Tahira Riaz

Postdoctoral Fellow - Department of Microbiology
Image of Tahira Riaz
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postal address Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo

 

Project

My postdoctoral project "Novel Mycobacterial Tolerance Inhibitors (MTIs) against Multidrug-Resistant Tuberculosis" is an international collaborative project on global initiative on antimicrobial resistance (AMR) funded by EU "The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)" through The Research Council of Norway. Our collaborators have developed a new class of substances, called MTIs, with the potential to inhibit Mycobacterium tuberculosis (Mtb) biofilm formation and re-sensitize isoniazid resistant Mtb strains. My work focuses on testing these in different types of resistant and multi-resistant clinical Mtb isolates and as well as defining their mechanism of action. I also study whether MTIs work in synergy with other new and classic TB drugs. This front-line project is relevant to both drug discovery and precision medicine in general.

 

Teaching

  • 2021, 2022 Supervisor for bachelor students
  • 2016-2019 Laboratory course in Microbiolgy, Module 1, Medicine
  • 2016-2019 Laboratory course in Microbiolgy, Module 3, Medicine

 

Commission

  • 2022 Deputy representative for temporary academic staff of the Board of Faculty of Medicine
  • 2021 Deputy representative for temporary academic staff of the KLINMED institute council

 

Tags: Mass spectrometry, Proteomics, Bioinformatics, Immunology, Microbiology, Antimicrobial resistance

Publications

  • Birhanu, Alemayehu Godana; Gomez Munoz, Marta; Kalayou, Shewit; Riaz, Tahira; Lutter, Timo & Yimer, Solomon Abebe [Show all 8 contributors for this article] (2022). Proteome Profiling of Mycobacterium tuberculosis Cells Exposed to Nitrosative Stress. ACS Omega. ISSN 2470-1343. 7(4), p. 3470–3482. doi: 10.1021/acsomega.1c05923. Full text in Research Archive
  • Arenas, Jesús; Szabo, Zalan; van der Wal, Jelle; Maas, Coen; Riaz, Tahira & Tonjum, Tone [Show all 7 contributors for this article] (2021). Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin. Virulence. ISSN 2150-5594. 12(1), p. 2902–2917. doi: 10.1080/21505594.2021.2003115. Full text in Research Archive
  • Fernández Navarro, José; Croteau, Deborah L; Jurek, Aleksandra; Andrusivova, Zaneta; Yang, Beimeng & Wang, Yue [Show all 15 contributors for this article] (2020). Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease. iScience. ISSN 2589-0042. 23:101556(10), p. 1–19. doi: 10.1016/j.isci.2020.101556. Full text in Research Archive
  • Yimer, Solomon Abebe; Kalayou, Shewit; Homberset, Håvard; Birhanu, Alemayehu Godana; Riaz, Tahira & Zegeye, Ephrem Debebe [Show all 11 contributors for this article] (2020). Lineage-specific proteomic signatures in the Mycobacterium tuberculosis complex reveal differential abundance of proteins involved in virulence, DNA repair, CRISPR-Cas, bioenergetics and lipid metabolism. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.550760. Full text in Research Archive
  • Birhanu, Alemayehu Godana; Solomon, Abebe Yimer; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Holm-Hansen, Carol J C [Show all 10 contributors for this article] (2019). Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex. Scientific Reports. ISSN 2045-2322. 9:2927, p. 1–15. doi: 10.1038/s41598-019-39654-9. Full text in Research Archive
  • Jensen, Helge Leander B.; Lillenes, Meryl Sønderby; Rabano, Alberto; Günther, Clara-Cecilie; Riaz, Tahira & Kalayou, Shewit [Show all 9 contributors for this article] (2018). Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood. Neuroscience Letters. ISSN 0304-3940. 672, p. 53–58. doi: 10.1016/j.neulet.2018.02.043. Full text in Research Archive
  • Frye, Stephan Alfons; Beyene, Getachew Tesfaye; Namouchi, Amine; Munoz, Marta Gomez; Homberset, Håvard & Kalayou, Shewit [Show all 9 contributors for this article] (2017). The helicase DinG responds to stress due to DNA double strand breaks. PLOS ONE. ISSN 1932-6203. 12:e0187900(11), p. 1–23. doi: 10.1371/journal.pone.0187900.
  • Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Show all 11 contributors for this article] (2017). Comparative proteomic analysis of Mycobacterium tuberculosis lineage 7 and lineage 4 strains reveals differentially abundant proteins linked to slow growth and virulence. Frontiers in Microbiology. ISSN 1664-302X. 8:795, p. 1–14. doi: 10.3389/fmicb.2017.00795. Full text in Research Archive
  • Beyene, Getachew Tesfaye; Kalayou, Shewit; Riaz, Tahira & Tonjum, Tone (2017). Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis. BMC Microbiology. ISSN 1471-2180. 17:96, p. 1–18. doi: 10.1186/s12866-017-1004-8.
  • Beyene, Getachew Tesfaye; Balasingham, Seetha; Frye, Stephan Alfons; Namouchi, Amine; Homberset, Håvard & Kalayou, Shewit [Show all 8 contributors for this article] (2016). Characterization of the Neisseria meningitidis Helicase RecG. PLOS ONE. ISSN 1932-6203. 11:e0164588(10), p. 1–31. doi: 10.1371/journal.pone.0164588.
  • Lillenes, Meryl Sønderby; Rabano, Alberto; Støen, Mari; Riaz, Tahira; Misaghian, Dorna & Møllersen, Linda [Show all 12 contributors for this article] (2016). Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease. Molecular Brain. ISSN 1756-6606. 9:61, p. 1–14. doi: 10.1186/s13041-016-0237-z.
  • Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid & De Souza, Gustavo Antonio (2016). Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells. Molecular & Cellular Proteomics. ISSN 1535-9476. 15(3), p. 1007–1016. doi: 10.1074/mcp.M115.050138.
  • Kozielski, Frank; Riaz, Tahira; DeBonis, Salvatore; Koehler, Christian; Panse, Isabel & Strozynski, Margarita Anna [Show all 9 contributors for this article] (2011). Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino Acids. ISSN 0939-4451. 41(2), p. 363–385. doi: 10.1007/s00726-010-0649-5.
  • Bøhle, Liv Anette; Riaz, Tahira; Jacobsen, Wolfgang Mathias; Skaugen, Morten; Busk, Øyvind & Eijsink, Vincent [Show all 7 contributors for this article] (2011). Identification of surface proteins in Enterococcus faecalis V583. BMC Genomics. ISSN 1471-2164. 12. doi: 10.1186/1471-2164-12-135.
  • Kozielski, Frank; Riaz, Tahira; DeBonis, Salvatore; Koehler, Christian; Kröning, Mario & Panse, Isabel [Show all 9 contributors for this article] (2010). Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino Acids. ISSN 0939-4451. doi: 10.1007/s00726-010-0649-5.
  • Yimer, Solomon Abebe; Godana, Alemayehu; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Show all 11 contributors for this article] (2010). Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence. Frontiers in Microbiology. ISSN 1664-302X.

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  • Riaz, Tahira (2021). JPIAMR Capacity Building Ideathon - Rapporteur.
  • Riaz, Tahira (2021). Development of novel Mycobacterial Tolerance Inhibitors (MTIs) against MDR/XDR tuberculosis.
  • Kaniusaite, Milda; Riaz, Tahira; Lillenes, Meryl Sønderby; Detlie, Trond Espen; Alfredo, Rabano & Tonjum, Tone (2020). On the Brain-Gut axis: The gut microbiome affects the differential expression of DNA repair pathways in the human brain and mucosal gut tissue.
  • Riaz, Tahira (2020). Novel Mycobacterial Tolerance Inhibitors (MTIs) Against Multidrug-Resistant Tuberculosis.
  • Riaz, Tahira & Muñoz, Marta Gómez (2020). Genome dynamics in health and disease: Focus on AMR, TB and COVID-19.
  • Riaz, Tahira & Tonjum, Tone (2020). Resistance mechanisms and novel drug targets.
  • Riaz, Tahira (2019). Proteomics studies to combat Tuberculosis.
  • Riaz, Tahira (2019). Proteome characterization of Mycobacterium tuberculosis.
  • Lillenes, Meryl Sønderby; Riaz, Tahira; Støen, Mari; Kalayou, Shewit; Rabano, Alberto & Tonjum, Tone (2019). Proteomic Analysis of Brain Tissue from Patients with Alzheimer’s disease and Healthy Controls Reveals Differential Expression of Proteins Involved in Mitochondrial Dysfunction between Brain Domains.
  • Tonjum, Tone; Birhanu, Alemayehu Godana; Riaz, Tahira & Yimer, Solomon Abebe (2019). Abundance of post-translational modifications in Mycobacterium tuberculosis.
  • Riaz, Tahira (2018). Proteomics of selected microbes and man.
  • Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Shewit, Kalayou; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Show all 11 contributors for this article] (2016). First proteomic analysis of Mycobacterium tuberculosis lineage 7 differentially expressed proteins involved for growth.
  • Tonjum, Tone; Riaz, Tahira; Lillenes, Meryl Sønderby; Detlie, Trond Espen & Jensen, Helge Leander B. (2016). The Brain-Gut axis: Differential expression of DNA repair in human brain and mucosal gut tissue .
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Lillenes, Meryl Sønderby; Riaz, Tahira; Rabano, Alberto; Fladby, Tormod & Tonjum, Tone (2016). Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease.
  • Riaz, Tahira (2016). Th1 og Th1/Th17-cellekloner i tarmbiopsier fra pasienter med Crohns sykdom. BestPractice Gastroenterologi. ISSN 1903-6590.
  • Yimer, Solomon Abebe; Namouchi, Amine; Riaz, Tahira; Zegeye, Ephrem Debebe; Godana, Alemayehu & Holm-Hansen, Carol J C [Show all 9 contributors for this article] (2015). Genomic and proteomic analysis of Mycobacterium tuberculosis lineage 7 strains from Ethiopia. Oral presentation at the 46th Union World Conference on Lung Health Cape Town, South Africa: 2 December - 6 December 2015.
  • Mathiesen, Geir; Riaz, Tahira; Bøhle, Liv Anette; Skaugen, Morten; Busk, Øyvind & Jacobsen, Wolfgang Mathias [Show all 7 contributors for this article] (2011). Identification of surface proteins in Enterococcus faecalis V583.
  • Bøhle, Liv Anette; Riaz, Tahira; Egge-Jacobsen, Wolfgang; Skaugen, Morten; Busk, Øyvind & Eijsink, Vincent (2010). Direct LC-MS/MS-based identification of surface-associated proteins in Enterococcus faecalis V583.
  • Riaz, Tahira; Mathiesen, Geir; Busk, Øyvind; Skaugen, Morten; Bøhle, Liv Anette & Egge-Jacobsen, Wolfgang [Show all 7 contributors for this article] (2009). Identification of Enterococcus faecalisV583 surface-associated proteins.
  • Riaz, Tahira; Tønjum, Tone; Støen, Mari; Berge, Tone; Sukenthirarasa, Pravina & Ka Wai Kai, Celina (2021). New Drugs to Combat AMR. OsloMet - storbyuniversitetet.
  • Riaz, Tahira; Tonjum, Tone & Olsen, Ingrid (2019). Proteomic approaches to study CD4+ T cells and meningococci: New insight into life science and infection biology. University of Oslo. ISSN 978-82-8377-448-1.
  • Riaz, Tahira (2008). Proteome analysis of microtubule-associated proteins and S-trityl-L-cysteine-induced mitotic arrest and apoptosis. UMB.

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Published Sep. 23, 2016 12:30 PM - Last modified Aug. 29, 2022 11:29 AM