Tahira Riaz

Bilde av Tahira Riaz
English version of this page
Brukernavn
Besøksadresse Sognsvannsveien 20 Rikshospitalet 0372 Oslo
Postadresse Postboks 4950 Nydalen OUS HF Rikshospitalet 0424 Oslo

Prosjekt

Postdoktor-prosjektet mitt “Novel Mycobacterial Tolerance Inhibitors (MTIs) against Multidrug-Resistant Tuberculosis” er et internasjonalt samarbeidsprosjekt innen den globale satsningen mot antimikrobiell resistens (AMR) finansiert av EU “The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)”, kanalisert via Norges forskningsråd. Våre samarbeidspartnere har utviklet en ny klasse med nye medikamenter, 2-pyridoner kalt MTIs, med potensiale for å hemme Mycobacterium tuberculosis (Mtb) biofilm-dannelse og re-sensitivisere isoniazid-resistente Mtb-stammer. Mitt arbeid er å oppdage MTI’s virkningsmekanisme ved hjelp av høy-oppløselig massespektrometri og mutantanalyse. Jeg tester også om MTIs virker på ulike klasser av resistente og multiresistente kliniske Mtb-isolater i P3-lab og i synergi med andre nye og klassiske TB-medikamenter. Dette frontlinjeprosjektet er relevant for både drug discovery og presisjsonsmedisin generelt.

 

Undervisning

  • 2021 Veileder for bachelorstudenter
  • 2016-2019 Laboratoriekurs i mikrobiologi, medisinstudiet modul 1
  • 2016-2019 Laboratoriekurs i mikrobiologi, medisinstudiet modul 3

 

Verv

  • 2021 Vara representant for midlertidig vitenskapelige i instituttrådet ved KLINMED
Emneord: Mass spectrometry, Proteomics, Bioinformatics, Immunology, Microbiology, Antimicrobial resistance

Publikasjoner

  • Arenas, Jesús; Szabo, Zalan; van der Wal, Jelle; Maas, Coen; Riaz, Tahira & Tonjum, Tone [Vis alle 7 forfattere av denne artikkelen] (2021). Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin. Virulence. ISSN 2150-5594. 12(1), s. 2902–2917. doi: 10.1080/21505594.2021.2003115. Fulltekst i vitenarkiv
  • Fernández Navarro, José; Croteau, Deborah L; Jurek, Aleksandra; Andrusivova, Zaneta; Yang, Beimeng & Wang, Yue [Vis alle 15 forfattere av denne artikkelen] (2020). Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease. iScience. ISSN 2589-0042. 23:101556(10), s. 1–19. doi: 10.1016/j.isci.2020.101556. Fulltekst i vitenarkiv
  • Yimer, Solomon Abebe; Kalayou, Shewit; Homberset, Håvard; Birhanu, Alemayehu Godana; Riaz, Tahira & Zegeye, Ephrem Debebe [Vis alle 11 forfattere av denne artikkelen] (2020). Lineage-specific proteomic signatures in the Mycobacterium tuberculosis complex reveal differential abundance of proteins involved in virulence, DNA repair, CRISPR-Cas, bioenergetics and lipid metabolism. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.550760. Fulltekst i vitenarkiv
  • Birhanu, Alemayehu Godana; Solomon, Abebe Yimer; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Holm-Hansen, Carol J C [Vis alle 10 forfattere av denne artikkelen] (2019). Ample glycosylation in membrane and cell envelope proteins may explain the phenotypic diversity and virulence in the Mycobacterium tuberculosis complex. Scientific Reports. ISSN 2045-2322. 9:2927, s. 1–15. doi: 10.1038/s41598-019-39654-9. Fulltekst i vitenarkiv
  • Jensen, Helge Leander B.; Lillenes, Meryl Sønderby; Rabano, Alberto; Günther, Clara-Cecilie; Riaz, Tahira & Kalayou, Shewit [Vis alle 9 forfattere av denne artikkelen] (2018). Expression of nucleotide excision repair in Alzheimer's disease is higher in brain tissue than in blood. Neuroscience Letters. ISSN 0304-3940. 672, s. 53–58. doi: 10.1016/j.neulet.2018.02.043. Fulltekst i vitenarkiv
  • Frye, Stephan Alfons; Beyene, Getachew Tesfaye; Namouchi, Amine; Munoz, Marta Gomez; Homberset, Håvard & Kalayou, Shewit [Vis alle 9 forfattere av denne artikkelen] (2017). The helicase DinG responds to stress due to DNA double strand breaks. PLOS ONE. ISSN 1932-6203. 12:e0187900(11), s. 1–23. doi: 10.1371/journal.pone.0187900.
  • Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Vis alle 11 forfattere av denne artikkelen] (2017). Comparative proteomic analysis of Mycobacterium tuberculosis lineage 7 and lineage 4 strains reveals differentially abundant proteins linked to slow growth and virulence. Frontiers in Microbiology. ISSN 1664-302X. 8:795, s. 1–14. doi: 10.3389/fmicb.2017.00795. Fulltekst i vitenarkiv
  • Beyene, Getachew Tesfaye; Kalayou, Shewit; Riaz, Tahira & Tonjum, Tone (2017). Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis. BMC Microbiology. ISSN 1471-2180. 17:96, s. 1–18. doi: 10.1186/s12866-017-1004-8.
  • Beyene, Getachew Tesfaye; Balasingham, Seetha; Frye, Stephan Alfons; Namouchi, Amine; Homberset, Håvard & Kalayou, Shewit [Vis alle 8 forfattere av denne artikkelen] (2016). Characterization of the Neisseria meningitidis Helicase RecG. PLOS ONE. ISSN 1932-6203. 11:e0164588(10), s. 1–31. doi: 10.1371/journal.pone.0164588.
  • Lillenes, Meryl Sønderby; Rabano, Alberto; Støen, Mari; Riaz, Tahira; Misaghian, Dorna & Møllersen, Linda [Vis alle 12 forfattere av denne artikkelen] (2016). Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease. Molecular Brain. ISSN 1756-6606. 9:61, s. 1–14. doi: 10.1186/s13041-016-0237-z.
  • Riaz, Tahira; Sollid, Ludvig Magne; Olsen, Ingrid & De Souza, Gustavo Antonio (2016). Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells. Molecular & Cellular Proteomics. ISSN 1535-9476. 15(3), s. 1007–1016. doi: 10.1074/mcp.M115.050138.
  • Kozielski, Frank; Riaz, Tahira; DeBonis, Salvatore; Koehler, Christian; Panse, Isabel & Strozynski, Margarita Anna [Vis alle 9 forfattere av denne artikkelen] (2011). Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino Acids. ISSN 0939-4451. 41(2), s. 363–385. doi: 10.1007/s00726-010-0649-5.
  • Bøhle, Liv Anette; Riaz, Tahira; Jacobsen, Wolfgang Mathias; Skaugen, Morten; Busk, Øyvind & Eijsink, Vincent [Vis alle 7 forfattere av denne artikkelen] (2011). Identification of surface proteins in Enterococcus faecalis V583. BMC Genomics. ISSN 1471-2164. 12. doi: 10.1186/1471-2164-12-135.
  • Kozielski, Frank; Riaz, Tahira; DeBonis, Salvatore; Koehler, Christian; Kröning, Mario & Panse, Isabel [Vis alle 9 forfattere av denne artikkelen] (2010). Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain. Amino Acids. ISSN 0939-4451. doi: 10.1007/s00726-010-0649-5.
  • Yimer, Solomon Abebe; Godana, Alemayehu; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Vis alle 11 forfattere av denne artikkelen] (2010). Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence. Frontiers in Microbiology. ISSN 1664-302X.

Se alle arbeider i Cristin

  • Riaz, Tahira (2021). JPIAMR Capacity Building Ideathon - Rapporteur.
  • Riaz, Tahira (2021). Development of novel Mycobacterial Tolerance Inhibitors (MTIs) against MDR/XDR tuberculosis.
  • Kaniusaite, Milda; Riaz, Tahira; Lillenes, Meryl Sønderby; Detlie, Trond Espen; Alfredo, Rabano & Tonjum, Tone (2020). On the Brain-Gut axis: The gut microbiome affects the differential expression of DNA repair pathways in the human brain and mucosal gut tissue.
  • Riaz, Tahira (2020). Novel Mycobacterial Tolerance Inhibitors (MTIs) Against Multidrug-Resistant Tuberculosis.
  • Riaz, Tahira & Muñoz, Marta Gómez (2020). Genome dynamics in health and disease: Focus on AMR, TB and COVID-19.
  • Riaz, Tahira & Tonjum, Tone (2020). Resistance mechanisms and novel drug targets.
  • Riaz, Tahira (2019). Proteomics studies to combat Tuberculosis.
  • Riaz, Tahira (2019). Proteome characterization of Mycobacterium tuberculosis.
  • Lillenes, Meryl Sønderby; Riaz, Tahira; Støen, Mari; Kalayou, Shewit; Rabano, Alberto & Tonjum, Tone (2019). Proteomic Analysis of Brain Tissue from Patients with Alzheimer’s disease and Healthy Controls Reveals Differential Expression of Proteins Involved in Mitochondrial Dysfunction between Brain Domains.
  • Tonjum, Tone; Birhanu, Alemayehu Godana; Riaz, Tahira & Yimer, Solomon Abebe (2019). Abundance of post-translational modifications in Mycobacterium tuberculosis.
  • Riaz, Tahira (2018). Proteomics of selected microbes and man.
  • Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Shewit, Kalayou; Riaz, Tahira; Zegeye, Ephrem Debebe & Beyene, Getachew Tesfaye [Vis alle 11 forfattere av denne artikkelen] (2016). First proteomic analysis of Mycobacterium tuberculosis lineage 7 differentially expressed proteins involved for growth.
  • Tonjum, Tone; Riaz, Tahira; Lillenes, Meryl Sønderby; Detlie, Trond Espen & Jensen, Helge Leander B. (2016). The Brain-Gut axis: Differential expression of DNA repair in human brain and mucosal gut tissue .
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Birhanu, Alemayehu Godana; Yimer, Solomon Abebe; Riaz, Tahira & Tonjum, Tone (2016). Proteomic Analysis of Mycobacterium tuberculosis Membrane Vesicles.
  • Lillenes, Meryl Sønderby; Riaz, Tahira; Rabano, Alberto; Fladby, Tormod & Tonjum, Tone (2016). Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease.
  • Riaz, Tahira (2016). Th1 og Th1/Th17-cellekloner i tarmbiopsier fra pasienter med Crohns sykdom. BestPractice Gastroenterologi. ISSN 1903-6590.
  • Yimer, Solomon Abebe; Namouchi, Amine; Riaz, Tahira; Zegeye, Ephrem Debebe; Godana, Alemayehu & Holm-Hansen, Carol J C [Vis alle 9 forfattere av denne artikkelen] (2015). Genomic and proteomic analysis of Mycobacterium tuberculosis lineage 7 strains from Ethiopia. Oral presentation at the 46th Union World Conference on Lung Health Cape Town, South Africa: 2 December - 6 December 2015.
  • Mathiesen, Geir; Riaz, Tahira; Bøhle, Liv Anette; Skaugen, Morten; Busk, Øyvind & Jacobsen, Wolfgang Mathias [Vis alle 7 forfattere av denne artikkelen] (2011). Identification of surface proteins in Enterococcus faecalis V583.
  • Bøhle, Liv Anette; Riaz, Tahira; Egge-Jacobsen, Wolfgang; Skaugen, Morten; Busk, Øyvind & Eijsink, Vincent (2010). Direct LC-MS/MS-based identification of surface-associated proteins in Enterococcus faecalis V583.
  • Riaz, Tahira; Mathiesen, Geir; Busk, Øyvind; Skaugen, Morten; Bøhle, Liv Anette & Egge-Jacobsen, Wolfgang [Vis alle 7 forfattere av denne artikkelen] (2009). Identification of Enterococcus faecalisV583 surface-associated proteins.
  • Riaz, Tahira; Tønjum, Tone; Støen, Mari; Berge, Tone; Sukenthirarasa, Pravina & Ka Wai Kai, Celina (2021). New Drugs to Combat AMR. OsloMet - storbyuniversitetet.
  • Riaz, Tahira; Tonjum, Tone & Olsen, Ingrid (2019). Proteomic approaches to study CD4+ T cells and meningococci: New insight into life science and infection biology. University of Oslo. ISSN 978-82-8377-448-1.
  • Riaz, Tahira (2008). Proteome analysis of microtubule-associated proteins and S-trityl-L-cysteine-induced mitotic arrest and apoptosis. UMB.

Se alle arbeider i Cristin

Publisert 23. sep. 2016 12:28 - Sist endret 5. nov. 2021 10:30