Structural biology and DNA repair
The group works with the structural biology of DNA repair with the aim to understand the damage recognition mechanisms and enzymatic catalysis at the atomic level.
The major focus is on base excision repair and DNA glycosylases, which are involved in detection and elimination of chemically modified nucleotides with a mutagenic potential.
The human DNA glycosylases are also potential drug targets in cancer therapy, and we also use structure-based methods to identify possible inhibitors that may work as adjuvants in cancer therapy.
The group is also responsible for the daily operation of the Helse Sør-Øst regional core facility for structural biology. The core facility has been involved in projects related to a diverse range of topics such as immunology, DNA repair and replication, metabolic diseases (tyrosinemia, MSUD, vitamin B12-metabolism), glycosylation defects, cancer and protein kinases.
- Structural biology of DNA base repair
- Inhibitors of human DNA glycosylases
- Endonuclease V and RNA metabolism/editing
- Single-molecule imaging and DNA scanning
- Metabolic disorders related to glycosylation defects or amino acid metabolism
- Core-facility projects
- Inhibitors for human BCAT1 and BCAT2
- Antimicrobal resistance