Public Defence: Naiyereh Mohammadzadeh
MSc Naiyereh Mohammadzadeh at Institute of Clinical Medicine will be defending the thesis “Roles of the proteoglycans lumican and fibromodulin in cardiac remodeling following pressure overload” for the degree of PhD (Philosophiae Doctor).
Trial Lecture – time and place
See Trial Lecture.
- First opponent: Professor Nikos Karamanos, Department of Chemistry, University of Patras, Greece
- Second opponent: Professor II Kristian Bartnes, Department of Clinical Medicine, UiT - The Arctic University of Norway
- Third member and chair of the evaluation committee: Professor II Ingebjørg Seljeflot, University of Oslo
Chair of the Defence
Professor II Kjetil Sunde, University of Oslo.
Professor II Theis Tønnessen, University of Oslo
Cardiac remodeling following pressure overload is seen in patients with hypertension and aortic stenosis, and can lead to heart failure. Cardiac fibrosis is a hallmark of cardiac remodeling. Lumican (LUM) and fibromodulin (FMOD) are structural proteins which are increased in experimental and clinical models of pressure overload and cardiac fibrosis. We have induced pressure overload by aortic banding in genetically-modified mouse models to investigate the role of LUM and FMOD in cardiac remodeling, with focus on cardiac fibrosis.
We have used echocardiography, microscopy and gene or protein expression analysis to look at cardiac function and structure following AB-induced pressure overload. We have shown that total and moderate LUM deficiency attenuates cardiac collagen production and deposition i.e. fibrosis post-AB. Moreover, we showed that total LUM deficiency increases mortality and exacerbates cardiac dilatation and function post-AB, while moderate LUM deficiency does not impact mortality and improves cardiac function. These data indicate that LUM has a gene dosage effect. In vitro cell culture experiments showed that LUM is a pro-fibrotic protein.
Total FMOD deficiency mildly increased cardiac hypertrophy with no effect on mortality or cardiac fibrosis post-AB. In vitro, FMOD had anti-fibrotic characteristics.
In conclusion, LUM and FMOD might be future potential therapeutic targets for diagnosis and treatment of cardiac fibrosis.
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