Projects
Examples of ongoing projects in our group:
- Antiarrhythmic effects of exercise training
- Mechanisms and therapeutic strategies for arrhythmias in CPVT
- Novel therapeutic targets for arrhythmias induced by ischemia and reperfusion
- Beneficial effects of exercise training in hypertrophic cardiomyopathy
Selected publications
- Stokke MK, Briston SJ, Jølle GF, Louch WE, Øyehaug L, Christensen G, Eisner DA, Trafford AW, Sjaastad I. Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content. Cardiovasc Res. 2011;90(3):503-512
- Stokke MK*, Tovsrud N*, Louch WE, Øyehaug L, Hougen K, Sejersted OM, Swift F, Sjaastad I. ICaL inhibition prevents arrhythmogenic Ca2+ release caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation. Cardiovasc Res. 2013;98(2):315-25
- Manotheepan R, Saberniak J, Danielsen TK, Edvardsen T, Sjaastad I, Haugaa KH, Stokke MK. Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1. Am J Cardiol. 2014; 113(11):1829-33.
- Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK. Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release. Cardiovasc Res. 2016;111(3):295-306.
- Danielsen T, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent K, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK. Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation. PLoS One. 2018 Nov 6;13(11):e0207100
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Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK. CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H446-H460. doi: 10.1152/ajpheart.00011.2021. Epub 2021 Jul 16. PMID: 34270372.
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Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK. Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure. Front Cardiovasc Med. 2021 Jan 25;7:623922. doi: 10.3389/fcvm.2020.623922. PMID: 33569394; PMCID: PMC7868397.