Tom Hemming Karlsen

Professor of Internal Medicine
Image of Tom Hemming Karlsen
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Visiting address Oslo University Hospital Rikshospitalet

Background

  • MD University of Bergen, 1997
  • PhD University of Oslo, 2007

Present positions

  • Research Head, Division of Surgery, Inflammatory diseases and Transplantation, Oslo University Hospital.
  • Full professor of Internal Medicine, University of Oslo.
  • Senior consultant, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet.

Main Previous Positions

  • 2012 - 2014 Full Professor of Gastroenterology, UiB

  • 2007 - 2012 Executive Manager, Norwegian PSC research center, UiO/OUH

  • 2007 - 2014 M.D., Internal Medicine and Gastroenterology, OUH

  • 2004 - 2006 PhD fellow, Institute of Immunology, UiO

  • 1999 - 2003  M.D., Internal Medicine and Gastroenterology, Sørlandet Hospital Arendal

Honors (selected items)

  • 2019 Elected member of the Norwegian Academy of Science and Letters
  • 2015 International Hans Popper Award
  • 2013 Oslo University Hospital Early Career Award
  • 2012 United European Gastroenterology (UEG) Association Rising Star Award

Commissions of trust (selected items)

  • 2020 - Board member, the Biomedical Alliance in Europe (https://www.biomedeurope.org/)
  • 2019 - Board member, European Reference Network (ERN) for Rare Liver Diseases
  • 2019 - Associate Editor, Journal of Hepatology
  • 2019 - Board member, the University of Oslo “UiO:Life Science”
  • 2019 - Co-chair, The Lancet-EASL Commission on Liver Disease in Europe
  • 2018 - Chairman of the Board, Norwegian Center of Excellence “Hybrid Technology Hub”
  • 2017 - 2019 Secretary General (Chairman), European Association for the Study of the Liver (EASL)
  • 2016 - Member, Scientific Advisory Board, Carlos foundation, Mayo Clinic Rochester, US
  • 2014 - 2016 Vice Secretary and Board member, EASL (www.easl.eu)
  • 2006 - 2014 Coordinator, Nordic Liver Transplant Registry (www.scandiatransplant.org)

Institutional Responsibilities (selected items)

  • 2019 - Project leader, Implementation of Personalized Medicine at OUH (hospital level)

  • 2015 - 2019 Member of “Forskningsutvalget” (Research Council), hospital level (OUH)


  • 2017 - 2018 Working group for action plan “Personalized medicine”, Norwegian Research Council

  • 2010 - 2016 Member of “Forskningsutvalget” (Research Council), division level (KKT, OUH)

  • 2015 - 2016 National project group for personalized medicine, Norwegian Directorate for Health

  • 2010 - 2014 Member of “Biobankutvalget” (Biobank Council) hospital level (OUH)

  • 2009 - Working group for “action plan for biobank and registries” in Helse Sør-Øst

  • 2001- 2002 Project leader, electronic patient records evaluation, Norwegian Health Directorate

  • 1994 - 1996 Establishing of small group educational activities, Faculty of Medicine, UiB

 

 

Publications

Thaventhiran JED, Lango Allen H, Burren OS et al. (2020) Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature 583:90-95. 

Ellinghaus D, Degenhardt F, Bujanda L et al. (2020) Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine 383:1522-1534.

Melum E, Jiang X, Baker KD, et al. (2019) Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology, 20, 1644-1655.

Schneditz G, Elias JE, Pagano E, et al. (2019) GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling, 562, eaau9048.

Manns MP, Burra P, Sargent J, Horton R, Karlsen TH (2018) The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities. Lancet, 10148, 621-622.

Sampaziotis F, Justin AW, Tysoe OC et al. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine, 23, 954-963. 

Ji SG, Juran BD, Mucha S, et al. (2017) Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49, 269-273.

Wang J, Thingholm LB, Skiecevièienë J, et al. (2016) Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48,1396-1406.

Ellinghaus D, Jostins L, Spain SL, et al. (2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48, 510-8.

Sampaziotis F, Cardoso de Brito M, Madrigal P, et al. (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33,845-52.

Goyette P, Boucher G, Mallon D, et al. (2015). High density mapping of the MHC reveals a common role for HLADRB1* 01:03 in IBD and heterozygous advantage in ulcerative colitis; Nature Genetics, 47 (2), 172-179.

Hirschfield GM, Karlsen TH, Lindor K, Adams D, (2013). Primary sclerosing cholangitisLancet, 382 (9904), 1587-99.

Liu JZ, Hov JR, Folseraas T, et al., (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis; Nature Genetics, 45 (6), 670-5.

Jostins L, Ripke S, Weersma RK, et al., (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease; Nature, 491 (7422), 119-24.

Anderson CA, Boucher G, Lees CW, et al., (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47; Nature Genetics, 43 (3), 246-52.

Melum E, Franke A, Schramm C, et al., (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci; Nature Genetics, 43 (1), 17-9.

Ellinghaus E, Ellinghaus D, Stuart PE, et al., (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2; Nature Genetics, 42 (11), 991-5.

Franke A, Balschun T, Sina C, et al., (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL); Nature Genetics, 42 (4), 292-4.

Franke A, Balschun T, Karlsen TH, et al. (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility; Nature Genetics, 40 (11), 1319-23.

Franke A, Balschun T, Karlsen TH, et al. (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis; Nature Genetics, 40 (6), 713-5.

  • Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina & Leeming, Diana Julie [Show all 12 contributors for this article] (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 3(1), p. 1–11. doi: 10.1016/j.jhepr.2020.100178. Full text in Research Archive
  • Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund; Färkkilä, Martti; Rosenberg, William & Møller, Holger J. [Show all 9 contributors for this article] (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. ISSN 2155-384X. 12(3), p. e00315–e00315. doi: 10.14309/ctg.0000000000000315. Full text in Research Archive
  • Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine & Trøseid, Marius [Show all 12 contributors for this article] (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(4), p. 443–452. doi: 10.1080/00365521.2021.1880627. Full text in Research Archive
  • Schneider, Kai Markus; Candels, Lena Susanna; Hov, Johannes R.; Myllys, Maiju; Hassan, Reham & Schneider, Carolin Victoria [Show all 26 contributors for this article] (2021). Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nature Metabolism. 3(9), p. 1228–1241. doi: 10.1038/s42255-021-00452-1.
  • Jiang, Xiaojun; Bergquist, Annika; Löscher, Britt-Sabina; Venkatesh, Geetha; Mold, Jeff E. & Holm, Kristian [Show all 15 contributors for this article] (2021). A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis. Science Translational Medicine. ISSN 1946-6234. 13(582). doi: 10.1126/scitranslmed.abb0036.
  • Lapitz, Ainhoa; Arbelaiz, Ander; O'Rourke, Colm J; Lavin, José L.; Casta, Adelaida La & Ibarra, Cesar [Show all 26 contributors for this article] (2020). Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis. Cells. ISSN 2073-4409. 9(3). doi: 10.3390/cells9030721..
  • Valestrand, Laura Cecilie; Berntsen, Natalie Lie; Fei, Zheng; Schrumpf, Erik; Hansen, Simen Hyll & Karlsen, Tom Hemming [Show all 10 contributors for this article] (2020). Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells. Clinical and Experimental Immunology. ISSN 0009-9104. doi: 10.1111/cei.13541. Full text in Research Archive
  • Thaventhiran, James; Allen, Hana Lango; Burren, Oliver S; Rae, William; Greene, Daniel & Staples, Emily [Show all 50 contributors for this article] (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. ISSN 0028-0836. 583(7814), p. 90–95. doi: 10.1038/s41586-020-2265-1. Full text in Research Archive
  • Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Show all 22 contributors for this article] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Full text in Research Archive
  • Goeppert, Benjamin; Folseraas, Trine; Roessler, Stephanie; Kloor, Matthias; Volckmar, Anna-Lena & Endris, Volker [Show all 36 contributors for this article] (2020). Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals therapeutic opportunities. Hepatology. ISSN 0270-9139. 72(4), p. 1253–1266. doi: 10.1002/hep.31110. Full text in Research Archive
  • Ellinghaus, David; Degenhardt, Frauke; Bujanda, Luis; Buti, Maria; Abillios, Agustin & Invernizzi, Pietro [Show all 30 contributors for this article] (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine. ISSN 0028-4793. doi: 10.1056/NEJMoa2020283.
  • Vesterhus, Mette & Karlsen, Tom Hemming (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. Journal of gastroenterology. ISSN 0944-1174. 55, p. 588–614. doi: 10.1007/s00535-020-01681-z. Full text in Research Archive
  • Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H.; Ytting, Henriette; Karlsen, Tom Hemming & Kelly, Deirdre [Show all 8 contributors for this article] (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology. ISSN 0168-8278. p. 1–12. doi: 10.1016/j.jhep.2020.07.023. Full text in Research Archive
  • Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Show all 18 contributors for this article] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, p. 1–9. doi: 10.1038/s41598-020-62261-y. Full text in Research Archive
  • Deeb, Maya; Karlsen, Tom Hemming & Hirschfield, Gideon M. (2020). The 6 C's of primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 73(5), p. 1255–1256. doi: 10.1016/j.jhep.2020.06.033.
  • Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine & Turgeon, Coleman T. [Show all 19 contributors for this article] (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.31652. Full text in Research Archive
  • Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia & Moum, Bjørn [Show all 10 contributors for this article] (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 39(2), p. 371–381. doi: 10.1111/liv.13979. Full text in Research Archive
  • Melum, Espen; Jiang, Xiaojun; Baker, Kirsti B; Macedo, M Fatima; Fritsch, Jürgen & Dowds, C Marie [Show all 21 contributors for this article] (2019). Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology. ISSN 1529-2908. 20(12), p. 1644–1655. doi: 10.1038/s41590-019-0504-0. Full text in Research Archive
  • Rühlemann, Malte C.; Liwinski, Timur; Heinsen, Femke-Anouska; Bang, Corinna; Zenouzi, Roman & Kummen, Martin [Show all 17 contributors for this article] (2019). Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 50(5), p. 580–589. doi: 10.1111/apt.15375. Full text in Research Archive
  • Liwinski, Timur; Zenouzi, Roman; John, Clara; Ehlken, Hanno; Rühlemann, Malte C. & Bang, Corinna [Show all 18 contributors for this article] (2019). Alterations of the bile microbiome in primary sclerosing cholangitis. Gut. ISSN 0017-5749. p. 1–8. doi: 10.1136/gutjnl-2019-318416. Full text in Research Archive
  • Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude & Karlsen, Tom Hemming [Show all 9 contributors for this article] (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-44762-7. Full text in Research Archive
  • Thingholm, Louise B.; Rühlemann, Malte C.; Koch, Manja; Fuqua, Brie; Laucke, Guido & Böhm, Ruwen [Show all 25 contributors for this article] (2019). Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition. Cell Host and Microbe. ISSN 1931-3128. 26(2), p. 252–264.e10. doi: 10.1016/j.chom.2019.07.004.
  • Schneditz, Georg Thomas; Elias, Joshua E.; Pagano, Ester; Cader, M. Zaeem; Saveljeva, Svetlana & Long, Kathleen [Show all 14 contributors for this article] (2019). GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling. ISSN 1945-0877. 12:eaau9048(562), p. 1–20. doi: 10.1126/scisignal.aau9048. Full text in Research Archive
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Show all 18 contributors for this article] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, p. 1–10. doi: 10.1038/s41598-018-35367-7. Full text in Research Archive
  • Banales, Jesus M.; Huebert, Robert C.; Karlsen, Tom Hemming; Strazzabosco, Mario; LaRusso, Nicholas F. & Gores, Gregory J. (2019). Cholangiocyte pathobiology. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 16(5), p. 269–281. doi: 10.1038/s41575-019-0125-y. Full text in Research Archive
  • Goode, EC; Clark, AB; Melis, GM; Srivastava, B; Spiess, K & Gelson, WTH [Show all 24 contributors for this article] (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. ISSN 0270-9139. 69(5), p. 2120–2135. doi: 10.1002/hep.30479. Full text in Research Archive
  • Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle & Moum, Bjørn [Show all 15 contributors for this article] (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 48, p. 179–189. doi: 10.1111/apt.14806.
  • Åberg, Fredrik; Isoniemi, Helena; Pukkala, Eero; Jalanko, Hannu; Rasmussen, Allan & Storm, Hans H. [Show all 17 contributors for this article] (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver transplantation. ISSN 1527-6465. 24(9), p. 1252–1259. doi: 10.1002/lt.25305. Full text in Research Archive
  • Eaton, JE; Vesterhus, Mette; McCauley, Bryan M.; Atkinson, EJ; Schlicht, EM & Juran, BD [Show all 11 contributors for this article] (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. ISSN 0270-9139. p. 1–11. doi: 10.1002/hep.30085.
  • Pollheimer, Marion J.; Racedo, Silvia; Mikels-Vigdal, Amanda; Marshall, Derek; Bowlus, Christopher & Lackner, Carolin [Show all 21 contributors for this article] (2018). Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis. Journal of Hepatology. ISSN 0168-8278. 69(2), p. 368–377. doi: 10.1016/j.jhep.2018.04.009.
  • Momozawa, Yukihide; Dmitrieva, Julia; Théâtre, Emilie; Deffontaine, Valérie; Rahmouni, Souad & Charloteaux, Benoît [Show all 36 contributors for this article] (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications. ISSN 2041-1723. 9:2427, p. 1–18. doi: 10.1038/s41467-018-04365-8.
  • Cornberg, Markus; Tacke, Frank & Karlsen, Tom Hemming (2018). Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability. Journal of Hepatology. ISSN 0168-8278. p. 1–3. doi: 10.1016/j.jhep.2018.10.011.
  • Tronstad, Rune Rose; Polushina, Tatiana; Brattbakk, Hans-Richard; Stansberg, Christine; Volkmann, Hilde Løland Von & Hanevik, Kurt [Show all 19 contributors for this article] (2018). Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(10-11), p. 1264–1273. doi: 10.1080/00365521.2018.1521867.
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, Diletta; Grzyb, Krzysztof & Constantini, David [Show all 11 contributors for this article] (2018). Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis. Hepatology. ISSN 0270-9139. 69(2), p. 622–638. doi: 10.1002/hep.30210. Full text in Research Archive
  • Berntsen, Natalie Lie; Fosby, Bjarte; Tan, Corey; Reims, Henrik Mikael; Øgaard, Jonas & Jiang, Xiaojun [Show all 12 contributors for this article] (2018). Natural killer T cells mediate inflammation in the bile ducts. Mucosal Immunology. ISSN 1933-0219. p. 1–9. doi: 10.1038/s41385-018-0066-8.
  • Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng & Hong Tan, Chin [Show all 29 contributors for this article] (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Medicine. ISSN 1549-1277. 15:e1002487(1), p. 1–20. doi: 10.1371/journal.pmed.1002487. Full text in Research Archive
  • Chung, Brian Kai-Ho; Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Karlsen, Tom Hemming; Hirschfield, Gideon & Liaskou, Evaggelia (2018). Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease. Hepatology communications.. ISSN 2471-254X. 2(8), p. 960–971. doi: 10.1002/hep4.1200. Full text in Research Archive
  • Nordin, A; Åberg, F; Pukkala, E; Pedersen, CR; Storm, HH & Rasmussen, A. [Show all 15 contributors for this article] (2018). Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades. American Journal of Transplantation. ISSN 1600-6135. 18(4), p. 952–963. doi: 10.1111/ajt.14507.
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, D; Floreani, A & Franchitto, Antonio [Show all 12 contributors for this article] (2017). Hepatic stem/progenitor cell activation differs between primary sclerosing and primary biliary cholangitis. American Journal of Pathology. ISSN 0002-9440. 188(3), p. 627–639. doi: 10.1016/j.ajpath.2017.11.010.
  • de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus & Thorburn, Douglas [Show all 21 contributors for this article] (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). ISSN 1478-3223. 37(10), p. 1554–1561. doi: 10.1111/liv.13402. Full text in Research Archive
  • Hov, Johannes Espolin Roksund & Karlsen, Tom Hemming (2017). The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts. Seminars in liver disease (Print). ISSN 0272-8087. 37(4), p. 314–331. doi: 10.1055/s-0037-1608801. Full text in Research Archive
  • Alberts, R; de Vries, EMG; Goode, EC; Jiang, Xiaojun; Sampaziotis, Fotios & Rombouts, K [Show all 50 contributors for this article] (2017). Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. ISSN 0017-5749. 67(8), p. 1517–1524. doi: 10.1136/gutjnl-2016-313598.
  • Berntsen, Natalie Lie; Fosby, Bjarte; Valestrand, Laura Cecilie; Tan, Corey; Reims, Henrik Mikael & Schrumpf, Elisabeth [Show all 9 contributors for this article] (2017). Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree. American Journal of Physiology - Gastrointestinal and Liver Physiology. ISSN 0193-1857. 314(3), p. G349–G359. doi: 10.1152/ajpgi.00124.2017.
  • Chung, Brian K.; Karlsen, Tom Hemming & Folseraas, Trine (2017). Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1864(4), p. 1390–1400. doi: 10.1016/j.bbadis.2017.08.020.
  • Weismüller, Tobias J.; Trivedi, Palak J.; Bergquist, Annika; Imam, Mohamad; Lenzen, Henrike & Ponsioen, Cyriel Y. [Show all 59 contributors for this article] (2017). Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 152(8), p. 1975–1984.e8. doi: 10.1053/j.gastro.2017.02.038.
  • Henriksen, Eva Kristine Klemsdal; Viken, Marte K; Wittig, Michael; Holm, Kristian; Folseraas, Trine & Mucha, Sören [Show all 29 contributors for this article] (2017). HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA. ISSN 2059-2302. 90(4), p. 228–233. doi: 10.1111/tan.13076.
  • Schrumpf, Elisabeth; Jiang, Xiaojun; Zeissig, Sebastian; Pollheimer, Marion J.; Anmarkrud, Jarl Andreas & Tan, Corey [Show all 10 contributors for this article] (2017). The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation. Physiological Reports. ISSN 2051-817X. 5:e13117(4), p. 1–12. doi: 10.14814/phy2.13117.
  • Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik & Melum, Espen [Show all 23 contributors for this article] (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. ISSN 0168-8278. 66(6), p. 1214–1222. doi: 10.1016/j.jhep.2017.01.019.
  • Jiang, Xiaojun & Karlsen, Tom Hemming (2017). Genetics of primary sclerosing cholangitis and pathophysiological implications. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 14(5), p. 279–295. doi: 10.1038/nrgastro.2016.154.
  • Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Kaveh, Fatemeh; Holm, Kristian; Hamm, David & Olweus, Johanna [Show all 14 contributors for this article] (2017). Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. Journal of Hepatology. ISSN 0168-8278. 66(1), p. 116–122. doi: 10.1016/j.jhep.2016.09.002.
  • Malenicka, S; Ericzon, BG; Jørgensen, MH; Isoniemi, H; Karlsen, Tom Hemming & Krantz, M [Show all 14 contributors for this article] (2017). Impaired intention-to-treat survival after listing for liver transplantation in children with biliaratresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries. . Pediatric Transplantation. ISSN 1397-3142. 21(2). doi: 10.1111/petr.12851.
  • Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas; Widmann, Laila; Korf, Tobias & Michaels, Maike Anna [Show all 23 contributors for this article] (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 66(1), p. 137–144. doi: 10.1136/gutjnl-2016-311739. Full text in Research Archive
  • Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli; Vesterhus, Mette; Boyadzhieva, Maria & Solberg, Inger Camilla [Show all 11 contributors for this article] (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 37(3), p. 458–465. doi: 10.1111/liv.13238.
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  • Chung, Brian K. & Karlsen, Tom Hemming (2017). Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease. Digestive Diseases. ISSN 0257-2753. 35(4), p. 323–333. doi: 10.1159/000456583.
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  • Rosati, Elisa; Dowds, C. Marie; Liaskou, Evaggelia; Henriksen, Eva Kristine Klemsdal; Karlsen, Tom Hemming & Franke, Andre (2017). Overview of methodologies for T-cell receptor repertoire analysis. BMC Biotechnology. ISSN 1472-6750. 17:61, p. 1–16. doi: 10.1186/s12896-017-0379-9.
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  • Koch, Manja; Freitag-Wolf, Sandra; Schlesinger, Sabrina; Borggrefe, Jan; Hov, Johannes Espolin Roksund & Jensen, Majken K. [Show all 23 contributors for this article] (2017). Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. European Journal of Clinical Nutrition. ISSN 0954-3007. 71(8), p. 995–1001. doi: 10.1038/ejcn.2017.43.
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  • Zweers, Serge J.; Shiryaev, Alexey; Komuta, Mina; Vesterhus, Mette; Hov, Johannes Espolin Roksund & Perugorria, Maria J. [Show all 17 contributors for this article] (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 36(9), p. 1370–1377. doi: 10.1111/liv.13092.
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  • D'Agnolo, Hedwig M.A.; Kievit, Wietske; Andrade, Raul J.; Karlsen, Tom Hemming; Wedemeyer, Heiner & Drenth, Joost P.H. (2016). Creating an effective clinical registry for rare diseases. United European Gastroenterology journal. ISSN 2050-6406. 4(3), p. 333–338. doi: 10.1177/2050640615618042.
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  • Schrumpf, Elisabeth; Tan, Corey; Karlsen, Tom Hemming; Sponheim, Jon; Björkström, Niklas K. & Sundnes, Olav [Show all 16 contributors for this article] (2015). The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. ISSN 0270-9139. 62(4), p. 1249–1259. doi: 10.1002/hep.27840.
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  • Borgstrøm, Reidar; Karlsen, Tom Hemming & Lundin, Knut Erik Aslaksen (2019). Er årets villreinkvote på Hardangervidda en ny standard i norsk viltforvaltning? Nationen. ISSN 0805-3782.
  • Reimers, Eigil; Borgstrøm, Reidar; Hjeljord, Olav; Lundin, Knut Erik Aslaksen & Karlsen, Tom Hemming (2019). Faglig uforsvarlig tiltak mot skrantesyke. Dagens næringsliv. ISSN 0803-9372.
  • Karlsen, Tom Hemming & Newsome, Phil N (2019). The dawn of a new EASL – A new chapter in the history of the European Association for the Study of the liver. Journal of Hepatology. ISSN 0168-8278. 71(1), p. 5–8. doi: 10.1016/j.jhep.2019.03.010.
  • Karlsen, Tom Hemming & Tacke, Frank (2018). <The times they are a'changin?> ? Positioning the European Association for the Study of the Liver in the changing landscape of hepatology. Journal of Hepatology. ISSN 0168-8278. 68(5), p. 873–875. doi: 10.1016/j.jhep.2018.02.001.
  • Colombo, Massimo & Karlsen, Tom Hemming (2018). The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother. Journal of Hepatology. ISSN 0168-8278. doi: 10.1016/j.jhep.2018.11.017.
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild E; Bjøro, Kristian; Karlsen, Tom Hemming; Reims, Henrik Mikael & Grzyb, Krzysztof [Show all 10 contributors for this article] (2016). Liver transplantation in patients with primary antibody deficiency. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. doi: 10.1016/j.jaci.2016.10.025.
  • Karlsen, Tom Hemming & Hirschfield, Gideon M. (2016). Genetics of Primary Sclerosing Cholangitis. In Forman, Lisa (Eds.), Primary Sclerosing Cholangitis. Current Understanding, Management, and Future Developments. Springer. ISSN 978-3-319-40906-1. p. 99–110. doi: 10.1007/978-3-319-40908-5_8.
  • Tronstad, Rune Rose; Fiskerstrand, Torunn; Karlsen, Tom Hemming; Knappskog, Per & Le Hellard, Stephanie (2019). Clinical and molecular effects of guanylate cyclase C-activation. Universitetet i Bergen. ISSN 9788230854426.

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Published Nov. 25, 2014 1:11 PM - Last modified Oct. 14, 2021 4:03 PM