness in hands/feet (p = .046), and depressive symptoms (p < .001) in the multivariable model. Among survivors with CF, 60% reported that they had been tired since cancer treatment, and among these, 65% reported worsening or no change of fatigue with time. Conclusion: One of four YACSs reported CF 15 years from diagnosis (mean). CF was associated with several possibly treatable factors. Health professionals involved in the follow-up of YACSs should have knowledge of CF and approaches to manage it.

• Dahl, Alv A; Fosså, Sophie Dorothea; Lie, Hanne Cathrine; Loge, Jon Håvard; Reinertsen, Kristin Valborg; Ruud, Ellen & Kiserud, Cecilie E. (2019). Employment Status and Work Ability in Long-Term Young Adult Cancer Survivors. Journal of Adolescent and Young Adult Oncology.  ISSN 2156-5333.  8(3), s 304- 311 . doi: 10.1089/jayao.2018.0109 Full text in Research Archive.
• El Charif, Omar; Mapes, Brandon; Trendowski, Matthew R.; Wheeler, Heather E.; Wing, Claudia; Dinh, Paul C.; Frisina, Robert D.; Feldman, Darren R.; Hamilton, Robert J.; Vaughn, David J.; Fung, Chunkit; Kollmannsberger, Christian; Mushiroda, Taisei; Kubo, Michiaki; Gamazon, Eric R.; Cox, Nancy J.; Huddart, Robert; Ardeshir-Rouhani-Fard, Shirin; Monahan, Patrick; Fosså, Sophie Dorothea; Einhorn, Lawrence H.; Travis, Lois B. & Dolan, M. Eileen (2019). Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms. Clinical Cancer Research.  ISSN 1078-0432.  25(13), s 4104- 4116 . doi: 10.1158/1078-0432.CCR-18-3179
• Fosså, Sophie Dorothea; Beyer, Bud; Dahl, Alv A; Aas, Kirsti; Eri, Lars Magne; Kvan, Espen; Falk, Ragnhild Sørum; Graefen, Markus; Huland, Hartwig & Berge, Viktor (2019). Improved patient-reported functional outcomes after nerve-sparing radical prostatectomy by using NeuroSAFE technique. Scandinavian Journal of Urology.  ISSN 2168-1805.  s 1- 7 . doi: 10.1080/21681805.2019.1693625 Full text in Research Archive.
• Fung, Chunkit; Dinh, Paul C.; Fosså, Sophie Dorothea & Travis, Lois B. (2019). Testicular cancer survivorship. The Journal of the National Comprehensive Cancer Network.  ISSN 1540-1405.  17(12), s 1557- 1568 . doi: 10.6004/jnccn.2019.7369
• Gjerset, Gunhild Maria; Kiserud, Cecilie E.; Loge, Jon Håvard; Fosså, Sophie Dorothea; Wisløff, Torbjørn; Gudbergsson, Sævar Berg; Oldervoll, Line Merethe & Thorsen, Lene (2019). Changes in fatigue, health-related quality of life and physical activity after a one-week educational program for cancer survivors. Acta Oncologica.  ISSN 0284-186X.  58(5), s 682- 689 . doi: 10.1080/0284186X.2018.1562210 Full text in Research Archive.
• Hellesnes, Ragnhild; Kvammen, Øivind; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea & Haugnes, Hege Sagstuen (2019). Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era. International Journal of Cancer.  ISSN 0020-7136.  147(1), s 21- 32 . doi: 10.1002/ijc.32704 Full text in Research Archive.
• Kvammen, Øivind; Myklebust, Tor Åge; Solberg, Arne; Møller, Bjørn; Klepp, Olbjørn; Fosså, Sophie Dorothea & Tandstad, Torgrim (2019). Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study. PLOS ONE.  ISSN 1932-6203.  14:e0225942(12), s 1- 15 . doi: 10.1371/journal.pone.0225942 Full text in Research Archive.
• Kvåle, Rune; Myklebust, Tor Åge; Fosså, Sophie Dorothea; Aas, Kirsti; Ekanger, Christian; Helle, Svein Inge; Honore, Alfred & Møller, Bjørn (2019). Impact of positive surgical margins on secondary treatment, palliative radiotherapy and prostate cancer‐specific mortality. A population‐based study of 13 198 patients. The Prostate.  ISSN 0270-4137.  79(16), s 1852- 1860 . doi: 10.1002/pros.23911 Full text in Research Archive. Show summary

  Background: The results of studies evaluating the impact of positive surgical margins on prostate cancer‐specific mortality have been inconsistent. We, therefore, evaluated the impact of surgical margin status on subsequent secondary treatment, palliative radiotherapy, and prostate cancer‐specific mortality. Methods A total of 14 837 men treated with radical prostatectomy (RP) during the period 2001 to 2015 were identified from the Cancer Registry of Norway. Of those, 13 198 (89%) patients had complete data on the preoperative prostate‐specific antigen level, pathological T‐category, Gleason score in the prostatectomy specimen, and margin status. Multivariable Cox proportional hazards models were used to evaluate the risk, and flexible parametric models for the cumulative incidence were fitted to predict the probabilities of secondary treatment (salvage radiotherapy or prophylactic breast radiation), palliative radiotherapy, and prostate cancer‐specific mortality. Results After a median follow‐up time of 5.2 years (3591 patients with ≥8 years of follow‐up), positive surgical margins (PSMs) were independently predictive of secondary treatment (hazard ratio [HR] = 2.43, 95% confidence interval [CI] = 2.21‐2.66) and palliative radiotherapy (HR = 1.45, 95% CI = 1.03‐2.05). After 10 years, the absolute increased risk for palliative radiotherapy in patients with PSMs after RP varied between 0.1% in pT2 tumors with a Gleason score of 6, to 12% for pT3b tumors with a Gleason score of 9 to 10. PSMs were not independently associated with prostate cancer‐specific mortality (HR = 1.14, 95% CI = 0.82‐1.59). Conclusion PSMs were associated with increased application of secondary treatment and palliative radiotherapy but were not predictive of prostate cancer‐specific mortality. As the use of palliative radiotherapy was only marginally increased in patients with PSMs and the lowest‐risk disease characteristics, avoiding PSMs may be of greatest prognostic relevance in patients with higher‐risk disease characteristics.

• Lie, Hanne Cathrine; Rueegg, Corina Silvia; Fosså, Sophie Dorothea; Loge, Jon Håvard; Ruud, Ellen & Kiserud, Cecilie E. (2019). Limited evidence of non-response bias despite modest response rate in a nationwide survey of long-term cancer survivors?results from the NOR-CAYACS study. Journal of cancer survivorship.  ISSN 1932-2259.  13(3), s 353- 363 . doi: 10.1007/s11764-019-00757-x Full text in Research Archive.
• Solheim, Olesya; Skalleberg, Jakob Rasmussen; Warncke, Torhild; Ørstavik, Kristin; Tropé, Claes Gøran & Fosså, Sophie Dorothea (2019). Long‐term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin‐based chemotherapy for malignant ovarian germ cell tumor. Acta Obstetricia et Gynecologica Scandinavica.  ISSN 0001-6349.  98(2), s 240- 249 . doi: 10.1111/aogs.13477 Full text in Research Archive. Show summary

  Introduction The aim was to evaluate “overall neuropathy”, defined as peripheral paresthesia and Raynaud's phenomenon, in long‐term survivors of malignant ovarian germ cell tumors (MOGCTs) treated with cisplatin‐based chemotherapy (CBCT). Material and methods Ninety‐three MOGCT survivors recorded in Norway in 1980‐2009 (median follow up: 15 years) were included in this analysis. Forty‐nine received CBCT (CBCT group) and 44 received other or no chemotherapy (non‐CBCT group). Applying the scale for chemotherapy‐induced neurotoxicity, the prevalence of overall neuropathy (ie score >1 on a 0‐3 scale) was compared between the two groups. Forty women from the CBCT group also underwent neurophysiological and neurological examinations; results from the neurological examination were graded according to the National Cancer Institute‐Common Terminology Criteria for Adverse Effects version 4 (NCI‐CTCAE scale v4). These women were then categorized into subgroups of low (≤3 cycles of CBCT, n = 23) and high CBCT (≥4 cycles of CBCT, n = 17). Results Twenty‐eight (57%) women from the CBCT group reported overall neuropathy, compared with 20 (45%) in the non‐CBCT group (P = .06). Of the 40 MOGCT survivors in the CBCT group who underwent neurophysiological and neurological examinations, 14 (35%) showed NCI‐CTCAE grade ≥1 signs or symptoms of peripheral neuropathy. Pathological findings of NCI‐CTCAE grade 2 or 3 signs or symptoms were found in four survivors (10%) from the high CBCT subgroup, all of whom also showed objective signs of neuropathy. Conclusions Though about half of our MOGCT survivors reported overall neuropathy after CBCT, more severe pathological neurological/neurophysiological findings that impacted daily living were recorded in only 10% of them. Our observations of a similar prevalence of self‐reported overall neuropathy in the CBCT and non‐CBCT group, combined with limited objective neurological findings, warrant further study to increase the understanding of the specific pathophysiological pathways of long‐term CBCT‐induced neuropathy.

• Storås, Anne Marie Holck; Sanda, Martin G.; Garin, Olatz; Chang, Peter; Patil, Dattatraya; Crociani, Catrina; Suarez, Jose Francisco; Småstuen, Milada Cvancarova; Loge, Jon Håvard & Fosså, Sophie Dorothea (2019). A prospective study of patient reported urinary incontinence among American, Norwegian and Spanish men 1 year after prostatectomy. Asian Journal of Urology (AJU).  ISSN 2214-3882.  s 1- 9 . doi: 10.1016/j.ajur.2019.08.001 Full text in Research Archive.
• Trendowski, Matthew R.; El-Charif, Omar; El Charif, Omar; Ratain, Mark J.; Monahan, Patrick; Mu, Zepeng; Wheeler, Heather E.; Dinh, Paul C.; Feldman, Darren R.; Ardeshir-Rouhani-Fard, Shirin; Hamilton, Robert J.; Vaughn, David J.; Fung, Chunkit; Kollmannsberger, Christian; Mushiroda, Taisei; Kubo, Michiaki; Hannigan, Robyn; Strathmann, Frederick; Einhorn, Lawrence H.; Fosså, Sophie Dorothea; Travis, Lois B. & Dolan, M. Eileen (2019). Clinical and genome-wide analysis of serum platinum levels after cisplatin-based chemotherapy. Clinical Cancer Research.  ISSN 1078-0432.  25(19), s 5913- 5924 . doi: 10.1158/1078-0432.CCR-19-0113
• Zaid, Mohammad Abu; Dinh, Paul C.; Monahan, Patrick O.; Fung, Chunkit; El-Charif, Omar; Feldman, Darren R; Hamilton, Robert J; Vaughn, David J; Beard, Clair J.; Cook, Ryan; Althouse, Sandra; Ardeshir-Rouhani-Fard, Shirin; Sesso, Howard D; Huddart, Robert; Mushiroda, Taisei; Kubo, Michiaki; Eileen Dolan, M; Einhorn, Lawrence H; Fosså, Sophie Dorothea & Travis, Lois B (2019). Adverse health outcomes in relationship to hypogonadism after chemotherapy: A multicenter study of testicular cancer survivors. The Journal of the National Comprehensive Cancer Network.  ISSN 1540-1405.  17(5), s 459- 468 . doi: 10.6004/jnccn.2018.7109
• Aas, Kirsti; Fosså, Sophie Dorothea; Kvåle, Rune; Møller, Bjørn; Myklebust, Tor Åge; Vlatkovic, Ljiljana; Müller, Stig & Berge, Viktor (2018). Is time from diagnosis to radical prostatectomy associated with oncological outcomes?. World journal of urology.  ISSN 0724-4983.  37(8), s 1571- 1580 . doi: 10.1007/s00345-018-2570-6
• Ávila, Mónica; Patel, Laila; López, Silvia; Cortés-Sanabria, Laura; Garin, Olatz; Pont, Àngels; Ferrer, Ferran; Boladeras, Ana; Zamora, Victor; Fosså, Sophie Dorothea; Storås, Anne Marie Holck; Sanda, Martin; Serra-Sutton, Vicky & Ferrer, Montse (2018). Patient-reported outcomes after treatment for clinically localized prostate cancer: A systematic review and meta-analysis. Cancer Treatment Reviews.  ISSN 0305-7372.  66, s 23- 44 . doi: 10.1016/j.ctrv.2018.03.005
• Byrne, Julianne; Grabow, Desiree; Campbell, Helen; O'Brien, Kylie; Bielack, Stefan; am Zehnhoff-Dinnesen, Antoinette; Calaminus, Gabriele; Kremer, Leontien; Langer, Thorsten; van den Heuvel-Eibrink, Marry M.; van Dulmen-den Broeder, Eline; Baust, Katja; Bautz, Andrea; Beck, Jörn D.; Berger, Claire; Binder, Harald; Borgmann-Staudt, Anja; Broer, Linda; Cario, Holger; Casagranda, Leonie; Clemens, Eva; Deuster, Dirk; de Vries, Andrica; Dirksen, Uta; Falck Winther, Jeanette; Fosså, Sophie Dorothea; Font-Gonzalez, Anna; Grandage, Victoria; Haupt, Riccardo; Hecker-Nolting, Stefanie; Hjorth, Lars; Kaiser, Melanie; Kenborg, Line; Kepak, Tomas; Kepakova, Katerina; Knudsen, Lisbeth E; Krawczuk-Rybak, Maryna; Kruseova, Jarmila; Kuehni, Claudia E.; Kunstreich, Marina; Kuonen, Rahel; Lackner, Herwig; Leiper, Alison; Loeffen, Erik A.H.; Luks, Ales; Modan-Moses, Dalit; Mulder, Renee; Parfitt, Ross; Paul, Norbert W.; Ranft, Andreas; Ruud, Ellen; Schilling, Ralph; Spix, Claudia; Stefanowicz, Joanna; Strauβ, Gabriele; Uitterlinden, André G.; van den Berg, Marleen; van der Kooi, Anne-Lotte; van Dijk, Marloes; van Leeuwen, Flora; Zolk, Oliver; Zoller, Daniela & Kaatsch, Peter (2018). PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents. European Journal of Cancer.  ISSN 0959-8049.  103, s 227- 237 . doi: 10.1016/j.ejca.2018.08.007
• Bøhn, Synne-Kristin Hoffart; Fosså, Sophie Dorothea; Wisløff, Torbjørn & Thorsen, Lene (2018). Physical activity and associations with treatment-induced adverse effects among prostate cancer patients. Supportive Care in Cancer.  ISSN 0941-4355.  27(3), s 1001- 1011 . doi: 10.1007/s00520-018-4389-5
• Chen, Haitao; Ewing, Charles M; Zheng, Sigun; Grindedal, Eli Marie; Cooney, Kathleen A.; Wiley, Kathleen E.; Djurovic, Srdjan; Andreassen, Ole Andreas; Axcrona, Karol; Mills, Ian Geoffrey; Xu, Jianfeng; Mæhle, Lovise Olaug; Fosså, Sophie Dorothea & Isaacs, William B. (2018). Genetic factors influencing prostate cancer risk in Norwegian men. The Prostate.  ISSN 0270-4137.  78(3), s 186- 192 . doi: 10.1002/pros.23453 Full text in Research Archive.
• Feldman, Darren R.; Ardeshir-Rouhani-Fard, Shirin; Monahan, Patrick O.; Sesso, Howard D.; Fung, Chunkit; Williams, Annalynn M.; Hamilton, Robert J.; Vaughn, David J.; Beard, Clair J.; Cook, Ryan; Zaid, Mohammad Abu; Lipshultz, Steven E.; Einhorn, Lawrence H.; Oeffinger, Kevin Charles; Travis, Lois B. & Fosså, Sophie Dorothea (2018). Predicting cardiovascular disease among testicular cancer survivors after modern cisplatin-based chemotherapy: Application of the Framingham Risk Score. Clinical Genitourinary Cancer.  ISSN 1558-7673.  16(4), s e761- e769 . doi: 10.1016/j.clgc.2018.01.011
• Fosså, Sophie Dorothea; Fung, Chunkit & Dahl, Alv A (2018). Late adverse outcomes after treatment of testicular cancer. Der Onkologe.  ISSN 0947-8965.  24, s 104- 109 . doi: 10.1007/s00761-018-0442-8
• Fung, Chunkit; Dinh, Paul; Ardeshir-Rouhani-Fard, Shirin; Schaffer, Kerry; Fosså, Sophie Dorothea & Travis, Lois B. (2018). Toxicities associated with cisplatin-based chemotherapy and radiotherapy in long-term testicular cancer survivors. Advances in Urology.  ISSN 1687-6369.  2018:8671832, s 1- 20 . doi: 10.1155/2018/8671832
• Haugnes, Hege Sagstuen; Stenklev, Niels Christian; Brydøy, Marianne; Dahl, Olav; Wilsgaard, Tom; Laukli, Einar & Fosså, Sophie Dorothea (2018). Hearing loss before and after cisplatin-based chemotherapy in testicular cancer survivors: a longitudinal study. Acta Oncologica.  ISSN 0284-186X.  57(8), s 1075- 1083 . doi: 10.1080/0284186X.2018.1433323
• Hjelle, Line Veronika; Gundersen, Per Ole Mobråten; Hellesnes, Ragnhild; Sprauten, Mette; Brydøy, Marianne; Tanstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Oldenburg, Jan; Bremnes, Roy M. & Haugnes, Hege Sagstuen (2018). Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors. Acta Oncologica.  ISSN 0284-186X.  57(10), s 1392- 1400 . doi: 10.1080/0284186X.2018.1473641
• Honecker, F; Aparicio, J; Berney, D; Beyer, J; Bokemeyer, C; Cathomas, R; Clarke, N.; Cohn-Cedermark, G; Daugaard, G; Dieckmann, KP; Fizazi, K; Fosså, Sophie Dorothea; Germa-Lluch, JR; Giannatempo, P; Gietema, JA; Gillessen, S; Haugnes, Hege Sagstuen; Heidenreich, A; Hemminki, K; Huddart, R; Jewett, MAS; Joly, F; Lauritsen, Jens; Lorch, A; Necchi, A; Nicolai, N; Oing, C; Oldenburg, Jan; Ondrus, D; Papachristofilou, A; Powles, T; Sohaib, A; Ståhl, Olof; Tandstad, T.; Toner, G & Horwich, A (2018). ESMO consensus conference on testicular germ cell cancer: Diagnosis, treatment and follow-up. Annals of Oncology.  ISSN 0923-7534.  29(8), s 1658- 1686 . doi: 10.1093/annonc/mdy217
• Kerns, Sarah L.; Fung, Chunkit; Monahan, Patrick O.; Ardeshir-Rouhani-Fard, Shirin; Abu Zaid, Mohammad I.; Williams, Annalynn M.; Stump, Timothy E.; Sesso, Howard D.; Feldman, Darren R.; Hamilton, Robert J.; Vaughn, David J.; Beard, Clair; Huddart, Robert A.; Kim, Jeri; Kollmannsberger, Christian; Sahasrabudhe, Deepak M.; Cook, Ryan; Fosså, Sophie Dorothea; Einhorn, Lawrence H. & Travis, Lois B. (2018). Cumulative burden of morbidity among testicular cancer survivors after standard cisplatin-based chemotherapy: A multi-institutional study. Journal of Clinical Oncology.  ISSN 0732-183X.  36(15), s 1505- 1512 . doi: 10.1200/JCO.2017.77.0735
• Parker, Christopher C.; Coleman, Robert Edward; Sartor, Oliver; Vogelzang, Nicholas J.; Bottomley, David; Heinrich, Daniel; Helle, Svein Inge; O'Sullivan, Joe M.; Fosså, Sophie Dorothea; Chodacki, Aleš; Wiechno, Paweł; Logue, John; Seke, Mihalj; Widmark, Anders; Johannessen, Dag Clement; Hoskin, Peter; James, Nicholas D.; Solberg, Arne; Syndikus, Isabel; Kliment, Jan; Wedel, Steffen; Böhmer, Sibylle; Dall'Oglio, Marcos; Franzén, Lars; Bruland, Øyvind; Petrenciuc, Oana; Staudacher, Karin; Li, Rui & Nilsson, Sten (2018). Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial. European Urology.  ISSN 0302-2838.  73(3), s 353- 360 . doi: 10.1016/j.eururo.2017.06.021
• van den Berg, Marleen; van Dijk, Marloes; Byrne, Julianne; Campbell, Helen; Berger, Claire; Borgmann-Staudt, Anja; Calaminus, Gabriele; Dirksen, Uta; Winther, Jeanette F.; Fosså, Sophie Dorothea; Grabow, Desiree; Grandage, Victoria L.; van den Heuvel-Eibrink, Marry M.; Kaiser, Melanie; Kepák, Tomáš; Kremer, Leontien C.; Kruseova, Jarmilá; Kuehni, Claudia E.; Lambalk, Cornelis B.; van Leeuwen, Fllora E.; Leiper, Alison; Modan-Moses, Dalit; Morsellino, Vera; Spix, Claudia; Kaatsch, Peter & van Dulmen-den Broeder, Eline (2018). Fertility among female survivors of childhood, adolescent, and young adult cancer: Protocol for two pan-European studies (PanCareLIFE). Journal of Medical Internet Research.  ISSN 1438-8871.  20:e10824(9), s 1- 13 . doi: 10.2196/10824
• van der Kooi, Anne-Lotte; Clemens, Eva; Broer, Linda; Zolk, Oliver; Byrne, Julianne; Campbell, Helen; van den Berg, Marleen; Berger, Claire; Calaminus, Gabriele; Dirksen, Uta; Winther, Jeanette Falck; Fosså, Sophie Dorothea; Grabow, Desiree; Haupt, Riccardo; Kaiser, Melanie; Kepak, Tomas; Kremer, Leontien; Kruseova, Jarmila; Modan-Moses, Dalit; Ranft, Andreas; Spix, Claudia; Kaatsch, Peter; Laven, Joop S.E.; van Dulmen-den Broeder, Eline; Uitterlinden, André G. & van den Heuvel-Eibrink, Marry M. (2018). Genetic variation in gonadal impairment in female survivors of childhood cancer: a PanCareLIFE study protocol. BMC Cancer.  ISSN 1471-2407.  18(1), s 930 . doi: 10.1186/s12885-018-4834-3
• Wedde, Trude Baastad; Småstuen, Milada Cvancarova; Brabrand, Sigmund; Fosså, Sophie Dorothea; Kaasa, Stein; Tafjord, Gunnar; Russnes, Kjell Magne; Hellebust, Taran Paulsen & Lilleby, Wolfgang (2018). Ten-year survival after High-Dose-Rate Brachytherapy combined with External Beam Radiation Therapy in high-risk prostate cancer: A comparison with the Norwegian SPCG-7 cohort. Radiotherapy and Oncology.  ISSN 0167-8140.  s 1- 7 . doi: 10.1016/j.radonc.2018.10.013 Full text in Research Archive.
• Zaid, Mohammad Abu; Gathirua-Mwangi, Wambui G; Fung, Chunkit; Monahan, Patrick O.; El-Charif, Omar; Williams, Annalynn M; Feldman, Darren R; Hamilton, Robert J; Vaughn, David J; Beard, Clair J; Cook, Ryan; Althouse, Sandra; Ardeshir-Rouhani-Fard, Shirin; Dinh, Paul; Sesso, Howard D; Einhorn, Lawrence H; Fosså, Sophie Dorothea & Travis, Lois B (2018). Clinical and Genetic Risk Factors for Adverse Metabolic Outcomes in North American Testicular Cancer Survivors. The Journal of the National Comprehensive Cancer Network.  ISSN 1540-1405.  16(3), s 257- 265 . doi: 10.6004/jnccn.2017.7046
• Aas, Kirsti; Axcrona, Karol; Kvåle, Rune; Møller, Bjørn; Myklebust, Tor Åge; Axcrona, Ulrika; Berge, Viktor & Fosså, Sophie Dorothea (2017). Ten-year Mortality in Men With Nonmetastatic Prostate Cancer in Norway. Urology.  ISSN 0090-4295.  110, s 140- 147 . doi: 10.1016/j.urology.2017.07.048
• Axcrona, Karol; Nilsson, Rasmus; Brennhovd, Bjørn; Sørebø, Øystein; Fosså, Sophie Dorothea & Dahl, Alv A (2017). Psychometric properties of the expanded prostate cancer index composite - 26 instrument in a cohort of radical prostatectomy patients: theoretical and practical examinations. BMC Urology.  ISSN 1471-2490.  17(1) . doi: 10.1186/s12894-017-0302-7 Full text in Research Archive. Show summary

  Background Recently, the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26) was recommended for the assessment of adverse effects after the treatment of prostate cancer without clear reasons. This decision encouraged us to review the questionnaire development from the UCLA Prostate Cancer Index (UCLA-PCI) to the EPIC-16 CP with a focus on psychometric properties. We also reviewed PubMed for papers concerning such properties of the EPIC-26 since 2012 (latest review in 2011). Finally, we examined the psychometric properties of the EPIC-26 in a sample of Norwegian males treated with robot-assisted laparoscopic prostatectomy (RALP). Methods This study used three methods: (1) Comparison of the content of the UCLA-PCI, EPIC-50, EPIC-26, and EPIC-16 CP; (2) Review of EPIC-26 and EPIC-16 CP papers in PubMed from 2012 to 2016, identifying papers reporting on the psychometric properties of these questionnaires; and (3) Psychometric examination of the EPIC-26 rating in 651 Norwegian men treated with RALP at a mean of 3.2 years post-surgery. Results The questionnaire development showed a significant increase in bother versus function items, and the EPIC-26 contains eight function and 18 bother items. Twelve papers concerning the EPIC-26 available on PubMed since 2012 support the psychometric properties of the EPIC-26. The Norwegian EPIC-26 findings supported the psychometric properties of the EPIC-26, but suggested six subdomains both by exploratory and confirmatory factor analyses. Conclusions In general our examinations supported the adequate psychometric properties of the EPIC-26, although the factor structure, construct and predictive validity of the instrument should be examined further.

• Dolan, M. Eileen; El Charif, Omar; Wheeler, Heather E.; Gamazon, Eric R.; Ardeshir-Rouhani-Fard, Shirin; Monahan, Patrick; Feldman, Darren R.; Hamilton, Robert J.; Vaughn, David J.; Beard, Clair J.; Fung, Chunkit; Kim, Jeri; Fosså, Sophie Dorothea; Hertz, Daniel L.; Mushiroda, Taisei; Kubo, Michiaki; Einhorn, Lawrence H.; Cox, Nancy J. & Travis, Lois B. (2017). Clinical and genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer. Clinical Cancer Research.  ISSN 1078-0432.  23(19), s 5757- 5768 . doi: 10.1158/1078-0432.CCR-16-3224
• Fung, Chunkit; Sesso, Howard D.; Williams, Annalynn M.; Kerns, Sarah L.; Monahan, Patrick; Zaid, Mohammad Abu; Feldman, Darren R.; Hamilton, Robert J.; Vaughn, David J.; Beard, Clair J.; Kollmannsberger, Christian K.; Cook, Ryan; Althouse, Sandra; Ardeshir-Rouhani-Fard, Shirin; Lipshultz, Steve E.; Einhorn, Lawrence H.; Fosså, Sophie Dorothea & Travis, Lois B. (2017). Multi-institutional assessment of adverse health outcomes among north American testicular cancer survivors after modern cisplatin-based chemotherapy. Journal of Clinical Oncology.  ISSN 0732-183X.  35(11), s 1211- 1222 . doi: 10.1200/JCO.2016.70.3108
• Gilbert, Ethel S.; Curtis, Rochelle E.; Hauptmann, Michael; Kleinerman, Ruth A.; Lynch, Charles F.; Stovall, Marilyn; Smith, Susan A.; Weathers, Rita; Andersson, Michael; Dores, Graça M.; Fraumeni, Joseph F.; Fosså, Sophie Dorothea; Hall, Per; Hodgson, David C.; Holowaty, Eric J.; Joensuu, Heikki; Johannessen, Tom Børge; Langmark, Frøydis Tonning; Kaijser, Magnus; Pukkala, Eero; Rajaraman, Preetha; Storm, Hans H.; Vaalavirta, Leila; van den Belt-Dusebout, Alexandra W.; Aleman, Berthe M.; Travis, Lois B.; Morton, Lindsay M. & van Leeuwen, Flora E. (2017). Stomach cancer following Hodgkin lymphoma, testicular cancer and cervical cancer: a pooled analysis of three international studies with a focus on radiation effects. Radiation Research.  ISSN 0033-7587.  187(2), s 186- 195 . doi: 10.1667/RR14453.1
• Gjerset, Gunhild Maria; Loge, Jon Håvard; Kiserud, Cecilie E.; Fosså, Sophie Dorothea; Gudbergsson, Sævar Berg; Oldervoll, Line Merethe; Wisløff, Torbjørn & Thorsen, Lene (2017). Perceived needs for different components in a rehabilitation program among cancer survivors with chronic fatigue compared to survivors without chronic fatigue. Acta Oncologica.  ISSN 0284-186X.  56(2), s 245- 253 . doi: 10.1080/0284186X.2016.1266091 Full text in Research Archive.
• Grov, Ellen Karine; Fosså, Sophie Dorothea & Dahl, Alv A (2017). A controlled study of the influence of comorbidity on activities of daily living in elderly cancer survivors (the HUNT-3 survey).. Journal of Geriatric Oncology.  ISSN 1879-4068.  8(5), s 328- 335 . doi: 10.1016/j.jgo.2017.05.007 Show summary

  Objectives: To examine the influence of somatic comorbidity on Activity of Daily Living (ADL) problems in cancer survivors ≥70 years (ECSs) based on data from The Health Study of Nord-Trøndelag County (HUNT-3) 2006–08. Material andMethods: Among participants of the HUNT-3 survey, 599 ECSs had a diagnosis of one invasive cancer according to both The Cancer Registry of Norway and self-report. Three controls without cancer aged ≥70 years for each ECS were drawn from the HUNT-3 sample.We compared personal-ADL (P-ADL) and instrumental-ADL (I-ADL) problems for ECSs and differences between ADL problems for ECSs with and without comorbidity and controls with and without comorbidity. Results: The prevalence of P-ADL problems was 3.5% among ECSs and 2.9% among controls (p = 0.97) and for I-ADL 28.5% versus 21.4% (p = 0.01), respectively. In bivariate analyses where ECSs versus controls was the dependent variable, presence of I-ADL problems, higher age, being female, paired relationship, poor self-rated health, hospitalization last year, and low level of neuroticism were associated being ECSs. In multivariate analyses, these variables, except I-ADL-problems and paired relationship, remained significantly associated being ECSs. No significant differenceswere shown for P-ADL problemswhen comparing ECSs and controlswith comorbidity, and ECSswith andwithout comorbidity. ECSswith comorbidity reported significantlymore I-ADL-problems than controls with comorbidity, and ECSswith comorbidity had significantly more I-ADL-problems than ECSs without comorbidity. Conclusion: Our results reflect common factors found in ADL studies in the elderly population. Health personnel have to be particularly observant on I-ADL problems among female ECSs, and those reporting poor self-rated health or comorbidity.

• Holm, Henriette Veiby; Dahl, Alv A; Klepp, Olbjørn & Fosså, Sophie Dorothea (2017). Moderne behandling av prostatakreft med fjernmetastaser. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(11), s 803- 805 . doi: 10.4045/tidsskr.16.0265
• Jacobsen, Ellisiv Lærum; Bye, Asta; Aass, Nina Kathrine; Fosså, Sophie Dorothea; Grotmol, Kjersti Støen; Kaasa, Stein; Loge, Jon Håvard; Moum, Torbjørn Åge & Hjermstad, Marianne Jensen (2017). Norwegian reference values for the Short-Form Health Survey 36: development over time. Quality of Life Research.  ISSN 0962-9343.  s 1- 12 . doi: 10.1007/s11136-017-1684-4 Full text in Research Archive.
• Johannsdottir, Inga Marie; Hamre, Hanne Mari; Fosså, Sophie Dorothea; Loge, Jon Håvard; Drolsum, Liv; Lund, May-Brith; Nordsletten, Lars & Kiserud, Cecilie E. (2017). Adverse Health Outcomes and Associations with Self-Reported General Health in Childhood Lymphoma Survivors. Journal of Adolescent and Young Adult Oncology.  ISSN 2156-5333.  6(3), s 470- 476 . doi: 10.1089/jayao.2017.0018
• Johannsdottir, Inga Marie; Karlstad, Øystein; Loge, Jon Håvard; Fosså, Sophie Dorothea; Kiserud, Cecilie E. & Skurtveit, Svetlana (2017). Prescriptions of Antidepressants to Survivors of Cancer in Childhood, Adolescence, and Young Adulthood: A Population-Based Study. Journal of Adolescent and Young Adult Oncology.  ISSN 2156-5333.  6(1), s 120- 126 . doi: 10.1089/jayao.2016.0041
• Lie, Hanne Cathrine; Mellblom, Anneli; Brekke, Mette; Finset, Arnstein; Fosså, Sophie Dorothea; Kiserud, Cecilie E.; Ruud, Ellen & Loge, Jon Håvard (2017). Experiences with late effects-related care and preferences for long-term follow-up care among adult survivors of childhood lymphoma. Supportive Care in Cancer.  ISSN 0941-4355.  25(8), s 2445- 2454 . doi: 10.1007/s00520-017-3651-6
• Nome, Ragnhild Veline; Bjøro, Trine; Paus, Elisabeth; Bjerner, Johan; Fosså, Sophie Dorothea; Steen, Rita; Nustad, Kjell Johannes & Bolstad, Nils (2017). Lowered reference limits for hCG improve follow-up of patients with hCG-producing tumors. Clinical Biochemistry.  ISSN 0009-9120.  52, s 73- 79 . doi: 10.1016/j.clinbiochem.2017.11.016
• Selland, Mette; Smeland, Knut Bjøro; Bjøro, Trine; Falk, Ragnhild Sørum; Fosså, Sophie Dorothea; Gjesdal, Clara Gram; Godang, Kristin; Holte, Harald; Svartberg, Johan; Syversen, Unni; Bollerslev, Jens & Kiserud, Cecilie E. (2017). Bone mineral density is close to normal for age in long-term lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation. Acta Oncologica.  ISSN 0284-186X.  56(4), s 590- 598 . doi: 10.1080/0284186X.2016.1267870
• Skalleberg, Jakob Rasmussen; Popova, Olesya; Fosså, Sophie Dorothea; Småstuen, Milada C; Osnes, Terje; Gundersen, Per Ole Mobråten & Bunne, Bodil Iris Marie (2017). Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. Gynecologic Oncology.  ISSN 0090-8258.  145(1), s 148- 153 . doi: 10.1016/j.ygyno.2017.02.006
• Thorsen, Lene; Kirkegaard, Camilla; Loge, Jon Håvard; Kiserud, Cecilie E.; Johansen, Merethe Lia; Gjerset, Gunhild Maria; Edvardsen, Elisabeth; Hamre, Hanne Mari; Andersen, Tone Ikdahl & Fosså, Sophie Dorothea (2017). Feasibility of a physical activity intervention during and shortly after chemotherapy for testicular cancer. BMC Research Notes.  ISSN 1756-0500.  10(214) . doi: 10.1186/s13104-017-2531-y Full text in Research Archive.
• Van Leeuwen, Marieke; Kieffer, Jacobien M; Efficace, Fabio; Fosså, Sophie Dorothea; Bolla, Michel; Collette, Laurence; Colombel, Marc; De Giorgi, Ugo; Holzner, Bernhard; Van De Poll-Franse, Lonneke V.; Van Poppel, Hendrik; White, Jeff; de Wit, Ronald; Osanto, Susanne; Aaronson, Neil K.; Papiani, Giorgio; Basso, Umberto; Fornarini, Giuseppe; Palmieri, Giovanni; Banna, Giuseppe Luigi & Accettura, Caterina (2017). International evaluation of the psychometrics of health-related quality of life questionnaires for use among long-term survivors of testicular and prostate cancer. Health and Quality of Life Outcomes.  ISSN 1477-7525.  15(1), s 1 . doi: 10.1186/s12955-017-0670-4
• Vatne, Kari; Stensvold, Andreas; Myklebust, Tor Åge; Møller, Bjørn; Svindland, Aud; Kvåle, Rune & Fosså, Sophie Dorothea (2017). Pre- and post-prostatectomy variables associated with pelvic post-operative radiotherapy in prostate cancer patients: a national registry-based study. Acta Oncologica.  ISSN 0284-186X.  56(10), s 1295- 1301 . doi: 10.1080/0284186X.2017.1314006
• Wheeler, Heather E.; Gamazon, Eric R.; Frisina, Robert D.; Perez-Cervantes, Carlos; Charif, Omar El; Mapes, Brandon; Fosså, Sophie Dorothea; Feldman, Darren R.; Hamilton, Robert J; Vaughn, David J.; Beard, Clair J.; Fung, Chunkit; Kollmannsberger, Christian; Kim, Jeri; Mushiroda, Taisei; Kubo, Michiaki; Ardeshir-Rouhani-fard, Shirin; Einhorn, Lawrence H.; Cox, Nancy J; Dolan, M. Eileen & Travis, Lois B. (2017). Variants in WFS1 and other mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Research.  ISSN 1078-0432.  23(13), s 3325- 3333 . doi: 10.1158/1078-0432.CCR-16-2809
• Cameron, Marte; Kersten, Christian; Vistad, Ingvild; van Helvoirt, Rene; Weyde, Kjetil; Undseth, Christine; Mjaaland, Ingvil; Skovlund, Eva; Fosså, Sophie Dorothea & Guren, Marianne (2016). Palliative pelvic radiotherapy for symptomatic rectal cancer–a prospective multicenter study. Acta Oncologica.  ISSN 0284-186X.  55(12), s 1400- 1407 . doi: 10.1080/0284186X.2016.1191666
• Christiansen, Jon Runar; Massey, Richard; Dalen, Håvard; Kanellopoulos, Adriani; Hamre, Hanne Mari; Fosså, Sophie Dorothea; Ruud, Ellen; Kiserud, Cecilie E. & Aakhus, Svend (2016). Utility of Global Longitudinal Strain by Echocardiography to Detect Left Ventricular Dysfunction in Long-Term Adult Survivors of Childhood Lymphoma and Acute Lymphoblastic Leukemia. American Journal of Cardiology.  ISSN 0002-9149.  118(3), s 446- 452 . doi: 10.1016/j.amjcard.2016.05.021 Show summary

  Measuring left ventricular (LV) global longitudinal strain (GLS) is recommended in screening of long-term cancer survivors for cardiotoxicity. However, there are limited data on GLS in this setting, in particular in survivors with apparently normal LV function without risk factors of impaired GLS. In the present study, we measured GLS in 191 adult survivors of childhood lymphoma or acute lymphoblastic leukemia, with normal LV ejection fraction and fractional shortening (FS) and without known hypertension, diabetes mellitus, myocardial infarction, or stroke. We compared GLS in the survivors with 180 controls. Mean GLS was -19.0 ± 2.2% in the survivor group and -21.4 ± 2.0% in the controls (p <0.001). Impaired GLS, defined as mean - 1.96 SDs in the control group, occurred in 53 of 191 survivors (28%). We included survivors with impaired LV ejection fraction and/or FS or traditional risk factors (n = 231 in all) in multiple regression analyses to explore associations with previous cancer treatment. Survivors treated with mediastinal radiotherapy had an odds ratio of impaired GLS of 5.2 (95% confidence interval 2.2 to 12) compared with other survivors. Survivors treated with cumulative anthracycline doses >300 mg/m(2) had an odds ratio of 4.8 (95% confidence interval 1.7 to 14) of impaired GLS. In conclusion, this study demonstrates a high proportion of LV dysfunction assessed by GLS in apparently healthy adult survivors of childhood cancer. Impaired GLS was associated with previous exposure to mediastinal radiotherapy and high doses of anthracyclines. The prognostic role of measuring GLS in this specific patient population should be examined in prospective studies.

• Christiansen, Jon Runar; Massey, Richard; Dalen, Håvard; Kanellopoulos, Adriani; Hamre, Hanne Mari; Ruud, Ellen; Kiserud, Cecilie E.; Fosså, Sophie Dorothea & Aakhus, Svend (2016). Right ventricular function in long-term adult survivors of childhood lymphoma and acute lymphoblastic leukaemia. European Heart Journal-Cardiovascular Imaging.  ISSN 2047-2404.  17(7), s 735- 741 . doi: 10.1093/ehjci/jew018
• Dahl, Alv A; Østby-Deglum, Marie; Oldenburg, Jan; Bremnes, Roy M.; Dahl, Olav; Klepp, Olbjørn; Wist, Erik & Fosså, Sophie Dorothea (2016). Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings. Journal of cancer survivorship.  ISSN 1932-2259.  10(5), s 842- 849 . doi: 10.1007/s11764-016-0529-4
• Dahl, Sigrun; Småstuen, Milada; Dahl, Alv A & Fosså, Sophie Dorothea (2016). Work ability in prostate cancer survivors after radical prostatectomy. Scandinavian Journal of Urology.  ISSN 2168-1805.  50(2), s 116- 122 . doi: 10.3109/21681805.2015.1100674
• Fosså, Sophie Dorothea; Bengtsson, Thomas; Borre, Michael; Ahlgren, Göran; Rannikko, Antti & Dahl, Alv A (2016). Reduction of quality of life in prostate cancer patients: experience among 6200 men in the Nordic countries. Scandinavian Journal of Urology.  ISSN 2168-1805.  50(5), s 330- 337 . doi: 10.1080/21681805.2016.1201859
• Fosså, Sophie Dorothea; Storås, Anne Marie Holck; Steinsvik, Eivind Andreas Svaboe; Myklebust, Tor Åge; Eri, Lars Magne; Loge, Jon Håvard & Dahl, Alv A (2016). Psychometric testing of the Norwegian version of the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26). Scandinavian Journal of Urology.  ISSN 2168-1805.  50(4), s 280- 285 . doi: 10.3109/21681805.2016.1163617
• Fosså, Sophie Dorothea; Wiklund, Fredrik; Klepp, Olbjørn; Angelsen, Anders; Solberg, Arne; Damber, Jan-Erik; Hoyer, Morten & Widmark, Anders (2016). Ten- and 15-yr prostate cancer-specific mortality in patients with nonmetastatic locally advanced or aggressive intermediate prostate cancer, randomized to lifelong endocrine treatment alone or combined with radiotherapy: final results of The Scandinavian Prostate Cancer Group-7. European Urology.  ISSN 0302-2838.  70(4), s 684- 691 . doi: 10.1016/j.eururo.2016.03.021
• Frisina, Robert D.; Wheeler, Heather E.; Fosså, Sophie Dorothea; Kerns, Sarah L.; Fung, Chunkit; Sesso, Howard D.; Monahan, Patrick O.; Feldman, Darren R.; Hamilton, Robert; Vaughn, David J.; Beard, Clair J.; Budnick, Amy; Johnson, Eileen M.; Ardeshir-Rouhani-fard, Shirin; Einhorn, Lawrence H.; Lipshultz, Steven E.; Dolan, M. Eileen & Travis, Lois B. (2016). Comprehensive audiometric analysis of hearing impairment and tinnitus after cisplatin-based chemotherapy in survivors of adult-onset cancer. Journal of Clinical Oncology.  ISSN 0732-183X.  34(23), s 2712- 2720 . doi: 10.1200/JCO.2016.66.8822
• Hauptmann, Michael; Johannessen, Tom Børge; Gilbert, Ethel S.; Stovall, Marilyn; van Leeuwen, Flora E.; Rajaraman, Preetha; Smith, Susan A.; Weathers, Rita E.; Aleman, Berthe M.P.; Andersson, Michael; Curtis, Rochelle E.; Dores, Graça M.; Fraumeni, Joseph F.; Hall, Per; Holowaty, Eric J.; Joensuu, Heikki; Kaijser, Magnus; Kleinerman, Ruth A.; Langmark, Frøydis Tonning; Lynch, Charles F.; Pukkala, Eero; Storm, Hans H.; Vaalavirta, Leila; van den Belt-Dusebout, Alexandra W.; Morton, Lindsay M.; Fosså, Sophie Dorothea & Travis, Lois B. (2016). Increased pancreatic cancer risk following radiotherapy for testicular cancer. British Journal of Cancer.  ISSN 0007-0920.  115(7), s 901- 908 . doi: 10.1038/bjc.2016.272
• Hjelle, Line Veronika; Bremnes, Roy M.; Gundersen, Per Ole Mobråten; Sprauten, Mette; Brydøy, Marianne; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Oldenburg, Jan & Haugnes, Hege Sagstuen (2016). Associations between long-term serum platinum and neurotoxicity and ototoxicity, endocrine gonadal function, and cardiovascular disease in testicular cancer survivors. Urologic Oncology.  ISSN 1078-1439.  34(487), s e13- e20 . doi: 10.1016/j.urolonc.2016.06.012
• Jeppesen, Elisabeth; Bjelland, Ingvar; Fosså, Sophie Dorothea; Loge, Jon Håvard & Dahl, Alv A (2016). Health-related quality of life in teenagers with a parent with cancer. European Journal of Oncology Nursing.  ISSN 1462-3889.  22, s 46- 53 . doi: 10.1016/j.ejon.2016.03.004
• Kvammen, Øivind; Myklebust, Tor Åge; Solberg, Arne; Møller, Bjørn; Klepp, Olbjørn; Fosså, Sophie Dorothea & Tandstad, Torgrim (2016). Long-term relative survival after diagnosis of testicular germ cell tumor. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  25(5), s 773- 779 . doi: 10.1158/1055-9965.EPI-15-1153
• Nilsen, Tormod Skogstad; Thorsen, Lene; Fosså, Sophie Dorothea; Wiig, Martin; Kirkegaard, Camilla; Skovlund, Eva; Benestad, Haakon Breien & Raastad, Truls (2016). Effects of strength training on muscle cellular outcomes in prostate cancer patients on androgen deprivation therapy. Scandinavian Journal of Medicine & Science in Sports.  ISSN 0905-7188.  26(9), s 1026- 1035 . doi: 10.1111/sms.12543 Show summary

  Androgen deprivation therapy (ADT) improves lifeexpectancy in prostate cancer (PCa) patients, but is asso-ciated with adverse effects on muscle mass. Here, weinvestigated the effects of strength training during ADTon muscle fiber cross-sectional area (CSA) and regulatorsof muscle mass. PCa patients on ADT were randomizedto 16 weeks of strength training (STG) (n = 12) or acontrol group (CG; n = 11). Muscle biopsies wereobtained from m. vastus lateralis and analyzed by immu-nohistochemistry and western blot. Muscle fiber CSAincreased with strength training (898 μm2, P = 0.04), withthe only significant increase observed in type II fibers(1076 μm2, P = 0.03). There was a trend toward a differ-ence in mean change between groups myonuclei number(0.33 nuclei/fiber, P = 0.06), with the only significantincrease observed in type I fibers, which decreased themyonuclear domain size of type I fibers (P = 0.05). Satel-lite cell numbers and the content of androgen receptorand myostatin remained unchanged. Sixteen weeks ofstrength training during ADT increased type II fiber CSAand reduced myonuclear domain in type I fibers in PCapatients. The increased number of satellite cells normallyseen following strength training was not observed.

• Nilsen, Tormod Skogstad; Thorsen, Lene; Kirkegaard, Camilla; Ugelstad, Ingrid; Fosså, Sophie Dorothea & Raastad, Truls (2016). The effect of strength training on muscle cellular stress in prostate cancer patients on ADT. Endocrine Connections.  ISSN 2049-3614.  5(2), s 74- 82 . doi: 10.1530/EC-15-0120 Show summary

  Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with several side effects, including loss of muscle mass. Muscle atrophy is associated with reduced mitochondrial function and increased muscle cellular stress that may be counteracted by strength training. Thus, the aim of this study was to investigate the effect of strength training on mitochondrial proteins and indicators of muscle cellular stress in PCa patients on ADT. Methods: Men diagnosed with locally advanced PCa receiving ADT were randomised to a strength training group (STG) (n=16) or a control group (CG) (n=15) for 16 weeks. Muscle biopsies were collected pre- and post-intervention from the vastus lateralis muscle, and analysed for mitochondrial proteins (citrate synthase, cytochrome c oxidase subunit IV (COXIV), HSP60) and indicators of muscle cellular stress (heat shock protein (HSP) 70, alpha B-crystallin, HSP27, free ubiquitin, and total ubiquitinated proteins) using Western blot and ELISA. Results: No significant intervention effects were observed in any of the mitochondrial proteins or indicators of muscle cellular stress. However, within-group analysis revealed that the level of HSP70 was reduced in the STG and a tendency towards a reduction in citrate synthase levels was observed in the CG. Levels of total ubiquitinated proteins were unchanged in both groups. Conclusion: Although reduced HSP70 levels indicated reduced muscle cellular stress in the STG, the lack of an intervention effect precluded any clear conclusions.

• Paur, Ingvild; Lilleby, Wolfgang; Bøhn, Siv Kjølsrud; Hulander, Erik; Klein, Willibrord; Vlatkovic, Ljiljana; Axcrona, Karol; Bolstad, Nils; Bjøro, Trine; Laake, Petter; Tasken, Kristin Austlid; Svindland, Aud; Eri, Lars Magne; Brennhovd, Bjørn; Carlsen, Monica Hauger; Fosså, Sophie Dorothea; Smeland, Sigbjørn; Karlsen, Anette Solli & Blomhoff, Rune (2016). Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA. Clinical Nutrition.  ISSN 0261-5614.  36(3), s 672- 679 . doi: 10.1016/j.clnu.2016.06.014 Full text in Research Archive.
• Storås, Anne Marie Holck; Sanda, Martin G.; Boronat, Olatz Garin; Chang, Peter; Patil, Dattatraya; Crociani, Catrina; Suarez, Jose Francisco; Småstuen, Milada C; Loge, Jon Håvard & Fosså, Sophie Dorothea (2016). Erectile Dysfunction and Sexual Problems Two to Three Years after Prostatectomy among American, Norwegian, and Spanish Patients. Clinical Genitourinary Cancer.  ISSN 1558-7673.  14(3), s e265- e273 . doi: 10.1016/j.clgc.2015.10.009
• Kristiansen, Wenche; Karlsson, Robert; Rounge, Trine Ballestad; Whitington, Thomas; Kulle, Bettina; Magnusson, Patrik K.E.; Fosså, Sophie Dorothea; Adami, Hans Olov; Turnbull, Clare; Haugen, Trine B.; Grotmol, Tom & Wiklund, Fredrik (2015). Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. Human Molecular Genetics.  ISSN 0964-6906.  24(14), s 4138- 4146 . doi: 10.1093/hmg/ddv129
• Brabrand, Sigmund; Johannessen, Bjarne; Axcrona, Ulrika; Kraggerud, Sigrid M.; Berg, Kaja Christine Graue; Bakken, Anne Cathrine; Bruun, Jarle; Fosså, Sophie Dorothea; Lothe, Ragnhild A; Lehne, Gustav & Skotheim, Rolf Inge (2015). Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages. Neoplasia.  ISSN 1522-8002.  17(2), s 167- 174 . doi: 10.1016/j.neo.2014.12.005
• Cameron, Marte; Kersten, Christian; Vistad, Ingvild; van Helvoirt, Rene; Weyde, Kjetil; Undseth, Christine; Mjaaland, Ingvil; Skovlund, Eva; Fosså, Sophie Dorothea & Guren, Marianne (2015). Palliative pelvic radiotherapy for symptomatic incurable prostate cancer - A prospective multicenter study. Radiotherapy and Oncology.  ISSN 0167-8140.  115(3), s 314- 320 . doi: 10.1016/j.radonc.2015.05.021 Full text in Research Archive.
• Dahl, Sigrun; Loge, Jon Håvard; Berge, Viktor; Dahl, Alv A; Småstuen, Milada C & Fosså, Sophie Dorothea (2015). Influence of radical prostatectomy for prostate cancer on work status and working life 3 years after surgery. Journal of cancer survivorship.  ISSN 1932-2259.  9(2), s 172- 179 . doi: 10.1007/s11764-014-0399-6
• Fosså, Sophie Dorothea & Dahl, Alv A (2015). Global Quality of Life After Curative Treatment for Prostate Cancer: What Matters? A Study Among Members of the Norwegian Prostate Cancer Patient Association. Clinical Genitourinary Cancer.  ISSN 1558-7673.  13(6), s 518- 524 . doi: 10.1016/j.clgc.2015.07.004
• Fosså, Sophie Dorothea; Dahl, Alv A; Langhammer, Arnulf & Weedon-Fekjær, Harald (2015). Cancer patients' participation in population-based health surveys: Findings from the HUNT studies Cancer. BMC Research Notes.  ISSN 1756-0500.  8:649 . doi: 10.1186/s13104-015-1635-5 Full text in Research Archive.
• Fung, Chunkit; Fosså, Sophie Dorothea; Milano, Michael T.; Sahasrabudhe, Deepak M.; Peterson, Derick R. & Travis, Lois B. (2015). Cardiovascular disease mortality after chemotherapy or surgery for testicular nonseminoma: A population-based study. Journal of Clinical Oncology.  ISSN 0732-183X.  33(28), s 3106- 3114 . doi: 10.1200/JCO.2014.60.3654
• Fung, Chunkit; Fosså, Sophie Dorothea; Williams, Annalynn & Travis, Lois B. (2015). Long-term morbidity of testicular cancer treatment. Urologic clinics of North America.  ISSN 0094-0143.  42(3), s 393- 408 . doi: 10.1016/j.ucl.2015.05.002
• Gjerset, Gunhild Maria; Loge, Jon Håvard; Gudbergsson, Sævar Berg; Bye, Asta; Fosså, Sophie Dorothea; Oldervoll, Line Merethe; Kiserud, Cecilie E.; Demark-Wahnefried, Wendy & Thorsen, Lene (2015). Lifestyles of cancer survivors attending an inpatient educational program—a cross-sectional study. Supportive Care in Cancer.  ISSN 0941-4355.  24, s 1527- 1536 . doi: 10.1007/s00520-015-2936-x
• Hauptmann, Michael; Fosså, Sophie Dorothea; Stovall, Marilyn; van Leeuwen, Flora E.; Johannesen, Tom Børge; Rajaraman, Preetha; Gilbert, Ethel S.; Smith, Susan A.; Weathers, Rita E.; Aleman, Berthe M.P.; Andersson, Michael; Curtis, Rochelle E.; Dores, Graça M.; Fraumeni, Joseph F.; Hall, Peter S.; Holowaty, Eric J.; Joensuu, Heikki; Kaijser, Magnus; Kleinerman, Ruth A.; Langmark, Frøydis Tonning; Lynch, Charles F.; Pukkala, Eero; Storm, Hans Henrik; Vaalavirta, Leila; Van Den Belt-Dusebout, Alexandra W. Sandra; Travis, Lois B. & Morton, Lindsay M. (2015). Increased stomach cancer risk following radiotherapy for testicular cancer. British Journal of Cancer.  ISSN 0007-0920.  112(1), s 44- 51 . doi: 10.1038/bjc.2014.552
• Hjelle, Line Veronika; Gundersen, Per Ole M.; Oldenburg, Jan; Brydøy, Marianne; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Bremnes, Roy M. & Haugnes, Hege Sagstuen (2015). Long-term platinum retention after platinum-based chemotherapy in testicular cancer survivors: A 20-year follow-up study. Anticancer Research.  ISSN 0250-7005.  35(3), s 1619- 1625
• Holm, Henriette Veiby; Fosså, Sophie Dorothea; Hedlund, Hans Eric Magnus; Schultz, Alexander & Dahl, Alv A (2015). Severe postprostatectomy incontinence: Is there an association between preoperative urodynamic findings and outcome of incontinence surgery?. Scandinavian Journal of Urology.  ISSN 2168-1805.  49(3), s 250- 259 . doi: 10.3109/21681805.2014.980845
• Kanellopoulos, Adriani; Andersson, Stein; Zeller, Bernward; Tamnes, Christian Krog; Fjell, Anders Martin; Walhovd, Kristine B; Westlye, Lars Tjelta; Fosså, Sophie Dorothea & Ruud, Ellen (2015). Neurocognitive Outcome in Very Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia After Treatment with Chemotherapy Only. Pediatric Blood & Cancer.  ISSN 1545-5009.  63(1), s 133- 138 . doi: 10.1002/pbc.25690
• Kiserud, Cecilie E.; Selland, Mette; Holte, Harald; Fosså, Alexander; Fosså, Sophie Dorothea; Bollerslev, Jens; Bjøro, Trine & Loge, Jon Håvard (2015). Fatigue in male lymphoma survivors differs between diagnostic groups and is associated with latent hypothyroidism. Acta Oncologica.  ISSN 0284-186X.  54(1), s 49- 59 . doi: 10.3109/0284186X.2014.948057
• Lie, Hanne Cathrine; Loge, Jon Håvard; Fosså, Sophie Dorothea; Hamre, Hanne Mari; Hess, Siri Lothe; Mellblom, Anneli; Ruud, Ellen & Finset, Arnstein (2015). Providing information about late effects after childhood cancer: Lymphoma survivors' preferences for what, how and when. Patient Education and Counseling.  ISSN 0738-3991.  98(5), s 604- 611 . doi: 10.1016/j.pec.2015.01.016
• Löffeler, Sven; Weedon-Fekjær, Harald; Wang-Hansen, Marte Sofie; Sebakk, Karin; Hamre, Hanne Mari; Haug, Erik Skaaheim & Fosså, Sophie Dorothea (2015). "Natural course" of disease in patients with metastatic castrate-resistant prostate cancer: Survival and prognostic factors without life-prolonging treatment. Scandinavian Journal of Urology.  ISSN 2168-1805.  49(6), s 440- 445 . doi: 10.3109/21681805.2015.1059881
• Nilsen, Tormod Skogstad; Raastad, Truls; Skovlund, Eva; Courneya, Kerry S.; Langberg, Carl W.; Lilleby, Wolfgang; Fosså, Sophie Dorothea & Thorsen, Lene (2015). Effects of strength training on body composition, physical functioning, and quality of life in prostate cancer patients during androgen deprivation therapy. Acta Oncologica.  ISSN 0284-186X.  54(10), s 1805- 1813 . doi: 10.3109/0284186X.2015.1037008
• Nome, Ragnhild; Hernes, Eivor; Bogsrud, Trond; Bjøro, Trine & Fosså, Sophie Dorothea (2015). Changes in prostate-specific antigen, markers of bone metabolism and bone scans after treatment with radium-223. Scandinavian Journal of Urology.  ISSN 2168-1805.  49(3), s 211- 217 . doi: 10.3109/21681805.2014.982169
• Popova, Olesya; Tropé, Claes Gøran; Rokkones, Erik; Kærn, Janne; Paulsen, Torbjørn; Salvesen, Helga; Hagen, Bjørn; Vereide, Anne Beate & Fosså, Sophie Dorothea (2015). Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". Gynecologic Oncology.  ISSN 0090-8258.  136(2), s 224- 229 . doi: 10.1016/j.ygyno.2014.12.010
• Selland, Mette; Bjøro, Trine; Furre, Torbjørn; Schreiner, Thomas; Bollerslev, Jens; Fosså, Sophie Dorothea; Loge, Jon Håvard; Holte, Harald & Kiserud, Cecilie E. (2015). Hormonal dysfunction is frequent in cancer survivors treated with radiotherapy to the head and neck region. Journal of cancer survivorship.  ISSN 1932-2259.  9(4), s 630- 640 . doi: 10.1007/s11764-015-0439-x
• Selland, Mette; Holte, Harald; Bjøro, Trine; Schreiner, Thomas; Bollerslev, Jens; Loge, Jon Håvard; Fosså, Sophie Dorothea & Kiserud, Cecilie E. (2015). Chronic fatigue is prevalent and associated with hormonal dysfunction in long-term non-Hodgkin lymphoma survivors treated with radiotherapy to the head and neck region. Leukemia and Lymphoma.  ISSN 1042-8194.  56(12), s 3306- 3314 . doi: 10.3109/10428194.2015.1036258 Show summary

  The purposes of this study were to assess the prevalence of chronic fatigue (CF) in irradiated survivors of non-Hodgkin lymphoma, analyze for associations between hormonal dysfunction and CF, and to investigate the associations between CF and functioning. Invited survivors were all treated with radiation to the head and neck region, with or without additional chemotherapy. The participants (n =98) responded to questionnaires measuring CF, mental distress (HADS), and functioning (SF-36), and had blood drawn for analyses of four hormonal axes. Hormonal status was categorized as normal, hormone dysfunction in one or more axes, or hormone replacement therapy. A total of 29% of the survivors had CF. In multivariate analyses there was an increased risk of CF among survivors with untreated hormone dysfunction (OR 3.87, 95% CI: 1.20–12.51, P 0.02). Survivors on hormone substitution did not have increased risk for CF compared to survivors with normal hormonal status. CF was significantly associated with reduced functioning.

• Sprauten, Mette; Haugnes, Hege Sagstuen; Brydøy, Marianne; Kiserud, Cecilie E.; Tandstad, Torgrim; Bjøro, Trine; Bjerner, Johan; Småstuen, Milada C; Fosså, Sophie Dorothea & Oldenburg, Jan (2015). Chronic fatigue in 812 testicular cancer survivors during long-term follow-up: increasing prevalence and risk factors. Annals of Oncology.  ISSN 0923-7534.  26(10), s 2133- 2140 . doi: 10.1093/annonc/mdv328

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• Aas, Kirsti; Fosså, Sophie Dorothea; Kvåle, Rune; Møller, Bjørn; Myklebust, Tor Åge; Vlatkovic, Ljiljana; Müller, Stig & Berge, Viktor (2018). Increasing Time from Diagnosis to Radical Prostatectomy (RP-interval) is Not Associated with Adverse Oncological Outcomes: Implications for cancer patient pathways (CPPs). European urology. Supplement.  ISSN 1569-9056.  17(14), s e2825- e2827 . doi: 10.1016/S1569-9056(18)33709-6
• Bucher-Johannessen, Cecilie; Page, Christian M.; Haugen, Trine B.; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen; Grotmol, Tom & Rounge, Trine Ballestad (2018). Epigenetic changes in testicular cancer survivors treated with cisplatin.
• Fosså, Sophie Dorothea (2017). Re: Behandling eller aktiv monitorering ved prostatakreft?. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(4), s 259- 260 . doi: 10.4045/tidsskr.17.0046
• Holm, Henriette Veiby; Dahl, Alv A; Klepp, Olbjørn & Fosså, Sophie Dorothea (2017). H.V. Holm og medarbeidere svarer :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  137(14/15), s 976 . doi: 10.4045/tidsskr.17.0579
• Jacobsen, Ellisiv Lærum; Bye, Asta; Aass, Nina Kathrine; Fosså, Sophie Dorothea; Grotmol, Kjersti Støen; Kaasa, Stein; Loge, Jon Håvard; Moum, Torbjørn Åge & Hjermstad, Marianne Jensen (2017). Correction to: Norwegian reference values for the Short-Form Health Survey 36: development over time. Quality of Life Research.  ISSN 0962-9343.  s 1- 3 . doi: 10.1007/s11136-017-1708-0 Full text in Research Archive.
• Torstveit, Ann Helen; Dahl, Alv A; Fosså, Sophie Dorothea & Utne, Inger (2017). Chronic Fatigue in Testicular Cancer Survivors.
• Fung, Chunkit; Fosså, Sophie Dorothea; Milano, Michael T.; Sahasrabudhe, Deepak M.; Peterson, Derick R. & Travis, Lois B. (2016). Reply to S. Alanee et al. Journal of Clinical Oncology.  ISSN 0732-183X.  34(11), s 1285- 1286 . doi: 10.1200/JCO.2015.65.7015

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