Tom Hemming Karlsen

The COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19. Nature 621, E7–E26 (2023).

Serra-Burriel, Miquel, Alvarez, Marifé et al. (2023) Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study. Lancet 402:10406, 988-996.

Karlsen TH (2022) Understanding COVID-19 through genome-wide association studies. Nature Genetics 54:368-369. 

Karlsen TH, Sheron N, Zelber-Sagi S, et al. (2022) The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality. Lancet 399:61-116.

COVID-19 Host Genetics Initiative (2021) Mapping the human genetic architecture of COVID-19. Nature 600:472-477. 

Thaventhiran JED, Lango Allen H, Burren OS et al. (2020) Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature 583:90-95. 

Ellinghaus D, Degenhardt F, Bujanda L et al. (2020) Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine 383:1522-1534.

Melum E, Jiang X, Baker KD, et al. (2019) Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology, 20, 1644-1655.

Schneditz G, Elias JE, Pagano E, et al. (2019) GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling, 562, eaau9048.

Manns MP, Burra P, Sargent J, Horton R, Karlsen TH (2018) The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities. Lancet, 10148, 621-622.

Sampaziotis F, Justin AW, Tysoe OC et al. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine, 23, 954-963. 

Ji SG, Juran BD, Mucha S, et al. (2017) Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49, 269-273.

Wang J, Thingholm LB, Skiecevièienë J, et al. (2016) Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48,1396-1406.

Ellinghaus D, Jostins L, Spain SL, et al. (2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48, 510-8.

Sampaziotis F, Cardoso de Brito M, Madrigal P, et al. (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33,845-52.

Goyette P, Boucher G, Mallon D, et al. (2015). High density mapping of the MHC reveals a common role for HLADRB1* 01:03 in IBD and heterozygous advantage in ulcerative colitis; Nature Genetics, 47 (2), 172-179.

Hirschfield GM, Karlsen TH, Lindor K, Adams D, (2013). Primary sclerosing cholangitis; Lancet, 382 (9904), 1587-99.

Liu JZ, Hov JR, Folseraas T, et al., (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis; Nature Genetics, 45 (6), 670-5.

Jostins L, Ripke S, Weersma RK, et al., (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease; Nature, 491 (7422), 119-24.

Anderson CA, Boucher G, Lees CW, et al., (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47; Nature Genetics, 43 (3), 246-52.

Melum E, Franke A, Schramm C, et al., (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci; Nature Genetics, 43 (1), 17-9.

Ellinghaus E, Ellinghaus D, Stuart PE, et al., (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2; Nature Genetics, 42 (11), 991-5.

Franke A, Balschun T, Sina C, et al., (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL); Nature Genetics, 42 (4), 292-4.

Franke A, Balschun T, Karlsen TH, et al. (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility; Nature Genetics, 40 (11), 1319-23.

Franke A, Balschun T, Karlsen TH, et al. (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis; Nature Genetics, 40 (6), 713-5.

• Wacker, Eike Matthias; Uellendahl-Werth, Florian; Bej, Saptarshi; Wolkenhauer, Olaf; Vesterhus, Mette Nåmdal & Lieb, Wolfgang [Vis alle 10 forfattere av denne artikkelen] (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. JHEP Reports. 6(2). doi: 10.1016/j.jhepr.2023.100988. Fulltekst i vitenarkiv
• Akhlaghpour, Marzieh; Haritunians, Talin; More, Shyam K; Thomas, Lisa S; Stamps, Dalton T & Dube, Shishir [Vis alle 45 forfattere av denne artikkelen] (2023). Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. Gut. ISSN 0017-5749. 72(11). doi: 10.1136/gutjnl-2023-329689.
• Baumdick, Marin E; Niehrs, Annika; Degenhardt, Frauke; Schwerk, Maria; Hinrichs, Ole & Jordan-Paiz, Ana [Vis alle 33 forfattere av denne artikkelen] (2023). HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis. Gastroenterology. ISSN 0016-5085. 165(4), s. 946–962. doi: 10.1053/j.gastro.2023.06.034. Fulltekst i vitenarkiv
• Grant, Caroline W; Juran, Brian D; Ali, Ahmad H; Schlicht, Erik M; Bianchi, Jackie K & Hu, Xin [Vis alle 19 forfattere av denne artikkelen] (2023). Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis. Exposome. ISSN 2635-2265. 3(1). doi: 10.1093/exposome/osac011. Fulltekst i vitenarkiv
• Tedbury, Philip R.; Manfredi, Candela; Degenhardt, Frauke; Conway, Joseph; Horwath, Michael C. & McCracken, Courtney [Vis alle 37 forfattere av denne artikkelen] (2023). Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity. The FASEB Journal. ISSN 0892-6638. 37(11). doi: 10.1096/fj.202300077R.
• Serra-Burriel, Miquel; Juanola, Adrià; Serra-Burriel, Feliu; Thiele, Maja; Graupera, Isabel & Pose, Elisa [Vis alle 59 forfattere av denne artikkelen] (2023). Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study. The Lancet. ISSN 0140-6736. 402(10406), s. 988–996. doi: 10.1016/S0140-6736(23)01174-1.
• Mayer, Carlotta; Nehring, Sophie; Kücken, Michael; Repnik, Urska; Seifert, Sarah & Sljukic, Aleksandra [Vis alle 18 forfattere av denne artikkelen] (2023). Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease. EMBO Reports. ISSN 1469-221X. 24(9). doi: 10.15252/embr.202357181. Fulltekst i vitenarkiv
• Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine & Reims, Henrik Mikael [Vis alle 21 forfattere av denne artikkelen] (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. Journal of Hepatology. ISSN 0168-8278. 79(4), s. 955–966. doi: 10.1016/j.jhep.2023.05.038. Fulltekst i vitenarkiv
• Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr; Olaizola, Paula; Zhuravleva, Ekaterina & Grimsrud, Marit Mæhle [Vis alle 35 forfattere av denne artikkelen] (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. Journal of Hepatology. ISSN 0168-8278. 79(1), s. 93–108. doi: 10.1016/j.jhep.2023.02.027. Fulltekst i vitenarkiv
• Han, Younghun; Byun, Jinyoung; Zhu, Catherine; Sun, Ryan; Roh, Julia Y. & Cordell, Heather J. [Vis alle 26 forfattere av denne artikkelen] (2023). Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis. Nature Communications. ISSN 2041-1723. 14(1), s. 1–13. doi: 10.1038/s41467-023-36678-8. Fulltekst i vitenarkiv
• van der Meer, Dennis; Gurholt, Tiril Pedersen; Sønderby, Ida Elken; Shadrin, Alexey; Hindley, Guy Frederick Lanyon & Rahman, Zillur [Vis alle 18 forfattere av denne artikkelen] (2022). The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04237-4. Fulltekst i vitenarkiv
• Kaarbø, Mari; Yang, Mingyi; Hov, Johannes Espolin Roksund; Holm, Kristian; Sousa, Mirta & Macpherson, Magnhild Eide [Vis alle 15 forfattere av denne artikkelen] (2022). Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. doi: 10.1016/j.jaci.2022.09.029. Fulltekst i vitenarkiv Vis sammendrag

  Background A substantial proportion of common variable immunodeficiency (CVID) patients has duodenal inflammation of largely unknown etiology. However, because of its histologic similarities with celiac disease, gluten sensitivity has been proposed as a potential mechanism. Objective We aimed to elucidate the role of the duodenal microenvironment in the pathogenesis of duodenal inflammation in CVID by investigating the transcriptional, proteomic, and microbial signatures of duodenal biopsy samples in CVID. Methods DNA, total RNA, and protein were isolated from snap-frozen pieces of duodenal biopsy samples from CVID (with and without duodenal inflammation), healthy controls, and patients with celiac disease (untreated). RNA sequencing, mass spectrometry–based proteomics, and 16S ribosomal DNA sequencing (bacteria) were then performed. Results CVID separated from controls in regulation of transcriptional response to lipopolysaccharide and cellular immune responses. These differences were independent of mucosal inflammation. Instead, CVID patients with duodenal inflammation displayed alterations in transcription of genes involved in response to viral infections. Four proteins were differently regulated between CVID patients and healthy controls—DBNL, TRMT11, GCHFR, and IGHA2—independent of duodenal inflammation. Despite similar histology, there were major differences in CVID with duodenal inflammation and celiac disease both at the RNA and protein level. No significant difference was observed in the bacterial gut microbial signature between CVID, celiac, and healthy controls. Conclusion Our findings suggest the existence of altered functions of the duodenal epithelium, particularly in response to lipopolysaccharide and viruses. The latter finding was related to duodenal inflammation, suggesting that viruses, not gluten sensitivity, could be related to duodenal inflammation in CVID. Key words CVID RNA sequencing proteomics microbiome gut microbiota microbiota gastrointestinal tract duodenum celiac disease Primary immunodeficiency IgA

• Singh, Yashbir; Jons, William A.; Eaton, John E.; Vesterhus, Mette Nåmdal; Karlsen, Tom Hemming & Bjørk, Ida Torunn [Vis alle 21 forfattere av denne artikkelen] (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. European Radiology Experimental. 6. doi: 10.1186/s41747-022-00312-x. Fulltekst i vitenarkiv
• Cruz, Raquel; Diz-de Almeida, Silvia; López de Heredia, Miguel; Quintela, Inés; Ceballos, Francisco C. & Pita, Guillermo [Vis alle 165 forfattere av denne artikkelen] (2022). Novel genes and sex differences in COVID-19 severity. Human Molecular Genetics. ISSN 0964-6906. 31(22), s. 3789–3806. doi: 10.1093/hmg/ddac132. Fulltekst i vitenarkiv
• Hov, Johannes Espolin Roksund & Karlsen, Tom Hemming (2022). The microbiota and the gut–liver axis in primary sclerosing cholangitis. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. doi: 10.1038/s41575-022-00690-y.
• Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Vis alle 13 forfattere av denne artikkelen] (2022). A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32773. Fulltekst i vitenarkiv
• Braadland, Peder Rustøen; Schneider, Kai Markus; Bergquist, Annika; Molinaro, Antonio; Lövgren-Sandblom, Anita & Henricsson, Marcus [Vis alle 11 forfattere av denne artikkelen] (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. JHEP Reports. 4(11), s. 1–10. doi: 10.1016/j.jhepr.2022.100561. Fulltekst i vitenarkiv
• Chung, Brian K.; Øgaard, Jonas; Reims, Henrik Mikael; Karlsen, Tom Hemming & Melum, Espen (2022). Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis. Hepatology communications.. ISSN 2471-254X. 6(9), s. 2538–2550. doi: 10.1002/hep4.2001. Vis sammendrag

  Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet patient need. Recent use of single-cell RNA sequencing (scRNAseq) has identified enriched cell types infiltrating cirrhotic livers but without defining the microanatomical location of these lineages thoroughly. To assess whether fibrotic liver regions specifically harbor enriched cell types, we explored whether whole-tissue spatial transcriptomics combined with scRNAseq and gene deconvolution analysis could be used to localize cell types in cirrhotic explants of patients with end-stage liver disease (total n = 8; primary sclerosing cholangitis, n = 4; primary biliary cholangitis, n = 2, alcohol-related liver disease, n = 2). Spatial transcriptomics clearly identified tissue areas of distinct gene expression that strongly correlated with the total area (Spearman r = 0.97, p = 0.0004) and precise location (parenchyma, 87.9% mean congruency; range, 73.1%–97.1%; fibrosis, 68.5% mean congruency; range, 41.0%–91.7%) of liver regions classified as parenchymal or fibrotic by conventional histology. Deconvolution and enumeration of parenchymal and fibrotic gene content as measured by spatial transcriptomics into distinct cell states revealed significantly higher frequencies of ACTA2+ FABP4+ and COL3A1+ mesenchymal cells, IL17RA+ S100A8+ and FCER1G+ tissue monocytes, VCAM1+ SDC3+ Kupffer cells, CCL4+ CCL5+ KLRB1+ and GZMA+ IL17RA+ T cells and HLA-DR+, CD37+ CXCR4+ and IGHM+ IGHG+ B cells in fibrotic liver regions compared with parenchymal areas of cirrhotic explants. Conclusion: Our findings indicate that spatial transcriptomes of parenchymal and fibrotic liver regions express unique gene content within cirrhotic liver and demonstrate proof of concept that spatial transcriptomes combined with additional RNA sequencing methodologies can refine the localization of gene content and cell lineages in the search for antifibrotic targets.

• Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike & Maya-Miles, Douglas [Vis alle 51 forfattere av denne artikkelen] (2022). Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics. ISSN 0964-6906. 31(23), s. 3945–3966. doi: 10.1093/hmg/ddac158. Fulltekst i vitenarkiv Vis sammendrag

  Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ∼0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

• Lei, Lin; Bruneau, Alix; El Mourabit, Haquima; Guégan, Justine; Folseraas, Trine & Lemoinne, Sara [Vis alle 18 forfattere av denne artikkelen] (2022). Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32456.
• Valestrand, Laura Cecilie; Zheng, Fei; Hansen, Simen Hyll; Øgaard, Jonas; Hov, Johannes Espolin Roksund & Björkström, Niklas K. [Vis alle 9 forfattere av denne artikkelen] (2022). Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens. American Journal of Pathology. ISSN 0002-9440. 192(4), s. 629–641. doi: 10.1016/j.ajpath.2021.12.008. Fulltekst i vitenarkiv Vis sammendrag

  Primary sclerosing cholangitis (PSC) is associated with altered microbiota of the gut and bile. Mucosal-associated invariant T (MAIT) cells, enriched in human liver, uniquely recognize microbial-derived metabolites. This study aimed to determine whether bile from patients with PSC contains antigens activating MAIT cells. Bile was collected at the time of liver transplantation from patients with PSC (n = 28). The bile samples were either directly incubated with peripheral blood mononuclear cells from healthy donors or with antigen-presenting cells followed by co-culture with peripheral blood mononuclear cells. MAIT cell activation was assessed by flow cytometry. An anti-MR1 antibody was used to determine whether the activation was major histocompatibility complex class I–related protein (MR1) restricted. Biliary microbiota profiles were generated using 16S rRNA amplicon sequencing, and the abundance of the bacterial gene ribD was predicted. Eight of 28 bile samples could activate MAIT cells. This activation was partly MR1-dependent in five of eight bile samples. Microbial DNA was detected in 15 of 28 bile samples, including the five bile samples leading to MR1-dependent activation. A higher abundance of the ribD gene expression in the group of bile samples that could activate MAIT cells was predicted on the basis of the 16S sequencing. In co-culture experiments, cholangiocytes could take up and present biliary antigens to MAIT cells. These findings suggest a pathophysiological pathway in PSC connecting the immune system and the microbiome.

• Hammer, Quirin; Dunst, Josefine; Christ, Wanda; Picarazzi, Francesca; Wendorff, Mareike & Momayyezi, Pouria [Vis alle 51 forfattere av denne artikkelen] (2022). SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells. Cell reports. ISSN 2211-1247. 38(10). doi: 10.1016/j.celrep.2022.110503. Fulltekst i vitenarkiv Vis sammendrag

  Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.

• Uellendahl-Werth, Florian; Maj, Carlo; Borisov, Oleg; Juzenas, Simonas; Wacker, Eike Matthias & Jørgensen, Isabella Friis [Vis alle 21 forfattere av denne artikkelen] (2022). Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-03031-6. Fulltekst i vitenarkiv
• Degenhardt, Frauke; Mayr, Gabriele; Wendorff, Mareike; Boucher, Gabrielle; Ellinghaus, Eva & Ellinghaus, David [Vis alle 51 forfattere av denne artikkelen] (2021). Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations. Human Molecular Genetics. ISSN 0964-6906. 30(5), s. 356–369. doi: 10.1093/hmg/ddab017. Fulltekst i vitenarkiv
• Reich, Maria; Spomer, Lina; Klindt, Caroline; Fuchs, Katharina; Stindt, Jan & Deutschmann, Kathleen [Vis alle 33 forfattere av denne artikkelen] (2021). Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 75(3), s. 634–646. doi: 10.1016/j.jhep.2021.03.029. Fulltekst i vitenarkiv
• Karlsen, Tom Hemming; Sheron, Nick; Zelber-Sagi, Shira; Carrieri, Patrizia; Dusheiko, Geoffery & Bugianesi, Elisabetta [Vis alle 57 forfattere av denne artikkelen] (2021). The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality. The Lancet. ISSN 0140-6736. doi: 10.1016/S0140-6736(21)01701-3. Fulltekst i vitenarkiv
• Nakanishi, Tomoko; Pigazzini, Sara; Degenhardt, Frauke; Cordioli, Mattia; Butler-Laporte, Guillaume & Maya-Miles, Douglas [Vis alle 47 forfattere av denne artikkelen] (2021). Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Journal of Clinical Investigation. ISSN 0021-9738. 131(23). doi: 10.1172/JCI152386.
• Pagano, Ester; Elias, Joshua E.; Schneditz, Georg Thomas; Saveljeva, Svetlana; Holland, Lorraine M. & Borrelli, Francesca [Vis alle 9 forfattere av denne artikkelen] (2021). Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment. Gut. ISSN 0017-5749. doi: 10.1136/gutjnl-2020-323363. Fulltekst i vitenarkiv
• Fossdal, Guri; Mjelle, Anders Batman; Wiencke, Kristine; Bjørk, Ida Torunn; Gilja, Odd Helge & Folseraas, Trine [Vis alle 10 forfattere av denne artikkelen] (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. JHEP Reports. 3(5), s. 1–10. doi: 10.1016/j.jhepr.2021.100328. Fulltekst i vitenarkiv
• Zheng, Thenghao; Ellinghaus, David; Juzenas, Simonas; Cossais, François; Burmeister, Greta & Mayr, Gabriele [Vis alle 86 forfattere av denne artikkelen] (2021). Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut. ISSN 0017-5749. 70(8), s. 1538–1549. doi: 10.1136/gutjnl-2020-323868. Fulltekst i vitenarkiv Vis sammendrag

  Objective: Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date. Design: We conducted a GWAS meta-analysis of 218 920 patients with HEM and 725 213 controls of European ancestry. Using GWAS summary statistics, we performed multiple genetic correlation analyses between HEM and other traits as well as calculated HEM polygenic risk scores (PRS) and evaluated their translational potential in independent datasets. Using functional annotation of GWAS results, we identified HEM candidate genes, which differential expression and coexpression in HEM tissues were evaluated employing RNA-seq analyses. The localisation of expressed proteins at selected loci was investigated by immunohistochemistry. Results: We demonstrate modest heritability and genetic correlation of HEM with several other diseases from the GI, neuroaffective and cardiovascular domains. HEM PRS validated in 180 435 individuals from independent datasets allowed the identification of those at risk and correlated with younger age of onset and recurrent surgery. We identified 102 independent HEM risk loci harbouring genes whose expression is enriched in blood vessels and GI tissues, and in pathways associated with smooth muscles, epithelial and endothelial development and morphogenesis. Network transcriptomic analyses highlighted HEM gene coexpression modules that are relevant to the development and integrity of the musculoskeletal and epidermal systems, and the organisation of the extracellular matrix. Conclusion: HEM has a genetic component that predisposes to smooth muscle, epithelial and connective tissue dysfunction.

• Vedeld, Hege Marie; Grimsrud, Marit Mæhle; Andresen, Kim; Pharo, Heidi Dietrichson; von Seth, Erik & Karlsen, Tom Hemming [Vis alle 15 forfattere av denne artikkelen] (2021). Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32125. Fulltekst i vitenarkiv
• Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark & Ganna, Andrea [Vis alle 84 forfattere av denne artikkelen] (2021). Mapping the human genetic architecture of COVID-19. Nature. ISSN 0028-0836. 600(7889), s. 472–477. doi: 10.1038/s41586-021-03767-x. Fulltekst i vitenarkiv Vis sammendrag

  The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.

• Schneider, Kai Markus; Candels, Lena Susanna; Hov, Johannes R.; Myllys, Maiju; Hassan, Reham & Schneider, Carolin Victoria [Vis alle 26 forfattere av denne artikkelen] (2021). Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nature Metabolism. 3(9), s. 1228–1241. doi: 10.1038/s42255-021-00452-1.
• Jiang, Xiaojun; Bergquist, Annika; Löscher, Britt-Sabina; Venkatesh, Geetha; Mold, Jeff E. & Holm, Kristian [Vis alle 15 forfattere av denne artikkelen] (2021). A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis. Science Translational Medicine. ISSN 1946-6234. 13(582). doi: 10.1126/scitranslmed.abb0036.
• Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund; Färkkilä, Martti; Rosenberg, William & Møller, Holger J. [Vis alle 9 forfattere av denne artikkelen] (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. ISSN 2155-384X. 12(3), s. e00315–e00315. doi: 10.14309/ctg.0000000000000315. Fulltekst i vitenarkiv
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• Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina & Leeming, Diana Julie [Vis alle 12 forfattere av denne artikkelen] (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 3(1), s. 1–11. doi: 10.1016/j.jhepr.2020.100178. Fulltekst i vitenarkiv
• Ellinghaus, David; Degenhardt, Frauke; Bujanda, Luis; Buti, Maria; Abillios, Agustin & Invernizzi, Pietro [Vis alle 30 forfattere av denne artikkelen] (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine. ISSN 0028-4793. doi: 10.1056/NEJMoa2020283.
• Thaventhiran, James; Allen, Hana Lango; Burren, Oliver S; Rae, William; Greene, Daniel & Staples, Emily [Vis alle 50 forfattere av denne artikkelen] (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. ISSN 0028-0836. 583(7814), s. 90–95. doi: 10.1038/s41586-020-2265-1. Fulltekst i vitenarkiv
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• Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine & Turgeon, Coleman T. [Vis alle 19 forfattere av denne artikkelen] (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.31652. Fulltekst i vitenarkiv
• Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Vis alle 22 forfattere av denne artikkelen] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Fulltekst i vitenarkiv
• Deeb, Maya; Karlsen, Tom Hemming & Hirschfield, Gideon M. (2020). The 6 C's of primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 73(5), s. 1255–1256. doi: 10.1016/j.jhep.2020.06.033.
• Valestrand, Laura Cecilie; Berntsen, Natalie Lie; Fei, Zheng; Schrumpf, Erik; Hansen, Simen Hyll & Karlsen, Tom Hemming [Vis alle 10 forfattere av denne artikkelen] (2020). Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells. Clinical and Experimental Immunology. ISSN 0009-9104. doi: 10.1111/cei.13541. Fulltekst i vitenarkiv
• Goeppert, Benjamin; Folseraas, Trine; Roessler, Stephanie; Kloor, Matthias; Volckmar, Anna-Lena & Endris, Volker [Vis alle 36 forfattere av denne artikkelen] (2020). Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals therapeutic opportunities. Hepatology. ISSN 0270-9139. 72(4), s. 1253–1266. doi: 10.1002/hep.31110. Fulltekst i vitenarkiv
• Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H.; Ytting, Henriette; Karlsen, Tom Hemming & Kelly, Deirdre [Vis alle 8 forfattere av denne artikkelen] (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology. ISSN 0168-8278. s. 1–12. doi: 10.1016/j.jhep.2020.07.023. Fulltekst i vitenarkiv
• Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Vis alle 18 forfattere av denne artikkelen] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, s. 1–9. doi: 10.1038/s41598-020-62261-y. Fulltekst i vitenarkiv
• Vesterhus, Mette & Karlsen, Tom Hemming (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. Journal of gastroenterology. ISSN 0944-1174. 55, s. 588–614. doi: 10.1007/s00535-020-01681-z. Fulltekst i vitenarkiv
• Melum, Espen; Jiang, Xiaojun; Baker, Kirsti B; Macedo, M Fatima; Fritsch, Jürgen & Dowds, C Marie [Vis alle 21 forfattere av denne artikkelen] (2019). Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology. ISSN 1529-2908. 20(12), s. 1644–1655. doi: 10.1038/s41590-019-0504-0. Fulltekst i vitenarkiv
• Rühlemann, Malte C.; Liwinski, Timur; Heinsen, Femke-Anouska; Bang, Corinna; Zenouzi, Roman & Kummen, Martin [Vis alle 17 forfattere av denne artikkelen] (2019). Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 50(5), s. 580–589. doi: 10.1111/apt.15375. Fulltekst i vitenarkiv
• Liwinski, Timur; Zenouzi, Roman; John, Clara; Ehlken, Hanno; Rühlemann, Malte C. & Bang, Corinna [Vis alle 18 forfattere av denne artikkelen] (2019). Alterations of the bile microbiome in primary sclerosing cholangitis. Gut. ISSN 0017-5749. s. 1–8. doi: 10.1136/gutjnl-2019-318416. Fulltekst i vitenarkiv
• Thingholm, Louise B.; Rühlemann, Malte C.; Koch, Manja; Fuqua, Brie; Laucke, Guido & Böhm, Ruwen [Vis alle 25 forfattere av denne artikkelen] (2019). Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition. Cell Host and Microbe. ISSN 1931-3128. 26(2), s. 252–264.e10. doi: 10.1016/j.chom.2019.07.004.
• Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude & Karlsen, Tom Hemming [Vis alle 9 forfattere av denne artikkelen] (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-44762-7. Fulltekst i vitenarkiv
• Banales, Jesus M.; Huebert, Robert C.; Karlsen, Tom Hemming; Strazzabosco, Mario; LaRusso, Nicholas F. & Gores, Gregory J. (2019). Cholangiocyte pathobiology. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 16(5), s. 269–281. doi: 10.1038/s41575-019-0125-y. Fulltekst i vitenarkiv
• Schneditz, Georg Thomas; Elias, Joshua E.; Pagano, Ester; Cader, M. Zaeem; Saveljeva, Svetlana & Long, Kathleen [Vis alle 14 forfattere av denne artikkelen] (2019). GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling. ISSN 1945-0877. 12:eaau9048(562), s. 1–20. doi: 10.1126/scisignal.aau9048. Fulltekst i vitenarkiv
• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Vis alle 18 forfattere av denne artikkelen] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, s. 1–10. doi: 10.1038/s41598-018-35367-7. Fulltekst i vitenarkiv
• Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia & Moum, Bjørn [Vis alle 10 forfattere av denne artikkelen] (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 39(2), s. 371–381. doi: 10.1111/liv.13979. Fulltekst i vitenarkiv
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• Goode, EC; Clark, AB; Melis, GM; Srivastava, B; Spiess, K & Gelson, WTH [Vis alle 24 forfattere av denne artikkelen] (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. ISSN 0270-9139. 69(5), s. 2120–2135. doi: 10.1002/hep.30479. Fulltekst i vitenarkiv
• Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, Diletta; Grzyb, Krzysztof & Constantini, David [Vis alle 11 forfattere av denne artikkelen] (2018). Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis. Hepatology. ISSN 0270-9139. 69(2), s. 622–638. doi: 10.1002/hep.30210. Fulltekst i vitenarkiv
• Chung, Brian Kai-Ho; Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Karlsen, Tom Hemming; Hirschfield, Gideon & Liaskou, Evaggelia (2018). Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease. Hepatology communications.. ISSN 2471-254X. 2(8), s. 960–971. doi: 10.1002/hep4.1200. Fulltekst i vitenarkiv
• Eaton, JE; Vesterhus, Mette; McCauley, Bryan M.; Atkinson, EJ; Schlicht, EM & Juran, BD [Vis alle 11 forfattere av denne artikkelen] (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. ISSN 0270-9139. s. 1–11. doi: 10.1002/hep.30085.
• Tronstad, Rune Rose; Polushina, Tatiana; Brattbakk, Hans-Richard; Stansberg, Christine; Volkmann, Hilde Løland Von & Hanevik, Kurt [Vis alle 19 forfattere av denne artikkelen] (2018). Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(10-11), s. 1264–1273. doi: 10.1080/00365521.2018.1521867.
• Cornberg, Markus; Tacke, Frank & Karlsen, Tom Hemming (2018). Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability. Journal of Hepatology. ISSN 0168-8278. s. 1–3. doi: 10.1016/j.jhep.2018.10.011.
• Åberg, Fredrik; Isoniemi, Helena; Pukkala, Eero; Jalanko, Hannu; Rasmussen, Allan & Storm, Hans H. [Vis alle 17 forfattere av denne artikkelen] (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver transplantation. ISSN 1527-6465. 24(9), s. 1252–1259. doi: 10.1002/lt.25305. Fulltekst i vitenarkiv
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• Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng & Hong Tan, Chin [Vis alle 29 forfattere av denne artikkelen] (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Medicine. ISSN 1549-1277. 15:e1002487(1), s. 1–20. doi: 10.1371/journal.pmed.1002487. Fulltekst i vitenarkiv
• Nordin, A; Åberg, F; Pukkala, E; Pedersen, CR; Storm, HH & Rasmussen, A. [Vis alle 15 forfattere av denne artikkelen] (2018). Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades. American Journal of Transplantation. ISSN 1600-6135. 18(4), s. 952–963. doi: 10.1111/ajt.14507.
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  Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and characterized by cholestasis, chronic immune infiltration and progressive fibrosis of the intrahepatic and extrahepatic bile ducts. PSC confers a high risk of cholangiocarcinoma (CCA) with PSC-CCA representing the leading cause of PSC-associated mortality. PSC-CCA is derived from cholangiocytes and associated progenitor cells - a heterogeneous group of dynamic epithelial cells lining the biliary tree that modulate the composition and volume of bile production by the liver. Infection, inflammation and cholestasis can trigger cholangiocyte activation leading to an increased expression of adhesion and antigen-presenting molecules as well as the release of various inflammatory and fibrogenic mediators. As a result, activated cholangiocytes engage in a myriad of cellular processes, including hepatocellular proliferation, apoptosis, angiogenesis and fibrosis. Cholangiocytes can also regulate the recruitment of immune cells, mesenchymal cells, and endothelial cells that participate in tissue repair and destruction in settings of persistent inflammation. In PSC, the role of cholangiocytes and the mechanisms governing their transformation to PSC-CCA are unclear however localization of disease suggests that cholangiocytes are a key target and potential regulator of hepatobiliary immunity, fibrogenesis and tumorigenesis. Herein, we summarize mechanisms of cholangiocyte activation in PSC and highlight new insights into disease pathways that may contribute to the development of PSC-CCA. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen

• Rühlemann, Malte C.; Degenhardt, Frauke; Thingholm, Louise B.; Wang, J; Skieceviciene, Jurgita & Rausch, Philipp [Vis alle 13 forfattere av denne artikkelen] (2017). Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. Gut microbes. ISSN 1949-0976. doi: 10.1080/19490976.2017.1356979.
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• Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas & Vesterhus, Mette (2017). Primary sclerosing cholangitis - a comprehensive review. Journal of Hepatology. ISSN 0168-8278. 67(6), s. 1298–1323. doi: 10.1016/j.jhep.2017.07.022.
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• Weismüller, Tobias J.; Trivedi, Palak J.; Bergquist, Annika; Imam, Mohamad; Lenzen, Henrike & Ponsioen, Cyriel Y. [Vis alle 59 forfattere av denne artikkelen] (2017). Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 152(8), s. 1975–1984.e8. doi: 10.1053/j.gastro.2017.02.038.
• O'Hara, Steven P; Karlsen, Tom Hemming & LaRusso, Nicholas F. (2017). Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link? Gut. ISSN 0017-5749. 66(11), s. 1873–1877. doi: 10.1136/gutjnl-2017-314249.
• Koch, Manja; Freitag-Wolf, Sandra; Schlesinger, Sabrina; Borggrefe, Jan; Hov, Johannes Espolin Roksund & Jensen, Majken K. [Vis alle 23 forfattere av denne artikkelen] (2017). Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. European Journal of Clinical Nutrition. ISSN 0954-3007. 71(8), s. 995–1001. doi: 10.1038/ejcn.2017.43.

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• Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Vis alle 18 forfattere av denne artikkelen] (2024). Retraction to: Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency (Scientific Reports, (2019), 9, 1, (167), 10.1038/s41598-018-35367-7). Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-54117-6.
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• Haukeland, John Willy; Vesterhus, Mette Nåmdal; Jørgensen, Kristin Kaasen; Frigstad, Svein Oskar & Karlsen, Tom Hemming (2023). FIB-4-testen som beslutningsverktøy. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(5). doi: 10.4045/tidsskr.23.0176.
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• Karlsen, Tom Hemming (2022). Understanding COVID-19 through genome-wide association studies. Nature Genetics. ISSN 1061-4036. 54(4), s. 368–369. doi: 10.1038/s41588-021-00985-x.
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• Borgstrøm, Reidar; Karlsen, Tom Hemming & Lundin, Knut Erik Aslaksen (2019). Er årets villreinkvote på Hardangervidda en ny standard i norsk viltforvaltning? Nationen. ISSN 0805-3782.
• Reimers, Eigil; Borgstrøm, Reidar; Hjeljord, Olav; Lundin, Knut Erik Aslaksen & Karlsen, Tom Hemming (2019). Faglig uforsvarlig tiltak mot skrantesyke. Dagens næringsliv. ISSN 0803-9372.
• Karlsen, Tom Hemming & Newsome, Phil N (2019). The dawn of a new EASL – A new chapter in the history of the European Association for the Study of the liver. Journal of Hepatology. ISSN 0168-8278. 71(1), s. 5–8. doi: 10.1016/j.jhep.2019.03.010.
• Colombo, Massimo & Karlsen, Tom Hemming (2018). The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother. Journal of Hepatology. ISSN 0168-8278. doi: 10.1016/j.jhep.2018.11.017.
• Karlsen, Tom Hemming & Tacke, Frank (2018). <The times they are a'changin?> ? Positioning the European Association for the Study of the Liver in the changing landscape of hepatology. Journal of Hepatology. ISSN 0168-8278. 68(5), s. 873–875. doi: 10.1016/j.jhep.2018.02.001.
• Tronstad, Rune Rose; Fiskerstrand, Torunn; Karlsen, Tom Hemming; Knappskog, Per & Le Hellard, Stephanie (2019). Clinical and molecular effects of guanylate cyclase C-activation. Universitetet i Bergen. ISSN 9788230854426.

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