Publications

An overview of selected publications by the research network.

Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor. Myhre AE, Meyer-Myklestad MH, Gullaksen HH, Søgaard OS, Tolstrup M, Salgado M, Martinez-Picado J, Holberg-Petersen M, Juhl AK, Schleimann MH, Gunst JD, Thomsen A, Fisher K, Bhamra JS, Kran AB, Halvorsen B, Dyrhol-Riise AM, Reikvam DH, Aukrust P, Gedde-Dahl T; Oslo HIV Cure Study Group; Dahl TB, Kaarbø M, Trøseid M. Nat Microbiol. 2026 May;11(5):1374-1386. doi: 10.1038/s41564-026-02304-8. Epub 2026 Apr 13. PMID: 41975092
Transcriptomic and proteomic profiling reveal immune and metabolic dysregulation in the colonic mucosa of people living with HIV with incomplete immune recovery. Kaarbø M, Yang M, Meyer-Myklestad MH, Sundaram AYM, de Sousa MML, Sharma A, Medhus AW, Dyrhol-Riise AM, Kvale D, Hov JR, Aukrust P, Bjørås M, Reikvam DH. Front Immunol. 2025 Sep 17;16:1635523. doi: 10.3389/fimmu.2025.1635523. eCollection 2025. PMID: 41041301
Microbiome profiling reveals gut bacterial species associated with rapid lung function decline in people with HIV. Bai X, Raju SC, Knudsen AD, Thudium RF, Arentoft NS, Gelpi M, Heidari SL, Kunisaki KM, Kristiansen K, Hov JR, Nielsen SD, Trøseid M. Front Immunol. 2025 Jun 10;16:1555441. doi: 10.3389/fimmu.2025.1555441. eCollection 2025. PMID: 40557154
Markers of extracellular matrix degradation and inflammasome activation are associated with carotid plaques in virally suppressed people with HIV in Botswana. Ueland T, Nkele I, Hoel H, Lockman S, Michelsen AE, Moshomo T, Aukrust P, Mohammed T, Trøseid M, Mosepele M. AIDS. 2025 Jan 1;39(1):22-30. doi: 10.1097/QAD.0000000000004014. Epub 2024 Sep 13. PMID: 3928374
Chronic HIV Infection Increases Monocyte NLRP3 Inflammasome-Dependent IL-1α and IL-1β Release. Hoel H, Dahl TB, Yang K, Skeie LG, Michelsen AE, Ueland T, Damås JK, Dyrhol-Riise AM, Fevang B, Yndestad A, Aukrust P, Trøseid M, Sandanger Ø. Int J Mol Sci. 2024 Jun 28;25(13):7141. doi: 10.3390/ijms25137141. PMID: 39000248
Pulmonary comorbidities in people with HIV- the microbiome connection. Bai X, Nielsen SD, Kunisaki KM, Trøseid M. Curr Opin HIV AIDS. 2024 Sep 1;19(5):246-252. doi: 10.1097/COH.0000000000000871. Epub 2024 Jun 25. PMID: 38935049
Gut microbiome and cardiometabolic comorbidities in people living with HIV. Trøseid M, Nielsen SD, Vujkovic-Cvijin I. Microbiome. 2024 Jun 14;12(1):106. doi: 10.1186/s40168-024-01815-y. PMID: 38877521
Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV. Trøseid M, Molinaro A, Gelpi M, Vestad B, Kofoed KF, Fuchs A, Køber L, Holm K, Benfield T, Ueland PM, Hov JR, Nielsen SD, Knudsen AD. J Infect Dis. 2024 Mar 14;229(3):898-907. doi: 10.1093/infdis/jiad604. PMID: 38195204
Vaccine responses and hybrid immunity in people living with HIV after SARS-CoV-2 breakthrough infections. Alirezaylavasani A, Skeie LG, Egner IM, Chopra A, Dahl TB, Prebensen C, Vaage JT, Halvorsen B, Lund-Johansen F, Tonby K, Reikvam DH, Stiksrud B, Holter JC, Dyrhol-Riise AM, Munthe LA, Kared H.NPJ Vaccines. 2024 Oct 9;9(1):185. doi: 10.1038/s41541-024-00972-3. PMID: 39384763
Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial. Gunst JD, Højen JF, Pahus MH, Rosás-Umbert M, Stiksrud B, McMahon JH, Denton PW, Nielsen H, Johansen IS, Benfield T, Leth S, Gerstoft J, Østergaard L, Schleimann MH, Olesen R, Støvring H, Vibholm L, Weis N, Dyrhol-Riise AM, Pedersen KBH, Lau JSY, Copertino DC Jr, Linden N, Huynh TT, Ramos V, Jones RB, Lewin SR, Tolstrup M, Rasmussen TA, Nussenzweig MC, Caskey M, Reikvam DH, Søgaard OS.Nat Med. 2023. Oct;29(10):2547-2558. PMID: 37696935
Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer. Serrano-Villar S, Tincati C, Raju SC, Sáenz JS, Moreno E, Bargiela R, Cabello-Ubeda A, Sendagorta E, Kurz A, Perez Molina JA, de Benito A, Hov JR, Fernandez-Lopez L, Muriel A, Del Campo R, Moreno S, Trøseid M*, Seifert J*, Ferrer M*.Nat Med 2023; 29: 1738-49.
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction. Meyer-Myklestad MH, Medhus AW, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Stiksrud B, Trøseid M, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Reikvam DH. J Infect Dis. 2022 Feb 15;225(4):661-674. PMID: 33216130
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk. Vestad B, Nyman TA, Hove-Skovsgaard M, Stensland M, Hoel H, Siebke Trøseid AM, Trude A, Aass HC, Puhka M, Hov JR, Nielsen SD, Øvstebø R, Trøseid M, Sci Rep. 2021 Nov 9;11(1):21936. doi: 10.1038/s41598-021-01334-y.
Probiotics to HIV-infected immunological nonresponders; altered mucosal immunity and microbial diversity restricted to ileum. Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH. J Acquir Immune Defic Syndr. 2021 (Published Ahead-of-print)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders. Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH. Front Immunol. 2021 Oct 7;12:744155. PMID: 34691047
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. Drivsholm N, Knudsen AD, Faurholt-Jepsen M, Midttun Ø, Trøseid M, Kirkegaard-Klitbo DM, Ueland PM, Nielsen SD, Gelpi M. J Acquir Immune Defic Syndr. 2021 Jun 1;87(2):e177-e181. PMID: 33633032
Independent Associations of Tumor Necrosis Factor-Alpha and Interleukin-1 Beta With Radiographic Emphysema in People Living With HIV. Thudium RF, Ringheim H, Ronit A, Hoel H, Benfield T, Mocroft A, Gerstoft J, Trøseid M, Borges ÁH, Ostrowski SR, Vestbo J, Nielsen SD.Front Immunol. 2021 Apr 14;12:668113. PMID: 33936110
No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers. Hove-Skovsgaard M, Abildgaard J, Gelpi M, Gaardbo JC, Kolte L, Ullum H, Trøseid M, Lindegaard B, Nielsen SD. BMC Infect Dis. 2020 Nov 25;20(1):882. PMID: 33238950
Probiotics to manage inflammation in HIV infection. Reikvam DH, Meyer-Myklestad MH, Trøseid M, Stiksrud B. Curr Opin Infect Dis. 2020 Feb;33(1):34-43. PMID: 31789692
Impact of HIV-related gut microbiota alterations on metabolic comorbidities. Gelpi M & Vestad B, Hyll Hansen S, Holm K, Drivsholm N, Goetz A, Kirkby NS, Lindegaard B, Lebech AM, Hoel H, Michelsen AE, Ueland T, Gerstoft J, Lundgren J, Hov JR, Nielsen SD, Trøseid M. Clin Inf Dis 2020.
Soluble markers of IL-1 activation as predictors of first-time myocardial infarction in HIV-infected individuals. Hoel H , Ueland T, Knudsen A, Kjær A, Michelsen A, Sagen E, Halvorsen , Yndestad A, Dam Nielsen S, Aukrust P , Lebech AM, Trøseid M. J Inf Dis 2019.
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery. Stiksrud B, Aass HCD, Lorvik KB, Ueland T, Trøseid M, Dyrhol-Riise AM AIDS. 2019 Jun 1;33(7):1117-1129.
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals. Storm-Larsen C, Stiksrud B, Eriksen C, Nowak P, Holm K, Thalme A, Dyrhol-Riise AM, Brix S, Hov JR, Trøseid M*. AIDS. 2019 Mar 15;33(4):645-653.
Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis. Bösl, K., Ianevski, A., Than, T. T., Andersen, P. I., Kuivanen, S., Teppor, M., Zusinaite, E., Dumpis, U., Vitkauskiene, A., Cox, R. J., Kallio-Kokko, H., Bergqvist, A., Tenson, T., Merits, A., Oksenych, V., Bjørås, M., Anthonsen, M. W., Shum, D., Kaarbø, M., Vapalahti, O., Windisch, M. P., Superti-Furga, G., Snijder, B., Kainov, D., and Kandasamy, R. K. Frontiers in immunology 2019, 10, 2186
Gut microbiota diversity predicts immune status in HIV-1 infection. Nowak P*, Trøseid M, Avershina E, Nwosu F, Barqasho B, Holm K, Hov J, Noyan K, Vesterbacka J, Svard J, Rudi K, Sonnerborg A. AIDS 2015; 29: 2409-18.
Reduced levels of D-dimer and changes in gut microbiota composition after probiotic Intervention in HIV-individuals on stable ART. Stiksrud B, Nowak P, Nwosu F, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AE, Rudi K, Hov JR, Dyrhol-Riise AM, Trøseid M. JAIDS 2015: 70; 329-37.

Published Sep. 29, 2020 2:32 PM - Last modified June 9, 2026 8:38 AM