Digital Public Defence: Brede Kvisvik Brede Alexander Havneraas Kvisvik at Institute of Clinical Medicine will be defending the thesis “Cardiovascular risk stratification in the general population and patients with coronary artery disease – Clinical studies on novel biochemical and echocardiographic markers” for the degree of PhD (Philosophiae Doctor).

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Photo: Elisabeth Teigland/Elitefoto.

The University of Oslo arranges digital public defences this semester, thus the disputation will be held as a video conference over Zoom.

The public defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.

Click here to participate in the public defence

Download Zoom here


Digital Trial Lecture – time and place

See Digital Trial Lecture.

Adjudication committee

  • First opponent: Professor Stefan James, Uppsala University, Sweden
  • Second opponent: Associate professor Kristin M. Aakre, University of Bergen
  • Third member and chair of the evaluation committee: Professor II Henrik Schirmer, University of Oslo

Chair of the Defence

Professor Knut Stavem, University of Oslo

Principal Supervisor

Phd Jørgen Gravning, University of Oslo


Coronary artery disease is one of the leading causes of mortality in the western world, and early identification is essential to reduce the burden of cardiovascular disease. Patients with coronary artery disease range from persons with subclinical disease to patients with acute coronary syndrome.

The thesis aimed to improve the diagnostic and prognostic assessment of cardiovascular events in the general population, and in patients with stable and acute coronary syndrome.

Mechanical dispersion is a novel echocardiographic marker that measures the contraction heterogeneity of the left ventricle. In a general population, increased mechanical dispersion was associated with established cardiovascular risk factors.

NT-proBNP was superior to both novel and established biochemical and echocardiographic markers in the prediction of adverse outcomes. Mechanical dispersion gave incremental information to already established echocardiographic markers. Although high-sensitivity troponin T and I had similar abilities in the detection of coronary lesions, we found biological differences between the analytical assays that could impact the clinical interpretation.

Overall, novel biochemical and echocardiographic markers are vital in the evaluation of patients with coronary artery disease. However, there is still a lot to learn about this complex patient group.

Additional information

Contact the research support staff.

Published June 4, 2020 11:04 AM - Last modified June 19, 2020 2:27 PM