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Structural biology and DNA repair

The group works with the structural biology of DNA repair with the aim to understand the damage recognition mechanisms and enzymatic catalysis at the atomic level. 

The group also use structural biology and enzymatic assays as important methods to design novel drugs against cancer.

The major focus is on base excision repair and DNA glycosylases, which are involved in detection and elimination of chemically modified nucleotides with a mutagenic potential, and as such are also interesting targets for cancer drugs.

The group is also responsible for the daily operation of the Helse Sør-Øst regional core facility for structural biology. The core facility is involved in a series of projects related to a diverse range of topics such as immunology, DNA repair and replication, metabolic diseases (tyrosinemia, MSUD, vitamin B12-metabolism), glycosylation defects and various forms of cancer.

Projects

  • Structural biology of DNA base repair
  • Inhibitors of human DNA glycosylases
  • Inhibitors of transaminases
  • Single-molecule imaging and DNA scanning Metabolic disorders related to glycosylation defects or amino acid metabolism Core-facility projects
Published Mar. 14, 2017 2:14 PM - Last modified June 27, 2023 7:53 AM

Contact

Group leader

Participants

Detailed list of participants