Tom Hemming Karlsen

Professor - Forskningsleder KIT
Bilde av Tom Hemming Karlsen
English version of this page
Brukernavn
Besøksadresse Oslo universitetssykehus Rikshospitalet
Postadresse Postboks 4950 Nydalen OUS, Rikshospitalet 0424 Oslo

Bakgrunn

  • PhD Universitetet i Oslo, 2007
  • MD, Universitetet i Bergen, 1997

For mer informasjon, vennligst gå til Tom Hemming Karlsen's engelske presentasjon.

Publikasjoner

Thaventhiran JED, Lango Allen H, Burren OS et al. (2020) Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature 583:90-95. 

Ellinghaus D, Degenhardt F, Bujanda L et al. (2020) Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine 383:1522-1534.

Melum E, Jiang X, Baker KD, et al. (2019) Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology, 20, 1644-1655.

Schneditz G, Elias JE, Pagano E, et al. (2019) GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling, 562, eaau9048.

Manns MP, Burra P, Sargent J, Horton R, Karlsen TH (2018) The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities. Lancet, 10148, 621-622.

Sampaziotis F, Justin AW, Tysoe OC et al. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine, 23, 954-963. 

Ji SG, Juran BD, Mucha S, et al. (2017) Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49, 269-273.

Wang J, Thingholm LB, Skiecevièienë J, et al. (2016) Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 48,1396-1406.

Ellinghaus D, Jostins L, Spain SL, et al. (2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48, 510-8.

Sampaziotis F, Cardoso de Brito M, Madrigal P, et al. (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33,845-52.

Goyette P, Boucher G, Mallon D, et al. (2015). High density mapping of the MHC reveals a common role for HLADRB1* 01:03 in IBD and heterozygous advantage in ulcerative colitis; Nature Genetics, 47 (2), 172-179.

Hirschfield GM, Karlsen TH, Lindor K, Adams D, (2013). Primary sclerosing cholangitisLancet, 382 (9904), 1587-99.

Liu JZ, Hov JR, Folseraas T, et al., (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis; Nature Genetics, 45 (6), 670-5.

Jostins L, Ripke S, Weersma RK, et al., (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease; Nature, 491 (7422), 119-24.

Anderson CA, Boucher G, Lees CW, et al., (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47; Nature Genetics, 43 (3), 246-52.

Melum E, Franke A, Schramm C, et al., (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci; Nature Genetics, 43 (1), 17-9.

Ellinghaus E, Ellinghaus D, Stuart PE, et al., (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2; Nature Genetics, 42 (11), 991-5.

Franke A, Balschun T, Sina C, et al., (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL); Nature Genetics, 42 (4), 292-4.

Franke A, Balschun T, Karlsen TH, et al. (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility; Nature Genetics, 40 (11), 1319-23.

Franke A, Balschun T, Karlsen TH, et al. (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis; Nature Genetics, 40 (6), 713-5.

  • Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina & Leeming, Diana Julie [Vis alle 12 forfattere av denne artikkelen] (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 3(1), s. 1–11. doi: 10.1016/j.jhepr.2020.100178. Fulltekst i vitenarkiv
  • Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund; Färkkilä, Martti; Rosenberg, William & Møller, Holger J. [Vis alle 9 forfattere av denne artikkelen] (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. ISSN 2155-384X. 12(3), s. e00315–e00315. doi: 10.14309/ctg.0000000000000315. Fulltekst i vitenarkiv
  • Schneider, Kai Markus; Candels, Lena Susanna; Hov, Johannes R.; Myllys, Maiju; Hassan, Reham & Schneider, Carolin Victoria [Vis alle 26 forfattere av denne artikkelen] (2021). Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nature Metabolism. 3(9), s. 1228–1241. doi: 10.1038/s42255-021-00452-1.
  • Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine & Trøseid, Marius [Vis alle 12 forfattere av denne artikkelen] (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(4), s. 443–452. doi: 10.1080/00365521.2021.1880627. Fulltekst i vitenarkiv
  • Jiang, Xiaojun; Bergquist, Annika; Löscher, Britt-Sabina; Venkatesh, Geetha; Mold, Jeff E. & Holm, Kristian [Vis alle 15 forfattere av denne artikkelen] (2021). A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis. Science Translational Medicine. ISSN 1946-6234. 13(582). doi: 10.1126/scitranslmed.abb0036.
  • Lapitz, Ainhoa; Arbelaiz, Ander; O'Rourke, Colm J; Lavin, José L.; Casta, Adelaida La & Ibarra, Cesar [Vis alle 26 forfattere av denne artikkelen] (2020). Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis. Cells. ISSN 2073-4409. 9(3). doi: 10.3390/cells9030721..
  • Valestrand, Laura Cecilie; Berntsen, Natalie Lie; Fei, Zheng; Schrumpf, Erik; Hansen, Simen Hyll & Karlsen, Tom Hemming [Vis alle 10 forfattere av denne artikkelen] (2020). Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells. Clinical and Experimental Immunology. ISSN 0009-9104. doi: 10.1111/cei.13541. Fulltekst i vitenarkiv
  • Thaventhiran, James; Allen, Hana Lango; Burren, Oliver S; Rae, William; Greene, Daniel & Staples, Emily [Vis alle 50 forfattere av denne artikkelen] (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. ISSN 0028-0836. 583(7814), s. 90–95. doi: 10.1038/s41586-020-2265-1. Fulltekst i vitenarkiv
  • Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll & Moitinho-Silva, Lucas [Vis alle 22 forfattere av denne artikkelen] (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. doi: 10.1053/j.gastro.2020.12.058. Fulltekst i vitenarkiv
  • Goeppert, Benjamin; Folseraas, Trine; Roessler, Stephanie; Kloor, Matthias; Volckmar, Anna-Lena & Endris, Volker [Vis alle 36 forfattere av denne artikkelen] (2020). Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals therapeutic opportunities. Hepatology. ISSN 0270-9139. 72(4), s. 1253–1266. doi: 10.1002/hep.31110. Fulltekst i vitenarkiv
  • Ellinghaus, David; Degenhardt, Frauke; Bujanda, Luis; Buti, Maria; Abillios, Agustin & Invernizzi, Pietro [Vis alle 30 forfattere av denne artikkelen] (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine. ISSN 0028-4793. doi: 10.1056/NEJMoa2020283.
  • Vesterhus, Mette & Karlsen, Tom Hemming (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. Journal of gastroenterology. ISSN 0944-1174. 55, s. 588–614. doi: 10.1007/s00535-020-01681-z. Fulltekst i vitenarkiv
  • Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H.; Ytting, Henriette; Karlsen, Tom Hemming & Kelly, Deirdre [Vis alle 8 forfattere av denne artikkelen] (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology. ISSN 0168-8278. s. 1–12. doi: 10.1016/j.jhep.2020.07.023. Fulltekst i vitenarkiv
  • Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur & Trøseid, Marius [Vis alle 18 forfattere av denne artikkelen] (2020). Rosuvastatin alters the genetic composition of the human gut microbiome. Scientific Reports. ISSN 2045-2322. 10:5397, s. 1–9. doi: 10.1038/s41598-020-62261-y. Fulltekst i vitenarkiv
  • Deeb, Maya; Karlsen, Tom Hemming & Hirschfield, Gideon M. (2020). The 6 C's of primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 73(5), s. 1255–1256. doi: 10.1016/j.jhep.2020.06.033.
  • Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine & Turgeon, Coleman T. [Vis alle 19 forfattere av denne artikkelen] (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.31652. Fulltekst i vitenarkiv
  • Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia & Moum, Bjørn [Vis alle 10 forfattere av denne artikkelen] (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 39(2), s. 371–381. doi: 10.1111/liv.13979. Fulltekst i vitenarkiv
  • Melum, Espen; Jiang, Xiaojun; Baker, Kirsti B; Macedo, M Fatima; Fritsch, Jürgen & Dowds, C Marie [Vis alle 21 forfattere av denne artikkelen] (2019). Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology. ISSN 1529-2908. 20(12), s. 1644–1655. doi: 10.1038/s41590-019-0504-0. Fulltekst i vitenarkiv
  • Rühlemann, Malte C.; Liwinski, Timur; Heinsen, Femke-Anouska; Bang, Corinna; Zenouzi, Roman & Kummen, Martin [Vis alle 17 forfattere av denne artikkelen] (2019). Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 50(5), s. 580–589. doi: 10.1111/apt.15375. Fulltekst i vitenarkiv
  • Liwinski, Timur; Zenouzi, Roman; John, Clara; Ehlken, Hanno; Rühlemann, Malte C. & Bang, Corinna [Vis alle 18 forfattere av denne artikkelen] (2019). Alterations of the bile microbiome in primary sclerosing cholangitis. Gut. ISSN 0017-5749. s. 1–8. doi: 10.1136/gutjnl-2019-318416. Fulltekst i vitenarkiv
  • Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude & Karlsen, Tom Hemming [Vis alle 9 forfattere av denne artikkelen] (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-44762-7. Fulltekst i vitenarkiv
  • Thingholm, Louise B.; Rühlemann, Malte C.; Koch, Manja; Fuqua, Brie; Laucke, Guido & Böhm, Ruwen [Vis alle 25 forfattere av denne artikkelen] (2019). Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition. Cell Host and Microbe. ISSN 1931-3128. 26(2), s. 252–264.e10. doi: 10.1016/j.chom.2019.07.004.
  • Schneditz, Georg Thomas; Elias, Joshua E.; Pagano, Ester; Cader, M. Zaeem; Saveljeva, Svetlana & Long, Kathleen [Vis alle 14 forfattere av denne artikkelen] (2019). GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump. Science Signaling. ISSN 1945-0877. 12:eaau9048(562), s. 1–20. doi: 10.1126/scisignal.aau9048. Fulltekst i vitenarkiv
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin & Rashidi, Azita [Vis alle 18 forfattere av denne artikkelen] (2019). Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency. Scientific Reports. ISSN 2045-2322. 9:167, s. 1–10. doi: 10.1038/s41598-018-35367-7. Fulltekst i vitenarkiv
  • Banales, Jesus M.; Huebert, Robert C.; Karlsen, Tom Hemming; Strazzabosco, Mario; LaRusso, Nicholas F. & Gores, Gregory J. (2019). Cholangiocyte pathobiology. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 16(5), s. 269–281. doi: 10.1038/s41575-019-0125-y. Fulltekst i vitenarkiv
  • Goode, EC; Clark, AB; Melis, GM; Srivastava, B; Spiess, K & Gelson, WTH [Vis alle 24 forfattere av denne artikkelen] (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. ISSN 0270-9139. 69(5), s. 2120–2135. doi: 10.1002/hep.30479. Fulltekst i vitenarkiv
  • Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle & Moum, Bjørn [Vis alle 15 forfattere av denne artikkelen] (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 48, s. 179–189. doi: 10.1111/apt.14806.
  • Åberg, Fredrik; Isoniemi, Helena; Pukkala, Eero; Jalanko, Hannu; Rasmussen, Allan & Storm, Hans H. [Vis alle 17 forfattere av denne artikkelen] (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver transplantation. ISSN 1527-6465. 24(9), s. 1252–1259. doi: 10.1002/lt.25305. Fulltekst i vitenarkiv
  • Eaton, JE; Vesterhus, Mette; McCauley, Bryan M.; Atkinson, EJ; Schlicht, EM & Juran, BD [Vis alle 11 forfattere av denne artikkelen] (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. ISSN 0270-9139. s. 1–11. doi: 10.1002/hep.30085.
  • Pollheimer, Marion J.; Racedo, Silvia; Mikels-Vigdal, Amanda; Marshall, Derek; Bowlus, Christopher & Lackner, Carolin [Vis alle 21 forfattere av denne artikkelen] (2018). Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis. Journal of Hepatology. ISSN 0168-8278. 69(2), s. 368–377. doi: 10.1016/j.jhep.2018.04.009.
  • Momozawa, Yukihide; Dmitrieva, Julia; Théâtre, Emilie; Deffontaine, Valérie; Rahmouni, Souad & Charloteaux, Benoît [Vis alle 36 forfattere av denne artikkelen] (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications. ISSN 2041-1723. 9:2427, s. 1–18. doi: 10.1038/s41467-018-04365-8.
  • Cornberg, Markus; Tacke, Frank & Karlsen, Tom Hemming (2018). Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability. Journal of Hepatology. ISSN 0168-8278. s. 1–3. doi: 10.1016/j.jhep.2018.10.011.
  • Tronstad, Rune Rose; Polushina, Tatiana; Brattbakk, Hans-Richard; Stansberg, Christine; Volkmann, Hilde Løland Von & Hanevik, Kurt [Vis alle 19 forfattere av denne artikkelen] (2018). Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(10-11), s. 1264–1273. doi: 10.1080/00365521.2018.1521867.
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, Diletta; Grzyb, Krzysztof & Constantini, David [Vis alle 11 forfattere av denne artikkelen] (2018). Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis. Hepatology. ISSN 0270-9139. 69(2), s. 622–638. doi: 10.1002/hep.30210. Fulltekst i vitenarkiv
  • Berntsen, Natalie Lie; Fosby, Bjarte; Tan, Corey; Reims, Henrik Mikael; Øgaard, Jonas & Jiang, Xiaojun [Vis alle 12 forfattere av denne artikkelen] (2018). Natural killer T cells mediate inflammation in the bile ducts. Mucosal Immunology. ISSN 1933-0219. s. 1–9. doi: 10.1038/s41385-018-0066-8.
  • Broce, Iris J.; Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; Wang, Yunpeng & Hong Tan, Chin [Vis alle 29 forfattere av denne artikkelen] (2018). Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Medicine. ISSN 1549-1277. 15:e1002487(1), s. 1–20. doi: 10.1371/journal.pmed.1002487. Fulltekst i vitenarkiv
  • Chung, Brian Kai-Ho; Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Karlsen, Tom Hemming; Hirschfield, Gideon & Liaskou, Evaggelia (2018). Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease. Hepatology communications.. ISSN 2471-254X. 2(8), s. 960–971. doi: 10.1002/hep4.1200. Fulltekst i vitenarkiv
  • Nordin, A; Åberg, F; Pukkala, E; Pedersen, CR; Storm, HH & Rasmussen, A. [Vis alle 15 forfattere av denne artikkelen] (2018). Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades. American Journal of Transplantation. ISSN 1600-6135. 18(4), s. 952–963. doi: 10.1111/ajt.14507.
  • Carpino, Guido; Cardinale, Vincenzo; Folseraas, Trine; Overi, D; Floreani, A & Franchitto, Antonio [Vis alle 12 forfattere av denne artikkelen] (2017). Hepatic stem/progenitor cell activation differs between primary sclerosing and primary biliary cholangitis. American Journal of Pathology. ISSN 0002-9440. 188(3), s. 627–639. doi: 10.1016/j.ajpath.2017.11.010.
  • de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus & Thorburn, Douglas [Vis alle 21 forfattere av denne artikkelen] (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). ISSN 1478-3223. 37(10), s. 1554–1561. doi: 10.1111/liv.13402. Fulltekst i vitenarkiv
  • Hov, Johannes Espolin Roksund & Karlsen, Tom Hemming (2017). The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts. Seminars in liver disease (Print). ISSN 0272-8087. 37(4), s. 314–331. doi: 10.1055/s-0037-1608801. Fulltekst i vitenarkiv
  • Alberts, R; de Vries, EMG; Goode, EC; Jiang, Xiaojun; Sampaziotis, Fotios & Rombouts, K [Vis alle 50 forfattere av denne artikkelen] (2017). Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. ISSN 0017-5749. 67(8), s. 1517–1524. doi: 10.1136/gutjnl-2016-313598.
  • Berntsen, Natalie Lie; Fosby, Bjarte; Valestrand, Laura Cecilie; Tan, Corey; Reims, Henrik Mikael & Schrumpf, Elisabeth [Vis alle 9 forfattere av denne artikkelen] (2017). Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree. American Journal of Physiology - Gastrointestinal and Liver Physiology. ISSN 0193-1857. 314(3), s. G349–G359. doi: 10.1152/ajpgi.00124.2017.
  • Chung, Brian K.; Karlsen, Tom Hemming & Folseraas, Trine (2017). Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1864(4), s. 1390–1400. doi: 10.1016/j.bbadis.2017.08.020.
  • Weismüller, Tobias J.; Trivedi, Palak J.; Bergquist, Annika; Imam, Mohamad; Lenzen, Henrike & Ponsioen, Cyriel Y. [Vis alle 59 forfattere av denne artikkelen] (2017). Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 152(8), s. 1975–1984.e8. doi: 10.1053/j.gastro.2017.02.038.
  • Henriksen, Eva Kristine Klemsdal; Viken, Marte K; Wittig, Michael; Holm, Kristian; Folseraas, Trine & Mucha, Sören [Vis alle 29 forfattere av denne artikkelen] (2017). HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA. ISSN 2059-2302. 90(4), s. 228–233. doi: 10.1111/tan.13076.
  • Schrumpf, Elisabeth; Jiang, Xiaojun; Zeissig, Sebastian; Pollheimer, Marion J.; Anmarkrud, Jarl Andreas & Tan, Corey [Vis alle 10 forfattere av denne artikkelen] (2017). The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation. Physiological Reports. ISSN 2051-817X. 5:e13117(4), s. 1–12. doi: 10.14814/phy2.13117.
  • Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik & Melum, Espen [Vis alle 23 forfattere av denne artikkelen] (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. ISSN 0168-8278. 66(6), s. 1214–1222. doi: 10.1016/j.jhep.2017.01.019.
  • Jiang, Xiaojun & Karlsen, Tom Hemming (2017). Genetics of primary sclerosing cholangitis and pathophysiological implications. Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 14(5), s. 279–295. doi: 10.1038/nrgastro.2016.154.
  • Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Kaveh, Fatemeh; Holm, Kristian; Hamm, David & Olweus, Johanna [Vis alle 14 forfattere av denne artikkelen] (2017). Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. Journal of Hepatology. ISSN 0168-8278. 66(1), s. 116–122. doi: 10.1016/j.jhep.2016.09.002.
  • Malenicka, S; Ericzon, BG; Jørgensen, MH; Isoniemi, H; Karlsen, Tom Hemming & Krantz, M [Vis alle 14 forfattere av denne artikkelen] (2017). Impaired intention-to-treat survival after listing for liver transplantation in children with biliaratresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries. . Pediatric Transplantation. ISSN 1397-3142. 21(2). doi: 10.1111/petr.12851.
  • Jendrek, Sebastian Torben; Gotthardt, Daniel; Nitzsche, Thomas; Widmann, Laila; Korf, Tobias & Michaels, Maike Anna [Vis alle 23 forfattere av denne artikkelen] (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 66(1), s. 137–144. doi: 10.1136/gutjnl-2016-311739. Fulltekst i vitenarkiv
  • Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli; Vesterhus, Mette; Boyadzhieva, Maria & Solberg, Inger Camilla [Vis alle 11 forfattere av denne artikkelen] (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 37(3), s. 458–465. doi: 10.1111/liv.13238.
  • Schrumpf, Elisabeth; Kummen, Martin; Valestrand, Cecilie; Greiner, Thomas U; Holm, Kristian & Arulampalam, Velmurugesam [Vis alle 13 forfattere av denne artikkelen] (2017). The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation. Journal of Hepatology. ISSN 0168-8278. 66(2), s. 382–389. doi: 10.1016/j.jhep.2016.09.020. Fulltekst i vitenarkiv
  • O'Hara, Steven P; Karlsen, Tom Hemming & LaRusso, Nicholas F. (2017). Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link? Gut. ISSN 0017-5749. 66(11), s. 1873–1877. doi: 10.1136/gutjnl-2017-314249.
  • Maroni, Luca; Agostinelli, Laura; Saccomanno, Stefania; Pinto, Claudio; Giordano, Debora M & Rychilcki, Chiara [Vis alle 14 forfattere av denne artikkelen] (2017). Nlrp3 activation induces Il-18 synthesis and affects the epithelial barrier function in reactive cholangiocytes. American Journal of Pathology. ISSN 0002-9440. 187(2), s. 366–376. doi: 10.1016/j.ajpath.2016.10.010.
  • Guevel, Bardia T; Reynolds, Gary M; Udatha, D.B.R.K. Gupta; Henriksen, Eva Kristine Klemsdal; Stamataki, Zania & Hirschfield, Gideon M. [Vis alle 8 forfattere av denne artikkelen] (2017). Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. Journal of Autoimmunity. ISSN 0896-8411. 77, s. 45–54. doi: 10.1016/j.jaut.2016.10.003.
  • Chung, Brian K. & Karlsen, Tom Hemming (2017). Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease. Digestive Diseases. ISSN 0257-2753. 35(4), s. 323–333. doi: 10.1159/000456583.
  • Sampaziotis, Fotios; Justin, Alexander W.; Tysoe, Olivia C.; Sawiak, Stephen; Godfrey, Edmund M. & Upponi, Sara S. [Vis alle 43 forfattere av denne artikkelen] (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine. ISSN 1078-8956. 23(8), s. 954–963. doi: 10.1038/nm.4360.
  • Karlsen, Tom Hemming; Folseraas, Trine; Thorburn, Douglas & Vesterhus, Mette (2017). Primary sclerosing cholangitis - a comprehensive review. Journal of Hepatology. ISSN 0168-8278. 67(6), s. 1298–1323. doi: 10.1016/j.jhep.2017.07.022.
  • Tronstad, Rune Rose; Kummen, Martin; Holm, Kristian; Volkmann, Hilde Løland Von; Anmarkrud, Jarl Andreas & Høivik, Marte Lie [Vis alle 13 forfattere av denne artikkelen] (2017). Guanylate cyclase C activation shapes the intestinal microbiota in patients with familial diarrhea and increased susceptibility for Crohn's disease. Inflammatory Bowel Diseases. ISSN 1078-0998. 23(10), s. 1752–1761. doi: 10.1097/MIB.0000000000001264.
  • Witoelar, Aree; Jansen, Iris E.; Wang, Yunpeng; Desikan, Rahul S.; Gibbs, J. Raphael & Thompson, Wesley Kurt [Vis alle 26 forfattere av denne artikkelen] (2017). Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurology. ISSN 2168-6149. 74(7), s. 780–792. doi: 10.1001/jamaneurol.2017.0469.
  • Claussen, Jens Christian; Skieceviciene, Jurgita; Wang, Jun; Rausch, Philipp; Karlsen, Tom Hemming & Lieb, Wolfgang [Vis alle 9 forfattere av denne artikkelen] (2017). Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Computational Biology. ISSN 1553-734X. 13(6). doi: 10.1371/journal.pcbi.1005361.
  • Aabakken, Lars; Karlsen, Tom Hemming; Albert, Jörg; Arvanitakis, Marianna; Chazouilleres, Olivier & Dumonceau, Jean-Marc [Vis alle 20 forfattere av denne artikkelen] (2017). Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline. Endoscopy. ISSN 0013-726X. 49(6), s. 588–608. doi: 10.1055/s-0043-107029.
  • Rosati, Elisa; Dowds, C. Marie; Liaskou, Evaggelia; Henriksen, Eva Kristine Klemsdal; Karlsen, Tom Hemming & Franke, Andre (2017). Overview of methodologies for T-cell receptor repertoire analysis. BMC Biotechnology. ISSN 1472-6750. 17:61, s. 1–16. doi: 10.1186/s12896-017-0379-9.
  • Maroni, L.; Hohenester, SD; van de Graaf, SFJ; Tolenaars, D; van Lieden, K & Verheij, J [Vis alle 10 forfattere av denne artikkelen] (2017). Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice. Hepatology. ISSN 0270-9139. 66(2), s. 542–554. doi: 10.1002/hep.29029.
  • Koch, Manja; Freitag-Wolf, Sandra; Schlesinger, Sabrina; Borggrefe, Jan; Hov, Johannes Espolin Roksund & Jensen, Majken K. [Vis alle 23 forfattere av denne artikkelen] (2017). Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. European Journal of Clinical Nutrition. ISSN 0954-3007. 71(8), s. 995–1001. doi: 10.1038/ejcn.2017.43.
  • Rühlemann, Malte C.; Degenhardt, Frauke; Thingholm, Louise B.; Wang, J; Skieceviciene, Jurgita & Rausch, Philipp [Vis alle 13 forfattere av denne artikkelen] (2017). Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. Gut microbes. ISSN 1949-0976. doi: 10.1080/19490976.2017.1356979.
  • Zweers, Serge J.; Shiryaev, Alexey; Komuta, Mina; Vesterhus, Mette; Hov, Johannes Espolin Roksund & Perugorria, Maria J. [Vis alle 17 forfattere av denne artikkelen] (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 36(9), s. 1370–1377. doi: 10.1111/liv.13092.
  • Ellinghaus, David; Jostins, Luke; Spain, Sarah L.; Cortes, Adrian; Bethune, Jörn & Han, Buhm [Vis alle 45 forfattere av denne artikkelen] (2016). Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics. ISSN 1061-4036. 48(5), s. 510–518. doi: 10.1038/ng.3528.
  • Liaskou, Evaggelia; Henriksen, Eva Kristine Klemsdal; Holm, Kristian; Kaveh, Fatemeh; Hamm, D & Fear, Janine [Vis alle 13 forfattere av denne artikkelen] (2016). High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires. Hepatology. ISSN 0270-9139. 63(5), s. 1608–1619. doi: 10.1002/hep.28116.
  • Ponsioen, Cyriel Y.; Chapman, Roger W.; Chazouilleres, Olivier; Hirschfield, Gideon M.; Karlsen, Tom Hemming & Lohse, Ansgar W. [Vis alle 10 forfattere av denne artikkelen] (2016). Surrogate endpoints for clinical trials in primary sclerosing Cholangitis; review and results from an international PSC study Group consensus process. Hepatology. ISSN 0270-9139. 63(4), s. 1357–1367. doi: 10.1002/hep.28256.
  • Kevans, David; Tyler, Andrea D.; Holm, Kristian; Jørgensen, Kristin Kaasen; Vatn, Morten H & Karlsen, Tom Hemming [Vis alle 11 forfattere av denne artikkelen] (2016). Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis. Journal of Crohn's and colitis. ISSN 1873-9946. 10(3), s. 330–337. doi: 10.1093/ecco-jcc/jjv204.
  • Kapica, Aida; Hov, Johannes Espolin Roksund; Borthne, Arne Sigmund; Gleditsch, Jostein; Johannesen, Glenn & Tveit, Knut [Vis alle 19 forfattere av denne artikkelen] (2016). Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease. Gastroenterology. ISSN 0016-5085. 151(4), s. 660–669. doi: 10.1053/j.gastro.2016.06.021.
  • Skagen, Karolina Ryeng; Trøseid, Marius; Ueland, Thor; Holm, Sverre; Abbas, Azhar & Gregersen, Ida [Vis alle 17 forfattere av denne artikkelen] (2016). The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis. ISSN 0021-9150. 247, s. 64–69. doi: 10.1016/j.atherosclerosis.2016.01.033.
  • Harbord, M; Annese, V; Vavricka, SR; Allez, M.; Barreiro-de Acosta, M & Boberg, Kirsten Muri [Vis alle 21 forfattere av denne artikkelen] (2016). The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease. Journal of Crohn's and colitis. ISSN 1873-9946. 10(3), s. 239–254. doi: 10.1093/ecco-jcc/jjv213.
  • Saadati, Hamid Reza; Wittig, Michael; Helbig, Ingo; Häsler, Robert; Anderson, Carl A. & Mathew, Christopher G. [Vis alle 12 forfattere av denne artikkelen] (2016). Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci. BMC Medical Genetics. ISSN 1471-2350. 17(1). doi: 10.1186/s12881-016-0289-z.
  • Jørgensen, Silje Fjellgård; Trøseid, Marius; Kummen, Martin; Anmarkrud, Jarl Andreas; Michelsen, Annika & Osnes, Liv T. N. [Vis alle 21 forfattere av denne artikkelen] (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology. ISSN 1933-0219. doi: 10.1038/mi.2016.18.
  • Wang, Jun; Thingholm, Louise B.; Skiecevičienė, Jurgita; Rausch, Philipp; Kummen, Martin & Hov, Johannes Espolin Roksund [Vis alle 39 forfattere av denne artikkelen] (2016). Genome-wide association analysis identifies variation in Vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics. ISSN 1061-4036. 48(11), s. 1396–1406. doi: 10.1038/ng.3695.
  • Yokoyama, Jennifer S.; Wang, Yunpeng; Schork, Andrew J.; Thompson, Wesley K.; Karch, Celeste M. & Cruchaga, Carlos [Vis alle 28 forfattere av denne artikkelen] (2016). Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurology. ISSN 2168-6149. 73(6), s. 691–697. doi: 10.1001/jamaneurol.2016.0150.
  • D'Agnolo, Hedwig M.A.; Kievit, Wietske; Andrade, Raul J.; Karlsen, Tom Hemming; Wedemeyer, Heiner & Drenth, Joost P.H. (2016). Creating an effective clinical registry for rare diseases. United European Gastroenterology journal. ISSN 2050-6406. 4(3), s. 333–338. doi: 10.1177/2050640615618042.
  • Kummen, Martin; Holm, Kristian; Anmarkrud, Jarl Andreas; Nygård, Ståle; Vesterhus, Mette & Høivik, Marte [Vis alle 14 forfattere av denne artikkelen] (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. ISSN 0017-5749. 66(4), s. 611–619. doi: 10.1136/gutjnl-2015-310500.
  • Zenouzi, Roman; Weismüller, Tobias J; Jørgensen, Kristin Kaasen; Bubenheim, Michael; Lenzen, Henrike & Hübener, Peter [Vis alle 19 forfattere av denne artikkelen] (2016). No Evidence That Azathioprine Increases Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 14(12), s. 1806–1812. doi: 10.1016/j.cgh.2016.07.032.
  • Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M. & Boberg, Kirsten Muri [Vis alle 10 forfattere av denne artikkelen] (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology journal. ISSN 2050-6406. 5(4), s. 532–541. doi: 10.1177/2050640616663453.
  • Ji, Sun-Gou; Juran, Brian D.; Mucha, Sören; Folseraas, Trine; Jostins, Luke & Melum, Espen [Vis alle 39 forfattere av denne artikkelen] (2016). Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics. ISSN 1061-4036. 49(20), s. 269–273. doi: 10.1038/ng.3745.
  • Jørgensen, Silje Fjellgård; Reims, Henrik Mikael; Frydenlund, Didrik Søli; Holm, Kristian; Paulsen, Vemund & Michelsen, Annika [Vis alle 23 forfattere av denne artikkelen] (2016). A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients with Common Variable Immunodeficiency. American Journal of Gastroenterology. ISSN 0002-9270. 111(10), s. 1467–1475. doi: 10.1038/ajg.2016.329.
  • Karlsen, Tom Hemming (2016). Primary sclerosing cholangitis: 50 years of a gut-liver relationship and still no love? Gut. ISSN 0017-5749. 65(10), s. 1579–1581. doi: 10.1136/gutjnl-2016-312137.
  • Schrumpf, Elisabeth; Tan, Corey; Karlsen, Tom Hemming; Sponheim, Jon; Björkström, Niklas K. & Sundnes, Olav [Vis alle 16 forfattere av denne artikkelen] (2015). The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. ISSN 0270-9139. 62(4), s. 1249–1259. doi: 10.1002/hep.27840.
  • Hov, Johannes Espolin Roksund; Zhong, Huanzi; Qin, Bincai; Anmarkrud, Jarl Andreas; Holm, Kristian & Franke, Andre [Vis alle 8 forfattere av denne artikkelen] (2015). The influence of the autoimmunity-associated ancestral HLA haplotype AH8.1 on the human gut microbiota: A cross-sectional study. PLOS ONE. ISSN 1932-6203. 10:e0133804(7). doi: 10.1371/journal.pone.0133804.
  • Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders; Schrumpf, Erik; Nygård, Ståle & Godang, Kristin [Vis alle 25 forfattere av denne artikkelen] (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 62(1), s. 188–197. doi: 10.1002/hep.27825.
  • Thorsen, Trygve; Aandahl, Einar Martin; Bennet, William; Olausson, Michael; Ericzon, Bo-Göran & Nowak, Greg [Vis alle 11 forfattere av denne artikkelen] (2015). Transplantation with livers from deceased donors older than 75 years. Transplantation. ISSN 0041-1337. 99(12), s. 2534–2542. doi: 10.1097/TP.0000000000000728.
  • Vukcevic, Damjan; Traherne, James A.; Næss, Sigrid; Ellinghaus, Eva; Kamatani, Yoichiro & Dilthey, Alexander [Vis alle 15 forfattere av denne artikkelen] (2015). Imputation of KIR Types from SNP Variation Data. American Journal of Human Genetics. ISSN 0002-9297. 97(4), s. 593–607. doi: 10.1016/j.ajhg.2015.09.005.

Se alle arbeider i Cristin

  • Borgstrøm, Reidar; Karlsen, Tom Hemming & Lundin, Knut Erik Aslaksen (2019). Er årets villreinkvote på Hardangervidda en ny standard i norsk viltforvaltning? Nationen. ISSN 0805-3782.
  • Reimers, Eigil; Borgstrøm, Reidar; Hjeljord, Olav; Lundin, Knut Erik Aslaksen & Karlsen, Tom Hemming (2019). Faglig uforsvarlig tiltak mot skrantesyke. Dagens næringsliv. ISSN 0803-9372.
  • Karlsen, Tom Hemming & Newsome, Phil N (2019). The dawn of a new EASL – A new chapter in the history of the European Association for the Study of the liver. Journal of Hepatology. ISSN 0168-8278. 71(1), s. 5–8. doi: 10.1016/j.jhep.2019.03.010.
  • Karlsen, Tom Hemming & Tacke, Frank (2018). <The times they are a'changin?> ? Positioning the European Association for the Study of the Liver in the changing landscape of hepatology. Journal of Hepatology. ISSN 0168-8278. 68(5), s. 873–875. doi: 10.1016/j.jhep.2018.02.001.
  • Colombo, Massimo & Karlsen, Tom Hemming (2018). The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother. Journal of Hepatology. ISSN 0168-8278. doi: 10.1016/j.jhep.2018.11.017.
  • Jørgensen, Silje Fjellgård; Macpherson, Magnhild E; Bjøro, Kristian; Karlsen, Tom Hemming; Reims, Henrik Mikael & Grzyb, Krzysztof [Vis alle 10 forfattere av denne artikkelen] (2016). Liver transplantation in patients with primary antibody deficiency. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. doi: 10.1016/j.jaci.2016.10.025.
  • Karlsen, Tom Hemming & Hirschfield, Gideon M. (2016). Genetics of Primary Sclerosing Cholangitis. I Forman, Lisa (Red.), Primary Sclerosing Cholangitis. Current Understanding, Management, and Future Developments. Springer. ISSN 978-3-319-40906-1. s. 99–110. doi: 10.1007/978-3-319-40908-5_8.
  • Tronstad, Rune Rose; Fiskerstrand, Torunn; Karlsen, Tom Hemming; Knappskog, Per & Le Hellard, Stephanie (2019). Clinical and molecular effects of guanylate cyclase C-activation. Universitetet i Bergen. ISSN 9788230854426.

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Publisert 25. nov. 2014 13:07 - Sist endret 16. okt. 2020 11:20