Tom Hemming Karlsen

Bilde av Tom Hemming Karlsen
English version of this page
Brukernavn
Besøksadresse Oslo universitetssykehus Rikshospitalet
Postadresse Postboks 4950 Nydalen 0424 OSLO

Bakgrunn

PhD Universitetet i Oslo, 2007

MD, Universitetet i Bergen, 1997

Publikasjoner

Schneditz G, Elias JE, Pagano E, et al. (2019) GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling, 562, eaau9048.

Manns MP, Burra P, Sargent J, Horton R, Karlsen TH (2018) The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities. Lancet, 10148, 621-622.

Sampaziotis F, Justin AW, Tysoe OC et al. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine, 23, 954-963. 

Ji SG, Juran BD, Mucha S, et al. (2017) Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49, 269-273.

Wang J, Thingholm LB, Skiecevièienë J, et al. (2016) Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48,1396-1406.

Ellinghaus D, Jostins L, Spain SL, et al. (2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48, 510-8.

Sampaziotis F, Cardoso de Brito M, Madrigal P, et al. (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33,845-52.

Goyette P, Boucher G, Mallon D, et al. (2015). High density mapping of the MHC reveals a common role for HLADRB1* 01:03 in IBD and heterozygous advantage in ulcerative colitis; Nature Genetics, 47 (2), 172-179.

Hirschfield GM, Karlsen TH, Lindor K, Adams D, (2013). Primary sclerosing cholangitisLancet, 382 (9904), 1587-99.

Liu JZ, Hov JR, Folseraas T, et al., (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis; Nature Genetics, 45 (6), 670-5.

Jostins L, Ripke S, Weersma RK, et al., (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease; Nature, 491 (7422), 119-24.

Anderson CA, Boucher G, Lees CW, et al., (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47; Nature Genetics, 43 (3), 246-52

Melum E, Franke A, Schramm C, et al., (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci; Nature Genetics, 43 (1), 17-9

Ellinghaus E, Ellinghaus D, Stuart PE, et al., (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2; Nature Genetics, 42 (11), 991-5

Franke A, Balschun T, Sina C, et al., (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL); Nature Genetics, 42 (4), 292-4

Franke A, Balschun T, Karlsen TH, et al. (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility; Nature Genetics, 40 (11), 1319-23

Franke A, Balschun T, Karlsen TH, et al. (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis; Nature Genetics, 40 (6), 713-5

  • Banales, Jesus M.; Huebert, Robert C.; Karlsen, Tom Hemming; Strazzabosco, Mario; LaRusso, Nicholas F. & Gores, Gregory J. (2019). Cholangiocyte pathobiology. Nature reviews: Gastroenterology & hepatology.  ISSN 1759-5045.  16(5), s 269- 281 . doi: 10.1038/s41575-019-0125-y
  • Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude; Karlsen, Tom Hemming; Beuers, Ulrich; Vesterhus, Mette & Hov, Johannes Espolin Roksund (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports.  ISSN 2045-2322.  9(1) . doi: 10.1038/s41598-019-44762-7 Fulltekst i vitenarkiv.
  • Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg & Hov, Johannes Espolin Roksund (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print).  ISSN 1478-3223.  39(2), s 371- 381 . doi: 10.1111/liv.13979 Fulltekst i vitenarkiv.
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund & Fevang, Børre (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports.  ISSN 2045-2322.  9:167, s 1- 10 . doi: 10.1038/s41598-018-35367-7 Fulltekst i vitenarkiv.
  • Schneditz, Georg Thomas; Elias, Joshua E.; Pagano, Ester; Cader, M. Zaeem; Saveljeva, Svetlana; Long, Kathleen; Mukhopadhyay, Subhankar; Arasteh, Maryam; Lawley, Trevor D.; Dougan, Gordon; Bassett, Andrew; Karlsen, Tom Hemming; Kaser, Arthur & Kaneider, Nicole C. (2019). GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling.  ISSN 1945-0877.  12:eaau9048(562), s 1- 20 . doi: 10.1126/scisignal.aau9048
  • Berntsen, Natalie Lie; Fosby, Bjarte; Tan, Corey; Reims, Henrik Mikael; Øgaard, Jonas; Jiang, Xiaojun; Schrumpf, Erik; Valestrand, Laura Cecilie; Karlsen, Tom Hemming; Line, Pål Dag; Blumberg, Richard S. & Melum, Espen (2018). Natural killer T cells mediate inflammation in the bile ducts. Mucosal Immunology.  ISSN 1933-0219.  s 1- 9 . doi: 10.1038/s41385-018-0066-8
  • Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng; Hong Tan, Chin; Kouri, Naomi; Ross, Owen A.; Höglinger, Günter U.; Müller, Ulrich; Hardy, John; Momeni, Parastoo; Hess, Christopher P.; Dillon, William P.; Miller, Zachary A.; Bonham, Luke W.; Rabinovici, Gil D.; Rosen, Howard J.; Schellenberg, Gerard D.; Franke, Andre; Karlsen, Tom Hemming; Veldink, Jan H.; Ferrari, Raffaele; Yokoyama, Jennifer S.; Miller, Bruce L.; Andreassen, Ole Andreas; Dale, Anders; Desikan, Rahul S. & Sugrue, Leo P. (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.. PLoS Medicine.  ISSN 1549-1277.  15:e1002487(1), s 1- 20 . doi: 10.1371/journal.pmed.1002487 Fulltekst i vitenarkiv.
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, Diletta; Grzyb, Krzysztof; Constantini, David; Berloco, Pasquale Bartolomeo; Di Matteo, Sabina; Karlsen, Tom Hemming; Alvaro, Domenico & Gaudio, Eugenio (2018). Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis. Hepatology.  ISSN 0270-9139.  69(2), s 622- 638 . doi: 10.1002/hep.30210 Fulltekst i vitenarkiv.
  • Chung, Brian Kai-Ho; Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Karlsen, Tom Hemming; Hirschfield, Gideon & Liaskou, Evaggelia (2018). Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease. Hepatology communications..  ISSN 2471-254X.  2(8), s 960- 971 . doi: 10.1002/hep4.1200 Fulltekst i vitenarkiv.
  • Cornberg, Markus; Tacke, Frank & Karlsen, Tom Hemming (2018). Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability. Journal of Hepatology.  ISSN 0168-8278.  s 1- 3 . doi: 10.1016/j.jhep.2018.10.011
  • Eaton, JE; Vesterhus, Mette; McCauley, Bryan M.; Atkinson, EJ; Schlicht, EM; Juran, BD; Gossard, AA; LaRusso, NF; Gores, GJ; Karlsen, Tom Hemming & Lazaridis, KN (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology.  ISSN 0270-9139.  s 1- 11 . doi: 10.1002/hep.30085
  • Goode, EC; Clark, AB; Melis, GM; Srivastava, B; Spiess, K; Gelson, WTH; Trivedi, PJ; Lynch, KD; Castren, Eero; Vesterhus, Mette; Karlsen, Tom Hemming; Ji, SG; Anderson, CA; Thorburn, Douglas; Hudson, M; Heneghan, M; Aldersley, MA; Bathgate, A; Sandford, RN; Alexander, GJ; Chapman, RW; Walmsley, M; Hirschfield, Gideon M. & Rushbrook, SM (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology.  ISSN 0270-9139.  69(5), s 2120- 2135 . doi: 10.1002/hep.30479
  • Momozawa, Yukihide; Dmitrieva, Julia; Théâtre, Emilie; Deffontaine, Valérie; Rahmouni, Souad; Charloteaux, Benoît; Crins, François; Docampo, Elisa; Elansary, Mahmoud; Gori, Ann-Stephan; Lecut, Christelle; Mariman, Rob; Mni, Myriam; Oury, Cécile; Altukhov, Ilya; Alexeev, Dmitry; Aulchenko, Yuri; Amininejad, Leila; Bouma, Gerd; Hoentjen, Frank; Löwenberg, Mark; Oldenburg, Bas; Pierik, Marieke J.; vander Meulen-De Jong, Andrea E.; van der Woude, C. Janneke; Visschedijk, Marijn C.; Lathrop, Mark; Hugot, Jean-Pierre; Weersma, Rinse K.; De Vos, Martine; Franchimont, Denis; Vermeire, Severine; Kubo, Michiaki; Louis, Edouard; Georges, Michel & Karlsen, Tom Hemming (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications.  ISSN 2041-1723.  9:2427, s 1- 18 . doi: 10.1038/s41467-018-04365-8
  • Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle; Moum, Bjørn; Saffioti, Francesca; Gilja, Odd Helge; Boberg, Kirsten Muri; Mazza, Giuseppe; Røsjø, Helge; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, MA & Vesterhus, Mette (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics.  ISSN 0269-2813.  48, s 179- 189 . doi: 10.1111/apt.14806
  • Nordin, A; Åberg, F; Pukkala, E; Pedersen, CR; Storm, HH; Rasmussen, A.; Bennet, W; Olausson, M; Wilczek, H; Ericzon, BG; Tretli, Steinar; Line, Pål Dag; Karlsen, Tom Hemming; Boberg, Kirsten Muri & Isoniemi, H (2018). Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades. American Journal of Transplantation.  ISSN 1600-6135.  18(4), s 952- 963 . doi: 10.1111/ajt.14507
  • Pollheimer, Marion J.; Racedo, Silvia; Mikels-Vigdal, Amanda; Marshall, Derek; Bowlus, Christopher; Lackner, Carolin; Madl, Tobias; Karlsen, Tom Hemming; Hov, Johannes Espolin Roksund; Lyman, Susan K.; Adamkewicz, Joanne; Smith, Victoria; Moreau, Emmanuel; Zollner, Gernot; Eide, Tor Jacob; Stojakovic, Tatjana; Scharnagl, Hubert; Gruber, Hans-Jürgen; Stauber, Rudolf E.; Trauner, Michael & Fickert, Peter (2018). Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis. Journal of Hepatology.  ISSN 0168-8278.  69(2), s 368- 377 . doi: 10.1016/j.jhep.2018.04.009
  • Tronstad, Rune Rose; Polushina, Tatiana; Brattbakk, Hans-Richard; Stansberg, Christine; Volkmann, Hilde Løland Von; Hanevik, Kurt; Ellinghaus, Eva; Jørgensen, Silje Fjellgård; Ersland, Kari Merete; Pham, Khanh Do-Cong; Gilja, Odd Helge; Hovdenak, Nils; Hausken, Trygve; Vatn, Morten H; Franke, Andre; Knappskog, Per; Le Hellard, Stephanie; Karlsen, Tom Hemming & Fiskerstrand, Torunn (2018). Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  53(10-11), s 1264- 1273 . doi: 10.1080/00365521.2018.1521867
  • Åberg, Fredrik; Isoniemi, Helena; Pukkala, Eero; Jalanko, Hannu; Rasmussen, Allan; Storm, Hans H.; Schultz, Nicolai; Bennet, William; Ekvall, Nils; Ericzon, Bo-Göran; Malenicka, Silvia; Tretli, Steinar; Line, Pål Dag; Boberg, Kirsten Muri; Østensen, Inger Anniken Bjørnstad; Karlsen, Tom Hemming & Nordin, Arno (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver transplantation.  ISSN 1527-6465.  24(9), s 1252- 1259 . doi: 10.1002/lt.25305
  • Aabakken, Lars; Karlsen, Tom Hemming; Albert, Jörg; Arvanitakis, Marianna; Chazouilleres, Olivier; Dumonceau, Jean-Marc; Färkkilä, Martti; Fickert, Peter; Hirschfield, Gideon M.; Laghi, Andrea; Marzioni, Marco; Fernandez, Michael; Pereira, Stephen P.; Pohl, Jürgen; Poley, Jan-Werner; Ponsioen, Cyriel Y.; Schramm, Christoph; Swahn, Fredrik; Tringali, Andrea & Hassan, Cesare (2017). Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. Endoscopy.  ISSN 0013-726X.  49(6), s 588- 608 . doi: 10.1055/s-0043-107029
  • Alberts, R; de Vries, EMG; Goode, EC; Jiang, Xiaojun; Sampaziotis, Fotios; Rombouts, K; Böttcher, Kristin; Folseraas, Trine; Weismuller, TJ; Mason, AL; Wang, W; Alexander, G; Alvaro, D; Bergquist, A; Björkström, Niklas K.; Beuers, Ulrich; Bjornsson, E; Boberg, Kirsten Muri; Bowlus, CL; Bragazzi, Maria c.; Carbone, M.; Chazouilleres, O; Cheung, A; Dalekos, G; Eaton, J; Eksteen, B; Ellinghaus, David; Farkkila, M; Festen, EAM; Floreani, A; Franceschet, I; Gotthardt, DN; Hirschfield, GM; Hoek, BV; Holm, Kristian; Hohenester, S; Hov, Johannes Espolin Roksund; Imhann, F; Invernizzi, P; Juran, BD; Lenzen, H; Lieb, Wolfgang; Liu, JZ; Marschall, HU; Marzioni, M.; Melum, Espen; Milkiewicz, P; Müller, T; Schrumpf, Erik & Karlsen, Tom Hemming (2017). Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut.  ISSN 0017-5749.  67(8), s 1517- 1524 . doi: 10.1136/gutjnl-2016-313598
  • Berntsen, Natalie Lie; Fosby, Bjarte; Valestrand, Laura Cecilie; Tan, Corey; Reims, Henrik Mikael; Schrumpf, Elisabeth; Karlsen, Tom Hemming; Line, Pål Dag & Melum, Espen (2017). Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree. American Journal of Physiology - Gastrointestinal and Liver Physiology.  ISSN 0193-1857.  314(3), s G349- G359 . doi: 10.1152/ajpgi.00124.2017
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, D; Floreani, A; Franchitto, Antonio; Onori, P; Cazzagon, N; Berloco, Pasquale Bartolomeo; Karlsen, Tom Hemming; Alvaro, D & Gaudio, Eugenio (2017). Hepatic stem/progenitor cell activation differs between primary sclerosing and primary biliary cholangitis. American Journal of Pathology.  ISSN 0002-9440.  188(3), s 627- 639 . doi: 10.1016/j.ajpath.2017.11.010
  • Chung, Brian K. & Karlsen, Tom Hemming (2017). Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease. Digestive Diseases.  ISSN 0257-2753.  35(4), s 323- 333 . doi: 10.1159/000456583 Vis sammendrag
  • Chung, Brian K.; Karlsen, Tom Hemming & Folseraas, Trine (2017). Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma. Biochimica et Biophysica Acta - Molecular Basis of Disease.  ISSN 0925-4439.  1864(4), s 1390- 1400 . doi: 10.1016/j.bbadis.2017.08.020 Vis sammendrag
  • Claussen, Jens Christian; Skieceviciene, Jurgita; Wang, Jun; Rausch, Philipp; Karlsen, Tom Hemming; Lieb, Wolfgang; Baines, John F.; Franke, Andre & Hutt, Marc-Thorsten (2017). Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Computational Biology.  ISSN 1553-734X.  13(6) . doi: 10.1371/journal.pcbi.1005361
  • de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus; Thorburn, Douglas; Chazouillères, Olivier; Pares, Albert; Nygård, Ståle; Gilja, Odd Helge; Wunsch, Ewa; Invernizzi, Pietro; Carbone, Marco; Bernuzzi, Francesca; Boberg, Kirsten Muri; Røsjø, Helge; Rosenberg, William; Beuers, Ulrich H.; Ponsioen, Cyriel Y.; Karlsen, Tom Hemming & Vesterhus, Mette (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print).  ISSN 1478-3223.  37(10), s 1554- 1561 . doi: 10.1111/liv.13402 Fulltekst i vitenarkiv.
  • Guevel, Bardia T; Reynolds, Gary M; Udatha, D.B.R.K. Gupta; Henriksen, Eva Kristine Klemsdal; Stamataki, Zania; Hirschfield, Gideon M.; Karlsen, Tom Hemming & Liaskou, Evaggelia (2017). Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. Journal of Autoimmunity.  ISSN 0896-8411.  77, s 45- 54 . doi: 10.1016/j.jaut.2016.10.003
  • Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Kaveh, Fatemeh; Holm, Kristian; Hamm, David; Olweus, Johanna; Melum, Espen; Chung, Brian; Eide, Tor Jacob; Lundin, Knut Erik Aslaksen; Boberg, Kirsten Muri; Karlsen, Tom Hemming; Hirschfield, Gideon M. & Liaskou, Evaggelia (2017). Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. Journal of Hepatology.  ISSN 0168-8278.  66(1), s 116- 122 . doi: 10.1016/j.jhep.2016.09.002
  • Henriksen, Eva Kristine Klemsdal; Viken, Marte K; Wittig, Michael; Holm, Kristian; Folseraas, Trine; Mucha, Sören; Melum, Espen; Hov, Johannes Espolin Roksund; Lazaridis, Konstantinos N.; Juran, Brian D.; Chazouillères, Olivier; Färkkilä, Martti A.; Gotthardt, Daniel Nils; Invernizzi, Pietro; Carbone, Marco; Hirschfield, Gideon Morris; Rushbrook, Simon Matthew; Goode, Elizabeth C.; Ponsioen, Cyriel Y.; Weersma, Rinse K.; Eksteen, Bertus; Yimam, Kidist K.; Gordon, Stuart C.; Goldberg, David E.; Yu, Lei; Bowlus, Christopher L.; Franke, Andre; Lie, Benedicte Alexandra & Karlsen, Tom Hemming (2017). HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA.  ISSN 2059-2302.  90(4), s 228- 233 . doi: 10.1111/tan.13076
  • Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli; Vesterhus, Mette; Boyadzhieva, Maria; Solberg, Inger Camilla; Schrumpf, Erik; Vatn, Morten H; Lie, Benedicte Alexandra; Molberg, Øyvind & Karlsen, Tom Hemming (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print).  ISSN 1478-3223.  37(3), s 458- 465 . doi: 10.1111/liv.13238
  • Hov, Johannes Espolin Roksund & Karlsen, Tom Hemming (2017). The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts. Seminars in liver disease (Print).  ISSN 0272-8087.  37(4), s 314- 331 . doi: 10.1055/s-0037-1608801 Fulltekst i vitenarkiv.
  • Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas; Widmann, Laila; Korf, Tobias; Michaels, Maike Anna; Weiss, Karl Heinz; Liaskou, Evaggelia; Vesterhus, Mette; Karlsen, Tom Hemming; Mindorf, Swantje; Schemmer, Peter; Bär, Florian; Teegen, Bianca; Schröder, Torsten; Ehlers, Marc; Hammers, Christoph Matthias; Komorowski, Lars; Lehnert, Hendrik; Fellermann, Klaus; Derer, Stefanie; Hov, Johannes Espolin Roksund & Sina, Christian (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology.  ISSN 0270-9139.  66(1), s 137- 144 . doi: 10.1136/gutjnl-2016-311739 Fulltekst i vitenarkiv.
  • Jiang, Xiaojun & Karlsen, Tom Hemming (2017). Genetics of primary sclerosing cholangitis and pathophysiological implications. Nature reviews: Gastroenterology & hepatology.  ISSN 1759-5045.  14(5), s 279- 295 . doi: 10.1038/nrgastro.2016.154
  • Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas & Vesterhus, Mette (2017). Primary sclerosing cholangitis - a comprehensive review. Journal of Hepatology.  ISSN 0168-8278.  67(6), s 1298- 1323 . doi: 10.1016/j.jhep.2017.07.022
  • Koch, Manja; Freitag-Wolf, Sandra; Schlesinger, Sabrina; Borggrefe, Jan; Hov, Johannes Espolin Roksund; Jensen, Majken K.; Pick, Julia A.; Markus, Marcello R.P.; Höpfner, Thomas; Jacobs, Gunnar; Siegert, Sabine; Artati, Anna; Kastenmüller, Gabi; Römisch-Margl, Werner; Adamski, Jerzy; Illig, Thomas; Nothnagel, Michael; Karlsen, Tom Hemming; Schreiber, Stefan; Franke, Andre; Krawczak, Michael; Nöthlings, Ute & Lieb, Wolfgang (2017). Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. European Journal of Clinical Nutrition.  ISSN 0954-3007.  71(8), s 995- 1001 . doi: 10.1038/ejcn.2017.43
  • Malenicka, S; Ericzon, BG; Jørgensen, MH; Isoniemi, H; Karlsen, Tom Hemming; Krantz, M; Naeser, V; Olausson, M; Rasmussen, A.; Rönnholm, K; Sanengen, Truls; Scholz, T; Fischler, B & Nemeth, A (2017). Impaired intention-to-treat survival after listing for liver transplantation in children with biliaratresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries.. Pediatric Transplantation.  ISSN 1397-3142.  21(2) . doi: 10.1111/petr.12851
  • Maroni, L.; Hohenester, SD; van de Graaf, SFJ; Tolenaars, D; van Lieden, K; Verheij, J; Marzioni, M.; Karlsen, Tom Hemming; Oude Elferink, RPJ & Beuers, U (2017). Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice. Hepatology.  ISSN 0270-9139.  66(2), s 542- 554 . doi: 10.1002/hep.29029
  • Maroni, Luca; Agostinelli, Laura; Saccomanno, Stefania; Pinto, Claudio; Giordano, Debora M; Rychilcki, Chiara; De Minicis, Samuele; Trozzi, Luciano; Banales, Jesus M.; Melum, Espen; Karlsen, Tom Hemming; Benedetti, Antonio; Baroni, Gianluca & Marzioni, Marco (2017). Nlrp3 activation induces Il-18 synthesis and affects the epithelial barrier function in reactive cholangiocytes. American Journal of Pathology.  ISSN 0002-9440.  187(2), s 366- 376 . doi: 10.1016/j.ajpath.2016.10.010
  • O'Hara, Steven P; Karlsen, Tom Hemming & LaRusso, Nicholas F. (2017). Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link?. Gut.  ISSN 0017-5749.  66(11), s 1873- 1877 . doi: 10.1136/gutjnl-2017-314249
  • Rosati, Elisa; Dowds, C. Marie; Liaskou, Evaggelia; Henriksen, Eva Kristine Klemsdal; Karlsen, Tom Hemming & Franke, Andre (2017). Overview of methodologies for T-cell receptor repertoire analysis. BMC Biotechnology.  ISSN 1472-6750.  17:61, s 1- 16 . doi: 10.1186/s12896-017-0379-9
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  • Folseraas, Trine; Liaskou, Evaggelia; Anderson, Carl A. & Karlsen, Tom Hemming (2015). Genetics in PSC: What do the “Risk Genes” teach us?. Clinical reviews in allergy and immunology.  ISSN 1080-0549.  48(2-3), s 154- 164 . doi: 10.1007/s12016-014-8417-z
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  • Goyette, Philippe; Boucher, Gabrielle; Mallon, Dermot; Ellinghaus, Eva; Jostins, Luke; Huang, Hailiang; Ripke, Stephan; Gusareva, Elena S; Annese, Vito; Hauser, Stephen L; Oksenberg, Jorge R; Thomsen, Ingo; Leslie, Stephen; Daly, Mark J; Van Steen, Kristel; Duerr, Richard H; Barrett, Jeffrey C; McGovern, Dermot PB; Schumm, L Philip; Traherne, James A; Carrington, Mary N; Kosmoliaptsis, Vasilis; Karlsen, Tom Hemming; Franke, Andre; Rioux, John D; Abraham, Clara; Achkar, Jean-Paul; Ahmad, Tariq; Amininejad, Leila; Ananthakrishnan, Ashwin N; Andersen, Vibeke; Anderson, Carl A; Andrews, Jane M; Aumais, Guy; Baidoo, Leonard; Baldassano, Robert N; Balschun, Tobias; Bampton, Peter A; Barclay, Murray; Bayless, Theodore M; Bethge, Johannes; Bis, Joshua C; Bitton, Alain; Brand, Stephan; Brant, Steven R; Buning, Carsten; Chew, Angela; Cho, Judy H; Cleynen, Isabelle; Cohain, Ariella; Croft, Anthony; D'Amato, Mauro; Danese, Silvio; De Jong, Dirk; De Vos, Martine; Denapiene, Goda; Denson, Lee A; Devaney, Kathy L; Dewit, Olivier; D'Inca, Renata; Dubinsky, Marla; Edwards, Cathryn; Ellinghaus, David; Essers, Jonah; Ferguson, Lynnette R; Festen, Eleonora A; Fleshner, Philip; Florin, Tim; Franchimont, Denis; Fransen, Karin; Gearry, Richard; Georges, Michel; Gieger, Christian; Glas, Jurgen; Green, Todd; Griffiths, Anne M; Guthery, Stephen L; Hakonarson, Hakon; Halfvarson, Jonas; Hanigan, Katherine; Haritunians, Talin; Hart, Ailsa; Hawkey, Chris; Hayward, Nicholas K; Hedl, Matija; Henderson, Paul; Hu, Xinli; Hui, Ken Y; Imielinski, Marcin; Ippoliti, Andrew; Jonaitis, Laimas; Kennedy, Nicholas A; Khan, Mohammed Azam; Kiudelis, Gediminas; Kugathasan, Subra; Kupcinskas, Limas; Latiano, Anna; Laukens, Debby; Lawrance, Ian C; Lee, James C; Lees, Charlie W; Leja, Marcis; Van Limbergen, Johan; Lionetti, Paolo; Liu, Jimmy Z; Louis, Edouard; Mahy, Gillian; Mansfield, John; Massey, Dunecan; Mathew, Christopher G; Milgrom, Raquel; Mitrovic, Mitja; Montgomery, Grant; Mowat, Craig; Newman, Wwilliam; Ng, Aylwin; Ng, Siew C; Evelyn Ng, Sok Meng; Nikolaus, Susanna; Ning, Kaida; Nothen, Markus; Oikonomou, Ioannis; Palmieri, Orazio; Parkes, Miles; Phillips, Anne; Ponsioen, Cyriel Y; Potocnik, Uros; Prescott, Natalie J; Proctor, Deborah D; Radford-Smith, Graham; Rahier, Jean-Francois; Raychaudhur, Soumya; Regueiro, Miguel; Rieder, Florian; Roberts, Rebecca; Russell, Richard K; Sanderson, Jeremy D; Sans, Miquel; Satsangi, Jack; Schadt, Eric E; Schreiber, Stefan; Scott, Regan; Seielstad, Mark; Sharma, Yashoda; Silverberg, Mark S; Simms, Lisa A; Skieceviciene, Jurgita; Spain, Sarah L; Steinhart, A Hillary; Stempak, Joanne M; Stronati, Laura; Sventoraityte, Jurgita; Targan, Stephan R; Taylor, Kirstin M; Ter Velde, Anje; Theatre, Emilie; Torkvist, Leif; Tremelling, Mark; Van Der Meulen, Andrea; Van Sommeren, Suzanne; Vasiliauskas, Eric; Vermeire, Severine; Verspaget, Hein W; Walters, Thomas; Wwang, Kai; Wwang, Ming-Hsi; Wweersma, Rinse K; Wei, Zhi; Whiteman, David; Wijmenga, Cisca; Wilson, David C; Winkelmann, Juliane; Xavier, Ramnik J; Zeissig, Sebastian; Zhang, Bin; Zhang, Clarence K; Zhang, Hu; Zhang, Wwei; Zhao, Hongyu & Zhao, Zhen Z (2015). High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nature Genetics.  ISSN 1061-4036.  47(2), s 172- 179 . doi: 10.1038/ng.3176
  • Hov, Johannes Espolin Roksund; Zhong, Huanzi; Qin, Bincai; Anmarkrud, Jarl Andreas; Holm, Kristian; Franke, Andre; Lie, Benedicte Alexandra & Karlsen, Tom Hemming (2015). The influence of the autoimmunity-associated ancestral HLA haplotype AH8.1 on the human gut microbiota: A cross-sectional study. PLOS ONE.  ISSN 1932-6203.  10:e0133804(7) . doi: 10.1371/journal.pone.0133804
  • Karlsen, Tom Hemming & Chung, Brian (2015). Genetic Risk and the Development of Autoimmune Liver Disease. Digestive Diseases.  ISSN 0257-2753. . doi: 10.1159/000440706
  • Karlsen, Tom Hemming; Lammert, Frank & Thompson, Richard J. (2015). Genetics of liver disease: From pathophysiology to clinical practice. Journal of Hepatology.  ISSN 0168-8278.  62(1), s S6- S14 . doi: 10.1016/j.jhep.2015.02.025
  • Li, Jin; Jørgensen, Silje Fjellgård; Maggadóttir, Sólrún Melkorka; Bakay, Marina; Warnatz, Klaus; Glessner, Joseph; Pandey, Rahul; Salzer, Ulrich; Schmidt, Reinhold E.; Perez, Elena; Resnick, Elena; Goldacker, Sigune; Buchta, Mary; Witte, Torsten; Padyukov, Leonid; Videm, Vibeke; Folseraas, Trine; Atschekzei, Faranaz; Elder, James T.; Nair, Rajan P.; Winkelmann, Juliane; Gieger, Christian; Nöthen, Markus M.; Büning, Carsten; Brand, Stephan; Sullivan, Kathleen E.; Orange, Jordan S.; Fevang, Børre; Schreiber, Stefan; Lieb, Wolfgang; Aukrust, Pål; Chapel, Helen; Cunningham-Rundles, Charlotte; Franke, Andre; Karlsen, Tom Hemming; Grimbacher, Bodo; Hakonarson, Hakon; Hammarström, Lennart & Ellinghaus, Eva (2015). Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. Nature Communications.  ISSN 2041-1723.  6 . doi: 10.1038/ncomms7804
  • Maggadottir, S Melkorka; Li, Jin; Glessner, Joseph T.; Li, Yun R.; Wei, Zhi; Chang, Xiao; Mentch, Frank D.; Thomas, Kelly A.; Kim, Cecilia E.; Zhao, Yan; Hou, Cuiping; Wang, Fengxiang; Jørgensen, Silje Fjellgård; Perez, Elena E.; Sullivan, Kathleen E.; Orange, Jordan S.; Karlsen, Tom Hemming; Chapel, Helen; Cunningham-Rundles, Charlotte & Hakonarson, Hakon (2015). Rare variants at 16p11.2 are associated with common variable immunodeficiency. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749.  135(6), s 1569- 1577 . doi: 10.1016/j.jaci.2014.12.1939
  • Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming; Havre, Roald Flesland; Gilja, Odd Helge & Vesterhus, Mette (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis., In Ragnar Nortvedt; Ingfrid S. Haldorsen & Odd Helge Gilja (ed.),  Innovation in Imaging & Vizualization. The MedViz Conference 2015.  Allkopi Forlag.  ISBN 978-82-998920-5-6.  KAPITTEL.  s 136 - 137
  • Olin, Per Bertil Mårten; Hausken, John; Foss, Aksel; Karlsen, Tom Hemming; Melum, Espen & Haugaa, Håkon (2015). Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(9), s 1127- 1134 . doi: 10.3109/00365521.2015.1027262
  • Sampaziotis, Fotios; De Brito, Miguel Cardoso; Madrigal, Pedro; Bertero, Alessandro; Saeb-Parsy, Kourosh; Soares, Filipa A.C.; Schrumpf, Elisabeth; Melum, Espen; Karlsen, Tom Hemming; Bradley, J. Andrew; Gelson, William T.H.; Davies, Susan; Baker, Alastair; Kaser, Arthur; Alexander, Graeme J.; Hannan, Nicholas R.F. & Vallier, Ludovic (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology.  ISSN 1087-0156.  33(8), s 845- 852 . doi: 10.1038/nbt.3275
  • Schrumpf, Elisabeth; Tan, Corey; Karlsen, Tom Hemming; Sponheim, Jon; Björkström, Niklas K.; Sundnes, Olav; Alfsnes, Kristian; Kaser, Arthur; Jefferson, Douglas M.; Ueno, Yoshiyuki; Eide, Tor Jacob; Haraldsen, Guttorm; Zeissig, Sebastian; Exley, Mark A.; Blumberg, Richard S. & Melum, Espen (2015). The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology.  ISSN 0270-9139.  62(4), s 1249- 1259 . doi: 10.1002/hep.27840
  • Schrumpf, Erik; Boberg, Kirsten Muri & Karlsen, Tom Hemming (2015). Primary sclerosing cholangitis-the Norwegian experience. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  50(6), s 781- 796 . doi: 10.3109/00365521.2015.1028996
  • Thorsen, Trygve; Aandahl, Einar Martin; Bennet, William; Olausson, Michael; Ericzon, Bo-Göran; Nowak, Greg; Duraj, Frans; Isoniemi, Helena; Rasmussen, Allan; Karlsen, Tom Hemming & Foss, Aksel (2015). Transplantation with livers from deceased donors older than 75 years. Transplantation.  ISSN 0041-1337.  99(12), s 2534- 2542 . doi: 10.1097/TP.0000000000000728
  • Thorsen, Trygve; Dahlgren, Ulrika S.; Aandahl, Einar Martin; Grzyb, Krzysztof; Karlsen, Tom Hemming; Boberg, Kirsten Muri; Rydberg, Lennart; Naper, Christian; Foss, Aksel & Bennet, William (2015). Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications. Transplant International.  ISSN 0934-0874.  28(7), s 800- 812 . doi: 10.1111/tri.12552
  • Trøseid, Marius; Ueland, Thor; Hov, Johannes Espolin Roksund; Svardal, Asbjørn M.; Gregersen, Ida; Dahl, Christen Peder; Aakhus, Svend; Gude, Einar; Bjørndal, Bodil; Halvorsen, Bente; Karlsen, Tom Hemming; Aukrust, Pål; Gullestad, Lars; Berge, Rolf Kristian & Yndestad, Arne (2015). Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. Journal of Internal Medicine.  ISSN 0954-6820.  277(6), s 717- 726 . doi: 10.1111/joim.12328
  • Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders; Schrumpf, Erik; Nygård, Ståle; Godang, Kristin; Andersen, Ina Marie; Næss, Sigrid; Thorburn, Douglas; Saffioti, Francesca; Vatn, Morten; Gilja, Odd Helge; Lund-Johansen, Fridtjof; Syversveen, Trygve; Braband, Knut; Parés, Albert; Ponsioen, Cyriel Y.; Pinzani, Massimo; Färkkilä, Martti; Moum, Bjørn; Ueland, Thor; Røsjø, Helge; Rosenberg, William; Boberg, Kirsten Muri & Karlsen, Tom Hemming (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology.  ISSN 0270-9139.  62(1), s 188- 197 . doi: 10.1002/hep.27825
  • Vukcevic, Damjan; Traherne, James A.; Næss, Sigrid; Ellinghaus, Eva; Kamatani, Yoichiro; Dilthey, Alexander; Lathrop, Mark; Karlsen, Tom Hemming; Franke, Andre; Moffatt, Miriam; Cookson, William; Trowsdale, John; McVean, Gil; Sawcer, Stephen & Leslie, Stephen (2015). Imputation of KIR Types from SNP Variation Data. American Journal of Human Genetics.  ISSN 0002-9297.  97(4), s 593- 607 . doi: 10.1016/j.ajhg.2015.09.005
  • Wittig, Michael; Anmarkrud, Jarl Andreas; Kässens, Jan C.; Koch, Simon; Forster, Michael; Ellinghaus, Eva; Hov, Johannes Espolin Roksund; Sauer, Sascha; Schimmler, Manfred; Ziemann, Malte; Görg, Siegfried; Jacob, Frank; Karlsen, Tom Hemming & Franke, Andre (2015). Development of a high-resolution NGS-based HLA-typing and analysis pipeline. Nucleic Acids Research.  ISSN 0305-1048.  43:e70(11) . doi: 10.1093/nar/gkv184
  • Åberg, Fredrik; Gissler, Mika; Karlsen, Tom Hemming; Ericzon, Bo-Göran; Foss, Aksel; Rasmussen, Allan; Bennet, William; Olausson, Michael; Line, Pål Dag; Nordin, Arno; Bergquist, Annika; Boberg, Kirsten Muri; Castedal, Maria; Pedersen, Christian Ross & Isoniemi, Helena (2015). Differences in long-term survival among liver transplant recipients and the general population: A population-based nordic study. Hepatology.  ISSN 0270-9139.  61(2), s 668- 677 . doi: 10.1002/hep.27538

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  • Karlsen, Tom Hemming & Newsome, Phil N (2019). The dawn of a new EASL – A new chapter in the history of the European Association for the Study of the liver. Journal of Hepatology.  ISSN 0168-8278.  71(1), s 5- 8 . doi: 10.1016/j.jhep.2019.03.010
  • Tronstad, Rune Rose; Fiskerstrand, Torunn; Karlsen, Tom Hemming; Knappskog, Per & Le Hellard, Stephanie (2019). Clinical and molecular effects of guanylate cyclase C-activation.
  • Colombo, Massimo & Karlsen, Tom Hemming (2018). The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother. Journal of Hepatology.  ISSN 0168-8278. . doi: https://doi.org/10.1016/j.jhep.2018.11.017
  • Karlsen, Tom Hemming & Tacke, Frank (2018). <The times they are a'changin?> ? Positioning the European Association for the Study of the Liver in the changing landscape of hepatology. Journal of Hepatology.  ISSN 0168-8278.  68(5), s 873- 875 . doi: 10.1016/j.jhep.2018.02.001
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild E; Bjøro, Kristian; Karlsen, Tom Hemming; Reims, Henrik Mikael; Grzyb, Krzysztof; Fosby, Bjarte; Fevang, Børre; Aukrust, Pål & Nordøy, Ingvild (2016). Liver transplantation in patients with primary antibody deficiency. Journal of Allergy and Clinical Immunology.  ISSN 0091-6749. . doi: 10.1016/j.jaci.2016.10.025
  • Karlsen, Tom Hemming & Hirschfield, Gideon M. (2016). Genetics of Primary Sclerosing Cholangitis, In Lisa Forman (ed.),  Primary Sclerosing Cholangitis. Current Understanding, Management, and Future Developments.  Springer.  ISBN 978-3-319-40906-1.  8.  s 99 - 110
  • Andreassen, Ole Andreas; Desikan, Rahul S.; Wang, Yunpeng; Thompson, Wesley K.; Schork, Andrew J.; Zuber, Verena; Doncheva, Nadezhda T.; Ellinghaus, Eva; Albrecht, Mario; Mattingsdal, Morten; Franke, Andre; Lie, Benedicte A.; Mills, Ian Geoffrey; Aukrust, Pål; McEvoy, Linda K.; Djurovic, Srdjan; Karlsen, Tom Hemming & Dale, Anders (2015). Correction: Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLOS ONE.  ISSN 1932-6203.  10(5) . doi: 10.1371/journal.pone.0128048
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Vesterhus, Mette; Høivik, Marte; Trøseid, Marius; Marschall, Hanns-Ulrich; Schrumpf, Erik; Moum, Bjørn; Aukrust, Pål; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
  • Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M.; Boberg, Kirsten Muri; Aukrust, Pål; Karlsen, Tom Hemming; Berge, Rolf Kristian & Hov, Johannes Espolin Roksund (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
  • Mjelde, Anders Batman; Hausken, Trygve; Karlsen, Tom Hemming; Havre, Roald Flesland; Gilja, Odd Helge & Vesterhus, Mette (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis..

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Publisert 25. nov. 2014 13:07 - Sist endret 16. mai 2019 11:17