Digital Public Defence: Vibeke Bratseth

MSc Vibeke Bratseth at Institute of Clinical Medicine will be defending the thesis “Pro-thrombotic activity and circulating microvesicles in diabetes, with and without CAD. Special emphasis on the influence of exercise training and longitudinal development” for the degree of PhD (Philosophiae Doctor).

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Foto: Ine Eriksen, UiO

The public defence will be held as a video conference over Zoom.

The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.

Click here to participate in the public defence

Download Zoom here

Order a digital copy of the thesis here

Digital Trial Lecture – time and place

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Adjudication committee

  • First opponent: Professor Søren Risom Kristensen, Aalborg University Hospital, Denmark
  • Second opponent: Docent, Senior Consultant Christina Christersson, Uppsala University, Akademiska sjukhuset Uppsala, Sweden 
  • Third member and chair of the evaluation committee: Professor Kåre I. Birkeland, University of Oslo

Chair of the Defence

Professor II Pål Andre Holme, Faculty of Medicine, University of Oslo

Principal Supervisor

Professor II Ingebjørg Seljeflot, Faculty of Medicine, University of Oslo

Summary

In patients with diabetes mellitus (DM) accelerated atherosclerosis, cardiovascular disease (CVD) and atherothrombotic events are the major reasons for morbidity and mortality. Circulating microvesicles (cMVs), shed from the plasma membrane of activated and apoptotic cells, assess procoagulant properties. Exercise training is shown to be beneficial in patients with DM and in those with established CVD, however, in patients with combined diseases, long-term effects of exercise training, especially on prothrombotic activity is less explored. In the “EXercise training in patients with Coronary Artery disease and type 2 DIabetes” (EXCADI) study in which patients were randomized to 150 min organized exercise training per week or conventional follow-up for one-year, we investigated the effect on cMVs and selected markers of prothrombotic activity and the thrombin generation potential (n= 131). One-year exercise training had no significant effect on prothrombotic activity, independent of disease severity. Overall, our results thus contribute to safety of exercise training in this high-risk population. Hypercoagulability as well as cMVs from activated endothelial cells associated strongly with the presence of albuminuria, confirming the procoagulant state in these patients. In children and adolescents with type 1 DM (T1D) (n= 314) compared with healthy controls (n= 120), all participating in the prospective cohort “Atherosclerosis and Childhood Diabetes” (ACD), we explored the prothrombotic state and cMVs. In a five-year perspective, the T1D group showed comparable prothrombotic activity as healthy controls, indicating absence of thrombotic traits at this younger age. However, children/adolescents with T1D presented with higher levels of tissue factor pathway inhibitor (TFPI) that associated with deteriorated glycemic control, indicative of endothelial activation, and highlighting the importance of strict glycemic control.

Additional information

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Published Nov. 19, 2020 4:11 PM - Last modified Nov. 20, 2020 1:00 PM