About the group
Our aim is to understand how the tumor microenvironment influences NK cell functions, and to manipulate NK cells to resist tumor-mediated suppression
Projects
- Developing NK-cell derived exosomes for cancer therapy
- In-depth mechanistic studies of how leukemia blasts evade and suppress the immune system using rat models of T-ALL and AML. Projects include ex vivo manipulation of NK cells for immunotherapy, and investigations of whether exosomes released from leukemic blasts affect NK cell tumor immunosurveillance.
- Developmental and functional characterization of NK cell subsets and ILCs in different tissues in the rat, and their regulation of inflammation.
- Evaluation of exosomes as early prognostic markers for risk stratification of pediatric acute leukemia.
- Characterization of intracellular signaling cascades in human NK cells.
Cooperation
- Fridtjof Lund-Johansen, Dept of Immunology, Oslo University Hospital
- Professor Erik Dissen, IMB, University of Oslo
- Professor Anne Dickinson, Newcastle University, UK
- Professor Ralf Dressel, Göttingen University, Germany
- Professor Alexander Steinle, Goethe University Frankfurt, Germany
- Professor Helga Schmetzer, University Hospital of Munich, Germany